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Article: Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors.

Maideen, Naina Mohamed Pakkir

2023 Volume 59, Issue 2, Page(s) 115–127

Abstract: Proton Pump Inhibitors are used widely to manage many gastric acid-related conditions such as gastroesophageal disease, gastritis, esophagitis, Barrett's esophagus, Zollinger-Ellison syndrome, peptic ulcer disease, nonsteroidal anti-inflammatory drug- ... ...

Abstract	Proton Pump Inhibitors are used widely to manage many gastric acid-related conditions such as gastroesophageal disease, gastritis, esophagitis, Barrett's esophagus, Zollinger-Ellison syndrome, peptic ulcer disease, nonsteroidal anti-inflammatory drug-associated ulcers, and
Language	English
Publishing date	2023-05-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536217-3
ISSN	2233-7393 ; 2233-7385 ; 0377-9564
ISSN (online)	2233-7393
ISSN	2233-7385 ; 0377-9564
DOI	10.4068/cmj.2023.59.2.115
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antidiabetic Activity of

Maideen, Naina Mohamed Pakkir

Chonnam medical journal

2021 Volume 57, Issue 3, Page(s) 169–175

Abstract: The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic ... ...

Abstract	The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity of
Language	English
Publishing date	2021-09-24
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536217-3
ISSN	2233-7393 ; 2233-7385 ; 0377-9564
ISSN (online)	2233-7393
ISSN	2233-7385 ; 0377-9564
DOI	10.4068/cmj.2021.57.3.169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Correction: Prophetic Medicine-

Maideen, Naina Mohamed Pakkir

Journal of pharmacopuncture

2020 Volume 23, Issue 3, Page(s) 179

Abstract: This corrects the article on p. 62 in vol. 23, PMID: 32685234.]. ...

Abstract	[This corrects the article on p. 62 in vol. 23, PMID: 32685234.].
Keywords	covid19
Language	English
Publishing date	2020-10-10
Publishing country	Korea (South)
Document type	Published Erratum
ZDB-ID	2747301-6
ISSN	2234-6856 ; 2093-6966
ISSN (online)	2234-6856
ISSN	2093-6966
DOI	10.3831/KPI.2020.23.3.179
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paracetamol (Acetaminophen)-associated SJS, TEN, AGEP, and DRESS Syndromes - A Narrative Review.

Pakkir Maideen, Naina Mohamed / Barakat, Ibrahim Ramadan / Jumale, AbduRazak Hassan

Current drug safety

2023 Volume 19, Issue 2, Page(s) 218–223

Abstract: Introduction: Paracetamol (Acetaminophen) is a very common OTC drug that is found in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly used as an antipyretic to reduce fever and as an alternative to Non-steroidal ... ...

Abstract	Introduction: Paracetamol (Acetaminophen) is a very common OTC drug that is found in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly used as an antipyretic to reduce fever and as an alternative to Non-steroidal anti-inflammatory drugs (NSAIDs) that are contraindicated in certain patients to relieve mild-moderate pain. Objective: This review article focuses on SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes associated with the use of paracetamol or paracetamol-containing products. Methods: To find published articles relevant to paracetamol-associated SJS, TEN, AGEP, and DRESS, we searched the online databases Medline/Pubmed/PMC, Google Scholar, Science Direct, Ebsco, Scopus, Web of Science, Embase, and reference lists using keywords like Stevens-Johnson Syndrome, Acetaminophen, Paracetamol, Toxic epidermal necrolysis, Acute generalized exanthematous pustulosis, Drug reaction with eosinophilia and systemic symptoms. Results: The paracetamol-associated SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes have been identified by a number of publications. Conclusion: When evaluating drug-induced hypersensitivity skin reactions, healthcare professionals, including prescribers, pharmacists, and others, should be aware of this rare risk. Patients who exhibit signs and symptoms of paracetamol-associated hypersensitivity should be referred to physicians by pharmacists for further treatment. At the first sign of a skin rash or other hypersensitivity reaction while taking paracetamol, patients should be told to stop taking it and see a doctor right away.
MeSH term(s)	Humans ; Stevens-Johnson Syndrome/diagnosis ; Drug Hypersensitivity Syndrome/diagnosis ; Drug Hypersensitivity Syndrome/etiology ; Acute Generalized Exanthematous Pustulosis ; Acetaminophen/adverse effects ; Pain
Chemical Substances	Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2023-05-06
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/1574886318666230505144014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prophetic Medicine-Nigella Sativa (Black cumin seeds) - Potential herb for COVID-19?

Maideen, Naina Mohamed Pakkir

Journal of pharmacopuncture

2020 Volume 23, Issue 2, Page(s) 62–70

Abstract: Coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Currently, the management of patients with COVID-19 depends mainly on repurposed drugs which include chloroquine, hydroxychloroquine, ... ...

Abstract	Coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Currently, the management of patients with COVID-19 depends mainly on repurposed drugs which include chloroquine, hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir, favipiravir, umifenovir, interferon-α, interferon-β and others. In this review, the potential of Nigella sativa (black cumin seeds) to treat the patients with COVID-19 analyzed, as it has shown to possess antiviral, antioxidant, anti-inflammatory, anticoagulant, immunomodulatory, bronchodilatory, antihistaminic, antitussive, antipyretic and analgesic activities. PubMed, Google Scholar, Science Direct, Directory of open access journals (DOAJ) and reference lists were searched to identify articles associated with antiviral and other properties of N.sativa related to the signs and symptoms of COVID-19. Various randomized controlled trials, pilot studies, case reports and in vitro and in vivo studies confirmed that N.sativa has antiviral, antioxidant, anti-inflammatory, immunomodulatory, bronchodilatory, antihistaminic, antitussive activities related to causative oraganism and signs and symptoms of COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-07-19
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2747301-6
ISSN	2234-6856 ; 2093-6966
ISSN (online)	2234-6856
ISSN	2093-6966
DOI	10.3831/KPI.2020.23.010
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Article: Overview of Tendinopathy, Peripheral Neuropathy, Aortic Aneurysm, and Hypoglycemia Caused by Fluoroquinolones

Balasubramanian, Rajkapoor / Maideen, Naina Mohamed Pakkir / Narayanaswamy, Harikrishnan

Ibnosina Journal of Medicine and Biomedical Sciences

2024

Abstract: Background: Fluoroquinolones (FQs) are widely used in the management of several bacterial infections including urinary tract infections (UTIs), upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), skin and soft tissue, ...

Abstract	Background: Fluoroquinolones (FQs) are widely used in the management of several bacterial infections including urinary tract infections (UTIs), upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), skin and soft tissue, gastrointestinal tract infections (GITIs), and many other infections. Objective: This review article focuses on some serious side effects notified by United States Food and Drug Administration (US FDA) in different warning statements. Methods: The literature was searched, in databases such as Medline/PubMed/PMC, Google Scholar, Science Direct, Ebsco, Scopus, Web of science, Embase, and reference lists to identify publications relevant to the serious side effects associated with the use of FQs. Results: Several epidemiological studies and meta-analyses have documented the occurrence of serious side effects of FQs including tendinopathy, peripheral neuropathy, aortic aneurysm/dissection, hypoglycemia, QT prolongation, retinal detachment, and worsening of myasthenia gravis. Conclusion: The clinicians should be aware of serious side effects of FQs. The US FDA and European Medicines Agency recommend against the use of FQs as first-line therapies to treat infections such as acute sinusitis, acute bronchitis, and uncomplicated UTIs, as the risks outweigh the benefits. The risk of incidence of serious side effects of FQs is higher among patients with advanced age, renal insufficiency, and certain concomitant medications. To avoid occurrence of any serious side effects of FQs, the clinicians should prefer non-FQ antibacterial drugs to manage uncomplicated UTIs, respiratory tract infections, and other infections for which alternatives available.
Keywords	fluoroquinolones ; tendinopathy ; tendinitis ; tendon disorders ; arthropathy ; aortic aneurysm ; aortic dissection ; QT prolongation ; Torsades de pointes ; retinal detachment ; myasthenia gravis.
Language	English
Publishing date	2024-03-27
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2585341-7
ISSN	1947-489X ; 1947-489X
ISSN (online)	1947-489X
ISSN	1947-489X
DOI	10.1055/s-0043-1777825
Database	Thieme publisher's database

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Article: A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (

Balasubramanian, Rajkapoor / Maideen, Naina Mohamed Pakkir / Muthusamy, Sudha / Gobinath, Mirunalini

Journal of pharmacopuncture

2023 Volume 26, Issue 1, Page(s) 1–9

Abstract: Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as ... ...

Abstract	Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Methods: A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of Results: Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed ( Conclusion: N. sativa
Language	English
Publishing date	2023-02-26
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2747301-6
ISSN	2234-6856 ; 2093-6966
ISSN (online)	2234-6856
ISSN	2093-6966
DOI	10.3831/KPI.2023.26.1.1
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Article ; Online: An Overview of Clinically Imperative and Pharmacodynamically Significant Drug Interactions of Renin-Angiotensin-Aldosterone System (RAAS) Blockers.

Mohamed Pakkir Maideen, Naina / Balasubramanian, Rajkapoor / Muthusamy, Sudha / Nallasamy, Venkateswaramurthy

Current cardiology reviews

2022 Volume 18, Issue 6, Page(s) e110522204611

Abstract: Introduction: Hypertension is a leading cause of cardiovascular disease and chronic kidney disease, resulting in premature death and disability. The Renin-Angiotensin-Aldosterone System (RAAS) blockers, including Angiotensin-Converting Enzyme (ACE) ... ...

Abstract	Introduction: Hypertension is a leading cause of cardiovascular disease and chronic kidney disease, resulting in premature death and disability. The Renin-Angiotensin-Aldosterone System (RAAS) blockers, including Angiotensin-Converting Enzyme (ACE) inhibitors or Angiotensin Receptor Blockers (ARBs), are used as first-line antihypertensive therapy to treat hypertensive patients with comorbidities, including diabetes, ischemic heart disease, heart failure, and chronic kidney disease. The use of RAS blockers is associated with the risks, such as hyperkalemia, angioedema, etc. The drugs potentiating them interact pharmacodynamically, resulting in adverse consequences. This review article focuses on the clinically important drug interactions of RAAS blockers. Materials and methods: The electronic databases, such as Medline/PubMed Central/PubMed, Google Scholar, ScienceDirect, Cochrane Library, Directory of Open Access Journals (DOAJ), Embase, and reference lists were searched to identify relevant articles. Results: The risk of hyperkalemia may be enhanced potentially in patients receiving a RAS blocker and potassium-sparing diuretics, potassium supplements, trimethoprim, adrenergic betablockers, antifungal agents, calcineurin inhibitors, pentamidine, heparins or an NSAID, concomitantly. The patients taking ACE inhibitors and mTOR inhibitors, DPP4 inhibitors, alteplase, or sacubitril/valsartan concurrently may be at increased risk of developing angioedema. Conclusion: Clinicians, pharmacists, and other healthcare practitioners should be accountable for medication safety. To avoid adverse implications, prescribers and pharmacists must be aware of the drugs that interact with RAAS blockers.
MeSH term(s)	Humans ; Renin-Angiotensin System ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Hyperkalemia/chemically induced ; Hyperkalemia/drug therapy ; Hypertension/drug therapy ; Drug Interactions ; Renal Insufficiency, Chronic/drug therapy ; Potassium/therapeutic use ; Angioedema/chemically induced ; Angioedema/drug therapy
Chemical Substances	sacubitril (17ERJ0MKGI) ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Potassium (RWP5GA015D)
Language	English
Publishing date	2022-05-06
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ISSN	1875-6557
ISSN (online)	1875-6557
DOI	10.2174/1573403X18666220511152330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential of Black Seeds (

Pakkir Maideen, Naina Mohamed / Hassan Jumale, Abdurazak / Ramadan Barakat, Ibrahim / Khalifa Albasti, Ayesha

Infectious disorders drug targets

2023 Volume 23, Issue 4, Page(s) e230223213955

Abstract: Background: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care.: Objective: This review article focuses ... ...

Abstract	Background: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care. Objective: This review article focuses on the beneficial effects of black seeds (Nigella sativa) in the management of long COVID and persistent COVID symptoms. Methods: The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of long COVID. Results: Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic properties in various clinical, animal, in vitro, in vivo, and in silico studies, which would help the patients recovered from COVID to mitigate Long COVID complications. Conclusion: Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy in combination with symptomatic treatment and supportive care to prevent further deterioration and hospitalization. The safety and efficacy of N. sativa in patients with Long-COVID would further be established by future randomized controlled clinical trials.
MeSH term(s)	Animals ; Humans ; Plant Extracts/pharmacology ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Nigella sativa ; Seeds
Chemical Substances	Plant Extracts
Language	English
Publishing date	2023-02-24
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526523666230223112045
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Article ; Online: A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

Rajkapoor Balasubramanian / Naina Mohamed Pakkir Maideen / Sudha Muthusamy / Mirunalini Gobinath

Journal of Pharmacopuncture, Vol 26, Iss 1, Pp 1-

2023 Volume 9

Abstract	Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Nigella sativa to manage women with PCOS.Methods : : A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of N. sativa in the management of women with PCOS.Results : : Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed (N. sativa), thymoquinone, has potential for managing women with PCOS. Moreover, N. sativa may help to manage oligomenorrhea and amenorrhea in women with PCOS through its anti-inflammatory and antioxidant properties.Conclusion : : N. sativa has potential for use as a herbal medicine for managing women with PCOS as an integrative medicine along with traditional and modern medicine in conjunction with calorie restriction and regular exercise.
Keywords	nigella sativa ; black seeds ; thymoquinone ; polycystic ovarian syndrome ; antiinflammatory ; antioxidant ; Medicine ; R ; Miscellaneous systems and treatments ; RZ409.7-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Korean Pharmacopuncture Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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