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Article ; Online: Novel method for simultaneous determination of p-cresylsulphate and p-cresylglucuronide: clinical data and pathophysiological implications.

Meert, Natalie / Schepers, Eva / Glorieux, Griet / Van Landschoot, Maria / Goeman, Jan L / Waterloos, Marie-Anne / Dhondt, Annemieke / Van der Eycken, Johan / Vanholder, Raymond

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2012 Volume 27, Issue 6, Page(s) 2388–2396

Abstract: Background: The uraemic retention solutes p-cresylsulphate (pCS) and p-cresylglucuronide (pCG ... two conjugates of p-cresol, were never determined simultaneously. In the present paper, a high ...

Abstract	Background: The uraemic retention solutes p-cresylsulphate (pCS) and p-cresylglucuronide (pCG), two conjugates of p-cresol, were never determined simultaneously. In the present paper, a high-performance liquid chromatography (HPLC) method was developed and used to quantify both compounds in parallel in an in vivo observational study and their in vitro effect was evaluated by flow cytometry. Methods: pCS and pCG were determined in serum. For the validation specificity, linearity, recovery, precision and the quantification limit were evaluated. In vivo, concentrations of both compounds were determined in 15 controls and 77 haemodialysis patients, as well as protein binding in the dialysed group and the reduction ratios during haemodiafiltration. In addition, the in vitro effect of the solutes on leucocyte free radical production at measured concentrations was assessed. Results: A fast and accurate HPLC method was developed to simultaneously quantify pCS and pCG. Both conjugates are retained in uraemia with a substantially higher total serum pCS in comparison to pCG (31.4 ± 15.8 versus 7.3 ± 6.5 mg/L) but also a substantial difference in protein binding (92.4 ± 3.0 versus 8.3 ± 4.4%) and in reduction ratio during post-dilution haemodiafiltration (37.4 ± 7.1 versus 78.6 ± 6.4%). pCG per se has no effect on leucocyte oxidative burst activity, whereas in combination with pCS, a synergistic activating effect was observed. Conclusions: Serum concentrations of pCS and pCG are elevated in uraemia. Both conjugates show a different protein binding, resulting in a different dialytic behaviour. Biologically, both conjugates are synergistic in activating leucocytes.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Case-Control Studies ; Chromatography, High Pressure Liquid ; Cresols/blood ; Female ; Follow-Up Studies ; Free Radicals/metabolism ; Glucuronides/blood ; Humans ; Leukocytes/metabolism ; Male ; Middle Aged ; Prognosis ; Renal Dialysis ; Respiratory Burst ; Sulfuric Acid Esters/blood ; Uremia/blood ; Uremia/physiopathology
Chemical Substances	4-cresylglucuronide ; Biomarkers ; Cresols ; Free Radicals ; Glucuronides ; Sulfuric Acid Esters ; 4-cresol sulfate (56M34ZQY1S)
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfr672
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pathologies néoplasiques respiratoires : quel rôle pour les soins intensifs ?

Berghmans, T / Meert, A-P

Revue des maladies respiratoires

2023 Volume 40, Issue 4, Page(s) 303–305

Title translation	Respiratory cancer diseases: Which role for intensive care ?
MeSH term(s)	Humans ; Critical Care ; Intensive Care Units ; Respiratory Tract Diseases ; Respiration Disorders ; Neoplasms ; Respiratory Insufficiency
Language	French
Publishing date	2023-03-01
Publishing country	France
Document type	Editorial
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2023.02.004
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Article: P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production.

Schepers, Eva / Meert, Natalie / Glorieux, Griet / Goeman, Jan / Van der Eycken, Johan / Vanholder, Raymond

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2007 Volume 22, Issue 2, Page(s) 592–596

Abstract: ... excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute, has been shown ... to exert toxic effects in vitro. Recently, however, it has been demonstrated that p-cresol ... in the human body is conjugated, with p-cresylsulphate as the main metabolite.: Methods: The present study ...

Abstract	Background: Chronic renal insufficiency is associated with the retention of solutes normally excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute, has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite. Methods: The present study evaluates the effect of p-cresylsulphate on the respiratory burst activity of leucocytes. Results: P-cresylsulphate significantly increased the percentage of leucocytes displaying oxidative burst activity at baseline. Oxidative burst activity of stimulated leucocytes was however not affected. In contrast, p-cresol had no effect on the leucocytes at baseline, but inhibited leucocytes burst activity after stimulation. Conclusion: The present study demonstrates, for the first time, that p-cresylsulphate, the main in vivo metabolite of p-cresol, has a pro-inflammatory effect on unstimulated leucocytes. This effect could contribute to the propensity to vascular disease in the uraemic population.
MeSH term(s)	Biomarkers/blood ; Cresols/metabolism ; Cresols/pharmacology ; Endotoxins/pharmacology ; Escherichia coli ; Free Radicals/metabolism ; Humans ; Leukocytes/drug effects ; Leukocytes/metabolism ; Respiratory Burst/drug effects ; Sulfuric Acid Esters/pharmacology ; Uremia/blood
Chemical Substances	Biomarkers ; Cresols ; Endotoxins ; Free Radicals ; Sulfuric Acid Esters ; 4-cresol (1MXY2UM8NV) ; 4-cresol sulfate (56M34ZQY1S)
Language	English
Publishing date	2007-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfl584
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Complications sévères des traitements systémiques du patient cancéreux thoracique (complications hors infections et urgences respiratoires).

Berghmans, T / Brandão, M / Ilzkovitz, M / Meert, A-P

Revue des maladies respiratoires

2024 Volume 41, Issue 4, Page(s) 317–324

Abstract: Primary thoracic cancers affect a large number of patients, mainly those with lung cancer and to a lesser extent those with pleural mesothelioma and thymic tumours. Given their frequency and associated comorbidities, in patients whose mean age is high, ... ...

Title translation	Severe complications of systemic treatment in thoracic oncology.
Abstract	Primary thoracic cancers affect a large number of patients, mainly those with lung cancer and to a lesser extent those with pleural mesothelioma and thymic tumours. Given their frequency and associated comorbidities, in patients whose mean age is high, these diseases are associated with multiple complications. This article, the last of a series dedicated to emergencies in onco-haematological patients, aims to present a clinical picture of the severe complications (side effects, immune-related adverse events) associated with systemic treatments, excluding infections and respiratory emergencies, with which general practitioners and specialists can be confronted. New toxicities are to be expected with the implementation of innovative therapeutic approaches, such as CAR-T cells, along with immunomodulators and antibody-drug conjugates.
MeSH term(s)	Humans ; Emergencies ; Mesothelioma/drug therapy ; Mesothelioma, Malignant ; Thymoma/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Pleural Neoplasms/drug therapy
Language	French
Publishing date	2024-03-08
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2024.02.014
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Zs.A 1945: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management and outcome of oncological patients under immune checkpoint inhibitors presenting at the emergency department.

Pini, Francesco / Grigoriu, Bogdan / Lieveke, Ameye / Meert, Anne-Pascale

Emergency medicine journal : EMJ

2024

Abstract: ... Four clinical features were associated with an irAE: gastrointestinal complaints (p=0.01), skin rashes ... p=0.02), acute renal failure (p=0.002) and abnormal liver function (p=0.04). An irAE was also ...

Abstract	Introduction: With the rising use of immune checkpoint inhibitors ( Methods: A retrospective chart review of ED visits of patients on ICI from 15 December 2016 to 6 December 2020 was performed. Clinical presentation, cancer characteristics and type of ICI were extracted by a single abstractor. We recorded any suspicion of irAE in the ED and confirmation of an irAE was based on the patient's oncologist report. Outcome was based on mortality at date of last follow-up. Results: 227 patients on ICI presented to the ED, with a total of 451 visits. 54 (12%) of the visits resulted in a diagnosis of irAE. Four clinical features were associated with an irAE: gastrointestinal complaints (p=0.01), skin rashes (p=0.02), acute renal failure (p=0.002) and abnormal liver function (p=0.04). An irAE was also associated with three different factors: a cancer status in remission (OR=5.33, 95% CI 2.57 to 11.04), a combination of two ICIs (OR=4.43, 95% CI 2.09 to 9.42) and a medical history of irAE (OR=2.44, 95% CI 1.27 to 4.68). 30-day mortality was lower in the irAE group (0%) than in the non-irAE group (13%, 95% CI 9% to 19%). Conclusions: Oncological patients under ICI presenting in the ED are more likely to have an irAE if they present with gastrointestinal and dermatological complaints, acute renal failure and abnormal liver function. This is also true for patients with any history of irAE, a concomitant use of two ICIs and with a cancer status in remission.
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2023-213605
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Zs.A 1941: Show issues

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Article ; Online: Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease.

Liabeuf, Sophie / Barreto, Daniela V / Barreto, Fellype C / Meert, Natalie / Glorieux, Griet / Schepers, Eva / Temmar, Mohammed / Choukroun, Gabriel / Vanholder, Raymond / Massy, Ziad A

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2010 Volume 25, Issue 4, Page(s) 1183–1191

Abstract: ... in chronic kidney disease (CKD) patients. p-Cresol (a prototype protein-bound uraemic retention solute) has been shown ... to exert toxic effects in vitro. Recently, it has been demonstrated that p-cresol is present in plasma ... as its sulphate conjugate, p-cresylsulphate. The present study evaluated the distribution of free and total p ...

Abstract	Background: Uraemic toxins are considered to be emerging mortality risk factors in chronic kidney disease (CKD) patients. p-Cresol (a prototype protein-bound uraemic retention solute) has been shown to exert toxic effects in vitro. Recently, it has been demonstrated that p-cresol is present in plasma as its sulphate conjugate, p-cresylsulphate. The present study evaluated the distribution of free and total p-cresylsulphate and sought to determine whether these parameters were associated with vascular calcification, arterial stiffness and mortality risk in a cohort of CKD patients. Methods: One hundred and thirty-nine patients (mean +/- SD age: 67 +/- 12; males: 60%) at different stages of CKD (8% at Stage 2, 26.5% at Stage 3, 26.5% at Stage 4, 7% at Stage 5 and 32% at Stage 5D) were enrolled in this study. Results: Baseline total and free p-cresylsulphate presented an inverse relationship with renal function and were significantly associated with vascular calcification. During the study period (mean follow-up period: 779 +/- 185 days), 38 patients died [including 22 from cardiovascular (CV) causes]. In crude survival analyses, free (but not total) p-cresylsulphate was shown to be a predictor of overall and CV death. Higher free p-cresylsulphate levels (>0.051 mg/100 mL; median) were associated with mortality independently of well-known predictors of survival such as age, vascular calcification, anaemia and inflammation. Conclusions: Serum levels of free and total p-cresylsulphate (the main in vivo circulating metabolites of p-cresol) were elevated in later CKD stages. However, only free p-cresylsulphate seems to be a predictor of survival in CKD.
MeSH term(s)	Aged ; Biomarkers/blood ; Cresols/blood ; Female ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/mortality ; Male ; Predictive Value of Tests ; Sulfuric Acid Esters/blood ; Survival Rate
Chemical Substances	Biomarkers ; Cresols ; Sulfuric Acid Esters ; 4-cresol sulfate (56M34ZQY1S)
Language	English
Publishing date	2010-04
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfp592
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Article: Mycobacterium tuberculosis infection of a reverse total shoulder arthroplasty: a case report.

Meert, C / Poinot, N / Haumont, E / Tollet, P

Acta orthopaedica Belgica

2023 Volume 89, Issue 1, Page(s) 152–155

Abstract: We describe the case of a 78-years-old male with dyspnea, inappetence and weight loss over a period of two weeks. The CT scan suggested disseminated tuberculosis and T5-T6 spondylodiscitis. During hospitalization, he developed a left shoulder pain where ... ...

Abstract	We describe the case of a 78-years-old male with dyspnea, inappetence and weight loss over a period of two weeks. The CT scan suggested disseminated tuberculosis and T5-T6 spondylodiscitis. During hospitalization, he developed a left shoulder pain where a reverse total shoulder arthroplasty was implanted 11 years ago. Open debridement and lavage with retention of the implant was performed first and intraveinous antibiotics were administered. 3 months after surgery the patient developed a painful sinus track at the incision site. Resection of the fistula tract, soft tissue debridement and removal of the implants were performed before restarting chemotherapy. As the incidence of reverse total shoulder arthroplasty continues to increase throughout the world, periprosthetic joint infection (PJI) will probably raise as well. Diagnosing and treatment of shoulder PJI with atypical germs remains a challenge and explantation seems to be the safer surgical option to avoid recurrent surgeries on patient with increasing comorbidities.
MeSH term(s)	Humans ; Male ; Aged ; Arthroplasty, Replacement, Shoulder/adverse effects ; Treatment Outcome ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/therapy ; Prosthesis-Related Infections/diagnosis ; Arthroplasty ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/surgery ; Anti-Bacterial Agents/therapeutic use ; Tuberculosis/drug therapy ; Tuberculosis/surgery ; Arthritis, Infectious/surgery ; Retrospective Studies ; Debridement ; Reoperation
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-06-09
Publishing country	Belgium
Document type	Case Reports ; Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
DOI	10.52628/89.1.10971
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Zs.A 37: Show issues

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Article ; Online: Preventive action with a population of excavator drivers exposed to whole-body vibration.

Bossi, P / Meert, P

Work (Reading, Mass.)

2021 Volume 68, Issue 2, Page(s) 473–481

Abstract: Background: Whole-body vibration is a major cause of lower back pain among employees, and the medical and preventive care teams of occupational health departments are often confronted with lower back pain problems among machine operators.: Objectives!# ...

Abstract	Background: Whole-body vibration is a major cause of lower back pain among employees, and the medical and preventive care teams of occupational health departments are often confronted with lower back pain problems among machine operators. Objectives: The objectives of this research are to determine the number of excavator drivers exposed to whole-body vibration levels above 0.5m/s2, identify other exposure factors that may contribute to back pain, and propose corrective measures. Methods: Vibration measurements were carried out on individual excavator drivers while they were observed carrying out working tasks, after which prevention advice is given. Factors which determine vibration levels are logged on to a database. Results: The multivariate analysis of several determining factors shows vibration exposure levels vary depending on the varied work tasks being carried out. Conclusion: This study identifies exposed employees among excavator operators. For each workstation, the determining factors that could explain the high exposures to vibrations are identified. This work shows the important role of tasks on exposure levels. A better adaptation of the tools used to carry out work tasks would allow a decrease in the vibration level of this type of machine.
MeSH term(s)	Back Pain ; Humans ; Low Back Pain/etiology ; Low Back Pain/prevention & control ; Occupational Diseases/etiology ; Occupational Diseases/prevention & control ; Occupational Exposure/adverse effects ; Vibration/adverse effects
Language	English
Publishing date	2021-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1394194-x
ISSN	1875-9270 ; 1051-9815
ISSN (online)	1875-9270
ISSN	1051-9815
DOI	10.3233/WOR-203387
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Zs.A 4810: Show issues

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Article: Functional role of exogenous administration of substance P in chronic constriction injury model of neuropathic pain in gerbils.

Meert, Theo F / Vissers, Kris / Geenen, Frank / Kontinen, Vesa K

Pharmacology, biochemistry, and behavior

2003 Volume 76, Issue 1, Page(s) 17–25

Abstract: Substance P (SP) acts as a transmitter of nociception in both the peripheral and ... Intraplantar injections of SP and the selective NK-1 receptor agonist, [Sar(9)-Met(O(2))(11)]-substance P (Sar ...

Abstract	Substance P (SP) acts as a transmitter of nociception in both the peripheral and the central nervous system. Because the NK-1 receptors in gerbils are comparable to those in humans, gerbil models could be used to study the role of SP in neuropathic pain. A modification of the rat chronic constriction injury (CCI) model of neuropathic pain was produced in male gerbils by placing four loose chromic catgut ligatures around the sciatic nerve. This procedure clearly resulted in mechanical hypersensitivity. Intraplantar injections of SP and the selective NK-1 receptor agonist, [Sar(9)-Met(O(2))(11)]-substance P (Sar-SP), to the paw ipsilateral to the nerve injury and intrathecal administration of these peptides produced paw-lifting behavior in the CCI gerbils in thermoneutral conditions. In sham-operated and nonoperated controls, no such effects were observed. Systemic administration of the NK-1 antagonist R116301 attenuated the SP and the Sar-SP-induced paw-lifting behavior in the CCI gerbils indicating the role of NK-1 receptors in these effects. Intraplantar injection of the highest dose of SP (200 ng) to the paw contralateral to the CCI produced lifting of the paw ipsilateral to the injury, indicative for spinal mechanisms especially since administration of SP to the ipsilateral front paw or even intracardially did not have any effect at all. The SP-induced responses were not antagonized by the NMDA antagonist MK801. These results indicate that the peripheral and spinal SP reveal an increased reactivity in a neuropathic pain model. This increased pain sensitivity seems to involve spinal NK-1 mechanisms.
MeSH term(s)	Animals ; Constriction, Pathologic ; Dose-Response Relationship, Drug ; Gerbillinae ; Male ; Neurokinin-1 Receptor Antagonists ; Pain Measurement/drug effects ; Pain Measurement/methods ; Receptors, Neurokinin-1/agonists ; Receptors, Neurokinin-1/physiology ; Sciatic Neuropathy/chemically induced ; Sciatic Neuropathy/physiopathology ; Substance P/administration & dosage ; Substance P/physiology
Chemical Substances	Neurokinin-1 Receptor Antagonists ; Receptors, Neurokinin-1 ; Substance P (33507-63-0)
Language	English
Publishing date	2003-08
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	191042-5
ISSN	1873-5177 ; 0091-3057
ISSN (online)	1873-5177
ISSN	0091-3057
DOI	10.1016/s0091-3057(03)00187-4
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Zs.A 1060: Show issues

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Article ; Online: Quel rôle pour l’irradiation cérébrale prophylactique dans le cancer à petites cellules ? Une étude rétrospective unicentrique.

Fievet, L / Sculier, J-P / Meert, A-P / Berghmans, T

Revue des maladies respiratoires

2021 Volume 38, Issue 2, Page(s) 137–146

Abstract: ... to the brain progression status (P=0.11).: Conclusions: The expected impact of PCI seems limited in terms ...

Title translation	The role of prophylactic cranial irradiation in small cell lung cancer.
Abstract	Introduction: Prophylactic cranial irradiation (PCI) is considered standard therapeutic management in small cell lung cancer (SCLC). This is based on old randomised trials with methodological limitations, namely the absence of magnetic resonance imaging (MRI) of the brain. The aim of this study is to assess the risk not administering PCI when systematic brain imaging is applied. Methods: Retrospective study including untreated SCLC, without PCI and receiving brain imaging at the time of diagnosis. Kaplan-Meier and log-rank statistics were used for survival analyses. Results: Among 150 patients, 75 were possibly eligible for PCI. Thirteen patients presented with an isolated brain recurrence as the first site of progression with no other metastatic sites apparent, and in 6 patients, the brain was the only recurrent site during the whole follow-up. In the group of patients eligible for PCI, there was no statistically significant survival difference according to the brain progression status (P=0.11). Conclusions: The expected impact of PCI seems limited in terms of overall survival and prevention of isolated brain metastases in patients having systematic brain imaging during SCLC work-up.
MeSH term(s)	Brain Neoplasms/prevention & control ; Brain Neoplasms/secondary ; Cranial Irradiation ; Humans ; Lung Neoplasms/radiotherapy ; Neoplasm Recurrence, Local ; Retrospective Studies ; Small Cell Lung Carcinoma/radiotherapy
Language	French
Publishing date	2021-02-03
Publishing country	France
Document type	Journal Article
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2021.01.003
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