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  1. Book: Twenty years of Nipah virus research

    Wit, Emmie de

    (The journal of infectious diseases ; volume 221, supplement 4 (1 June 2020))

    2020  

    Author's details editors: Emmie de Wit, Ph.D., Emily S. Gurley, Ph.D., and Christina F. Spiropoulou, Ph.D
    Series title The journal of infectious diseases ; volume 221, supplement 4 (1 June 2020)
    Collection
    Language English
    Size Seite S359-S498, Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT020531805
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh II Zs 50 -221,Suppl.4- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Antiviral agents for the treatment of COVID-19: Progress and challenges.

    Singh, Manmeet / de Wit, Emmie

    Cell reports. Medicine

    2022  Volume 3, Issue 3, Page(s) 100549

    Abstract: The COVID-19 pandemic has seen clinical development and use of antiviral therapies at an unprecedented speed. Antiviral therapies have greatly improved the clinical outcome in COVID-19 patients, especially when administered early after diagnosis. Here, ... ...

    Abstract The COVID-19 pandemic has seen clinical development and use of antiviral therapies at an unprecedented speed. Antiviral therapies have greatly improved the clinical outcome in COVID-19 patients, especially when administered early after diagnosis. Here, we discuss the successes and challenges of COVID-19 antiviral therapies and lessons for future pandemics.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Forecasting ; Humans ; Influenza, Human/drug therapy ; Pandemics
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type News
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Replication-Competent Virus Detected in Blood of a Fatal COVID-19 Case.

    Platt, Andrew / Singh, Manmeet / Stein, Sydney / Soherwardi, Shahabuddin / de Wit, Emmie / Chertow, Daniel S

    Annals of internal medicine

    2023  Volume 177, Issue 1, Page(s) 113–115

    MeSH term(s) Humans ; COVID-19 ; DNA, Viral ; Virus Replication
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Twenty Years of Nipah Virus Research: Where Do We Go From Here?

    Gurley, Emily S / Spiropoulou, Christina F / de Wit, Emmie

    The Journal of infectious diseases

    2020  Volume 221, Issue Suppl 4, Page(s) S359–S362

    MeSH term(s) Animals ; Disease Outbreaks ; Henipavirus Infections/epidemiology ; Henipavirus Infections/history ; Henipavirus Infections/virology ; History, 21st Century ; Humans ; India/epidemiology ; Nipah Virus/classification ; Nipah Virus/isolation & purification ; Philippines/epidemiology
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 445: Show issues

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  5. Article: Next-generation vaccine platforms for COVID-19.

    van Riel, Debby / de Wit, Emmie

    Nature materials

    2020  Volume 19, Issue 8, Page(s) 810–812

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Viral Vaccines/immunology ; Viral Vaccines/therapeutic use
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-020-0746-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure.

    Fischer, Robert J / Bushmaker, Trenton / Williamson, Brandi N / Pérez-Pérez, Lizzette / Feldmann, Friederike / Lovaglio, Jamie / Scott, Dana / Saturday, Greg / Feldmann, Heinz / Munster, Vincent J / de Wit, Emmie / van Doremalen, Neeltje

    The Journal of infectious diseases

    2024  

    Abstract: Non-human primate models are essential for the development of vaccines and antivirals against infectious diseases. Rhesus macaques are a widely utilized infection model for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We compared ... ...

    Abstract Non-human primate models are essential for the development of vaccines and antivirals against infectious diseases. Rhesus macaques are a widely utilized infection model for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We compared cellular tropism and virus replication in rhesus macaques inoculated with SARS-CoV-2 via the intranasal route, or via exposure to aerosols. Intranasal inoculation results in replication in the upper respiratory tract and limited lower respiratory tract involvement, whereas exposure to aerosols results in infection throughout the respiratory tract. In comparison to multi-route inoculation, the intranasal and aerosol inoculation routes result in reduced SARS-CoV-2 replication in the respiratory tract.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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  8. Article ; Online: The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans.

    Bauer, Lisa / Benavides, Feline F W / Veldhuis Kroeze, Edwin J B / de Wit, Emmie / van Riel, Debby

    Trends in neurosciences

    2023  Volume 46, Issue 11, Page(s) 953–970

    Abstract: Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological ... ...

    Abstract Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
    MeSH term(s) Animals ; Humans ; Influenza in Birds ; Influenza A virus ; Birds ; Mammals
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2023.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1442: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 53: Show issues

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  9. Article ; Online: Low level of tonic interferon signalling is associated with enhanced susceptibility to SARS-CoV-2 variants of concern in human lung organoids.

    Flagg, Meaghan / Goldin, Kerry / Pérez-Pérez, Lizzette / Singh, Manmeet / Williamson, Brandi N / Pruett, Nathanael / Hoang, Chuong D / de Wit, Emmie

    Emerging microbes & infections

    2023  Volume 12, Issue 2, Page(s) 2276338

    Abstract: There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta (B.1. ...

    Abstract There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta (B.1.617.2) and Omicron (B.1.1.529) further compounded this heterogeneity. Virus replication and host cell damage in the distal lung is often associated with severe clinical disease, making this an important site to consider when evaluating pathogenicity of SARS-CoV-2 VOCs. Using distal human lung organoids (hLOs) derived from multiple human donors, we compared the fitness and pathogenicity of SARS-CoV-2 VOC Delta and Omicron, along with an ancestral clade B variant D614G, and evaluated donor-dependent differences in susceptibility to infection. We observed substantial attenuation of Omicron in hLOs and demonstrated enhanced susceptibility to Omicron and D614G replication in hLOs from one donor. Transcriptomic analysis revealed that increased susceptibility to SARS-CoV-2 infection in these hLOs was associated with reduced tonic interferon signaling activity at baseline. We show that hLOs can be used to model heterogeneity of SARS-CoV-2 pathogenesis in humans, and propose that variability in tonic interferon signaling set point may impact susceptibility to SARS-CoV-2 VOCs and subsequent COVID-19 disease progression.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Organoids ; Interferons/genetics
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2276338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Next-generation vaccine platforms for COVID-19

    van Riel, Debby / de Wit, Emmie

    Nature Materials

    2020  Volume 19, Issue 8, Page(s) 810–812

    Keywords Mechanical Engineering ; General Materials Science ; Mechanics of Materials ; General Chemistry ; Condensed Matter Physics ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-020-0746-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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