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  1. Article ; Online: Actual practice of melanoma follow-up and treatment in Germany: results of a prospective, longitudinal cohort study.

    Livingstone, E / Eigentler, T K / Windemuth-Kieselbach, C / Hauschild, A / Rompel, R / Trefzer, U / Nashan, D / Kilian, K / Debus, D / Kähler, K C / Mauerer, A / Möllenhoff, K / Dippel, E / Schadendorf, D

    The British journal of dermatology

    2015  Volume 172, Issue 6, Page(s) 1646–1650

    MeSH term(s) Disease Progression ; Female ; Follow-Up Studies ; Germany/epidemiology ; Humans ; Male ; Melanoma/epidemiology ; Melanoma/pathology ; Melanoma/therapy ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Prospective Studies ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
    Language English
    Publishing date 2015-04-29
    Publishing country England
    Document type Letter ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.13612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: Auswirkungen des Autoklavierungsprozesses auf die strukturelle und qualitative Beschaffenheit einer antibakteriellen CuTiO2-Oberflächenbeschichtung (TiAl4V6) in Abhängigkeit von der Anzahl der Beschichtungen

    Mauerer, A. / Henkel, M. / Holzwarth, U. / Heidenau, F. / Reichstein, W. / Forst, R.

    2009  , Page(s) EF10–477

    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie; Deutscher Kongress für Orthopädie und Unfallchirurgie; Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2009
    Keywords Medizin, Gesundheit
    Publishing date 2009-10-15
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/09dkou002
    Database German Medical Science

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  3. Article: Regulation of an inwardly rectifying ATP-sensitive K+ channel in the basolateral membrane of renal proximal tubule.

    Mauerer, U R / Boulpaep, E L / Segal, A S

    The Journal of general physiology

    1998  Volume 111, Issue 1, Page(s) 161–180

    Abstract: Functional coupling of Na+,K+-ATPase pump activity to a basolateral membrane (BLM) K+ conductance is crucial for sustaining transport in the proximal tubule. Apical sodium entry stimulates pump activity, lowering cytosolic [ATP], which in turn ... ...

    Abstract Functional coupling of Na+,K+-ATPase pump activity to a basolateral membrane (BLM) K+ conductance is crucial for sustaining transport in the proximal tubule. Apical sodium entry stimulates pump activity, lowering cytosolic [ATP], which in turn disinhibits ATP-sensitive K+ (KATP) channels. Opening of these KATP channels mediates hyperpolarization of the BLM that facilitates Na+ reabsorption and K+ recycling required for continued Na+,K+-ATPase pump turnover. Despite its physiological importance, little is known about the regulation of this channel. The present study focuses on the regulation of the BLM KATP channel by second messengers and protein kinases using membrane patches from dissociated, polarized Ambystoma proximal tubule cells. The channel is regulated by protein kinases A and C, but in opposing directions. The channel is activated by forskolin in cell-attached (c/a) patches, and by PKA in inside-out (i/o) membrane patches. However, phosphorylation by PKA is not sufficient to prevent channel rundown. In contrast, the channel is inhibited by phorbol ester in c/a patches, and PKC decreases channel activity (nPo) in i/o patches. The channel is pH sensitive, and lowering cytosolic pH reduces nPo. Increasing intracellular [Ca2+] ([Ca2+]i) in c/a patches decreases nPo, and this effect is direct since [Ca2+]i inhibits nPo with a Ki of approximately 170 nM in i/o patches. Membrane stretch and hypotonic swelling do not significantly affect channel behavior, but the channel appears to be regulated by the actin cytoskeleton. Finally, the activity of this BLM KATP channel is coupled to transcellular transport. In c/a patches, maneuvers that inhibit turnover of the Na+,K+-ATPase pump reduce nPo, presumably due to a rise in intracellular [ATP], although the associated cell depolarization cannot be ruled out as the possible cause. Conversely, stimulation of transport (and thus pump turnover) leads to increases in nPo, presumably due to a fall in intracellular [ATP]. These results show that the inwardly rectifying KATP channel in the BLM of the proximal tubule is a key element in the feedback system that links cellular metabolism with transport activity. We conclude that coupling of this KATP channel to the activity of the Na+,K+-ATPase pump is a mechanism by which steady state NaCl reabsorption in the proximal tubule may be maintained.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Ambystoma ; Animals ; Biological Transport/drug effects ; Biological Transport/physiology ; Calcium/metabolism ; Calcium/pharmacology ; Cell Membrane/chemistry ; Colforsin/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/pharmacology ; Enzyme Activation ; Epithelial Cells/chemistry ; Hydrogen-Ion Concentration ; Ion Channel Gating/drug effects ; Ion Channel Gating/physiology ; Kidney Tubules, Proximal/chemistry ; Kidney Tubules, Proximal/enzymology ; Patch-Clamp Techniques ; Phosphorylation ; Potassium Channels/physiology ; Protein Kinase C/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Sodium-Potassium-Exchanging ATPase/pharmacology
    Chemical Substances Potassium Channels ; Colforsin (1F7A44V6OU) ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Protein Kinase C (EC 2.7.11.13) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1998-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.111.1.161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Properties of an inwardly rectifying ATP-sensitive K+ channel in the basolateral membrane of renal proximal tubule.

    Mauerer, U R / Boulpaep, E L / Segal, A S

    The Journal of general physiology

    1998  Volume 111, Issue 1, Page(s) 139–160

    Abstract: The potassium conductance of the basolateral membrane (BLM) of proximal tubule cells is a critical regulator of transport since it is the major determinant of the negative cell membrane potential and is necessary for pump-leak coupling to the Na+,K+- ... ...

    Abstract The potassium conductance of the basolateral membrane (BLM) of proximal tubule cells is a critical regulator of transport since it is the major determinant of the negative cell membrane potential and is necessary for pump-leak coupling to the Na+,K+-ATPase pump. Despite this pivotal physiological role, the properties of this conductance have been incompletely characterized, in part due to difficulty gaining access to the BLM. We have investigated the properties of this BLM K+ conductance in dissociated, polarized Ambystoma proximal tubule cells. Nearly all seals made on Ambystoma cells contained inward rectifier K+ channels (gammaslope, in = 24.5 +/- 0.6 pS, gammachord, out = 3.7 +/- 0.4 pS). The rectification is mediated in part by internal Mg2+. The open probability of the channel increases modestly with hyperpolarization. The inward conducting properties are described by a saturating binding-unbinding model. The channel conducts Tl+ and K+, but there is no significant conductance for Na+, Rb+, Cs+, Li+, NH4+, or Cl-. The channel is inhibited by barium and the sulfonylurea agent glibenclamide, but not by tetraethylammonium. Channel rundown typically occurs in the absence of ATP, but cytosolic addition of 0. 2 mM ATP (or any hydrolyzable nucleoside triphosphate) sustains channel activity indefinitely. Phosphorylation processes alone fail to sustain channel activity. Higher doses of ATP (or other nucleoside triphosphates) reversibly inhibit the channel. The K+ channel opener diazoxide opens the channel in the presence of 0.2 mM ATP, but does not alleviate the inhibition of millimolar doses of ATP. We conclude that this K+ channel is the major ATP-sensitive basolateral K+ conductance in the proximal tubule.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Ambystoma ; Animals ; Barium/pharmacology ; Biological Transport/drug effects ; Biological Transport/physiology ; Cations/metabolism ; Cells, Cultured ; Cytidine Triphosphate/pharmacology ; Diazoxide/pharmacology ; Diuretics ; Electric Conductivity ; Glyburide/pharmacology ; Guanosine Triphosphate/pharmacology ; Hypoglycemic Agents/pharmacology ; Inosine Triphosphate/pharmacology ; Ion Channel Gating/drug effects ; Ion Channel Gating/physiology ; Kidney Tubules, Proximal/chemistry ; Kidney Tubules, Proximal/cytology ; Kinetics ; Microvilli/chemistry ; Microvilli/enzymology ; Patch-Clamp Techniques ; Potassium Channels/physiology ; Sodium Chloride Symporter Inhibitors/pharmacology ; Sodium-Potassium-Exchanging ATPase/metabolism ; Thallium ; Thymine Nucleotides/pharmacology ; Uridine Triphosphate/pharmacology
    Chemical Substances Cations ; Diuretics ; Hypoglycemic Agents ; Potassium Channels ; Sodium Chloride Symporter Inhibitors ; Thymine Nucleotides ; Inosine Triphosphate (132-06-9) ; Barium (24GP945V5T) ; Cytidine Triphosphate (65-47-4) ; Guanosine Triphosphate (86-01-1) ; Adenosine Triphosphate (8L70Q75FXE) ; Thallium (AD84R52XLF) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Diazoxide (O5CB12L4FN) ; thymidine 5'-triphosphate (QOP4K539MU) ; Glyburide (SX6K58TVWC) ; Uridine Triphosphate (UT0S826Z60)
    Language English
    Publishing date 1998-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.111.1.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Drogentote in Bayern 1990 bis einschliesslich 2002.

    Wolfersdorf, Manfred / Mauerer, Christian / Keller, Ferdinand / Schmeisser, Ulrike / Härtel-Petri, Roland / Steinmann, Johannes / Wurst, Friedrich M

    Psychiatrische Praxis

    2004  Volume 31 Suppl 1, Page(s) S96–8

    Abstract: Objective and method: In our paper we report about drug mortality in Bavaria in the years 1990 up to 2002, using statistical trend tests (Spearman rho, Kendall tau).: Results: We observed an increase of deaths by illegal drugs in Bavaria as whole, on ...

    Title translation Death by illegal drugs in Bavaria 1990 up to 2002.
    Abstract Objective and method: In our paper we report about drug mortality in Bavaria in the years 1990 up to 2002, using statistical trend tests (Spearman rho, Kendall tau).
    Results: We observed an increase of deaths by illegal drugs in Bavaria as whole, on the other hand also decreases in different parts of the country.
    MeSH term(s) Cause of Death/trends ; Cross-Sectional Studies ; Drug Overdose/mortality ; Germany ; Humans ; Poisoning/mortality ; Street Drugs/poisoning
    Chemical Substances Street Drugs
    Language German
    Publishing date 2004-11
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/s-2004-828445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Drogentote in Bayern 1990 bis einschließlich 2002

    Steinmann, Johannes / Wurst, Friedrich M. / Mauerer, Christian / Keller, Ferdinand / Schmeisser, Ulrike / Härtel-Petri, Roland / Wolfersdorf, Manfred

    Psychiatrische Praxis

    2004  Volume 31, Issue S1, Page(s) S96

    Language German
    Document type Article
    ZDB-ID 124981-2
    ISSN 0303-4259
    Database Current Contents Medicine

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  7. Article: Drogentote in Bayern 1990 bis einschließlich 2002

    Wolfersdorf, Manfred / Mauerer, Christian / Keller, Ferdinand / Schmeisser, Ulrike / Härtel-Petri, Roland / Steinmann, Johannes / Wurst, Friedrich M.

    Psychiatrische Praxis

    2004  Volume 31, Issue S 1, Page(s) 96–98

    Abstract: ANLIEGEN UND METHODE: Vorgestellt wird die Zahl der Drogentoten in Bayern von 1990 bis einschließlich 2002, gegliedert nach den Bereichen der Polizeipräsidien und den offiziellen Angaben. Insgesamt verstarben in diesem Zeitraum 3203 Menschen, deren Tod ... ...

    Abstract ANLIEGEN UND METHODE: Vorgestellt wird die Zahl der Drogentoten in Bayern von 1990 bis einschließlich 2002, gegliedert nach den Bereichen der Polizeipräsidien und den offiziellen Angaben. Insgesamt verstarben in diesem Zeitraum 3203 Menschen, deren Tod ursächlich in Zusammenhang mit der Einnahme von Drogen gesehen wurde. ERGEBNISSE: Statistische Trendtests (Spearman rho, Kendall tau) zeigen für Bayern insgesamt eine signifikante Zunahme der Drogenmortalität, die einzelnen Polizeipräsidien bzw. Länder in Bayern dagegen unterschiedliche Verläufe.
    Language German
    Publishing date 2004-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/s-2004-828445
    Database Thieme publisher's database

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