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Book: Neuronal hyperexcitability and pathological pain

Lai, Josephine

(Neurosignals ; 14,4)

2005

Author's details	ed. Josephine Lai
Series title	Neurosignals ; 14,4
Collection
Language	English
Size	S. 148 - 205 : Ill., graph. Darst.
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT016094785
ISBN	3-8055-8025-8 ; 380551424862X ; 978-3-8055-8025-0
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 3503 -14-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: Dislodgment Resistance, Adhesive Pattern, and Dentinal Tubule Penetration of a Novel Experimental Algin Biopolymer-Incorporated Bioceramic-Based Root Canal Sealer.

Lin, Galvin Sim Siang / Luddin, Norhayati / Ghani, Huwaina Abd / Lai, Josephine Chang Hui / Noorani, Tahir Yusuf

Polymers

2023 Volume 15, Issue 5

Abstract: The currently available bioceramic-based sealers still demonstrate low bond strength with a poor seal in root canal despite desirable biological properties. Hence, the present study aimed to determine the dislodgment resistance, adhesive pattern, and ... ...

Abstract	The currently available bioceramic-based sealers still demonstrate low bond strength with a poor seal in root canal despite desirable biological properties. Hence, the present study aimed to determine the dislodgment resistance, adhesive pattern, and dentinal tubule penetration of a novel experimental algin-incorporated bioactive glass 58S calcium silicate-based (Bio-G) sealer and compared it with commercialised bioceramic-based sealers. A total of 112 lower premolars were instrumented to size 30. Four groups (
Language	English
Publishing date	2023-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15051317
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cadmium adsorption from aqueous solution using alkali modified oil palm empty fruit bunch

Naihi, Hafizah / Baini, Rubiyah / Yakub, Ibrahim / Lai, Josephine

Biocatalysis and agricultural biotechnology. 2022 Sept., v. 44

2022

Abstract: Oil palm empty fruit bunch (OPEFB) is constantly generated by the oil palm industry which constitutes a disposal problem due to its large quantity. Some countries are still facing cadmium pollution in their waterways and polluted the edible aquatic ... ...

Abstract	Oil palm empty fruit bunch (OPEFB) is constantly generated by the oil palm industry which constitutes a disposal problem due to its large quantity. Some countries are still facing cadmium pollution in their waterways and polluted the edible aquatic species. It is critical to remove the cadmium from treated wastewater before discharging it into the environment. The goal of this research was to determine the best conditions settings for NaOH-treated OPEFB in adsorbing cadmium. In this investigation, NaOH-treated OPEFB was evaluated and employed for Cd (II) ion adsorption. pH 6, 0.030 g, 150 rpm, 90 min, 5 mg/L, and 45 °C were found to be the best values for adsorbent dosage, stirring speed, contact time, initial Cd (II) concentration, and temperature, respectively. The maximum removal % of Cd (II) by NaOH-treated OPEFB was 88.07% at these best conditions. The study showed that the alkali-modified OPEFB waste can be used as a long-term solution for effectively removing cadmium from wastewater.
Keywords	Elaeis guineensis ; adsorbents ; adsorption ; agricultural biotechnology ; aquatic organisms ; aqueous solutions ; biocatalysis ; cadmium ; fruits ; industry ; pH ; pollution ; temperature ; wastewater
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2022.102480
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Free-Standing DNA Origami Superlattice to Facilitate Cryo-EM Visualization of Membrane Vesicles.

Aissaoui, Nesrine / Mills, Allan / Lai-Kee-Him, Josephine / Triomphe, Nicolas / Cece, Quentin / Doucet, Christine / Bonhoure, Anne / Vidal, Michel / Ke, Yonggang / Bellot, Gaetan

Journal of the American Chemical Society

2024

Abstract: Technological breakthroughs in cryo-electron microscopy (cryo-EM) methods open new perspectives for highly detailed structural characterizations of extracellular vesicles (EVs) and synthetic liposome-protein assemblies. Structural characterizations of ... ...

Abstract	Technological breakthroughs in cryo-electron microscopy (cryo-EM) methods open new perspectives for highly detailed structural characterizations of extracellular vesicles (EVs) and synthetic liposome-protein assemblies. Structural characterizations of these vesicles in solution under a nearly native hydrated state are of great importance to decipher cell-to-cell communication and to improve EVs' application as markers in diagnosis and as drug carriers in disease therapy. However, difficulties in preparing holey carbon cryo-EM grids with low vesicle heterogeneities, at low concentration and with kinetic control of the chemical reactions or assembly processes, have limited cryo-EM use in the EV study. We report a straightforward membrane vesicle cryo-EM sample preparation method that assists in circumventing these limitations by using a free-standing DNA-affinity superlattice for covering holey carbon cryo-EM grids. Our approach uses DNA origami to self-assemble to a solution-stable and micrometer-sized ordered molecular template in which structure and functional properties can be rationally controlled. We engineered the template with cholesterol-binding sites to specifically trap membrane vesicles. The advantages of this DNA-cholesterol-affinity lattice (DCAL) include (1) local enrichment of artificial and biological vesicles at low concentration and (2) isolation of heterogeneous cell-derived membrane vesicles (exosomes) from a prepurified pellet of cell culture conditioned medium on the grid.
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c07328
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Article ; Online: Dislodgment Resistance, Adhesive Pattern, and Dentinal Tubule Penetration of a Novel Experimental Algin Biopolymer-Incorporated Bioceramic-Based Root Canal Sealer

Galvin Sim Siang Lin / Norhayati Luddin / Huwaina Abd Ghani / Josephine Chang Hui Lai / Tahir Yusuf Noorani

Polymers, Vol 15, Iss 1317, p

2023 Volume 1317

Abstract	The currently available bioceramic-based sealers still demonstrate low bond strength with a poor seal in root canal despite desirable biological properties. Hence, the present study aimed to determine the dislodgment resistance, adhesive pattern, and dentinal tubule penetration of a novel experimental algin-incorporated bioactive glass 58S calcium silicate-based (Bio-G) sealer and compared it with commercialised bioceramic-based sealers. A total of 112 lower premolars were instrumented to size 30. Four groups ( n = 16) were assigned for the dislodgment resistance test: control, gutta-percha + Bio-G, gutta-percha + BioRoot RCS, and gutta-percha + iRoot SP, with exclusion of the control group in adhesive pattern and dentinal tubule penetration tests. Obturation was done, and teeth were placed in an incubator to allow sealer setting. For the dentinal tubule penetration test, sealers were mixed with 0.1% of rhodamine B dye. Subsequently, teeth were cut into a 1 mm-thick cross section at 5 mm and 10 mm levels from the root apex, respectively. Push-out bond strength, adhesive pattern, and dentinal tubule penetration tests were performed. Bio-G showed the highest mean push-out bond strength ( p < 0.05), while iRoot SP showed the greatest sealer penetration ( p < 0.05). Bio-G demonstrated more favourable adhesive patterns. No significant association was noted between dislodgment resistance and dentinal tubule penetration ( p > 0.05).
Keywords	alginate ; biomaterials ; biopolymer ; bond strength ; dentistry ; endodontics ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic accuracy of using capnography in verification of nasogastric tube placement among adult patients in hospital settings: Protocol of a diagnostic study.

Chau, Janita Pak Chun / Tong, Danny Wah Kun / Lo, Suzanne Hoi Shan / Sze, Savina Yee Man / Kwok, Molly Lai Mei / Lai, Peter Chi Keung / Lam, Harris Kai Cheong / Chung, Josephine Yuen Man / Liu, Xu / Chien, Wai Tong / Choi, Kai Chow

PloS one

2023 Volume 18, Issue 10, Page(s) e0292667

Abstract: Objective: To determine the diagnostic accuracy of end-tidal carbon dioxide (ETCO2) detection using capnography for verifying the correct placement of nasogastric tubes (NGTs) among adult patients in hospital settings.: Materials and methods: A ... ...

Abstract	Objective: To determine the diagnostic accuracy of end-tidal carbon dioxide (ETCO2) detection using capnography for verifying the correct placement of nasogastric tubes (NGTs) among adult patients in hospital settings. Materials and methods: A prospective observational diagnostic study will be conducted. Patients ≥ 18-year-old and requiring the insertion of an NGT will be recruited using a convenience sampling method from 39 general medical and geriatric wards, intensive care units, accident and emergency departments, and subacute/rehabilitation/infirmary wards in 21 acute or subacute/convalescent/extended care hospitals. ETCO2 detection by sidestream capnography, which indicates an airway intubation of an NGT when a capnogram waveform or an ETCO2 level > 10mmHg (1.33 kPa) occurs, will serve as the index test. The reference standards will be the X-ray performed and pH value of gastric aspiration (pH ≤ 5.5) after the index test. Each participant will be included only once. Sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve of capnography will be calculated to assess the diagnostic performance of capnography. The variability in diagnostic accuracy in participants with different characteristics will be explored by using chi-squared or Fisher's exact tests. The time spent and the cost of the tests will be compared using the paired t-test. All statistical tests will be two-sided with a level of significance set at 0.05. Discussion: This study will provide evidence on the diagnostic accuracy of capnography in verifying NGT placement and its applicability to patients in hospitals settings, since this evidence is limited in the current literature. In addition, it will help identify the optimal combination of tests in verifying the correct placement of NGTs and inform the update of clinical practice guidelines and stakeholders' decisions on the adoption of ETCO2 detection as a routine method for verifying NGT placement. Trial registration: ClinicalTrials.gov ID: NCT05817864.
MeSH term(s)	Humans ; Adult ; Aged ; Adolescent ; Capnography/methods ; Carbon Dioxide ; Intubation, Gastrointestinal/methods ; Hospitals ; Intensive Care Units ; Observational Studies as Topic
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292667
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Insight into the Role of Marine Biopolymer Alginate in Endodontics: A Review.

Lin, Galvin Sim Siang / Cher, Chia Yee / Goh, Yong Hong / Chan, Daryl Zhun Kit / Karobari, Mohmed Isaqali / Lai, Josephine Chang Hui / Noorani, Tahir Yusuf

Marine drugs

2022 Volume 20, Issue 8

Abstract: Alginate is a natural marine biopolymer that has been widely used in biomedical applications, but research on its use as an endodontic material is still sparse in the literature. This pioneer review aims to summarize the emerging roles of alginate and to ...

Abstract	Alginate is a natural marine biopolymer that has been widely used in biomedical applications, but research on its use as an endodontic material is still sparse in the literature. This pioneer review aims to summarize the emerging roles of alginate and to outline its prospective applications as a core biomaterial in endodontics. Ten electronic databases and five textbooks were used to perform a search of English-language literature on the use of alginate in endodontics published between January 1980 and June 2022. The risk of bias (RoB) of each included study was assessed using the Office of Health Assessment and Translation (OHAT) tool. Subsequently, studies were categorized into three tiers to represent the overall risk. Qualitative analysis was performed, and the articles were sorted into different thematic categories. An initial search yielded a total of 1491 articles, but only 13 articles were chosen. For most domains, all the studies were rated with 'probably low' or 'definitely low' RoB, except for domains 2 and 6. All included studies fall in the Tier 1 category and were either in vitro, in vivo, or ex vivo. Four thematic categories were identified: endodontic regeneration, intracanal medicament, filing material, and chelating agent. Based on the available evidence, alginate has emerged as a cell carrier and scaffold in regenerative endodontics, a microcapsule delivery system for intracanal medicaments, a chelating agent reinforcing material, and a root canal sealer. More well-designed experiments and clinical trials are needed to warrant the promising advent of this hydrogel-based biomaterial.
MeSH term(s)	Alginates ; Biocompatible Materials ; Biopolymers ; Chelating Agents ; Endodontics
Chemical Substances	Alginates ; Biocompatible Materials ; Biopolymers ; Chelating Agents
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md20080539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Formulation and Evaluation of SNEDDS Loaded with Original Lipophenol for the Oral Route to Prevent Dry AMD and Stragardt's Disease.

Vincent, Maxime / Simon, Laurianne / Brabet, Philippe / Legrand, Philippe / Dorandeu, Christophe / Him, Josephine Lai Kee / Durand, Thierry / Crauste, Céline / Begu, Sylvie

Pharmaceutics

2022 Volume 14, Issue 5

Abstract: Dry age-related macular degeneration (Dry AMD) and Stargardt's disease (STGD1) are common eye diseases, characterized by oxidative and carbonyl stress (COS)-inducing photoreceptor degeneration and vision loss. Previous studies have demonstrated the ... ...

Abstract	Dry age-related macular degeneration (Dry AMD) and Stargardt's disease (STGD1) are common eye diseases, characterized by oxidative and carbonyl stress (COS)-inducing photoreceptor degeneration and vision loss. Previous studies have demonstrated the protective effect of photoreceptors after the intravenous administration of a new lipophenol drug, phloroglucinol-isopropyl-DHA (IP-DHA). In this study, we developed an oral formulation of IP-DHA (BCS Class IV) relying on a self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS, composed of Phosal
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14051029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fabrication and characterisation of novel algin incorporated bioactive-glass 58S calcium-silicate-based root canal sealer.

Lin, Galvin Sim Siang / Sim, Daniel Hong Heng / Luddin, Norhayati / Lai, Josephine Chang Hui / Ghani, Huwaina Abd / Noorani, Tahir Yusuf

Journal of dental sciences

2022 Volume 18, Issue 2, Page(s) 604–612

Abstract: Background/purpose: The usage of bioceramic-based root canal sealers has escalated over the years due to their excellent properties. The present study aimed to fabricate a novel algin incorporated bioactive glass 58S calcium-silicate (Bio-G) sealer and ... ...

Abstract	Background/purpose: The usage of bioceramic-based root canal sealers has escalated over the years due to their excellent properties. The present study aimed to fabricate a novel algin incorporated bioactive glass 58S calcium-silicate (Bio-G) sealer and characterise its surface microstructure and chemical compositions in comparison to commercially available bioceramic sealers (BioRoot RCS and iRoot SP). Materials and methods: The powder form of experimental Bio-G sealer consisted of synthesised BG 58S particle, calcium silicate, zirconia dioxide, calcium carbonate and alginic acid powder as binder. The liquid composed of 5% calcium chloride solution. Five standardised disc specimens were prepared for each sealer group according to the manufacturer's instructions. Subsequently, sealer disc-specimens were placed in an incubator at 37 °C, 95% relative humidity for 72 h to allow setting prior to testing under scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), Fourier transformed infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Results: Experimental Bio-G sealer revealed irregular micro-sized particles ranging from 0.5 μm to 105 μm aggregated in clusters comparable to those of BioRoot RCS and iRoot SP. EDS microanalysis showed that Bio-G had high content of oxygen, silicon, and calcium, with the presence of aluminium and chloride similar to BioRoot RCS. Meanwhile, the FTIR and XRD findings suggested that all sealers predominantly contained calcium silicate hydrate, calcium carbonate, and zirconium dioxide, while calcium aluminium silicate oxide was detected in Bio-G. Conclusion: The present novel Bio-G sealer demonstrated desirable particle size distribution and acceptable degree of purity. Future studies are warranted to explore its properties and clinical application.
Language	English
Publishing date	2022-09-06
Publishing country	Netherlands
Document type	Journal Article
ISSN	2213-8862
ISSN (online)	2213-8862
DOI	10.1016/j.jds.2022.08.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Renal and Vascular Effects of Combined SGLT2 and Angiotensin-Converting Enzyme Inhibition.

Lytvyn, Yuliya / Kimura, Karen / Peter, Nuala / Lai, Vesta / Tse, Josephine / Cham, Leslie / Perkins, Bruce A / Soleymanlou, Nima / Cherney, David Z I

Circulation

2022 Volume 146, Issue 6, Page(s) 450–462

Abstract: Background: The cardiorenal effects of sodium-glucose cotransporter 2 inhibition (empagliflozin 25 mg QD) combined with angiotensin-converting enzyme inhibition (ramipril 10 mg QD) were assessed in this mechanistic study in patients with type 1 diabetes ...

Abstract	Background: The cardiorenal effects of sodium-glucose cotransporter 2 inhibition (empagliflozin 25 mg QD) combined with angiotensin-converting enzyme inhibition (ramipril 10 mg QD) were assessed in this mechanistic study in patients with type 1 diabetes with potential renal hyperfiltration. Methods: Thirty patients (out of 31 randomized) completed this double-blind, placebo-controlled, crossover trial. Recruitment was stopped early because of an unexpectedly low proportion of patients with hyperfiltration. Measurements were obtained after each of the 6 treatment phases over 19 weeks: (1) baseline without treatment, (2) 4-week run-in with ramipril treatment alone, (3) 4-week combined empagliflozin-ramipril treatment, (4) a 4-week washout, (5) 4-week combined placebo-ramipril treatment, and (6) 1-week follow-up. The primary end point was glomerular filtration rate (GFR) after combination treatment with empagliflozin-ramipril compared with placebo-ramipril. GFR was corrected for ramipril treatment alone before randomization. At the end of study phase, the following outcomes were measured under clamped euglycemia (4 to 6 mmol/L): inulin (GFR) and para-aminohippurate (effective renal plasma flow) clearances, tubular sodium handling, ambulatory blood pressure, arterial stiffness, heart rate variability, noninvasive cardiac output monitoring, plasma and urine biochemistry, markers of the renin-angiotensin-aldosterone system, and oxidative stress. Results: Combination treatment with empagliflozin-ramipril resulted in an 8 mL/min/1.73 m Conclusions: Adding sodium-glucose cotransporter 2 inhibitor treatment to angiotensin-converting enzyme inhibitor resulted in an expected GFR dip, suppression of oxidative stress markers, additive declines in blood pressure and total peripheral resistance. These changes are consistent with a protective physiologic profile characterized by the lowering of intraglomerular pressure and related cardiorenal risk when adding a sodium-glucose cotransporter 2 inhibitor to conservative therapy. Registration: URL: https://www. Clinicaltrials: gov; Unique identifier: NCT02632747.
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensins ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Double-Blind Method ; Glomerular Filtration Rate ; Glucose ; Humans ; Ramipril/pharmacology ; Ramipril/therapeutic use ; Sodium ; Sodium-Glucose Transporter 2
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Angiotensins ; Sodium-Glucose Transporter 2 ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2) ; Ramipril (L35JN3I7SJ)
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.122.059150
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