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  1. Article ; Online: Performance of spinal cord injury individuals while standing with the Mohammad Taghi Karimi reciprocal gait orthosis (MTK-RGO).

    Karimi, Mohammad Taghi / Amiri, Pouya / Esrafilian, Amir / Sedigh, Jafar / Fatoye, Francis

    Australasian physical & engineering sciences in medicine

    2013  Volume 36, Issue 1, Page(s) 35–42

    Abstract: Most patients with spinal cord injury use a wheelchair to transfer from place to place, however they need to stand and walk with orthosis to improve their health status. Although many orthoses have been designed for paraplegic patients, they have ... ...

    Abstract Most patients with spinal cord injury use a wheelchair to transfer from place to place, however they need to stand and walk with orthosis to improve their health status. Although many orthoses have been designed for paraplegic patients, they have experienced various problems while in use. A new type of reciprocal gait orthosis was designed in the Bioengineering Unit of Strathclyde University to solve the problems of the available orthoses. Since there was no research undertaken regarding testing of the new orthosis on paraplegic subjects, this study was aimed to evaluate the new orthosis during standing of paraplegic subjects. Five paraplegic patients with lesion level between T12 and L1 and aged matched normal subjects were recruited into this study. The stability of subjects was evaluated during quiet standing and while undertaking hand tasks during standing with the new orthosis and the knee ankle foot orthosis (KAFO). The difference between the performances of paraplegic subjects while standing with both orthoses, and between the function of normal and paraplegic subjects were compared using the paired t test and independent sample t test, respectively. The stability of paraplegic subjects in standing with the new orthosis was better than that of the KAFO orthosis (p < 0.05). Moreover, the force applied on the crutch differed between the orthoses. The functional performance of paraplegic subjects was better with the new orthosis compared with normal subjects. The performance of paraplegic subjects while standing with the new orthosis was better than the KAFO. Therefore, the new orthosis may be useful to improve standing and walking in patients with paraplegia.
    MeSH term(s) Adult ; Case-Control Studies ; Gait/physiology ; Humans ; Male ; Orthotic Devices ; Paraplegia/physiopathology ; Posture/physiology ; Pressure ; Spinal Cord Injuries/physiopathology ; Task Performance and Analysis
    Language English
    Publishing date 2013-03
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article
    ZDB-ID 46226-3
    ISSN 1879-5447 ; 0158-9938
    ISSN (online) 1879-5447
    ISSN 0158-9938
    DOI 10.1007/s13246-013-0183-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cu-BTC MOF/ionic liquid nanocomposite as novel catalyst to electrochemical monitoring of digoxin in pharmaceutical and environmental samples.

    Shojaei, Moein / Taher, Mohammad Ali / Karimi-Maleh, Hassan

    Chemosphere

    2023  Volume 339, Page(s) 139722

    Abstract: There is no effective environmental treatment strategy that does not include monitoring for pharmaceutical compounds in environmental and biological fluids. The widespread presence of pharmaceutical-based pollutants in water sources is a significant ... ...

    Abstract There is no effective environmental treatment strategy that does not include monitoring for pharmaceutical compounds in environmental and biological fluids. The widespread presence of pharmaceutical-based pollutants in water sources is a significant public health concern. The treatment process relies heavily on maintaining a stable digoxin concentration in bodily fluids. Finding the correct dose for this medication appears to be crucial. In this research, an easy and high sensibility electrochemical sensor was developed to determine digoxin based on a paste electrode (CPE) that was modified with Cu-BTC MOF and ion liquid ((IL); 1-Methyl-3-Butyl-imidazolinium bromide in this case) using voltammetric methods in 0.1 M phosphate buffer solution (PBS) at pH 5.0. The sensor's selectivity was significantly increased by using Cu-BTC MOF and IL to detect digoxin. The characteristics of the electrode modifiers were evaluated by SEM, XRD and EDS techniques. The LDR was found to be 0.1-40 μM and the LOD of 0.08 μM, respectively.
    MeSH term(s) Ionic Liquids/chemistry ; Electrochemical Techniques/methods ; Nanocomposites/chemistry ; Electrodes ; Pharmaceutical Preparations
    Chemical Substances Ionic Liquids ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dynamic stability evaluation of trunk accelerations during walking in blind and sighted individuals.

    Rasouli Kahaki, Zeinab / Choobineh, Alireza / Razeghi, Mohsen / Karimi, Mohammad Taghi / Safarpour, Ali Reza

    BMC ophthalmology

    2024  Volume 24, Issue 1, Page(s) 127

    Abstract: Background: Dynamic stability is a fundamental goal in standing activities. In this regard, monitoring, analysis, and interventions made to improve stability is a research topic investigated in the biomechanics of human movements. Vision has a major ... ...

    Abstract Background: Dynamic stability is a fundamental goal in standing activities. In this regard, monitoring, analysis, and interventions made to improve stability is a research topic investigated in the biomechanics of human movements. Vision has a major role to play in controlling human movement. Nonetheless, little is known about the effects of visual deprivation, especially from birth on dynamic gait stability.
    Methods: The current study was conducted on 20 congenital blind and 10 sighted people (15-38 years). To evaluate the dynamic stability, descriptive data, harmonic ratio (HR), improved harmonic ratio (iHR), and root mean square (RMS), based on trunk acceleration data were measured in three axes: anteroposterior (AP), vertical (V), and mediolateral (ML) while participants walked an eight-meter straight path.
    Results: In the comparison of blind and sighted people (eyes open), standard deviation, HR, iHR, and RMS indices were found to be significantly different in both AP and V directions. All the mentioned parameters were significantly lower in blind than in sighted participants. In the comparison of blind people and sighted ones with closed eyes, changes were observed in the maximum, range, standard deviation, and RMS only in the AP axis. In the comparison between eyes open and closed in sighted people, a significant difference was found only in the harmonic ratio of the vertical axis.
    Conclusion: Visual deprivation led to a decrease in dynamic stability parameters in the AP and V axes. Even the movement of sighted people in unchallenged conditions is dependent on visual information.
    MeSH term(s) Humans ; Acceleration ; Blindness ; Gait ; Postural Balance ; Walking ; Adolescent ; Young Adult ; Adult
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Clinical Study ; Comparative Study ; Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-024-03394-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: The effect of toe‑only rocker sole shoes on gait variability of the elderly.

    Hemmati, Fatemeh / Karimi, Mohammad Taghi / Hosseini, Seyed Iman / Mardani, Mohammad Ali / Fadayevatan, Reza

    Medical & biological engineering & computing

    2022  Volume 60, Issue 9, Page(s) 2499

    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-022-02629-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Outcomes of proximal humeral reconstruction with cemented osteoarticular allograft in pediatric patients: a retrospective cohort study.

    Jamshidi, Khodamorad / Karimi, Amin / Babaei Zarch, Mohammad Ali / Mirzaei, Alireza

    Journal of shoulder and elbow surgery

    2023  Volume 32, Issue 12, Page(s) e608–e615

    Abstract: Background: There is no agreement on the best choice of proximal humeral reconstruction following tumor resection in pediatric patients. We reviewed the functional outcomes, oncologic outcomes, and surgical complications in pediatric patients after ... ...

    Abstract Background: There is no agreement on the best choice of proximal humeral reconstruction following tumor resection in pediatric patients. We reviewed the functional outcomes, oncologic outcomes, and surgical complications in pediatric patients after proximal humeral reconstruction with cemented osteoarticular allograft.
    Methods: Eighteen patients aged 8-13 years who underwent proximal humeral osteoarticular allograft reconstruction following resection of primary bone sarcoma were included. The mean follow-up period was 88 ± 31.7 months. At the last follow-up assessment, limb function was evaluated based on shoulder range of motion, Musculoskeletal Tumor Society score, and Toronto Extremity Salvage Score. Tumor recurrence and postoperative complications were extracted from the patients' medical records.
    Results: Mean active forward flexion of the shoulder was 38° ± 18°. Mean active abduction was 48° ± 18°. Mean active external rotation was 23° ± 9°. The mean Musculoskeletal Tumor Society score was 73.4% ± 11.2%. The mean Toronto Extremity Salvage Score was 75.6% ± 12.9%. Local recurrence occurred in 1 patient. Metastasis developed after the operation in 2 additional patients. We recorded 6 postoperative complications in this series, including 1 superficial infection, 1 late-onset deep infection, 1 allograft fracture, 2 cases of nonunion, and 2 cases of shoulder instability. Two complications required allograft removal.
    Conclusion: In pediatric patients, reconstruction of the proximal humerus with cemented osteoarticular allograft results in acceptable oncologic and functional outcomes while the postoperative complication rate seems to be lower than that of other available techniques.
    MeSH term(s) Child ; Humans ; Allografts ; Bone Neoplasms/pathology ; Humerus/pathology ; Joint Instability/pathology ; Postoperative Complications/epidemiology ; Retrospective Studies ; Shoulder ; Shoulder Joint ; Treatment Outcome ; Adolescent
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2023.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Photosensitive Chitosan-Based Injectable Hydrogel Chemically Cross-Linked by Perylene Bisimide Dopamine with Robust Antioxidant and Cytotoxicity Enhancer Properties for In Vitro Photodynamic Therapy of Breast Cancer.

    Rostaminejad, Bahareh / Karimi, Ali Reza / Dinari, Mohammad / Hadizadeh, Mahnaz

    ACS applied bio materials

    2023  Volume 6, Issue 3, Page(s) 1242–1251

    Abstract: Here, we report the fabrication of an antioxidant photosensitizing hydrogel system based on chitosan (CS-Cy/PBI-DOPA) covalently cross-linked with perylene bisimide dopamine (PBI-DOPA) as a photosensitizer. The severe insolubility and low tumor ... ...

    Abstract Here, we report the fabrication of an antioxidant photosensitizing hydrogel system based on chitosan (CS-Cy/PBI-DOPA) covalently cross-linked with perylene bisimide dopamine (PBI-DOPA) as a photosensitizer. The severe insolubility and low tumor selectivity limitations of perylene were overcome by conjugation with dopamine and then to the chitosan hydrogel. The mechanical and rheological study of CS-Cy/PBI-DOPA photodynamic antioxidant hydrogels illustrated interconnected microporous morphologies with high elasticity, swelling ability, and suitable shear-thinning behavior. Bio-friendly properties, such as biodegradability and biocompatibility, excellent singlet oxygen production abilities, and antioxidant properties were also delivered. The antioxidant effects of the hydrogels control the physiological levels of reactive oxygen species (ROS) generated by photochemical reactions in photodynamic therapy (PDT), which are responsible for oxidative damage to tumor cells while protecting normal cells and tissues from ROS damage, including blood and endothelial cells. In vitro, PDT tests of hydrogels were conducted on two human breast cancer cell lines, MDA-MB-231 and MCF-7. These hydrogels offered more than 90% cell viability in the dark and good photocytotoxicity performance with 53 and 43% cell death for MCF-7 and MDA-MB-231 cells, which confirmed their promising potential for cancer therapeutic applications.
    MeSH term(s) Humans ; Female ; Chitosan/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Antioxidants/pharmacology ; Perylene/pharmacology ; Dopamine ; Breast Neoplasms/drug therapy ; Endothelial Cells ; Reactive Oxygen Species ; Photochemotherapy ; Dihydroxyphenylalanine
    Chemical Substances Chitosan (9012-76-4) ; Hydrogels ; Antioxidants ; perylene bisimide ; Perylene (5QD5427UN7) ; Dopamine (VTD58H1Z2X) ; Reactive Oxygen Species ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c01086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats.

    Karimi, Mohammad Ali / Goudarzi, Mehdi / Khodayar, Mohammad Javad / Khorsandi, Layasadat / Mehrzadi, Saeed / Fatemi, Iman

    Tissue & cell

    2023  Volume 82, Page(s) 102037

    Abstract: Adriamycin (ADR), an antineoplastic drug, is widely used to treat different types of cancers. Yet, the usage is limited because of its severe side effects on testis. On the other hand, gemfibrozil (GEM), as an anti-hyperlipidemic drug, has other ... ...

    Abstract Adriamycin (ADR), an antineoplastic drug, is widely used to treat different types of cancers. Yet, the usage is limited because of its severe side effects on testis. On the other hand, gemfibrozil (GEM), as an anti-hyperlipidemic drug, has other pharmacological effects independent of lipid- lowering activity including anti-inflammatory and antioxidant properties. The present experiment was designed to investigate the effect of GEM on ADR-induced testicular injury in male rats. A total of 28 male Wistar rats were divided into 4 equal groups: Control; ADR; ADR + GEM; GEM. Serum level of testosterone, luteinizing hormone and follicle stimulating hormone were assessed. Also, testicular tissue oxidant/antioxidant markers (malondialdehyde, total antioxidant capacity, nitric oxide, superoxide dismutase, catalase, glutathione peroxidase and glutathione) and proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) were measured. Histopathological studies were conducted on testes. GEM improved hormonal profile and antioxidant defenses in comparison with ADR-treated animals. GEM, significantly reduced the production of proinflammatory cytokines compared with ADR-treated animals. Hormonal and biochemical results were further supported by testicular histopathological findings. Thus, GEM might represent a promising therapeutic modality for the attenuation of testicular injury induced by ADR in clinic.
    MeSH term(s) Rats ; Male ; Animals ; Doxorubicin/toxicity ; Antioxidants/metabolism ; Gemfibrozil/pharmacology ; Gemfibrozil/metabolism ; Rats, Wistar ; Oxidative Stress ; Testis/metabolism ; Cytokines/metabolism
    Chemical Substances Doxorubicin (80168379AG) ; Antioxidants ; Gemfibrozil (Q8X02027X3) ; Cytokines
    Language English
    Publishing date 2023-02-11
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2023.102037
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  8. Article: Surface modified polythiophene/Al

    Karimi, Zeynab / Khalili, Reza / Ali Zazouli, Mohammad

    Water science and technology : a journal of the International Association on Water Pollution Research

    2021  Volume 84, Issue 1, Page(s) 182–199

    Abstract: In this study, polythiophene/ ... ...

    Abstract In this study, polythiophene/Al
    MeSH term(s) Adsorption ; Aniline Compounds ; Hydrogen-Ion Concentration ; Ions ; Kinetics ; Metals, Heavy ; Nanocomposites ; Polymers ; Polyvinyl Alcohol ; Thermodynamics ; Thiophenes ; Water ; Water Pollutants, Chemical/analysis
    Chemical Substances Aniline Compounds ; Ions ; Metals, Heavy ; Polymers ; Thiophenes ; Water Pollutants, Chemical ; polyaniline ; Water (059QF0KO0R) ; polythiophene (25233-34-5) ; Polyvinyl Alcohol (9002-89-5)
    Language English
    Publishing date 2021-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2021.224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cu-BTC MOF/ionic liquid nanocomposite as novel catalyst to electrochemical monitoring of digoxin in pharmaceutical and environmental samples

    Shojaei, Moein / Taher, Mohammad Ali / Karimi-Maleh, Hassan

    Chemosphere. 20232023 Oct. 08, Aug. 08, v. 339 p.139722-

    2023  

    Abstract: There is no effective environmental treatment strategy that does not include monitoring for pharmaceutical compounds in environmental and biological fluids. The widespread presence of pharmaceutical-based pollutants in water sources is a significant ... ...

    Abstract There is no effective environmental treatment strategy that does not include monitoring for pharmaceutical compounds in environmental and biological fluids. The widespread presence of pharmaceutical-based pollutants in water sources is a significant public health concern. The treatment process relies heavily on maintaining a stable digoxin concentration in bodily fluids. Finding the correct dose for this medication appears to be crucial. In this research, an easy and high sensibility electrochemical sensor was developed to determine digoxin based on a paste electrode (CPE) that was modified with Cu-BTC MOF and ion liquid ((IL); 1-Methyl-3-Butyl-imidazolinium bromide in this case) using voltammetric methods in 0.1 M phosphate buffer solution (PBS) at pH 5.0. The sensor's selectivity was significantly increased by using Cu-BTC MOF and IL to detect digoxin. The characteristics of the electrode modifiers were evaluated by SEM, XRD and EDS techniques. The LDR was found to be 0.1–40 μM and the LOD of 0.08 μM, respectively.
    Keywords catalysts ; digoxin ; drug therapy ; electrochemistry ; electrodes ; ionic liquids ; liquids ; nanocomposites ; pH ; phosphates ; public health ; sensors (equipment) ; voltammetry ; Electrochemical sensor ; Cu-BTC MOF ; Ion liquid
    Language English
    Dates of publication 2023-0808
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139722
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Modelling the probability of presence of Aedes aegypti and Aedes albopictus in Iran until 2070

    Mohammad Mehdi Sedaghat / Faramarz Bozorg Omid / Mohammad Karimi / Sajjad Haghi / Ahmad Ali Hanafi-Bojd

    Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 1, Pp 16-

    2023  Volume 25

    Abstract: Objective: To determine the suitable ecological habitats of Aedes (Ae.) aegypti and Ae. albopictus in Iran due to climate change by the 2070s. Methods: All data relating to the spatial distribution of Ae. aegypti and Ae. albopictus worldwide, which ... ...

    Abstract Objective: To determine the suitable ecological habitats of Aedes (Ae.) aegypti and Ae. albopictus in Iran due to climate change by the 2070s. Methods: All data relating to the spatial distribution of Ae. aegypti and Ae. albopictus worldwide, which indicated the geographical coordinates of the collection sites of these mosquitoes, were extracted from online scientific websites and entered into an Excel file. The effect of climatic and environmental variables on these mosquitoes was evaluated using the MaxEnt model in the current and future climatic conditions in the 2030s, 2050s, and 2070s. Results: The most suitable areas for the establishment of Ae. aegypti are located in the southern and northern coastal areas of Iran, based on the model outputs. The modelling result for suitable ecological niches of Ae. albopictus shows that in the current climatic conditions, the southern half of Iran from east to west, and parts of the northern coasts are prone to the presence of this species. In the future, some regions, such as Gilan and Golestan provinces, will have more potential to exist/establish Ae. albopictus. Also, according to the different climate change scenarios, suitable habitats for this species will gradually change to the northwest and west of the country. The temperature of the wettest season of the year (Bio8) and average annual temperature (Bio1) were the most effective factors in predicting the model for Ae. aegypti and Ae. albopictus, respectively. Conclusions: It is required to focus on entomological studies using different collection methods in the vulnerable areas of Iran. The future modelling results can also be used for long-term planning to prevent the entry and establishment of these invasive Aedes vectors in the country.
    Keywords aedes aegypti ; aedes albopictus ; dengue fever ; chikungunya ; ecological niche modeling ; climate change ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 550
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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