LIVIVO - Search results -

Search results

Result 1 - 10 of total 58

Search options

Article ; Online: Moving away from chemotherapy in newly diagnosed Philadelphia chromosome-positive B-cell acute lymphoblastic leukaemia.

Haddad, Fadi G / Kourie, Hampig Raphael / Saleh, Khalil

2023 Volume 202, Issue 6, Page(s) 1084–1086

Abstract: ... arm, multicentre, phase 2 trial. Br J Haematol 2023;202:1119-1126. ...

Abstract	Chemotherapy-free regimens are reshaping the treatment landscape of Philadelphia chromosome-positive acute lymphoblastic leukaemia. The report by Xie et al. suggests that the combination of dasatinib and prednisone is effective as induction and early consolidation. Survival was improved in patients who subsequently underwent allogeneic stem cell transplantation. Commentary on: Xie et al. Dasatinib plus prednisone as induction and consolidation for adults with Ph-positive acute lymphoblastic leukaemia: A single-arm, multicentre, phase 2 trial. Br J Haematol 2023;202:1119-1126.
MeSH term(s)	Adult ; Humans ; Dasatinib/therapeutic use ; Philadelphia Chromosome ; Prednisone/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Dasatinib (RBZ1571X5H) ; Prednisone (VB0R961HZT) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.182: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Implication of

Matar, Marianne / Prince, Gilles / Hamati, Ibrahim / Baalbaky, Maria / Fares, Jonas / Aoude, Marc / Matar, Charbel / Kourie, Hampig Raphael

Pharmacogenomics

2023 Volume 24, Issue 9, Page(s) 509–522

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Histone Demethylases/genetics
Chemical Substances	Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2023-0027
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review.

Gemayel, Jack / Chebly, Alain / Kourie, Hampig / Hanna, Colette / Mheidly, Kayane / Mhanna, Melissa / Karam, Farah / Ghoussaini, Daniel / Najjar, Paula El / Khalil, Charbel

Advanced genetics (Hoboken, N.J.)

2024 Volume 5, Issue 1, Page(s) 2300201

Abstract: Cancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive ... ...

Abstract	Cancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop. The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome-based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2641-6573
ISSN (online)	2641-6573
DOI	10.1002/ggn2.202300201
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Perioperative chemotherapy with modified FOLFIRINOX for nonmetastatic pancreatic cancer: a new standard of care?

Radi, Imad / Samaha, Ramy / El Hajj, Joanna / Samaha, Hady / Kourie, Hampig Raphael

Future oncology (London, England)

2020 Volume 17, Issue 3, Page(s) 229–233

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Chemotherapy, Adjuvant ; Humans ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Perioperative Period ; Standard of Care ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2020-12-11
Publishing country	England
Document type	Editorial
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2020-0836
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6478: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Painless chronic pancreatitis: experiences from a high-volume center.

Vujasinovic, Miroslav / Asplund, Ebba / Kourie, Mourad / Guliaieva, Margaryta / Dugic, Ana / Waldthaler, Alexander / Baldaque-Silva, Francisco / Löhr, J Matthias / Ghorbani, Poya

Scandinavian journal of gastroenterology

2022 Volume 58, Issue 4, Page(s) 417–421

Abstract: Introduction: Although abdominal pain is the most prevalent and disabling symptom in patients with chronic pancreatitis (CP), there are also patients who have painless CP.: Patients and methods: We performed a retrospective analysis of patients with ... ...

Abstract	Introduction: Although abdominal pain is the most prevalent and disabling symptom in patients with chronic pancreatitis (CP), there are also patients who have painless CP. Patients and methods: We performed a retrospective analysis of patients with a diagnosis of CP. A total of 279 patients with definite CP with completed demographic and clinical data were included in the final analysis. Results: There were 75 (26.9%) patients with painless CP. These patients had a significantly higher mean age at diagnosis, 61.7 years, than the 52.5 years of patients with pain ( Conclusion: Patients with painless CP had a significantly higher mean age than patients with painful CP and increased aOR for those older than 55 at CP diagnosis. Painless and painful CP patients had similar rates of DM and PEI, confirming the necessity of routine follow up in all patients with CP.
MeSH term(s)	Humans ; Middle Aged ; Retrospective Studies ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/epidemiology ; Abdominal Pain/epidemiology ; Abdominal Pain/etiology ; Exocrine Pancreatic Insufficiency/epidemiology ; Exocrine Pancreatic Insufficiency/etiology ; Odds Ratio
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2022.2137692
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 567: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Autoimmune Pancreatitis Type 1 with Biliary, Nasal, Testicular, and Pulmonary Involvement: A Case Report and a Systematic Review.

Kourie, Mourad / Bogdanovic, Darko / Mahmutyazicioglu, Kamran / Ghazi, Sam / Panic, Nikola / Fjellgren, Eva / Hellkvist, Laila / Thiel, Tomas / Kjellman, Anders / Kartalis, Nikolaos / Danielsson, Olof / Dani, Lara / Löhr, J-Matthias / Vujasinovic, Miroslav

Journal of clinical medicine

2023 Volume 12, Issue 19

Abstract: Introduction: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition associated with fibroinflammatory lesions that can occur at almost any anatomical site. It often presents as a multiorgan disease that may mimic malignancy, ... ...

Abstract	Introduction: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition associated with fibroinflammatory lesions that can occur at almost any anatomical site. It often presents as a multiorgan disease that may mimic malignancy, infection, or other immune-mediated conditions. Autoimmune pancreatitis (AIP) type 1 is the most prominent manifestation of IgG4-RD in the digestive tract, with common extra-pancreatic inflammation. We present the first patient with AIP and involvement of the testicles and nasal cavity. Patient and methods: A case of a patient with AIP type 1 and other organ involvement (bile ducts, testicles, nasal polyps, and lungs) is described. Additionally, a systematic review of AIP type 1 with testicular and nasal involvement was conducted. Results: The systematic review found two cases of AIP type 1 with testicular involvement and 143 cases with AIP type 1 with nasal cavity involvement. None of them had both testicular and nasal involvement. Conclusions: This is the first case of AIP type 1 with other organ involvement, including testicular and nasal involvement, to be described. The number of patients with nasal and testicular involvement described in the literature is low. Creating awareness of this rare clinical condition is necessary, especially due to the very effective available treatment with corticosteroids and rituximab.
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196340
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Epidemiology of bone tumors in Lebanon: a retrospective study from 2000 to 2022 at a tertiary center.

Daher, Mohammad / Zalaquett, Ziad / Mekhael, Elio / Aoun, Marven / Chalhoub, Ralph / Abdo, Majd / Aoude, Marc / Farraj, Sami Abi / Ghoul, Ali / Tarchichi, Jean / Rassi, Joe / Sebaaly, Amer / Trak-Smayra, Viviane / Kesrouani, Carole / Kourie, Hampig-Raphaël / Ghanem, Ismat

Future science OA

2023 Volume 9, Issue 9, Page(s) FSO886

Abstract: Aim: Bone tumors are rare and have an uneven geographic distribution.: Methods: 730 patients diagnosed with bone tumors were included in this retrospective analysis.: Results: With a 64% rate of malignancy, the most common tumors were metastasis ( ... ...

Abstract	Aim: Bone tumors are rare and have an uneven geographic distribution. Methods: 730 patients diagnosed with bone tumors were included in this retrospective analysis. Results: With a 64% rate of malignancy, the most common tumors were metastasis (40%) mostly in the axial skeleton, Osteosarcoma (9%) mostly in the femur, Osteochondroma (8%) mostly in the femur, giant cell tumors (7%) mostly in the knee, and Ewing's sarcoma (6%) mostly in the axial skeleton. Conclusion: Even though a some of the tumors have a predilection for certain localizations in the human body, they may differ in the middle-eastern population. One must also pay attention to the higher rates of malignancies as compared with other cohorts.
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ISSN	2056-5623
ISSN	2056-5623
DOI	10.2144/fsoa-2023-0102
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases.

Kourie, J I

Cellular and molecular neurobiology

2003 Volume 21, Issue 3, Page(s) 173–213

Abstract: 1. Alzheimer's disease (AD) is a neurodegenerative disorder that affects the cognitive function of the brain. Pathological changes in AD are characterized by the formation of amyloid plaques and neurofibrillary tangles as well as extensive neuronal loss. ...

Abstract	1. Alzheimer's disease (AD) is a neurodegenerative disorder that affects the cognitive function of the brain. Pathological changes in AD are characterized by the formation of amyloid plaques and neurofibrillary tangles as well as extensive neuronal loss. Abnormal proteolytic processing of amyloid precursor protein (APP) is the central step that leads to formation of amyloid plaque, neurofibrillary tangles, and neuronal loss. 2. The plaques, which accumulate extracellularly in the brain, are composed of aggregates and cause direct neurotoxic effects and/or increase neuronal vulnerability to excitotoxic insults. The aggregates consist of soluble pathologic amyloid beta peptides AbetaP[1-42] and AbetaP[1-43] and soluble nonpathologic AbetaP[1-40]. Both APP and AbetaP interact with ion transport systems. AbetaP induces a wide range of effects as the result of activating a cascade of mechanisms. 3. The major mechanisms proposed for AbetaP-induced cytotoxicity involve the loss of Ca2+ homeostasis and the generation of reactive oxygen species (ROS). The changes in Ca2+ homeostasis could be the result of (1) changes in endogenous ion transport systems, e.g. Ca2+ and K+ channels and Na+/K+-ATPase, and membrane receptor proteins, such as ligand-driven ion channels and G-protein-driven releases of second messengers, and (2) formation of heterogeneous ion channels. 4. The consequences of changes in Ca2+-homeostasis-induced generation of ROS are (a) direct modification of intrinsic ion transport systems and their regulatory mechanisms, and (b) indirect effects on ion transport systems via peroxidation of phospholipids in the membrane, inhibition of phosphorylation, and reduction of ATP levels and cytoplasmic pH. 5. We propose that in AD, AbetaP with its different conformations alters cell regulation by modifying several ion transport systems and also by forming heterogeneous ion channels. The changes in membrane transport systems are proposed as early steps in impairing neuronal function preceding plaque formation. We conclude that these changes damage the membrane by compromising its integrity and increasing its ion permeability. This mechanism of membrane damage is not only central for AD but also may explain other malfunctioned protein-processing-related pathologies.
MeSH term(s)	Amyloid beta-Peptides/metabolism ; Animals ; Humans ; Ion Channels/metabolism ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology
Chemical Substances	Amyloid beta-Peptides ; Ion Channels
Language	English
Publishing date	2003-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	283404-2
ISSN	0272-4340
ISSN	0272-4340
DOI	10.1023/a:1010932603406
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1727: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Transient Cl- and K+ Currents during the Action Potential in Chara inflata (Effects of External Sorbitol, Cations, and Ion Channel Blockers).

Kourie, J. I.

Plant physiology

2002 Volume 106, Issue 2, Page(s) 651–660

Abstract: In voltage-clamp experiments, a two-pulse procedure was used to investigate the ionic currents underlying the action potential in Chara inflata. A prepulse hyperpolarized the membrane from a resting potential of about -100 to -200 mV. The prepulse was ... ...

Abstract	In voltage-clamp experiments, a two-pulse procedure was used to investigate the ionic currents underlying the action potential in Chara inflata. A prepulse hyperpolarized the membrane from a resting potential of about -100 to -200 mV. The prepulse was followed by a second pulse that changed the potential difference (p.d.) to -100 mV and less negative values in steps of 20 mV. This two-pulse procedure induces action potentials that have a reproducible time course, which is essential for any comparative investigation of the action potential. The two-pulse procedure reveals that in the charophyte C. inflata the electric current flowing across the cell membranes during positive voltage-clamp steps from the resting p.d. consists of a leak current flowing from the start of the pulse, followed by a transient inward-going current, Ii, commencing after a delay, and preceding a delayed transient outward current, Io. The characteristics of the current components and their response to various ion channel blockers and ionic treatments suggest that: (a) Ii, which is blocked by the external application of 9-anthracenecarboxylic acid, is carried by Cl- and (b) Io, which is blocked by the external application of the organic anions tetraethylammonium (TEA+) and nonyltriethylammonium, is carried mainly by K+. The magnitude and behavior of these K+ and Cl- currents could be modified by changes in the external concentration of CaCl2, LiCl, or NaCl but not sorbitol. Hence, it is concluded that NaCl-enhanced transient inward Cl- current, Ii, is due to ionic effects of NaCl rather than to its osmotic effects. The modification of the K+ current, Io, either by changing external K+ concentrations or by blocking the current with TEA+, also alters the Cl- currents Ii.
Language	English
Publishing date	2002-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.106.2.651
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 1193: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Mechanisms of prion-induced modifications in membrane transport properties: implications for signal transduction and neurotoxicity.

Kourie, J I

Chemico-biological interactions

2001 Volume 138, Issue 1, Page(s) 1–26

Abstract: Prion-related encephalopathies are associated with the conversion of a normal cellular isoform of prion protein (PrP(c)) to an abnormal pathologic scrapie isoform (PrP(Sc)). The conversion of this single polypeptide chain involves a reduction in the ... ...

Abstract	Prion-related encephalopathies are associated with the conversion of a normal cellular isoform of prion protein (PrP(c)) to an abnormal pathologic scrapie isoform (PrP(Sc)). The conversion of this single polypeptide chain involves a reduction in the alpha-helices and an increase in beta-sheet content. This change in the content ratio of alpha-helices to beta-sheets may explain the diversity in the proposed mechanisms of action. Many of the pathogenic properties of PrP(Sc), such as neurotoxicity, proteinase-resistant properties and induction of hypertrophy and proliferation of astrocytes, have been attributed to the peptide fragment corresponding to residues 106-126 of prion (PrP[106-126]). In particular, the amyloidogenic and hydrophobic core AGAAAAGA has been implicated in modulation of neurotoxicity and the secondary structure of PrP[106-126]. Because of some similarities between the properties of PrP[106-126] and PrP(Sc), the former is used as a useful tool to characterize the pharmacological and biophysical properties of PrP(Sc) in general and of that domain in particular, by various laboratories. However, it is important to note that by no means can PrP[106-126] be considered a complete equivalent to PrP(Sc) in function. Several hypotheses have been proposed to explain prion-induced neurodegenerative diseases. These non-exclusive hypotheses include: (i) changes in the membrane microviscosity; (ii) changes in the intracellular Ca(2+) homeostasis; (iii) superoxide dismutase and Cu(2+) homeostasis; and (iv) changes in the immune system. The prion-induced modification in Ca(2+) homeostasis is the result of: (1) prion interaction with intrinsic ion transport proteins, e.g. L-type Ca(2+) channels in the surface membrane, and IP(3)-modulated Ca(2+) channels in the internal membranes, and/or (2) formation of cation channels. These two mechanisms of action lead to changes in Ca(2+) homeostasis that further augment the abnormal electrical activity and the distortion of signal transduction causing cell death. It is concluded that the hypothesis of the interaction of PrP[106-126] with membranes and formation of redox-sensitive and pH-modulated heterogeneous ion channels is consistent with: (a) PrP-induced changes in membrane fluidity and viscosity; (b) PrP-induced changes in Ca(2+) homeostasis (and does not exclude changes in endogenous Ca(2+) transport pathways and Cu(2+) homeostasis); (c) PrP role as an antioxidant; and (d) the PrP structural properties, i.e. beta sheets, protein aggregation, hydrophobicity, functional significance of specific amino acids (e.g. methionine, histidine) and regulation with low pH.
MeSH term(s)	Animals ; Brain/drug effects ; Cattle ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Humans ; Ion Transport/drug effects ; Peptide Fragments/pharmacology ; Prion Diseases/etiology ; Prion Diseases/metabolism ; Prions/pharmacology ; Signal Transduction/drug effects
Chemical Substances	Peptide Fragments ; Prions ; prion protein (106-126)
Language	English
Publishing date	2001-09-11
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/s0009-2797(01)00228-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 686: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito