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Book ; Online: Apiterapia

Sforcin, José Maurício / Weis, Wilson Antonio / Ripari, Nicolas / Conte, Fernanda Lopes / Honorio, Mariana da Silva / Sartori, Arthur Alves / Santiago, Karina Basso

medicamentos das abelhas e possíveis tratamentos

2022

Keywords	Apiculture (beekeeping)
Language	Portuguese
Size	1 electronic resource (107 pages)
Publisher	Fundação Editora da UNESP
Document type	Book ; Online
Note	Portuguese
HBZ-ID	HT030375581
ISBN	9786557111482 ; 6557111485
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Brazilian red propolis in combination with β-lactams exerts an efficient antibacterial action over methicillin-resistant Staphylococcus aureus (MRSA) strains.

Ripari, Nicolas / Pereira, Ana Flávia Marques / Júnior, Ary Fernandes / Rall, Vera Lúcia Mores / Aldana-Mejía, Jennyfer A / Bastos, Jairo Kenupp / Sforcin, José Maurício

Journal of applied microbiology

2023 Volume 134, Issue 2

Abstract: Aims: The antibacterial activity of red propolis extract (RPE) and brown propolis extracts (BPE) and the synergistic effect of RPE with cefoxitin (CEFO), imipenem (IMI), and ertapenem (ERTA) was evaluated in vitro against methicillin-resistant ... ...

Abstract	Aims: The antibacterial activity of red propolis extract (RPE) and brown propolis extracts (BPE) and the synergistic effect of RPE with cefoxitin (CEFO), imipenem (IMI), and ertapenem (ERTA) was evaluated in vitro against methicillin-resistant Staphylococcus aureus (MRSA) strains. Methods and results: MRSA ATCC 33591, community-associated (CA-MRSA) USA300, and four clinical isolates were used. A broth microdilution assay was performed to obtain inhibitory and bactericidal concentrations of BPE, RPE, CEFO, IMI, and ERTA. RPE in combination with CEFO, IMI, and ERTA was evaluated on the formation or eradication of biofilm. The bacterial relative membrane conductivity of the strains was assessed after RPE and combinations exposition. Surface/binding computational analyzes between RPE compounds and penicillin binding protein 2a (PBP2a) were performed. BPE samples had no activity against MRSA (MICs 3.2-5 g l-1; MBCs 10-15 g l-1), so the subsequent assays were carried out only with RPE and antimicrobials. RPE exerted a bacteriostatic action (MICs 0.0156-0.125 g l-1; MBCs 0.5-2 g l-1) but the combinations with IMI and ERTA showed the highest inhibition, as observed in the time-kill curve. However, the FICI index showed synergism (≥0.5) only to RPE + IMI. This combination was the most effective in inhibiting the biofilm and showed the highest values of membrane conductivity. Computational predictions indicated that RPE constituents may interact with PBP2a. Conclusion: RPE and RPE + IMI exerted an antibacterial and antibiofilm activity on MRSA strains probably due to membrane/wall damage and interactions with PBP2a.
MeSH term(s)	Methicillin-Resistant Staphylococcus aureus ; beta-Lactams/pharmacology ; Propolis/pharmacology ; Brazil ; Drug Synergism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Cefoxitin/metabolism ; Cefoxitin/pharmacology ; Imipenem/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	beta-Lactams ; Propolis (9009-62-5) ; Anti-Bacterial Agents ; Cefoxitin (6OEV9DX57Y) ; Imipenem (71OTZ9ZE0A)
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxac080
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Article ; Online: Effects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells.

Sartori, Arthur Alves / Son, Ninh The / da Silva Honorio, Mariana / Ripari, Nicolas / Santiago, Karina Basso / Gomes, Anderson Moreira / Zambuzzi, Willian Fernando / Bastos, Jairo Kenupp / Sforcin, José Maurício

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 2, Page(s) 117297

Abstract: Ethnopharmacological relevance: Propolis is a bee product used in folk medicine to treat inflammatory diseases. Diverse types of propolis are produced worldwide depending on the local flora. Recently, research has been focused on a propolis sample ... ...

Abstract	Ethnopharmacological relevance: Propolis is a bee product used in folk medicine to treat inflammatory diseases. Diverse types of propolis are produced worldwide depending on the local flora. Recently, research has been focused on a propolis sample produced in the northeast Brazilian "caatinga" from Mimosa tenuiflora, popularly known as "jurema-preta". Aim of the study: A possible immunomodulatory/anti-inflammatory action was analyzed to verify the potential of M. tenuiflora propolis (MP) and its constituents (santin, sakuranetin and kaempferide) in human immune cells under baseline conditions or in LPS-stimulated cells. Methods: Cell viability, cytokine (TNF-α, IL-1β, IL-6, IL-8, IL-10) production and intracellular pathways (NF-kB and p38 MAPK) were evaluated. Results: Under basal conditions, MP and sakuranetin did not affect cytokine production; santin enhanced TNF-α, IL-1β, IL-6, while kaempferide inhibited IL-8 and IL-10. In LPS-stimulated cells, MP and its compounds exerted an inhibitory activity on TNF-α and IL-1β, while no effects were seen on IL-6 and IL-8. Santin and kaempferide inhibited IL-10 production. No significant differences were seen on NF-kB and p38 MAPK intracellular pathways. Conclusion: Data indicated the immunomodulatory action of caatinga propolis and its constituents at noncytotoxic concentrations, specifically an anti-inflammatory activity in LPS-treated cells by inhibiting cytokine production. Santin, sakuranetin and kaempferide appeared to be involved in MP activities.
MeSH term(s)	Humans ; Interleukin-10 ; Propolis/pharmacology ; Mimosa/metabolism ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; NF-kappa B ; Lipopolysaccharides/pharmacology ; Interleukin-8 ; Cytokines/metabolism ; Anti-Inflammatory Agents/pharmacology ; p38 Mitogen-Activated Protein Kinases
Chemical Substances	santin (27782-63-4) ; Interleukin-10 (130068-27-8) ; Propolis (9009-62-5) ; sakuranetin (3O38P61299) ; kaempferide (508XL61MPD) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; NF-kappa B ; Lipopolysaccharides ; Interleukin-8 ; Cytokines ; Anti-Inflammatory Agents ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2023-10-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117297
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1494: Show issues

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Article ; Online: Propolis antiviral and immunomodulatory activity: a review and perspectives for COVID-19 treatment.

Ripari, Nicolas / Sartori, Arthur Alves / da Silva Honorio, Mariana / Conte, Fernanda Lopes / Tasca, Karen Ingrid / Santiago, Karina Basso / Sforcin, José Maurício

The Journal of pharmacy and pharmacology

2021 Volume 73, Issue 3, Page(s) 281–299

Abstract: Objectives: Viral outbreaks are a frequent concern for humans. A great variety of drugs has been used to treat viral diseases, which are not always safe and effective and may induce adverse effects, indicating the need for new antiviral drugs extracted ... ...

Abstract	Objectives: Viral outbreaks are a frequent concern for humans. A great variety of drugs has been used to treat viral diseases, which are not always safe and effective and may induce adverse effects, indicating the need for new antiviral drugs extracted from natural sources. Propolis is a bee-made product exhibiting many biological properties. An overview of viruses, antiviral immunity, propolis safety and its immunomodulatory and antiviral action is reported, as well as perspectives for coronavirus disease 2019 (COVID-19) treatment. PubMed platform was used for data collection, searching for the keywords "propolis", "virus", "antiviral", "antimicrobial" and "coronavirus". Key findings: Propolis is safe and exerts antiviral and immunomodulatory activity; however, clinical trials should investigate its effects on individuals with viral diseases, in combination or not with antiviral drugs or vaccines. Summary: Regarding COVID-19, the effects of propolis should be investigated directly on the virus in vitro or on infected individuals alone or in combination with antiviral drugs, due to its immunomodulatory and anti-inflammatory action. Propolis administration simultaneously with vaccines should be analyzed, due to its adjuvant properties, to enhance the individuals' immune response. The search for therapeutic targets may be useful to find out how propolis can help to control COVID-19.
MeSH term(s)	Animals ; Antiviral Agents/immunology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/immunology ; Humans ; Immunologic Factors/immunology ; Immunologic Factors/therapeutic use ; Propolis/immunology ; Propolis/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology
Chemical Substances	Antiviral Agents ; Immunologic Factors ; Propolis (9009-62-5)
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgaa067
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma

Guillermo A. Videla-Richardson / Olivia Morris-Hanon / Nicolás I. Torres / Myrian I. Esquivel / Mariana B. Vera / Luisina B. Ripari / Diego O. Croci / Gustavo E. Sevlever / Gabriel A. Rabinovich

International Journal of Molecular Sciences, Vol 23, Iss 316, p

2022 Volume 316

Abstract: Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a family of glycan-binding ... ...

Abstract	Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a family of glycan-binding proteins, are highly expressed in the tumor microenvironment (TME) and delineate prognosis and clinical outcome in patients with GBM. These endogenous lectins play key roles in different hallmarks of cancer by modulating tumor cell proliferation, oncogenic signaling, migration, vascularization and immunity. Additionally, they have emerged as mediators of resistance to different anticancer treatments, including chemotherapy, radiotherapy, immunotherapy, and antiangiogenic therapy. Particularly in GBM, galectins control tumor cell transformation and proliferation, reprogram tumor cell migration and invasion, promote vascularization, modulate cell death pathways, and shape the tumor-immune landscape by targeting myeloid, natural killer (NK), and CD8 + T cell compartments. Here, we discuss the role of galectins, particularly galectin-1, -3, -8, and -9, as emerging glyco-checkpoints that control different mechanisms associated with GBM progression, and discuss possible therapeutic opportunities based on inhibition of galectin-driven circuits, either alone or in combination with other treatment modalities.
Keywords	central nervous system ; glioblastoma ; galectins ; glycans ; angiogenesis ; immunomodulation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma.

Videla-Richardson, Guillermo A / Morris-Hanon, Olivia / Torres, Nicolás I / Esquivel, Myrian I / Vera, Mariana B / Ripari, Luisina B / Croci, Diego O / Sevlever, Gustavo E / Rabinovich, Gabriel A

International journal of molecular sciences

2021 Volume 23, Issue 1

Abstract	Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a family of glycan-binding proteins, are highly expressed in the tumor microenvironment (TME) and delineate prognosis and clinical outcome in patients with GBM. These endogenous lectins play key roles in different hallmarks of cancer by modulating tumor cell proliferation, oncogenic signaling, migration, vascularization and immunity. Additionally, they have emerged as mediators of resistance to different anticancer treatments, including chemotherapy, radiotherapy, immunotherapy, and antiangiogenic therapy. Particularly in GBM, galectins control tumor cell transformation and proliferation, reprogram tumor cell migration and invasion, promote vascularization, modulate cell death pathways, and shape the tumor-immune landscape by targeting myeloid, natural killer (NK), and CD8
MeSH term(s)	Animals ; Disease Progression ; Drug Resistance, Neoplasm ; Galectins/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/immunology ; Glioblastoma/metabolism ; Humans ; Molecular Targeted Therapy ; Polysaccharides/metabolism
Chemical Substances	Galectins ; Polysaccharides
Language	English
Publishing date	2021-12-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23010316
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An overview about apitherapy and its clinical applications

Weis, Wilson Antonio / Ripari, Nicolas / Conte, Fernanda Lopes / Honorio, Mariana da Silva / Sartori, Arthur Alves / Matucci, Ramon Hage / Sforcin, José Maurício

Phytomedicine plus. 2022,

2022

Abstract: Humanity has benefited from bee products over the centuries for treating and preventing various illnesses, and apitherapy has been employed in several countries as a complementary medicine. This review aimed to discuss scientific research and clinical ... ...

Abstract	Humanity has benefited from bee products over the centuries for treating and preventing various illnesses, and apitherapy has been employed in several countries as a complementary medicine. This review aimed to discuss scientific research and clinical trials using bee products and their relationship with apitherapy. Scientific researches based on studies carried out in vitro using different cell cultures, and in vivo studying mice or other experimental animals are discussed. Clinical trials using bee products are also documented. The most common applications of bee products in apitherapy are presented, as well as cases of allergy to bee products and apitherapy for treating allergies. Standardization of bee products and their use in research and apitherapy are discussed. Apitherapy is practiced in some parts of the world, bringing benefits for healthy individuals and patients, with no clear consensus on its application according to the world regions or a prevalent use of bee product and treated disease. Different recommendations regarding the use of bee products are found and people ingest different amounts of bee products once or several times a day. Although we have advanced a lot about the knowledge of bee products, it is imperative to exploit their potential and standardize their use, communicating the results in scientific and alternative events to reinforce the exchange of information between beekeepers, researchers, apitherapists, nutritionists, physicians, sellers and consumers of bee products. If not, we will always be working separately, without complementing our expertise.
Keywords	alternative medicine ; bees ; honey and bee products ; hypersensitivity
Language	English
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ISSN	2667-0313
DOI	10.1016/j.phyplu.2022.100239
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An overview about apitherapy and its clinical applications

Wilson Antonio Weis / Nicolas Ripari / Fernanda Lopes Conte / Mariana da Silva Honorio / Arthur Alves Sartori / Ramon Hage Matucci / José Maurício Sforcin

Phytomedicine Plus, Vol 2, Iss 2, Pp 100239- (2022)

2022

Abstract: Background: Humanity has benefited from bee products over the centuries for treating and preventing various illnesses, and apitherapy has been employed in several countries as a complementary medicine. This review aimed to discuss scientific research and ...

Abstract	Background: Humanity has benefited from bee products over the centuries for treating and preventing various illnesses, and apitherapy has been employed in several countries as a complementary medicine. This review aimed to discuss scientific research and clinical trials using bee products and their relationship with apitherapy. Methods: Scientific researches based on studies carried out in vitro using different cell cultures, and in vivo studying mice or other experimental animals are discussed. Clinical trials using bee products are also documented. Results: The most common applications of bee products in apitherapy are presented, as well as cases of allergy to bee products and apitherapy for treating allergies. Standardization of bee products and their use in research and apitherapy are discussed. Conclusion: Apitherapy is practiced in some parts of the world, bringing benefits for healthy individuals and patients, with no clear consensus on its application according to the world regions or a prevalent use of bee product and treated disease. Different recommendations regarding the use of bee products are found and people ingest different amounts of bee products once or several times a day. Although we have advanced a lot about the knowledge of bee products, it is imperative to exploit their potential and standardize their use, communicating the results in scientific and alternative events to reinforce the exchange of information between beekeepers, researchers, apitherapists, nutritionists, physicians, sellers and consumers of bee products. If not, we will always be working separately, without complementing our expertise.
Keywords	Apitherapy ; Honey ; Propolis ; Bee venom ; Bee pollen ; Royal jelly ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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