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Article ; Online: Radha Mohan Mishra.

Mishra, Bet

2017 Volume 356, Page(s) j1144

Language	English
Publishing date	2017--17
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.j1144
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Article ; Online: Prone positioning.

Mishra, Mohan

Clinical medicine (London, England)

2020 Volume 20, Issue 6, Page(s) e280

MeSH term(s)	COVID-19 ; Humans ; Patient Positioning ; Prone Position ; Respiratory Distress Syndrome ; SARS-CoV-2
Language	English
Publishing date	2020-11-13
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.Let.20.6.4
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Article ; Online: Antigen loss following CAR-T cell therapy: Mechanisms, implications, and potential solutions.

Mishra, Archana / Maiti, Rituparna / Mohan, Prafull / Gupta, Pooja

European journal of haematology

2023 Volume 112, Issue 2, Page(s) 211–222

Abstract: Chimeric Antigen Receptor T-cell (CAR-T cell) therapy has emerged as a groundbreaking immunotherapeutic approach for treating various hematological malignancies. CAR-T cells are engineered to express synthetic receptors that target specific antigens on ... ...

Abstract	Chimeric Antigen Receptor T-cell (CAR-T cell) therapy has emerged as a groundbreaking immunotherapeutic approach for treating various hematological malignancies. CAR-T cells are engineered to express synthetic receptors that target specific antigens on cancer cells, leading to their eradication. While the therapy has shown remarkable efficacy, a significant challenge that has been observed in 30%-70% of patients showing recurrent disease is antigen loss or downregulation. We searched PubMed/MEDLINE, EMBASE, and Google scholar for articles on antigen loss/escape following Chimeric antigen receptor T-cell therapy in malignancies. Antigen loss refers to the loss or reduction in the expression of the target antigen on cancer cells, rendering CAR-T cells ineffective. This phenomenon poses a significant clinical concern, as it can lead to disease relapse and limited treatment options. This review explores the mechanisms underlying antigen loss following CAR-T cell therapy, its implications on treatment outcomes, and potential strategies to overcome the problem.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes ; Neoplasm Recurrence, Local ; Immunotherapy, Adoptive/adverse effects ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.14101
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Article: Prehospital care and interfacility transfer of trauma patients before reaching the emergency of a level-1 trauma care center.

Hansda, Upendra / Mishra, Tushar S / Topno, Nitish / Sahoo, Sangeeta / Mohan, Sreshtaa / Chakola, Sebastian

Journal of family medicine and primary care

2024 Volume 13, Issue 2, Page(s) 656–659

Abstract: Background: Management of trauma patients includes prevention, prehospital care, appropriate resuscitation at a hospital, definitive treatment, and rehabilitation. Timely and adequate care for a trauma patient is paramount, which can dramatically impact ...

Abstract	Background: Management of trauma patients includes prevention, prehospital care, appropriate resuscitation at a hospital, definitive treatment, and rehabilitation. Timely and adequate care for a trauma patient is paramount, which can dramatically impact survival. This study was planned to assess the proportion of patients who failed to receive adequate prehospital care before reaching our institute. Materials and methods: A retrospective study was conducted in the trauma and emergency department of a level-1 trauma center in eastern India from February to April 2022. The demographic profile, vital parameters, injury, mode of transport, travel duration, referring hospital, and any interventions as per airway/breathing/circulation/hypothermia were collected. Results: The records of a hundred-two patients who were brought to the trauma and emergency department in the study period were reviewed. Road traffic accident involving two wheelers was the leading cause of injury. Eighty-three percent of the patients were referred from other health centers, of which 49 were referred from district headquarters hospitals. Only three patients out of 14 had been provided with an oropharyngeal airway for whom endotracheal intubation was indicated. Only one among the 41 patients needing Philadelphia collar actually received. Sixteen patients were provided supplemental oxygen out of the 35 for whom it was indicated. Out of 68 patients in whom intravenous cannulation and fluid administration were indicated, only 35 patients had received it. Out of 31 patients with fractures, none were provided immobilization. Conclusion: The care of the trauma patients with respect to airway, breathing, circulation, and fracture immobilization was found to be grossly inadequate, emphasizing the need of structured and protocol based prehospital trauma care.
Language	English
Publishing date	2024-03-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_1271_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrosion behavior and degradation mechanism of micro-extruded 3D printed ordered pore topological Fe scaffolds.

Mishra, Dipesh Kumar / Pandey, Pulak Mohan

Journal of biomedical materials research. Part B, Applied biomaterials

2022 Volume 110, Issue 6, Page(s) 1439–1459

Abstract: The fabrication of ordered pore topological structures (OPTS) with an improved biodegradation profile offers unique attributes required for bone reconstruction. These attributes consisted of fully interconnected porous structure, bone-mimicking ... ...

Abstract	The fabrication of ordered pore topological structures (OPTS) with an improved biodegradation profile offers unique attributes required for bone reconstruction. These attributes consisted of fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most of the biomaterials based on magnesium were associated with the problem of too fast degradation rate. Here, the present aim was based on the fabrication of ordered pore topological Fe structures (OPTFS) using micro-extrusion-based 3D printing followed by pressureless microwave sintering. Two different kinds of pore features namely randomly distributed interconnected micropores and designed interconnected macropores were investigated. Static in vitro degradation results inferred that the H-2 mm pore size of hexagonal based ordered pore topological Fe structures (H-OPTFS) exhibited the highest degradation rate of 6.45 mg cm
MeSH term(s)	Biocompatible Materials/chemistry ; Corrosion ; Iron/chemistry ; Porosity ; Printing, Three-Dimensional ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35011
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Article ; Online: A review on multifaceted biomedical applications of heparin nanocomposites: Progress and prospects.

Meher, Mukesh Kumar / Naidu, Goutami / Mishra, Amit / Poluri, Krishna Mohan

International journal of biological macromolecules

2024 Volume 260, Issue Pt 2, Page(s) 129379

Abstract: Advances in polymer-based nanocomposites have revolutionized biomedical applications over the last two decades. Heparin (HP), being a highly bioactive polymer of biological origin, provides strong biotic competence to the nanocomposites, broadening the ... ...

Abstract	Advances in polymer-based nanocomposites have revolutionized biomedical applications over the last two decades. Heparin (HP), being a highly bioactive polymer of biological origin, provides strong biotic competence to the nanocomposites, broadening the horizon of their applicability. The efficiency, biocompatibility, and biodegradability properties of nanomaterials significantly improve upon the incorporation of heparin. Further, inclusion of structural/chemical derivatives, fractionates, and mimetics of heparin enable fabrication of versatile nanocomposites. Modern nanotechnological interventions have exploited the inherent biofunctionalities of heparin by formulating various nanomaterials, including inorganic/polymeric nanoparticles, nanofibers, quantum dots, micelles, liposomes, and nanogels ensuing novel functionalities targeting diverse clinical applications involving drug delivery, wound healing, tissue engineering, biocompatible coatings, nanosensors and so on. On this note, the present review explicitly summarises the recent HP-oriented nanotechnological developments, with a special emphasis on the reported successful engagement of HP and its derivatives/mimetics in nanocomposites for extensive applications in the laboratory and health-care facility. Further, the advantages and limitations/challenges specifically associated with HP in nanocomposites, undertaken in this current review are quintessential for future innovations/discoveries pertaining to HP-based nanocomposites.
MeSH term(s)	Heparin ; Tissue Engineering ; Nanocomposites/chemistry ; Polymers ; Nanoparticles
Chemical Substances	Heparin (9005-49-6) ; Polymers
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129379
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Article ; Online: Protein-Based Nanocarriers and Nanotherapeutics for Infection and Inflammation.

Nagar, Nupur / Naidu, Goutami / Mishra, Amit / Poluri, Krishna Mohan

The Journal of pharmacology and experimental therapeutics

2024 Volume 388, Issue 1, Page(s) 91–109

Abstract: Infectious and inflammatory diseases are one of the leading causes of death globally. The status quo has become more prominent with the onset of the coronavirus disease 2019 (COVID-19) pandemic. To combat these potential crises, proteins have been proven ...

Abstract	Infectious and inflammatory diseases are one of the leading causes of death globally. The status quo has become more prominent with the onset of the coronavirus disease 2019 (COVID-19) pandemic. To combat these potential crises, proteins have been proven as highly efficacious drugs, drug targets, and biomarkers. On the other hand, advancements in nanotechnology have aided efficient and sustained drug delivery due to their nano-dimension-acquired advantages. Combining both strategies together, the protein nanoplatforms are equipped with the advantageous intrinsic properties of proteins as well as nanoformulations, eloquently changing the field of nanomedicine. Proteins can act as carriers, therapeutics, diagnostics, and theranostics in their nanoform as fusion proteins or as composites with other organic/inorganic materials. Protein-based nanoplatforms have been extensively explored to target the major infectious and inflammatory diseases of clinical concern. The current review comprehensively deliberated proteins as nanocarriers for drugs and nanotherapeutics for inflammatory and infectious agents, with special emphasis on cancer and viral diseases. A plethora of proteins from diverse organisms have aided in the synthesis of protein-based nanoformulations. The current study specifically presented the proteins of human and pathogenic origin to dwell upon the field of protein nanotechnology, emphasizing their pharmacological advantages. Further, the successful clinical translation and current bottlenecks of the protein-based nanoformulations associated with the infection-inflammation paradigm have also been discussed comprehensively. SIGNIFICANCE STATEMENT: This review discusses the plethora of promising protein-based nanocarriers and nanotherapeutics explored for infectious and inflammatory ailments, with particular emphasis on protein nanoparticles of human and pathogenic origin with reference to the advantages, ADME (absorption, distribution, metabolism, and excretion parameters), and current bottlenecks in development of protein-based nanotherapeutic interventions.
MeSH term(s)	Humans ; Drug Delivery Systems ; Nanomedicine ; Nanotechnology ; Pharmaceutical Preparations ; Nanoparticles/therapeutic use ; Inflammation/drug therapy ; Drug Carriers
Chemical Substances	Pharmaceutical Preparations ; Drug Carriers
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.123.001673
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Article ; Online: Re-estimation of the location and size of the pre-instrumented 1 September 1803 Garhwal–Kumaon Himalaya earthquake: Evidence from site characterization and strong motion seismology

Mohan, Kapil / Sharma, Babita / Mishra, O.P.

Earth-Science Reviews. 2023 Feb., v. 237 p.104299-

2023

Abstract: The historical 1 September 1803 Garhwal–Kumaon Himalaya earthquake (Mw 8.1) was a solitary Himalayan earthquake reported felt widely in the Indo-Gangetic Plain with severe shaking observed from Punjab to Bengal. There was no common consensus among 9 ... ...

Abstract	The historical 1 September 1803 Garhwal–Kumaon Himalaya earthquake (Mw 8.1) was a solitary Himalayan earthquake reported felt widely in the Indo-Gangetic Plain with severe shaking observed from Punjab to Bengal. There was no common consensus among 9 different researchers on the source location and size of the Pre-instrumented 1 September 1803 earthquake. In this study, we attempted to resolve the issues based on source, path, and site characterization by estimating peak ground accelerations (PGAs) and correlation between estimated and reported intensities based on the concept of strong motion seismology. In order to arrive at a plausible epicenter location of the pre-instrumented 1803 earthquake, we conducted a detailed postmortem, for the first time of its all of 9-different source locations propounded by different researchers and examined those locations based on the nature and extent of damage pattern; extent of earthquake shaking; intensity at source rock; source characterization; path characterization; and estimates of peak ground acceleration (PGA) at different earthquake hypocenters. In order to achieve a better correlation, the hypocentre is considered at 11 locations at MHT from Higher Himalaya to Sub Himalaya. The surface PGA and MMI are estimated at all locations where the intensity was reported for the 1803 earthquake by considering about 100 scenario earthquakes. Out of nine locations proposed by previous researchers, the five locations fall in the highest and one in the higher seismic attenuation zone that negates the nature and extent of earthquake shaking up to the distance of more than 1200 km at Kolkata then Calcutta where the intensity was reported to be IV. The other locations propsed in least atteuation zone were of less magnitude. We, therefore infer that the 1803 earthquake occurred at the depth of 20 km located in the least seismic attenuation zone in the NW Himalaya with a location of 31.2ᵒN, 78.7°E (130 km north of the HFT, 50 km north of the 1991 Uttarkashi earthquake) with a rupture dimension of 190 × 81 Sq. km with a slip of 3.0 m that corresponds to a magnitude of Mw 8.1. We also inferred that the mainshock rupture was directed toward the south along the Main Himalayan Thrust and the rupture found stopped at 50 km north of the HFT below the Ton Thrust in the Lesser Himalaya. This study also confirms that the rupture of the 1803 Garhwal–Kumaon earthquake has not reached up to the HFT. The 1991 Uttarkashi and 1999 Chamoli earthquakes are inferred to be located at the southern end of the 1803 Garhwal Kumaon earthquake rupture area. A slip deficiency of 1.3 m has been computed with reference to the source zones of the 1803 Garhwal–Kumaon, 1991 Uttarkashi, and 1999 Chamoli earthquakes, suggesting a maximum magnitude potential of Mw 7.2 The Tehri Dam is located approximately 20 km south of the 1991 Uttarkashi earthquake source zone and is believed to lie outside the rupture zone of the 1803 Garhwal–Kumaon earthquake.
Keywords	earthquakes ; geophysics ; Himalayan region ; Indo-Gangetic Plain ; 1803 Garhwal-Kumaon earthquake ; Macroseismic intensity ; Rupture direction ; Peak ground acceleration ; Epicentral location
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1792-9
ISSN	0012-8252
ISSN	0012-8252
DOI	10.1016/j.earscirev.2022.104299
Database	NAL-Catalogue (AGRICOLA)

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Article: The Relationship between Contralateral Suppression of Transient Evoked Otoacoustic Emission and Unmasking of Speech Evoked Auditory Brainstem Response.

Kalaiah, Mohan Kumar / Mishra, Keshav / Shastri, Usha

International archives of otorhinolaryngology

2022 Volume 26, Issue 4, Page(s) e676–e682

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2022-04-20
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0042-1742774
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Article ; Online: India's Response to the COVID-19 Pandemic: A Frontal Assault on the "Historically Dispossessed".

Mohan, Malu / Mishra, Sapna

International journal of health services : planning, administration, evaluation

2020 Volume 51, Issue 1, Page(s) 107–114

Abstract: During the nationwide lockdown as part of the state response to the COVID-19 pandemic, the predicament of interstate migrant laborers in India, caught in crowded cities without means of livelihood and basic resources needed to sustain life, gained ... ...

Abstract	During the nationwide lockdown as part of the state response to the COVID-19 pandemic, the predicament of interstate migrant laborers in India, caught in crowded cities without means of livelihood and basic resources needed to sustain life, gained national and international attention. This article explores the context of the current migrant crisis through the historical trajectories and political roots of internal migration in India and its relationship with the urban informal labor market and the structural determinants of precarious employment. We argue that the both the response to the pandemic and the disproportionate impact on migrant laborers are reflections and consequences of an established pattern of neglect and poor accountability of the state toward the employment and living conditions of migrant workers who toil precariously in the informal labor market.
MeSH term(s)	COVID-19/epidemiology ; Communicable Disease Control/organization & administration ; Developing Countries ; Health Policy ; Humans ; India/epidemiology ; Pandemics ; Politics ; Population Dynamics ; Population Surveillance/methods ; Public Health Practice ; SARS-CoV-2 ; Transients and Migrants
Keywords	covid19
Language	English
Publishing date	2020-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	184936-0
ISSN	1541-4469 ; 0020-7314
ISSN (online)	1541-4469
ISSN	0020-7314
DOI	10.1177/0020731420968438
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