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  1. Article: A

    Gilcrease, Eddie B / Casjens, Sherwood R / Bhattacharjee, Ananda / Goel, Ramesh

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1100607

    Abstract: Bacteriophage KL-2146 is a lytic virus isolated to ... ...

    Abstract Bacteriophage KL-2146 is a lytic virus isolated to infect
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1100607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 'SAXS-osmometer' method provides measurement of DNA pressure in viral capsids and delivers an empirical equation of state.

    Villanueva Valencia, José Ramón / Li, Dong / Casjens, Sherwood R / Evilevitch, Alex

    Nucleic acids research

    2023  Volume 51, Issue 21, Page(s) 11415–11427

    Abstract: We present a novel method that provides a measurement of DNA pressure in viral capsids using small angle X-ray scattering (SAXS). This method, unlike our previous assay, does not require triggering genome release with a viral receptor. Thus, it can be ... ...

    Abstract We present a novel method that provides a measurement of DNA pressure in viral capsids using small angle X-ray scattering (SAXS). This method, unlike our previous assay, does not require triggering genome release with a viral receptor. Thus, it can be used to determine the existence of a pressurized genome state in a wide range of virus systems, even if the receptor is not known, leading to a better understanding of the processes of viral genome uncoating and encapsidation in the course of infection. Furthermore, by measuring DNA pressure for a collection of bacteriophages with varying DNA packing densities, we derived an empirical equation of state (EOS) that accurately predicts the relation between the capsid pressure and the packaged DNA density and includes the contribution of both DNA-DNA interaction energy and DNA bending stress to the total DNA pressure. We believe that our SAXS-osmometer method and the EOS, combined, provide the necessary tools to investigate physico-chemical properties of confined DNA condensates and mechanisms of infection, and may also provide essential data for the design of viral vectors in gene therapy applications and development of antivirals that target the pressurized genome state.
    MeSH term(s) Capsid/chemistry ; DNA, Viral/chemistry ; Scattering, Small Angle ; X-Ray Diffraction ; Bacteriophages/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The small genome, virulent, non-contractile tailed bacteriophages that infect Enterobacteriales hosts.

    Casjens, Sherwood R / Davidson, Alan R / Grose, Julianne H

    Virology

    2022  Volume 573, Page(s) 151–166

    Abstract: Tailed bacteriophages are abundant and extremely diverse. Understanding this diversity is a challenge, and here we examine a small slice of that diversity in some detail. We contrast and compare the small genome, virulent, non-contractile tailed phages ... ...

    Abstract Tailed bacteriophages are abundant and extremely diverse. Understanding this diversity is a challenge, and here we examine a small slice of that diversity in some detail. We contrast and compare the small genome, virulent, non-contractile tailed phages that infect the bacterial order Enterobacteriales. These phages, with genomes in the 35-60 kbp range, have very similar virions that are often difficult to distinguish by negative stain electron microscopy. There are currently 651 genome sequences of such phages in the public database. We show that these can be robustly parsed into fifteen well-defined clusters that have very different nucleotide sequences. We examine the similarities and differences among these clusters, as well as genetic exchange among clusters and the relationships between host species and phage clusters.
    MeSH term(s) Bacteriophages/genetics ; Caudovirales/genetics ; Genome, Viral ; Host Specificity ; Phylogeny
    Language English
    Publishing date 2022-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2022.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bacteriophage P22 SieA-mediated superinfection exclusion.

    Leavitt, Justin C / Woodbury, Brianna M / Gilcrease, Eddie B / Bridges, Charles M / Teschke, Carolyn M / Casjens, Sherwood R

    mBio

    2024  Volume 15, Issue 2, Page(s) e0216923

    Abstract: Many temperate phages encode prophage-expressed functions that interfere with superinfection of the host bacterium by external phages. ...

    Abstract Many temperate phages encode prophage-expressed functions that interfere with superinfection of the host bacterium by external phages.
    MeSH term(s) Humans ; Bacteriophage P22/genetics ; Superinfection ; Bacteriophages/genetics ; Prophages/genetics ; Prophages/metabolism ; Membrane Proteins/metabolism ; DNA/metabolism ; Amino Acids/metabolism
    Chemical Substances Membrane Proteins ; DNA (9007-49-2) ; Amino Acids
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02169-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genomic analysis of Anderson typing phages of Salmonella Typhimrium: towards understanding the basis of bacteria-phage interaction.

    Mohammed, Manal / Casjens, Sherwood R / Millard, Andrew D / Harrison, Christian / Gannon, Lucy / Chattaway, Marie Anne

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10484

    Abstract: The Anderson phage typing scheme has been successfully used worldwide for epidemiological surveillance of Salmonella enterica serovar Typhimurium. Although the scheme is being replaced by whole genome sequence subtyping methods, it can provide a valuable ...

    Abstract The Anderson phage typing scheme has been successfully used worldwide for epidemiological surveillance of Salmonella enterica serovar Typhimurium. Although the scheme is being replaced by whole genome sequence subtyping methods, it can provide a valuable model system for study of phage-host interaction. The phage typing scheme distinguishes more than 300 definitive types of Salmonella Typhimurium based on their patterns of lysis to a unique collection of 30 specific Salmonella phages. In this study, we sequenced the genomes of 28 Anderson typing phages of Salmonella Typhimurium to begin to characterize the genetic determinants that are responsible for the differences in these phage type profiles. Genomic analysis of typing phages reveals that Anderson phages can be classified into three different groups, the P22-like, ES18-like and SETP3-like clusters. Most Anderson phages are short tailed P22-like viruses (genus Lederbergvirus); but phages STMP8 and STMP18 are very closely related to the lambdoid long tailed phage ES18, and phages STMP12 and STMP13 are related to the long noncontractile tailed, virulent phage SETP3. Most of these typing phages have complex genome relationships, but interestingly, two phage pairs STMP5 and STMP16 as well as STMP12 and STMP13 differ by a single nucleotide. The former affects a P22-like protein involved in DNA passage through the periplasm during its injection, and the latter affects a gene whose function is unknown. Using the Anderson phage typing scheme would provide insights into phage biology and the development of phage therapy for the treatment of antibiotic resistant bacterial infections.
    MeSH term(s) Bacteriophages/genetics ; Genomics ; Bacteria ; Salmonella typhimurium/genetics ; Bacteriophage Typing
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37307-6
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  6. Article ; Online: Genome Sequence of Salmonella enterica Serovar Typhimurium Bacteriophage MG40.

    Gilcrease, Eddie B / Leavitt, Justin C / Casjens, Sherwood R

    Microbiology resource announcements

    2020  Volume 9, Issue 37

    Abstract: We report the complete genome sequence of P22- ... ...

    Abstract We report the complete genome sequence of P22-like
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00905-20
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  7. Article: Bacteriophage P22 SieA mediated superinfection exclusion.

    Leavitt, Justin C / Woodbury, Brianna M / Gilcrease, Eddie B / Bridges, Charles M / Teschke, Carolyn M / Casjens, Sherwood R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Many temperate phages encode prophage-expressed functions that interfere with superinfection of the host bacterium by external phages. ...

    Abstract Many temperate phages encode prophage-expressed functions that interfere with superinfection of the host bacterium by external phages.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.15.553423
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  8. Article ; Online: Roger Hendrix: Gentle Provocateur.

    Casjens, Sherwood R / Hatfull, Graham F

    Journal of bacteriology

    2018  Volume 200, Issue 9

    Abstract: Roger W. Hendrix was at the forefront of bacteriophage biology for nearly 50 years and was central to our understanding of both viral capsid assembly and phage genomic diversity and evolution. Roger's warm and gentle demeanor belied a razor-sharp mind ... ...

    Abstract Roger W. Hendrix was at the forefront of bacteriophage biology for nearly 50 years and was central to our understanding of both viral capsid assembly and phage genomic diversity and evolution. Roger's warm and gentle demeanor belied a razor-sharp mind and warmed him to numerous highly productive collaborations that amplified his scientific impact. Roger was always completely open with scientific ideas while at the same time quietly agitating with a stream of new ways of thinking about problems and nudging our communities to search for innovative solutions: a gentle but highly effective provocateur.
    MeSH term(s) Bacteriophages ; History, 20th Century ; History, 21st Century ; United States ; Universities ; Virology/history
    Language English
    Publishing date 2018-04-09
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait ; Review
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00058-18
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  9. Article: The small genome, virulent, non-contractile tailed bacteriophages that infect Enterobacteriales hosts

    Casjens, Sherwood R. / Davidson, Alan R. / Grose, Julianne H.

    Virology. 2022 June 01,

    2022  

    Abstract: Tailed bacteriophages are abundant and extremely diverse. Understanding this diversity is a challenge, and here we examine a small slice of that diversity in some detail. We contrast and compare the small genome, virulent, non-contractile tailed phages ... ...

    Abstract Tailed bacteriophages are abundant and extremely diverse. Understanding this diversity is a challenge, and here we examine a small slice of that diversity in some detail. We contrast and compare the small genome, virulent, non-contractile tailed phages that infect the bacterial order Enterobacteriales. These phages, with genomes in the 35–60 kbp range, have very similar virions that are often difficult to distinguish by negative stain electron microscopy. There are currently 651 genome sequences of such phages in the public database. We show that these can be robustly parsed into fifteen well-defined clusters that have very different nucleotide sequences. We examine the similarities and differences among these clusters, as well as genetic exchange among clusters and the relationships between host species and phage clusters.
    Keywords Enterobacteriales ; bacteriophages ; databases ; electron microscopy ; genetic recombination ; genome ; hosts ; virology ; virulence
    Language English
    Dates of publication 2022-0601
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2022.06.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3686: Show issues

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  10. Article ; Online: The genome sequence of Escherichia coli tailed phage D6 and the diversity of Enterobacteriales circular plasmid prophages.

    Gilcrease, Eddie B / Casjens, Sherwood R

    Virology

    2018  Volume 515, Page(s) 203–214

    Abstract: The temperate Escherichia coli bacteriophage D6 can exist as a circular plasmid prophage, and we report here its 91,159bp complete genome sequence. It is a distant relative of the well-studied phage P1, but it is sufficiently different that it typifies a ...

    Abstract The temperate Escherichia coli bacteriophage D6 can exist as a circular plasmid prophage, and we report here its 91,159bp complete genome sequence. It is a distant relative of the well-studied phage P1, but it is sufficiently different that it typifies a previously undescribed tailed phage type or cluster. Examination of the database of bacterial genome sequences revealed that phage P1 and D6 prophage plasmids are common in the Enterobacteriales, and in addition, previously described Salmonella phage SSU5 represents a different type of temperate tailed phage with a circular plasmid prophage that is also very common in this host order. This analysis also discovered additional divergent clusters of putative circular plasmid prophages within the two larger P1 and SSU5 groups (superclusters) that inhabit the Enterobacteriales as well as bacteria in several other orders in the Gamma-proteobacteria class. Very few of these sequences are annotated as putative prophages.
    MeSH term(s) Bacteriophages/classification ; Bacteriophages/genetics ; Bacteriophages/isolation & purification ; Escherichia coli/virology ; Genome, Viral ; Plasmids/genetics ; Plasmids/metabolism ; Prophages/classification ; Prophages/genetics ; Prophages/isolation & purification ; Sequence Analysis, DNA
    Language English
    Publishing date 2018-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2017.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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