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Article: Non-volatile compounds from Araucaria columnaris (G.Forst.) Hook leaves

Frezza, Claudio / Sciubba, Fabio / De Vita, Daniela / Toniolo, Chiara / Foddai, Sebastiano / Tomassini, Lamberto / Petrucci, Rita / Bianco, Armandodoriano / Serafini, Mauro

Biochemical systematics and ecology. 2022 Aug., v. 103

2022

Abstract: The phytochemical analysis on the leaves of a new population of Araucaria columnaris (G.Forst ...

Abstract	The phytochemical analysis on the leaves of a new population of Araucaria columnaris (G.Forst.) Hook. was reported. Seven compounds were identified i.e., 15-agathic acid methyl ester (1), ladanein (2), 7,4′,7″,4‴-tetra-O-methyl-robustaflavone (3), 3-O-trans-p-coumaroyl-quinic acid (4), 4-O-trans-p-coumaroyl-quinic acid (5), 5-O-trans-p-coumaroyl-quinic acid (6) and shikimic acid (7). Chromatographic and spectroscopic techniques were utilized for this. Their presence is important from the chemophenetic point of view, but further research is necessary to make final conclusions on this species.
Keywords	Araucaria columnaris ; chemotaxonomy ; chromatography ; ecology ; phytochemicals ; shikimic acid ; spectroscopy
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0305-1978
DOI	10.1016/j.bse.2022.104430
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study.

Frezza, Elisa / Amans, Tina-Méryl / Martin, Juliette

Biomolecules

2020 Volume 10, Issue 9

Abstract: ... scale molecular dynamics simulations on the AC5 isoform of adenylyl cyclase bound to the inhibitory G ...

Abstract	Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP). Using homology models developed from existing structural data and docking experiments, we have carried out all-atom, microsecond-scale molecular dynamics simulations on the AC5 isoform of adenylyl cyclase bound to the inhibitory G-protein subunit Gαi in the presence and in the absence of ATP. The results show that Gαi has significant effects on the structure and flexibility of adenylyl cyclase, as observed earlier for the binding of ATP and Gsα. New data on Gαi bound to the C1 domain of AC5 help explain how Gαi inhibits enzyme activity and obtain insight on its regulation. Simulations also suggest a crucial role of ATP in the regulation of the stimulation and inhibition of AC5.
MeSH term(s)	Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Adenylyl Cyclases/chemistry ; Adenylyl Cyclases/metabolism ; Allosteric Regulation ; Animals ; GTP-Binding Protein alpha Subunits, Gi-Go/chemistry ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Kinetics ; Mice ; Molecular Dynamics Simulation ; Protein Binding ; Protein Domains
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylyl cyclase type V (EC 4.6.1.1)
Language	English
Publishing date	2020-09-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10091330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding.

Frezza, Elisa / Martin, Juliette / Lavery, Richard

PloS one

2018 Volume 13, Issue 4, Page(s) e0196207

Abstract: ... of ACs is carefully controlled by a variety of molecules, including G-protein subunits ... of adenylyl cyclase and on its complexes with ATP and with the stimulatory G-protein subunit Gsα. The results show ... and interactions with the inhibitory G-protein subunit Gαi. ...

Abstract	Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways. The enzymatic activity of ACs is carefully controlled by a variety of molecules, including G-protein subunits that can both stimulate and inhibit cAMP production. Using homology models developed from existing structural data, we have carried out all-atom, microsecond-scale molecular dynamics simulations on the AC5 isoform of adenylyl cyclase and on its complexes with ATP and with the stimulatory G-protein subunit Gsα. The results show that both ATP and Gsα binding have significant effects on the structure and flexibility of adenylyl cyclase. New data on ATP bound to AC5 in the absence of Gsα notably help to explain how Gsα binding enhances enzyme activity and could aid product release. Simulations also suggest a possible coupling between ATP binding and interactions with the inhibitory G-protein subunit Gαi.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Adenylyl Cyclases/chemistry ; Adenylyl Cyclases/metabolism ; Animals ; Binding Sites ; GTP-Binding Proteins/metabolism ; Mice ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Structural Homology, Protein
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; GTP-Binding Proteins (EC 3.6.1.-) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylyl cyclase type V (EC 4.6.1.1)
Language	English
Publishing date	2018-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0196207
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Article ; Online: Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues.

Franceschin, Marco / Cianni, Lorenzo / Pitorri, Massimo / Micheli, Emanuela / Cacchione, Stefano / Frezza, Claudio / Serafini, Mauro / Hu, Ming-Hao / Su, Huafi / Huang, Zhishu / Gu, Lianquan / Bianco, Armandodoriano

Molecules (Basel, Switzerland)

2018 Volume 23, Issue 6

Abstract: ... berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works ... reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex ... that the presence of suitable side chains is very useful for improving the interaction of the ligands with G ...

Abstract	In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.
MeSH term(s)	Berberine/analogs & derivatives ; Berberine/chemistry ; Berberine Alkaloids/chemical synthesis ; Berberine Alkaloids/chemistry ; Berberine Alkaloids/pharmacology ; DNA/chemistry ; DNA/metabolism ; G-Quadruplexes ; Ligands ; Models, Molecular ; Molecular Structure
Chemical Substances	Berberine Alkaloids ; Ligands ; Berberine (0I8Y3P32UF) ; DNA (9007-49-2) ; palmatine (G50C034217)
Language	English
Publishing date	2018-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules23061423
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Article ; Online: Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands

Marco Franceschin / Lorenzo Cianni / Massimo Pitorri / Emanuela Micheli / Stefano Cacchione / Claudio Frezza / Mauro Serafini / Ming-Hao Hu / Huafi Su / Zhishu Huang / Lianquan Gu / Armandodoriano Bianco

Molecules, Vol 23, Iss 6, p

From Previously Reported Berberine Derivatives to New Palmatine Analogues

2018 Volume 1423

Abstract	In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.
Keywords	G-quadruplex DNA ; interactions ; berberine and palmatine derivatives ; NMR ; FRET and MST assays ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In praise of serendipity.

Kneebone, Roger / Frezza, Giulia

Lancet (London, England)

2024 Volume 403, Issue 10434, Page(s) 1330–1331

MeSH term(s)	Humans ; Motivation ; Self Concept
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(24)00644-5
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Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 94: Show issues

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Book ; Online: The metabolic challenges of immune cells in health and disease

Frezza, Christian / Mauro, Claudio

2015

Abstract: Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work ...

Abstract	Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome.- This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells.- It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism
Keywords	Immunologic diseases. Allergy ; Medicine (General)
Size	1 electronic resource (80 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020091816
ISBN	9782889196227 ; 2889196224
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than 1250 g.

Frezza, Simonetta / Maggio, Luca / De Carolis, Maria Pia / Gallini, Francesca / Puopolo, Maria / Polimeni, Valentina / Costa, Simonetta / Vento, Giovanni / Tortorolo, Giuseppe

European journal of pediatrics

2005 Volume 164, Issue 2, Page(s) 88–92

Abstract: ... risk factors in premature infants during the 1st month of life, all infants with a birth weight <1250 g ... with a birth weight <1250 g, 20 out of 233 ventilated infants (8.6%) developed PC. Candida albicans ( n =12) and C ... considered in the preventive efforts to reduce this disease in infants with a birth weight <1250 g. ...

Abstract	Unlabelled: To evaluate the epidemiology of pulmonary candidiasis (PC) and to identify risk factors in premature infants during the 1st month of life, all infants with a birth weight <1250 g admitted to our neonatal intensive care unit with PC between January 1994 and December 2001 were retrospectively reviewed. Infants with PC ( n =20) were compared with a control group ( n =20), matched for gestational age and birth weight, with regard to possible perinatal and postnatal risk factors. Among 325 infants with a birth weight <1250 g, 20 out of 233 ventilated infants (8.6%) developed PC. Candida albicans ( n =12) and C. parapsilosis ( n =4) were the predominant isolates. Neonates with PC were significantly different from controls with regard to male prevalence ( P =0.002), rates of preterm premature rupture of membranes (PPROM) ( P =0.02), longer duration of antibiotic therapy ( P =0.01) and of ventilation ( P =0.02). The difference between groups did not attain significance with regard to postnatal dexamethasone administration, duration of central vein catheterisation and duration of parenteral nutrition. Multivariate logistic regression analysis indicated as significant predictors of PC, among perinatal data, the male gender (OR =26.3; 95%CI 2.44 to 284) and PPROM (OR =12.3; 95%CI 1.16 to 130) and, among postnatal data, the duration of ventilation (OR =1.54; 95%CI 1.01 to 2.34). Conclusion: The presence of preterm premature rupture of membranes and the duration of ventilation are significant risk factors for developing pulmonary candidiasis and should be considered in the preventive efforts to reduce this disease in infants with a birth weight <1250 g.
MeSH term(s)	Candidiasis/diagnosis ; Candidiasis/epidemiology ; Case-Control Studies ; Female ; Fetal Membranes, Premature Rupture/epidemiology ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Italy/epidemiology ; Lung Diseases, Fungal/diagnosis ; Lung Diseases, Fungal/epidemiology ; Male ; Multivariate Analysis ; Pregnancy ; Respiration, Artificial ; Retrospective Studies ; Risk Factors ; Sex Factors ; Time Factors
Language	English
Publishing date	2005-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-004-1571-1
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Article: Housing and “confinement”. COVID-19, visiting right of the non-custodial parent and succesion mortis causa in housing law

Frezza, G.

Actualidad Juridica Iberoamericana

Abstract: The essay analyses the effects of COVID-19 in relation to the cohabitation and the rights of visitation of the non-custodial parent of the children Particular attention is then focused on the application problems of the death of the spouse due to ... ...

Abstract	The essay analyses the effects of COVID-19 in relation to the cohabitation and the rights of visitation of the non-custodial parent of the children Particular attention is then focused on the application problems of the death of the spouse due to coronavirus and the right of the survivor to live in the family home © 2020 Ibero-American Law Institute All rights reserved
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #825172
Database	COVID19

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Article: Cisplatin-epirubicin-paclitaxel weekly administration with G-CSF support in advanced breast cancer. A Southern Italy Cooperative Oncology Group (SICOG) phase II study.

Frasci, G / D'Aiuto, G / Comella, P / Thomas, R / Capasso, I / Di Bonito, M / Rivellini, F / Carteni, G / De Lucia, L / Maiorino, L / D'Aniello, R / Frezza, P / Lapenta, L / Comella, G

Breast cancer research and treatment

2000 Volume 62, Issue 2, Page(s) 87–97

Abstract: ... sqm plus G-CSF (day 3-5), for a maximum of 12 cycles. Thirty-five patients had stage IIIB and 33 stage ...

Abstract	Purpose: It has been shown in vitro that both cisplatin and epirubicin increase the antitumor activity of paclitaxel. Weekly administration could give a substantial improvement in the therapeutic index of cisplatin and paclitaxel. This study was aimed at defining the antitumor activity of a weekly cisplatin-epirubicin-paclitaxel (PET) administration in locally advanced or metastatic breast cancer patients. Patients and methods: Sixty-eight breast cancer patients with advanced disease, who had not received prior chemotherapy (except adjuvant), received weekly cisplatin 30 mg/sqm, paclitaxel 120 mg/sqm and epirubicin 50 mg/sqm plus G-CSF (day 3-5), for a maximum of 12 cycles. Thirty-five patients had stage IIIB and 33 stage IV disease (14 with visceral metastases). Results: All patients were evaluable for response on an intent to treat basis. Overall, 21 complete and 38 partial responses have been recorded for an 87% ORR (95% CI = 76-94%). Fourteen CRs and 19 PRs have been registered in the 35 patients with locally advanced disease for a 94% ORR (95% CI = 81-99%) while 7 CRs and 19 PRs were observed in the 33 patients with metastatic disease for a 79% ORR (95% CI-61-91%). Surgery was performed in 33/35 women with locally advanced disease. Four of these patients (11%) showed no invasive cancer on pathologic examination, and in an additional 8 patients tumor < 1 cm was found in the breast. Only 4/33 patients who underwent surgery relapsed. The projected one-year RFS was greater than 80%. At an 11-month median follow-up (range, 3-19), 11 patients had progressed and 5 had died among the 33 patients with metastatic disease, the median progression-free survival in this group being 14 months. Severe hematologic toxicity was uncommon, grade 3-4 neutropenia and thrombocytopenia occurring in 32% and 4% of patients, respectively. Only 2 episodes of neutropenic sepsis were registered. Packed red blood cell transfusions were required in 7 patients. Vomiting, diarrhoea, mucositis and skin toxicity were severe in 6%, 9%, 10%, and 9% of patients, respectively. Peripheral neuropathy was observed in 47% of patients. Conclusions: The weekly PET administration is a well tolerated and very effective approach in advanced breast cancer patients. It can produce a 40% clinical complete response rate, with a more than 10% pCR rate in patients with T4 disease, and an about 80% ORR in those with distant metastases. A phase III trial comparing PET with a standard every 3 weeks epirubicin-taxol administration is underway.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cisplatin/administration & dosage ; Disease-Free Survival ; Drug Administration Schedule ; Epirubicin/administration & dosage ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Humans ; Italy/epidemiology ; Middle Aged ; Neoplasm Metastasis ; Paclitaxel/administration & dosage ; Treatment Outcome
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7) ; Epirubicin (3Z8479ZZ5X) ; Paclitaxel (P88XT4IS4D) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2000-02-23
Publishing country	Netherlands
Document type	Clinical Trial ; Clinical Trial, Phase II ; Journal Article ; Multicenter Study
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1023/a:1006429205363
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