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  1. Article ; Online: Phase 3 trial results bring hope for patients with IgA nephropathy.

    Haraldsson, Börje

    Lancet (London, England)

    2023  Volume 402, Issue 10405, Page(s) 827–829

    MeSH term(s) Humans ; Glomerulonephritis, IGA/therapy ; Patients
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Clinical Trial, Phase III ; Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01633-1
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  2. Article: The Glomerular Endothelium Restricts Albumin Filtration.

    Ballermann, Barbara J / Nyström, Jenny / Haraldsson, Börje

    Frontiers in medicine

    2021  Volume 8, Page(s) 766689

    Abstract: Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory ... ...

    Abstract Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory episodes like sepsis and COVID-19 illness. Another example is the chronic endothelial dysfunction that develops in cardiovascular disease and in metabolic disorders like diabetes. While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. This endothelial barrier function is ascribed predominantly to the endothelial glycocalyx with its endothelial surface layer, that together form a relatively thick, mucinous coat composed of glycosaminoglycans, proteoglycans, glycolipids, sialomucins and other glycoproteins, as well as secreted and circulating proteins. The glycocalyx/endothelial surface layer not only covers the glomerular endothelium; it extends into the endothelial fenestrae. Some glycocalyx components span or are attached to the apical endothelial cell plasma membrane and form the formal glycocalyx. Other components, including small proteoglycans and circulating proteins like albumin and orosomucoid, form the endothelial surface layer and are bound to the glycocalyx due to weak intermolecular interactions. Indeed, bound plasma albumin is a major constituent of the endothelial surface layer and contributes to its barrier function. A role for glomerular endothelial cells in the barrier of the glomerular capillary wall to protein filtration has been demonstrated by many elegant studies. However, it can only be fully understood in the context of other components, including the glomerular basement membrane, the podocytes and reabsorption of proteins by tubule epithelial cells. Discovery of the precise mechanisms that lead to glycocalyx/endothelial surface layer disruption within glomerular capillaries will hopefully lead to pharmacological interventions that specifically target this important structure.
    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.766689
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  3. Article ; Online: A new era of podocyte-targeted therapy for proteinuric kidney disease.

    Haraldsson, Börje

    The New England journal of medicine

    2013  Volume 369, Issue 25, Page(s) 2453–2454

    MeSH term(s) Abatacept ; B7-1 Antigen/metabolism ; Female ; Glomerulosclerosis, Focal Segmental/drug therapy ; Humans ; Immunoconjugates/pharmacology ; Male
    Chemical Substances B7-1 Antigen ; Immunoconjugates ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2013-12-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1312835
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    Ua VI Zs.34: Show issues Location:
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  4. Article ; Online: The Glomerular Endothelium Restricts Albumin Filtration

    Barbara J. Ballermann / Jenny Nyström / Börje Haraldsson

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory ... ...

    Abstract Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory episodes like sepsis and COVID-19 illness. Another example is the chronic endothelial dysfunction that develops in cardiovascular disease and in metabolic disorders like diabetes. While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. This endothelial barrier function is ascribed predominantly to the endothelial glycocalyx with its endothelial surface layer, that together form a relatively thick, mucinous coat composed of glycosaminoglycans, proteoglycans, glycolipids, sialomucins and other glycoproteins, as well as secreted and circulating proteins. The glycocalyx/endothelial surface layer not only covers the glomerular endothelium; it extends into the endothelial fenestrae. Some glycocalyx components span or are attached to the apical endothelial cell plasma membrane and form the formal glycocalyx. Other components, including small proteoglycans and circulating proteins like albumin and orosomucoid, form the endothelial surface layer and are bound to the glycocalyx due to weak intermolecular interactions. Indeed, bound plasma albumin is a major constituent of the endothelial surface layer and contributes to its barrier function. A role for glomerular endothelial cells in the barrier of the glomerular capillary wall to protein filtration has been demonstrated by many elegant studies. However, it can only be fully understood in the context of other components, including the glomerular basement membrane, the podocytes and reabsorption of proteins by tubule epithelial cells. Discovery of the precise mechanisms that lead to glycocalyx/endothelial surface layer disruption within glomerular capillaries will ...
    Keywords endothelial surface layer ; endothelial dysfunction ; fenestrae ; glycocalyx ; hyaluronan ; permselectivity ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The endothelium as part of the integrative glomerular barrier complex.

    Haraldsson, Börje S

    Kidney international

    2014  Volume 85, Issue 1, Page(s) 8–11

    Abstract: A new study by Xu et al. presents compelling evidence for an important role of the glomerular endothelium in acute kidney injury. They show that lipopolysaccharide reduces the endothelial surface layer, resulting in mild albuminuria, reduced glomerular ... ...

    Abstract A new study by Xu et al. presents compelling evidence for an important role of the glomerular endothelium in acute kidney injury. They show that lipopolysaccharide reduces the endothelial surface layer, resulting in mild albuminuria, reduced glomerular filtration rate, and fewer endothelial fenestrae. Tumor necrosis factor-α (TNF-α) is identified as instrumental in these lipopolysaccharide effects through the TNF-α type 1 receptor. The study highlights that the glomerular endothelium has a key role in the maintenance of the glomerular filtration barrier.
    MeSH term(s) Acute Kidney Injury/etiology ; Animals ; Kidney Glomerulus/physiopathology ; Male ; Sepsis/complications ; Tumor Necrosis Factor-alpha/physiology ; Urothelium/physiopathology
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2013.317
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Book: Physiological studies of macromolecular transport across capillary walls

    Haraldsson, Börje

    studies on continuous capillaries in rat skeletal muscle

    (Acta physiologica Scandinavica : Supplementum ; 553)

    1986  

    Author's details Börje Haraldsson
    Series title Acta physiologica Scandinavica : Supplementum ; 553
    Acta physiologica Scandinavica
    Acta physiologica Scandinavica ; Supplementum
    Collection Acta physiologica Scandinavica
    Acta physiologica Scandinavica ; Supplementum
    Keywords Biological Transport ; Capillaries / physiology ; Cell Membrane Permeability ; Kapille <Anatomie> ; Gefäßwand ; Makromolekül ; Molekültransport ; Kapillarwand ; Transportprozess
    Subject Riesenmolekül ; Hochmolekulare Verbindungen ; Transporterscheinung ; Transportvorgang ; Transportphänomen ; Blutgefäßwand ; Blutgefäß
    Language English
    Size 40 S. : graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Sweden
    Document type Book
    HBZ-ID HT002854195
    ISBN 91-7900-102-5 ; 978-91-7900-102-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 229 -Suppl.553- verfügbar in Königswinter Königswinter

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  7. Article ; Online: Tubular reabsorption of albumin: it's all about cubilin.

    Haraldsson, Börje

    Journal of the American Society of Nephrology : JASN

    2010  Volume 21, Issue 11, Page(s) 1810–1812

    MeSH term(s) Absorption ; Albumins/metabolism ; Animals ; Disease Models, Animal ; Glomerular Filtration Rate/physiology ; Kidney Tubules, Proximal/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/metabolism ; Mice ; Proteinuria/metabolism ; Receptors, Cell Surface/metabolism
    Chemical Substances Albumins ; Low Density Lipoprotein Receptor-Related Protein-2 ; Receptors, Cell Surface ; intrinsic factor-cobalamin receptor
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2010090984
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    Zs.A 3344: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Urinary albumin excretion in healthy adults: a cross sectional study of 24-hour versus timed overnight samples and impact of GFR and other personal characteristics.

    Fagerstrom, Peter / Sallsten, Gerd / Akerstrom, Magnus / Haraldsson, Borje / Barregard, Lars

    BMC nephrology

    2015  Volume 16, Page(s) 8

    Abstract: Background: Urinary albumin can be measured in 24 h or spot samples. The 24 h urinary albumin excretion rate is considered the gold standard, but is cumbersome to collect. Instead, often an overnight sample is collected, and adjusted for dilution. ... ...

    Abstract Background: Urinary albumin can be measured in 24 h or spot samples. The 24 h urinary albumin excretion rate is considered the gold standard, but is cumbersome to collect. Instead, often an overnight sample is collected, and adjusted for dilution. Proxies for 24 h excretion rate have been studied in diabetics, but seldom in healthy individuals. Our aims were to compare 24 h and overnight albumin excretion, to assess the impact of personal characteristics, and to examine correlations between the 24 h excretion rate and proxies such as the albumin to creatinine ratio (ACR).
    Methods: Separate 24 h and overnight urine samples were collected from 152 healthy kidney donors. Urinary creatinine, specific gravity, collection time, and sample volume determined. Differences between 24 h and overnight samples were examined, and the effects of age, sex, smoking, body mass, glomerular filtration rate, and urinary flow rate were assessed.
    Results: The 24 h albumin excretion rate and ACR were both significantly higher than their overnight counterparts. Unadjusted albumin was unsurprisingly higher in the more concentrated overnight samples, while concentrations adjusted for specific gravity were similar. In multivariate analysis, the 24 h excretion rate and proxies were positively associated with glomerular filtration rate, as was ACR in overnight samples. There were positive associations between urinary albumin and body mass.
    Conclusions: Proxies for the 24 h albumin excretion rate showed relatively high correlations with this gold standard, but differences due to sampling period, adjustment method, and personal characteristics were large enough to be worth considering in studies of albumin excretion in healthy individuals.
    MeSH term(s) Adult ; Aged ; Albuminuria/urine ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Kidney/physiology ; Living Donors ; Male ; Middle Aged ; Time Factors ; Urine Specimen Collection ; Young Adult
    Language English
    Publishing date 2015-01-24
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/1471-2369-16-8
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  9. Article ; Online: Zeroing in on the albumin glomerular sieving coefficient.

    Haraldsson, Börje / Tanner, George A

    American journal of physiology. Renal physiology

    2014  Volume 306, Issue 6, Page(s) F577–8

    MeSH term(s) Albumins/metabolism ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Animals ; Female ; Kidney Glomerulus/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Receptor, Angiotensin, Type 2/metabolism
    Chemical Substances Albumins ; Angiotensin II Type 1 Receptor Blockers ; Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2
    Language English
    Publishing date 2014-03-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00645.2013
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    Uc I Zs.89: Show issues Location:
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  10. Article ; Online: Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice.

    La Merrill, Michele A / Sethi, Sunjay / Benard, Ludovic / Moshier, Erin / Haraldsson, Borje / Buettner, Christoph

    Environmental health perspectives

    2016  Volume 124, Issue 11, Page(s) 1722–1727

    Abstract: ... Sethi S, Benard L, Moshier E, Haraldsson B, Buettner C. 2016. Perinatal DDT exposure induces ...

    Abstract Background: Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, the use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans.
    Objective: We hypothesized that perinatal DDT exposure causes hypertension in adult mice.
    Methods: DDT was administered to C57BL/6J dams from gestational day 11.5 to postnatal day 5. Blood pressure (BP) and myocardial wall thickness were measured in male and female adult offspring. Adult mice were treated with an angiotensin converting enzyme (ACE) inhibitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition. We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP through renal ion transport.
    Results: Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increased myocardial wall thickness, and elevated expression of mRNAs of several renal ion transporters. Captopril completely reversed hypertension in mice perinatally exposed to DDT.
    Conclusions: These data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult offspring. A key mechanism underpinning this hypertension is an overactivated renin angiotensin system because ACE inhibition reverses the hypertension induced by perinatal DDT exposure. Citation: La Merrill M, Sethi S, Benard L, Moshier E, Haraldsson B, Buettner C. 2016. Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice. Environ Health Perspect 124:1722-1727; http://dx.doi.org/10.1289/EHP164.
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Blood Pressure ; Captopril/therapeutic use ; Cardiomegaly/chemically induced ; DDT/toxicity ; Environmental Exposure ; Female ; Hypertension/chemically induced ; Male ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Captopril (9G64RSX1XD) ; DDT (CIW5S16655)
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP164
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    Zs.MO 379: Show issues

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