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Article ; Online: Spread of hyperplastic pulmonary neuroendocrine cells into air spaces (S.H.I.P.M.E.N.T.S): A proof for artifact.

Pelosi, Giuseppe / Nesa, Francesco / Taietti, Davide / Servillo, Sascia Pietro / Papanikolaou, Nikolaos / Zompatori, Maurizio / Meroni, Alberto / Harari, Sergio / Incarbone, Matteo

Lung cancer (Amsterdam, Netherlands)

2019 Volume 137, Page(s) 43–47

Abstract: Objectives: Spread through air spaces (STAS) is a recently proposed invasion way of lung cancer, including neuroendocrine (NE) neoplasms. However, if this phenomenon is a real one or an artifact while manipulating lung specimens, it is still matter of ... ...

Abstract	Objectives: Spread through air spaces (STAS) is a recently proposed invasion way of lung cancer, including neuroendocrine (NE) neoplasms. However, if this phenomenon is a real one or an artifact while manipulating lung specimens, it is still matter of debate. Material and methods: Three consecutive patients with newly diagnosed diffuse idiopathic pulmonary NE cell hyperplasia (DIPNECH) were reviewed for STAS. Results: In well-fixed lung specimens, DIPNECH was seen to coexist with atypical carcinoid, bifocal typical carcinoid and adenocarcinoma in the three patients, respectively. While STAS was not observed at the growing edges of tumors, a few freely-floating aggregates of hyperplastic NE cells within air spaces were noticed to emanate from foci of NE hyperplasia and tumorlets and in intimate association with normal bronchiolar cells and erythrocytes to denote artifactual derivation upon tissue manipulation. Conclusions: Traveling of hyperplastic NE cells through air spaces is likely to artifactually occur via knife, surgeon or other way, thus challenging invasion by STAS.
MeSH term(s)	Adenocarcinoma of Lung/pathology ; Aged ; Artifacts ; Carcinoid Tumor/pathology ; Female ; Humans ; Hyperplasia/pathology ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neuroendocrine Cells/pathology ; Neuroendocrine Tumors/pathology ; Prognosis
Language	English
Publishing date	2019-09-13
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2019.09.006
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The relationship between the P wave and local atrial electrogram in predicting conduction block during catheter ablation of cavo-tricuspid isthmus-dependent atrial flutter.

Yokokawa, Miki / Sinno, Mohamad C / Saeed, Mohammed / Latchamsetty, Rakesh / Ghanbari, Hamid / Crawford, Thomas / Jongnarangsin, Krit / Cunnane, Ryan / Pelosi, Frank / Bogun, Frank / Chugh, Aman / Morady, Fred / Oral, Hakan

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2018 Volume 53, Issue 2, Page(s) 187–193

Abstract: ... to evaluate the utility of the temporal relationship between the P wave and the local atrial electrograms ... During pacing from the coronary sinus (CS), the intervals from the peak of the P wave (P: Results ... The mean P: Conclusions: During pacing from the CS, the temporal relationship between the P wave in lead ...

Abstract	Purpose: The endpoint for radiofrequency catheter ablation (RFA) of cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL) is complete conduction block along the CTI. The purpose of this study is to evaluate the utility of the temporal relationship between the P wave and the local atrial electrograms in determining complete CTI block. Methods: RFA of CTI was performed in 125 patients (age 63 ± 11 years). During pacing from the coronary sinus (CS), the intervals from the peak of the P wave (P Results: The mean P Conclusions: During pacing from the CS, the temporal relationship between the P wave in lead V
MeSH term(s)	Adult ; Aged ; Atrial Flutter/diagnostic imaging ; Atrial Flutter/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Cohort Studies ; Coronary Sinus/diagnostic imaging ; Coronary Sinus/pathology ; Electrocardiography/methods ; Electrophysiologic Techniques, Cardiac ; Female ; Follow-Up Studies ; Heart Block/diagnostic imaging ; Heart Block/physiopathology ; Heart Conduction System/pathology ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Observer Variation ; ROC Curve ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/pathology
Language	English
Publishing date	2018-05-11
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-018-0378-3
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Article ; Online: A personal trip into spirituality and religion in critical care.

Pelosi, Paolo

Intensive care medicine

2023 Volume 49, Issue 8, Page(s) 1038–1039

MeSH term(s)	Humans ; Spirituality ; Religion ; Critical Care
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Editorial
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-023-07120-w
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Zs.A 1089: Show issues

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Article: P wave polarity during pacing in pulmonary veins.

Tse, H F / Lau, C P / Lee, K L / Pelosi, F / Oral, H / Knight, B P / Strickberger, S A / Morady, F

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2001 Volume 5, Issue 2, Page(s) 167–172

Abstract: ... atrial fibrillation often arise in pulmonary veins. The purpose of this study was to evaluate whether P wave polarity ... ablation of paroxysmal atrial fibrillation, P wave polarity on a 12-lead electrocardiogram (ECG) was ... and within each of the 4 pulmonary veins. P waves were categorized as positive, negative, biphasic or ...

Abstract	Introduction: Recent studies have demonstrated that premature depolarizations that trigger atrial fibrillation often arise in pulmonary veins. The purpose of this study was to evaluate whether P wave polarity is helpful in distinguishing which of the 4 pulmonary veins is the site of origin of a premature depolarization. Methods and results: In 28 patients without structural heart disease who underwent focal ablation of paroxysmal atrial fibrillation, P wave polarity on a 12-lead electrocardiogram (ECG) was analyzed during sinus rhythm, and during pacing at a cycle length of 500--600 ms in the high right atrium and within each of the 4 pulmonary veins. P waves were categorized as positive, negative, biphasic or isoelectric. A negative or biphasic P wave in lead I (sensitivity 85 %, specificity 71 %) or a positive P wave in V1 (sensitivity 85 %, specificity 89 %) were helpful in predicting a pulmonary venous site of origin as opposed to a right atrial site of origin. A positive P wave in lead II and III distinguished superior from inferior pulmonary veins (sensitivity 90 %, specificity 84 %). The sensitivity and specificity of negative or biphasic P waves in lead aVL in distinguishing a left from right pulmonary vein site of origin were 94 % and 42 %, respectively. Conclusions: Analysis of P waves polarity may be helpful in localizing the pulmonary vein that is the site of origin of a premature depolarization. Among the 12 ECG leads, I, II, III, aVL, and V1 are the most helpful in regionalizing premature depolarizations arising in the pulmonary veins.
MeSH term(s)	Adult ; Cardiac Pacing, Artificial ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Pulmonary Veins/physiology ; Sensitivity and Specificity
Language	English
Publishing date	2001-04-24
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1023/a:1011429524859
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Article: A long R-P paroxysmal supraventricular tachycardia: What is the mechanism?

Crawford, Thomas C / Morady, Fred / Pelosi, Frank

Heart rhythm

2007 Volume 4, Issue 10, Page(s) 1364–1365

MeSH term(s)	Atrioventricular Node/physiopathology ; Atrioventricular Node/surgery ; Cardiac Pacing, Artificial ; Diagnosis, Differential ; Electrocardiography ; Heart Atria/physiopathology ; Heart Atria/surgery ; Heart Ventricles/physiopathology ; Heart Ventricles/surgery ; Humans ; Male ; Middle Aged ; Signal Processing, Computer-Assisted ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Atrioventricular Nodal Reentry/physiopathology ; Tachycardia, Atrioventricular Nodal Reentry/surgery ; Tachycardia, Paroxysmal/diagnosis ; Tachycardia, Paroxysmal/physiopathology ; Tachycardia, Paroxysmal/surgery ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/physiopathology ; Tachycardia, Supraventricular/surgery
Language	English
Publishing date	2007-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2007.01.025
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Zs.A 6278: Show issues

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Article ; Online: Developing a bioinformatics pipeline for comparative protein classification analysis

Pelosi, Benedetta

BMC Genom Data. 2022 Dec., v. 23, no. 1 p.43-43

2022

Abstract: BACKGROUND: Protein classification is a task of paramount importance in various fields of biology. Despite the great momentum of modern implementation of protein classification, machine learning techniques such as Random Forest and Neural Network could ... ...

Abstract	BACKGROUND: Protein classification is a task of paramount importance in various fields of biology. Despite the great momentum of modern implementation of protein classification, machine learning techniques such as Random Forest and Neural Network could not always be used for several reasons: data collection, unbalanced classification or labelling of the data.As an alternative, I propose the use of a bioinformatics pipeline to search for and classify information from protein databases. Hence, to evaluate the efficiency and accuracy of the pipeline, I focused on the carotenoid biosynthetic genes and developed a filtering approach to retrieve orthologs clusters in two well-studied plants that belong to the Brassicaceae family: Arabidopsis thaliana and Brassica rapa Pekinensis group. The result obtained has been compared with previous studies on carotenoid biosynthetic genes in B. rapa where phylogenetic analysis was conducted. RESULTS: The developed bioinformatics pipeline relies on commercial software and multiple databeses including the use of phylogeny, Gene Ontology terms (GOs) and Protein Families (Pfams) at a protein level. Furthermore, the phylogeny is coupled with “population analysis” to evaluate the potential orthologs. All the steps taken together give a final table of potential orthologs. The phylogenetic tree gives a result of 43 putative orthologs conserved in B. rapa Pekinensis group. Different A. thaliana proteins have more than one syntenic ortholog as also shown in a previous finding (Li et al., BMC Genomics 16(1):1–11, 2015). CONCLUSIONS: This study demonstrates that, when the biological features of proteins of interest are not specific, I can rely on a computational approach in filtering steps for classification purposes. The comparison of the results obtained here for the carotenoid biosynthetic genes with previous research confirmed the accuracy of the developed pipeline which can therefore be applied for filtering different types of datasets.
Keywords	Arabidopsis thaliana ; Brassica rapa ; bioinformatics ; biosynthesis ; carotenoids ; computer software ; data collection ; gene ontology ; genomics ; momentum ; phylogeny ; protein content
Language	English
Dates of publication	2022-12
Size	p. 43.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2730-6844
DOI	10.1186/s12863-022-01045-x
Database	NAL-Catalogue (AGRICOLA)

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Article: Synthesis, structural characterization and biological activity of p-fluorobenzaldehyde thiosemicarbazones and of a nickel complex.

Ferrari, M B / Capacchi, S / Reffo, G / Pelosi, G / Tarasconi, P / Albertini, R / Pinelli, S / Lunghi, P

Journal of inorganic biochemistry

2000 Volume 81, Issue 1-2, Page(s) 89–97

Abstract: New thiosemicarbazones (1-7), derived from p-fluorobenzaldehyde and differently substituted ... thiosemicarbazides, were synthetized and characterized by means of NMR and IR techniques. The p-fluorobenzaldehyde ... thiosemicarbazone Hfbt (1), the p-fluorobenzaldehyde 4-phenylthiosemicarbazone Ph-Hfbt (4) and complex [Ni(fbt)2] (8 ...

Abstract	New thiosemicarbazones (1-7), derived from p-fluorobenzaldehyde and differently substituted thiosemicarbazides, were synthetized and characterized by means of NMR and IR techniques. The p-fluorobenzaldehyde thiosemicarbazone Hfbt (1), the p-fluorobenzaldehyde 4-phenylthiosemicarbazone Ph-Hfbt (4) and complex [Ni(fbt)2] (8) were also characterized by X-ray diffractometry. Molecules 1 and 4 consist of two units: the p-fluorobenzaldehyde residue and the thiosemicarbazonic chain. In the reaction of 1 with NiAc2.4H2O, complex 8 was afforded. The molecular structure of 8 consists of the neutral molecules [Ni(fbt)2] with the metal placed on a symmetry centre. The coordination results in a square planar configuration and involves the sulphur atom and the hydrazine nitrogen atom of the two ligands in a trans configuration. Moreover, for compounds 1, 2, 4, and 8, assays of proliferation inhibition and apoptosis tests in vitro on human leukemia cell line U937 were carried out.
MeSH term(s)	Apoptosis/drug effects ; Benzaldehydes/chemical synthesis ; Benzaldehydes/chemistry ; Benzaldehydes/pharmacology ; Cell Division/drug effects ; Crystallography, X-Ray ; Humans ; Indicators and Reagents ; Models, Molecular ; Molecular Conformation ; Nickel ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Structure-Activity Relationship ; Thiosemicarbazones/chemical synthesis ; Thiosemicarbazones/chemistry ; Thiosemicarbazones/pharmacology ; U937 Cells ; X-Ray Diffraction
Chemical Substances	Benzaldehydes ; Indicators and Reagents ; Organometallic Compounds ; Thiosemicarbazones ; Nickel (7OV03QG267)
Language	English
Publishing date	2000-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/s0162-0134(00)00087-8
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Article: CAR-T Cell Therapy for T-Cell Malignancies.

Testa, Ugo / Chiusolo, Patrizia / Pelosi, Elvira / Castelli, Germana / Leone, Giuseppe

Mediterranean journal of hematology and infectious diseases

2024 Volume 16, Issue 1, Page(s) e2024031

Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially ... ...

Abstract	Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas, B-ALLs, and multiple myeloma. These therapeutic successes have triggered the application of CAR-T cell therapy to other hematologic tumors, including T-cell malignancies. However, the success of CAR-T cell therapies in T-cell neoplasms was considerably more limited due to the existence of some limiting factors, such as: 1) the sharing of mutual antigens between normal T-cells and CAR-T cells and malignant cells, determining fratricide events and severe T-cell aplasia; 2) the contamination of CAR-T cells used for CAR transduction with malignant T-cells. Allogeneic CAR-T products can avoid tumor contamination but raise other problems related to immunological incompatibility. In spite of these limitations, there has been significant progress in CD7- and CD5-targeted CAR-T cell therapy of T-cell malignancies in the last few years.
Language	English
Publishing date	2024-03-01
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/MJHID.2024.031
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Article: Discovery of antibacterial manganese(i) tricarbonyl complexes through combinatorial chemistry.

Scaccaglia, Mirco / Birbaumer, Michael P / Pinelli, Silvana / Pelosi, Giorgio / Frei, Angelo

Chemical science

2024 Volume 15, Issue 11, Page(s) 3907–3919

Abstract: The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current ... ...

Abstract	The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current antibiotic arsenal, they are falling short in providing new drugs with novel modes of action able to treat multidrug resistant bacteria. Metal complexes have recently shown promising results as antimicrobial agents, but the number of studied compounds is still vanishingly small, making it difficult to identify promising compound classes or elucidate structure-activity relationships. To accelerate the pace of discovery we have applied a combinatorial chemistry approach to the synthesis of metalloantibiotics. Utilizing robust Schiff-base chemistry and combining 7 picolinaldehydes with 10 aniline derivatives, and 6 axial ligands, either imidazole/pyridine-based or solvent, we have prepared a library of 420 novel manganese tricarbonyl complexes. All compounds were evaluated for their antibacterial properties and 10 lead compounds were identified, re-synthesised and fully characterised. All 10 compounds showed high and broad activity against Gram-positive bacteria. The best manganese complex displayed low toxicity against human cells with a therapeutic index of >100. In initial mode of action studies, we show that it targets the bacterial membrane without inducing pore formation or depolarisation. Instead, it releases its carbon monoxide ligands around the membrane and inhibits the bacterial respiratory chain. This work demonstrates that large numbers of metal complexes can be accessed through combinatorial synthesis and evaluated for their antibacterial potential, allowing for the rapid identification of promising metalloantibiotic lead compounds.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc05326a
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Article ; Online: New frontiers in neuroanesthesia.

Robba, Chiara / Pelosi, Paolo

Best practice & research. Clinical anaesthesiology

2021 Volume 35, Issue 2, Page(s) 155–157

Language	English
Publishing date	2021-02-27
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2051316-1
ISSN	1878-1608 ; 1753-3740 ; 1521-6896
ISSN (online)	1878-1608
ISSN	1753-3740 ; 1521-6896
DOI	10.1016/j.bpa.2021.02.001
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