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  1. Article ; Online: Serratus Plane Block: New Insights But Still Many Questions.

    Fuzier, Régis / Despres, Cyrielle

    Regional anesthesia and pain medicine

    2018  Volume 43, Issue 6, Page(s) 644

    MeSH term(s) Anesthetics ; Humans ; Nerve Block ; Pain, Postoperative
    Chemical Substances Anesthetics
    Language English
    Publishing date 2018-07-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1097/AAP.0000000000000799
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  2. Article ; Online: Lung Recruiting Effect of Prone Positioning in Spontaneously Breathing Patients with COVID-19 Assessed by Electrical Impedance Tomography.

    Brunin, Yannick / Despres, Cyrielle / Pili-Floury, Sebastien / Besch, Guillaume

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 4, Page(s) 476–477

    MeSH term(s) Aged ; COVID-19/therapy ; Exhalation ; High-Frequency Ventilation/standards ; Humans ; Male ; Patient Positioning/standards ; Practice Guidelines as Topic ; Prone Position ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3044IM
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients.

    Despres, Cyrielle / Brunin, Yannick / Berthier, Francis / Pili-Floury, Sebastien / Besch, Guillaume

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 256

    MeSH term(s) Administration, Inhalation ; Administration, Intranasal ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Humans ; Male ; Middle Aged ; Oxygen Inhalation Therapy/methods ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Prone Position/physiology ; Respiration, Artificial/methods ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03001-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients

    Cyrielle Despres / Yannick Brunin / Francis Berthier / Sebastien Pili-Floury / Guillaume Besch

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Papaya Fruit Pulp and Resulting Lactic Fermented Pulp Exert Antiviral Activity against Zika Virus.

    Haddad, Juliano G / Carcauzon, Victoria / El Kalamouni, Omar / Desprès, Philippe / Garcia, Cyrielle / Remize, Fabienne / El Kalamouni, Chaker

    Microorganisms

    2020  Volume 8, Issue 9

    Abstract: There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide ...

    Abstract There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide because of its association with severe congenital malformations and neurological disorders in adults. Several polyphenol-rich extracts from plants were used as nutraceuticals which exhibit potent in vitro antiviral effects. Here, we demonstrated that the papaya pulp extracted from
    Language English
    Publishing date 2020-08-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8091257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients

    Despres, Cyrielle / Brunin, Yannick / Berthier, Francis / Pili-Floury, Sebastien / Besch, Guillaume

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #378150
    Database COVID19

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  7. Article ; Online: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients

    Despres, Cyrielle / Brunin, Yannick / Berthier, Francis / Pili-Floury, Sebastien / Besch, Guillaume

    Critical Care

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03001-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Papaya Fruit Pulp and Resulting Lactic Fermented Pulp Exert Antiviral Activity against Zika Virus

    Juliano G. Haddad / Victoria Carcauzon / Omar El Kalamouni / Philippe Desprès / Cyrielle Garcia / Fabienne Remize / Chaker El Kalamouni

    Microorganisms, Vol 8, Iss 1257, p

    2020  Volume 1257

    Abstract: There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide ...

    Abstract There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide because of its association with severe congenital malformations and neurological disorders in adults. Several polyphenol-rich extracts from plants were used as nutraceuticals which exhibit potent in vitro antiviral effects. Here, we demonstrated that the papaya pulp extracted from Carica papaya fruit inhibits the infection of ZIKV in human cells without loss of cell viability. At the non-cytotoxic concentrations, papaya pulp extract has the ability to reduce the virus progeny production in ZIKV-infected human cells by at least 4-log, regardless of viral strains tested. Time-of-drug-addition assays revealed that papaya pulp extract interfered with the attachment of viral particles to the host cells. With a view of preserving the properties of papaya pulp over time, lactic fermentation based on the use of bacterial strains Weissella cibaria 64, Lactobacillus plantarum 75 and Leuconostoc pseudomesenteroides 56 was performed and the resulting fermented papaya pulp samples were tested on ZIKV. We found that lactic fermentation of papaya pulp causes a moderate loss of antiviral activity against ZIKV in a bacterial strain-dependent manner. Whereas IC 50 of the papaya pulp extract was 0.3 mg/mL, we found that fermentation resulted in IC 50 up to 4 mg/mL. We can conclude that papaya pulp possesses antiviral activity against ZIKV and the fermentation process has a moderate effect on the antiviral effect.
    Keywords lactic fermentation ; Carica papaya ; antiviral activity ; Zika virus ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Papaya Fruit Pulp and Resulting Lactic Fermented Pulp Exert Antiviral Activity against Zika Virus

    Haddad, Juliano G. / Carcauzon, Victoria / El Kalamouni, Omar / Desprès, Philippe / Garcia, Cyrielle / Remize, Fabienne / El Kalamouni, Chaker

    Microorganisms. 2020 Aug. 20, v. 8, no. 9

    2020  

    Abstract: There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide ...

    Abstract There are a several emerging and re-emerging RNA viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. Zika virus (ZIKV) is an example of an emerging virus that has become a significant concern worldwide because of its association with severe congenital malformations and neurological disorders in adults. Several polyphenol-rich extracts from plants were used as nutraceuticals which exhibit potent in vitro antiviral effects. Here, we demonstrated that the papaya pulp extracted from Carica papaya fruit inhibits the infection of ZIKV in human cells without loss of cell viability. At the non-cytotoxic concentrations, papaya pulp extract has the ability to reduce the virus progeny production in ZIKV-infected human cells by at least 4-log, regardless of viral strains tested. Time-of-drug-addition assays revealed that papaya pulp extract interfered with the attachment of viral particles to the host cells. With a view of preserving the properties of papaya pulp over time, lactic fermentation based on the use of bacterial strains Weissella cibaria 64, Lactobacillus plantarum 75 and Leuconostoc pseudomesenteroides 56 was performed and the resulting fermented papaya pulp samples were tested on ZIKV. We found that lactic fermentation of papaya pulp causes a moderate loss of antiviral activity against ZIKV in a bacterial strain-dependent manner. Whereas IC₅₀ of the papaya pulp extract was 0.3 mg/mL, we found that fermentation resulted in IC₅₀ up to 4 mg/mL. We can conclude that papaya pulp possesses antiviral activity against ZIKV and the fermentation process has a moderate effect on the antiviral effect.
    Keywords Carica papaya ; Lactobacillus plantarum ; Leuconostoc pseudomesenteroides ; RNA ; Weissella cibaria ; Zika virus ; antiviral properties ; cell viability ; dietary supplements ; fruit pulp ; humans ; lactic fermentation ; papayas ; progeny ; viruses
    Language English
    Dates of publication 2020-0820
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8091257
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: β-lactam dosing at the early phase of sepsis: Performance of a pragmatic protocol for target concentration achievement in a prospective cohort study.

    Winiszewski, Hadrien / Despres, Cyrielle / Puyraveau, Marc / Lagoutte-Renosi, Jennifer / Montange, Damien / Besch, Guillaume / Floury, Sebastien Pili / Chaignat, Claire / Labro, Guylaine / Vettoretti, Lucie / Clairet, Anne-Laure / Capellier, Gilles / Vivet, Berengère / Piton, Gael

    Journal of critical care

    2021  Volume 67, Page(s) 141–146

    Abstract: Purpose: We hypothesized that a protocol of standardized fixed dose using prolonged infusion during the early phase of sepsis may avoid insufficient β-lactam concentrations.: Methods: In this single center prospective study, patients with sepsis and ... ...

    Abstract Purpose: We hypothesized that a protocol of standardized fixed dose using prolonged infusion during the early phase of sepsis may avoid insufficient β-lactam concentrations.
    Methods: In this single center prospective study, patients with sepsis and vasopressors were enrolled if they were treated by either piperacillin-tazobactam, meropenem or cefepime. Βeta-lactams were administered at fixed dose by prolonged infusion. Targeted plasma concentrations for piperacillin, meropenem and cefepime were above 80 mg/L, 8 mg/L and 38 mg/L respectively. Three blood samples were collected per patient over the first 48 h of treatment. Primary endpoint was target concentration achievement during the 48 first hours, defined as all plasma concentrations above the targeted threshold.
    Results: Among the 89 patients completing the three samples, target concentrations were achieved for 61 (69%). Target concentrations were achieved in 20 (53%), 32 (89%), and 9 (60%) of the patients treated with piperacillin, meropenem and cefepime, respectively. By multivariate analysis, lower APACHE 2 score, higher baseline MDRD creatinine clearance, and piperacillin use were independently associated with insufficient β-lactam concentrations.
    Conclusion: Despite a fixed dose antibiotic administration protocol with prolonged infusion insufficient β-lactam concentration was frequent at the early phase of sepsis, especially in less severe patients, without renal failure, and treated with piperacillin. In septic patients with vasopressors, piperacillin dosing higher than 16 g may be needed to achieve the recommended target concentration.
    Trial registration: NCT02820987.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Critical Illness/therapy ; Humans ; Meropenem ; Piperacillin/therapeutic use ; Prospective Studies ; Sepsis/drug therapy ; beta-Lactams/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; Meropenem (FV9J3JU8B1) ; Piperacillin (X00B0D5O0E)
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2021.10.023
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