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  1. Book ; Online ; E-Book: Verhaltenssüchte erfolgreich behandeln

    Arnhold, Julia / Hoppe, Hannah

    ein schematherapeutisches Praxisbuch

    (Reihe Fachbuch Schematherapie)

    2020  

    Author's details Julia Arnhold & Hannah Hoppe
    Series title Reihe Fachbuch Schematherapie
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (283 Seiten), Illustrationen
    Publisher Junfermann Verlag
    Publishing place Paderborn
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020935240
    ISBN 978-3-7495-0118-2 ; 978-3-7495-0119-9 ; 9783749501120 ; 3-7495-0118-1 ; 3-7495-0119-X ; 3749501122
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Clarification of intellectual abilities in patients with GLI2 mutations cited by Kevelam et al., 2012 Am J Med Genet Part A.

    França, Marcela M / Arnhold, Ivo J P

    American journal of medical genetics. Part A

    2012  Volume 158A, Issue 6, Page(s) 1519

    MeSH term(s) Humans ; Intelligence/genetics ; Kruppel-Like Transcription Factors/genetics ; Mutation ; Zinc Finger Protein Gli2
    Chemical Substances Kruppel-Like Transcription Factors ; Zinc Finger Protein Gli2
    Language English
    Publishing date 2012-04-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.35317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; E-Book: Ausstieg aus Verhaltenssüchten

    Arnhold, Julia / Hoppe, Hannah

    wie Schematherapie helfen kann : mit CD

    (Reihe Aktive Lebensgestaltung Verhaltenssüchte)

    2019  

    Author's details Julia Arnhold & Hannah Hoppe
    Series title Reihe Aktive Lebensgestaltung Verhaltenssüchte
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (212 Seiten), Illustrationen
    Publisher Junfermann Verlag
    Publishing place Paderborn
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020108456
    ISBN 978-3-95571-871-8 ; 978-3-95571-872-5 ; 9783955718701 ; 3-95571-871-9 ; 3-95571-872-7 ; 3955718700
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Article: Inflammation-Associated Cytotoxic Agents in Tumorigenesis.

    Arnhold, Jürgen

    Cancers

    2023  Volume 16, Issue 1

    Abstract: Chronic inflammatory processes are related to all stages of tumorigenesis. As inflammation is closely associated with the activation and release of different cytotoxic agents, the interplay between cytotoxic agents and antagonizing principles is ... ...

    Abstract Chronic inflammatory processes are related to all stages of tumorigenesis. As inflammation is closely associated with the activation and release of different cytotoxic agents, the interplay between cytotoxic agents and antagonizing principles is highlighted in this review to address the question of how tumor cells overcome the enhanced values of cytotoxic agents in tumors. In tumor cells, the enhanced formation of mitochondrial-derived reactive species and elevated values of iron ions and free heme are antagonized by an overexpression of enzymes and proteins, contributing to the antioxidative defense and maintenance of redox homeostasis. Through these mechanisms, tumor cells can even survive additional stress caused by radio- and chemotherapy. Through the secretion of active agents from tumor cells, immune cells are suppressed in the tumor microenvironment and an enhanced formation of extracellular matrix components is induced. Different oxidant- and protease-based cytotoxic agents are involved in tumor-mediated immunosuppression, tumor growth, tumor cell invasion, and metastasis. Considering the special metabolic conditions in tumors, the main focus here was directed on the disturbed balance between the cytotoxic agents and protective mechanisms in late-stage tumors. This knowledge is mandatory for the implementation of novel anti-cancerous therapeutic approaches.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Host-Derived Cytotoxic Agents in Chronic Inflammation and Disease Progression.

    Arnhold, Jürgen

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: At inflammatory sites, cytotoxic agents are released and generated from invading immune cells and damaged tissue cells. The further fate of the inflammation highly depends on the presence of antagonizing principles that are able to inactivate these host- ... ...

    Abstract At inflammatory sites, cytotoxic agents are released and generated from invading immune cells and damaged tissue cells. The further fate of the inflammation highly depends on the presence of antagonizing principles that are able to inactivate these host-derived cytotoxic agents. As long as the affected tissues are well equipped with ready-to-use protective mechanisms, no damage by cytotoxic agents occurs and resolution of inflammation is initiated. However, long-lasting and severe immune responses can be associated with the decline, exhaustion, or inactivation of selected antagonizing principles. Hence, cytotoxic agents are only partially inactivated and contribute to damage of yet-unperturbed cells. Consequently, a chronic inflammatory process results. In this vicious circle of permanent cell destruction, not only novel cytotoxic elements but also novel alarmins and antigens are liberated from affected cells. In severe cases, very low protection leads to organ failure, sepsis, and septic shock. In this review, the major classes of host-derived cytotoxic agents (reactive species, oxidized heme proteins and free heme, transition metal ions, serine proteases, matrix metalloproteases, and pro-inflammatory peptides), their corresponding protective principles, and resulting implications on the pathogenesis of diseases are highlighted.
    MeSH term(s) Humans ; Cytotoxins ; Inflammation/metabolism ; Disease Progression ; Alarmins/metabolism ; Serine Proteases
    Chemical Substances Cytotoxins ; Alarmins ; Serine Proteases (EC 3.4.-)
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24033016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces.

    Arnhold, Jürgen

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: In our organism, mucous surfaces are important boundaries against the environmental milieu with defined fluxes of metabolites through these surfaces and specific rules for defense reactions. Major mucous surfaces are formed by epithelia of the ... ...

    Abstract In our organism, mucous surfaces are important boundaries against the environmental milieu with defined fluxes of metabolites through these surfaces and specific rules for defense reactions. Major mucous surfaces are formed by epithelia of the respiratory system and the digestive tract. The heme peroxidases lactoperoxidase (LPO), myeloperoxidase (MPO), and eosinophil peroxidase (EPO) contribute to immune protection at epithelial surfaces and in secretions. Whereas LPO is secreted from epithelial cells and maintains microbes in surface linings on low level, MPO and EPO are released from recruited neutrophils and eosinophils, respectively, at inflamed mucous surfaces. Activated heme peroxidases are able to oxidize (pseudo)halides to hypohalous acids and hypothiocyanite. These products are involved in the defense against pathogens, but can also contribute to cell and tissue damage under pathological conditions. This review highlights the beneficial and harmful functions of LPO, MPO, and EPO at unperturbed and inflamed mucous surfaces. Among the disorders, special attention is directed to cystic fibrosis and allergic reactions.
    Language English
    Publishing date 2021-11-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Dual Role of Myeloperoxidase in Immune Response.

    Arnhold, Jürgen

    International journal of molecular sciences

    2020  Volume 21, Issue 21

    Abstract: The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory sites, where they recognize, phagocytose, and inactivate foreign microorganisms. ...

    Abstract The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory sites, where they recognize, phagocytose, and inactivate foreign microorganisms. In the newly formed phagosomes, MPO is involved in the creation and maintenance of an alkaline milieu, which is optimal in combatting microbes. Myeloperoxidase is also a key component in neutrophil extracellular traps. These helpful properties are contrasted by the release of MPO and other neutrophil constituents from necrotic cells or as a result of frustrated phagocytosis. Although MPO is inactivated by the plasma protein ceruloplasmin, it can interact with negatively charged components of serum and the extracellular matrix. In cardiovascular diseases and many other disease scenarios, active MPO and MPO-modified targets are present in atherosclerotic lesions and other disease-specific locations. This implies an involvement of neutrophils, MPO, and other neutrophil products in pathogenesis mechanisms. This review critically reflects on the beneficial and harmful functions of MPO against the background of immune response.
    MeSH term(s) Animals ; Humans ; Immunity/immunology ; Inflammation/enzymology ; Inflammation/immunology ; Inflammation/pathology ; Neutrophils/enzymology ; Neutrophils/immunology ; Neutrophils/pathology ; Peroxidase/metabolism
    Chemical Substances Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21218057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Importance of Linguistic Factors: He Likes Subject Referents.

    Hert, Regina / Järvikivi, Juhani / Arnhold, Anja

    Cognitive science

    2024  Volume 48, Issue 4, Page(s) e13436

    Abstract: We report the results of one visual-world eye-tracking experiment and two referent selection tasks in which we investigated the effects of information structure in the form of prosody and word order manipulation on the processing of subject pronouns er ... ...

    Abstract We report the results of one visual-world eye-tracking experiment and two referent selection tasks in which we investigated the effects of information structure in the form of prosody and word order manipulation on the processing of subject pronouns er and der in German. Factors such as subjecthood, focus, and topicality, as well as order of mention have been linked to an increased probability of certain referents being selected as the pronoun's antecedent and described as increasing this referent's prominence, salience, or accessibility. The goal of this study was to find out whether pronoun processing is primarily guided by linguistic factors (e.g., grammatical role) or nonlinguistic factors (e.g., first-mention), and whether pronoun interpretation can be described in terms of referents' "prominence" / "accessibility" / "salience." The results showed an overall subject preference for er, whereas der was affected by the object role and focus marking. While focus increases the attentional load and enhances memory representation for the focused referent making the focused referent more available, ultimately it did not affect the final interpretation of er, suggesting that "prominence" or the related concepts do not explain referent selection preferences. Overall, the results suggest a primacy of linguistic factors in determining pronoun resolution.
    MeSH term(s) Male ; Humans ; Linguistics ; Emotions ; Eye-Tracking Technology ; Probability
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2002940-8
    ISSN 1551-6709 ; 0364-0213
    ISSN (online) 1551-6709
    ISSN 0364-0213
    DOI 10.1111/cogs.13436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Halogenation Activity of Mammalian Heme Peroxidases.

    Arnhold, Jürgen / Malle, Ernst

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Mammalian heme peroxidases are fascinating due to their unique peculiarity of oxidizing (pseudo)halides under physiologically relevant conditions. These proteins are able either to incorporate oxidized halides into substrates adjacent to the active site ... ...

    Abstract Mammalian heme peroxidases are fascinating due to their unique peculiarity of oxidizing (pseudo)halides under physiologically relevant conditions. These proteins are able either to incorporate oxidized halides into substrates adjacent to the active site or to generate different oxidized (pseudo)halogenated species, which can take part in multiple (pseudo)halogenation and oxidation reactions with cell and tissue constituents. The present article reviews basic biochemical and redox mechanisms of (pseudo)halogenation activity as well as the physiological role of heme peroxidases. Thyroid peroxidase and peroxidasin are key enzymes for thyroid hormone synthesis and the formation of functional cross-links in collagen IV during basement membrane formation. Special attention is directed to the properties, enzymatic mechanisms, and resulting (pseudo)halogenated products of the immunologically relevant proteins such as myeloperoxidase, eosinophil peroxidase, and lactoperoxidase. The potential role of the (pseudo)halogenated products (hypochlorous acid, hypobromous acid, hypothiocyanite, and cyanate) of these three heme peroxidases is further discussed.
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Thesis: Nichtlineare Analyse raum-zeitlicher Aspekte der hirnelektrischen Aktivität von Epilepsiepatienten

    Arnhold, Jochen

    (NIC-Serie ; 4)

    2000  

    Author's details Jochen Arnhold
    Series title NIC-Serie ; 4
    Collection
    Keywords Epilepsie ; Elektroencephalographie ; Raum-Zeit-System
    Subject Raum-Zeit-Plan ; EEG ; Elektroencephalografie ; Elektroenzephalographie ; Elektroenzephalografie ; Hirnstrommessung ; Elektroenzephalometrie ; Elektroencephalometrie ; Fallsucht
    Language German ; English
    Size II, 118 S. : Ill., graph. Darst.
    Publisher NIC-Sekretariat, Forschungszentrum Jülich
    Publishing place Jülich
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Wuppertal, Univ., Diss., 2000
    Note Zsfassung in engl. Sprache
    HBZ-ID HT012834552
    ISBN 3-00-006221-1 ; 978-3-00-006221-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 3818 order for loan Magazin

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