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  1. Article ; Online: Prechoroidal Cleft Regression After Switch to Intravitreal Brolucizumab.

    Forte, Paolo / Ferro Desideri, Lorenzo / Manocchio, Riccardo / Corazza, Paolo / Traverso, Carlo Enrico / Nicolò, Massimo

    European journal of ophthalmology

    2023  Volume 34, Issue 1, Page(s) NP123–NP126

    Abstract: Introduction: Prechoroidal cleft has been described as a negative prognostic biomarker in patients affected with neovascular age related macular degeneration (nAMD). This peculiar finding consists of a lenticular hyporeflective space located between an ... ...

    Abstract Introduction: Prechoroidal cleft has been described as a negative prognostic biomarker in patients affected with neovascular age related macular degeneration (nAMD). This peculiar finding consists of a lenticular hyporeflective space located between an outward bowing of Bruch's membrane and the base of a fibrovascular retinal pigment epithelium detachment (PED). Previous studies have reported the partial or complete regression of prechoroidal clefts after treatment with anti-vascular endothelial growth factor (VEGF) injections.
    Case report: To report a case of complete anatomical regression of an unresponsive prechoroidal cleft after switching to intravitreal Brolucizumab. The patient maintained cleft regression over time and no adverse events (i.e., RPE tears, intraocular inflammation) were observed during follow-up.
    Conclusions and importance: To our knowledge, this case report is the first to analyze the clinical efficacy of brolucizumab targeting prechoroidal clefts. Clinical implication and pathogenesis of prechoroidal clefts are yet to be fully elucidated.
    MeSH term(s) Humans ; Angiogenesis Inhibitors/therapeutic use ; Vascular Endothelial Growth Factor A ; Retrospective Studies ; Intravitreal Injections ; Wet Macular Degeneration/drug therapy
    Chemical Substances brolucizumab (XSZ53G39H5) ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721231185903
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    Zs.A 3342: Show issues Location:
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  2. Article ; Online: Subthreshold laser compared to oral spironolactone for the treatment of chronic central serous chorioretinopathy: a retrospective study.

    Mercuri, Stefano / D'Alterio, Francesco Maria / Gallo, Beatrice / Raslan, Walid / Gupta, Atul / Khairat, Nancy / Corazza, Paolo / Younis, Saad

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 131

    Abstract: Purpose: To compare functional and morphological outcomes of Subthreshold Laser (STL) and Oral Spironolactone (SPR) in treating chronic central serous chorioretinopathy (CSCR).: Methods: This is a retrospective observational study. Treatment-naïve ... ...

    Abstract Purpose: To compare functional and morphological outcomes of Subthreshold Laser (STL) and Oral Spironolactone (SPR) in treating chronic central serous chorioretinopathy (CSCR).
    Methods: This is a retrospective observational study. Treatment-naïve patients with chronic CSCR treated with STL or SPR were included, and data was reviewed at baseline, 1, 3, 6 and 12-month follow-up. Main outcome measures were changes in Central Macular Thickness (CMT) and Subretinal Fluid (SRF) height, and complete resolutions of SRF. Sub-analysis based on retinal pigmented epithelium (RPE) status at baseline was performed.
    Results: 47 and 47 patients received STL and SPR, respectively. At all timepoints, both treatments significantly improved CMT and SRF (p < 0.05). No significant changes in best corrected visual acuity (BCVA) were recorded and no significant differences between treatment groups were present at each corresponding follow-up. Complete resolution of SRF was achieved in 29% and 36% of patients treated with STL or SPR, respectively, at 12-months follow up. Eyes treated with STL and intact RPE showed significant SRF decrease at 6 months and significantly better BCVA at 1, 3 and 6 months compared to eyes with disrupted RPE layer (p < 0.05). In both treatment groups, intact RPE was associated with a higher rate of complete SRF resolutions, with 43% vs 13% in the STL group and 50% vs 26% in the SPR group.
    Conclusion: STL and SPR are effective treatments for chronic CSCR. Greater resolution of subretinal fluid was observed in eyes with intact RPE, hence both treatments should be initiated in the earlier stages of the disease.
    MeSH term(s) Humans ; Spironolactone/therapeutic use ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Retrospective Studies ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Fluorescein Angiography ; Tomography, Optical Coherence ; Lasers ; Chronic Disease
    Chemical Substances Spironolactone (27O7W4T232) ; Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-03063-3
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    Zs.A 1479: Show issues Location:
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  3. Article ; Online: Pregnancy vaccination predictive factors and uptake profiles among Italian women: A cross-sectional survey study on a large population.

    Ferrari, Amerigo / Moretti, Giaele / Corazza, Ilaria / Mannella, Paolo / Simoncini, Tommaso / Bonciani, Manila

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 162, Issue 1, Page(s) 105–115

    Abstract: Objectives: To assess influenza and Tdap (tetanus, diphtheria, pertussis) vaccine coverage during pregnancy, explore key socioeconomic and maternity pathway-related predictors of vaccination, and detect specific patterns of vaccination uptake.: ... ...

    Abstract Objectives: To assess influenza and Tdap (tetanus, diphtheria, pertussis) vaccine coverage during pregnancy, explore key socioeconomic and maternity pathway-related predictors of vaccination, and detect specific patterns of vaccination uptake.
    Methods: The authors cross-sectionally analyzed self-reported data obtained from the systematic survey on the maternity pathways of Tuscany. They selected all pregnant women that completed from March 2019 to June 2022 the third-trimester questionnaire (n = 25 160), which included two dichotomous items on influenza and Tdap vaccination, as well as socioeconomic and pathway-related questions. Multilevel logistic models were performed to assess vaccination predictors and cluster analysis to identify vaccination patterns.
    Results: Vaccination coverage was higher for pertussis (56.5%) than for influenza (18.9%). The main predictors of vaccination were high socioeconomic status, attending private gynecologists, and receiving vaccine information. Three clusters were identified: cluster 1 included women receiving both Tdap and influenza vaccines; cluster 2 included women receiving no vaccinations; and cluster 3 included women receiving only the pertussis vaccine. Although women from cluster 3 were of middle to low education status, vaccine information was the main adherence determinant also in this group.
    Conclusions: Health workers and policymakers should focus on groups of pregnant women less prone to vaccination to promote vaccination information and encourage wider uptake and coverage.
    MeSH term(s) Female ; Pregnancy ; Humans ; Influenza, Human/prevention & control ; Cross-Sectional Studies ; Whooping Cough/prevention & control ; Diphtheria-Tetanus-acellular Pertussis Vaccines ; Influenza Vaccines ; Surveys and Questionnaires
    Chemical Substances Diphtheria-Tetanus-acellular Pertussis Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14797
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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  4. Article ; Online: Influence of COVID-19 pandemic on self-reported urinary incontinence during pregnancy and postpartum: A prospective study.

    Ferrari, Amerigo / Corazza, Ilaria / Mannella, Paolo / Simoncini, Tommaso / Bonciani, Manila

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2022  

    Abstract: Objective: To explore how the COVID-19 pandemic influenced self-reported occurrence and severity of pregnancy-related urinary incontinence (UI) in the maternity pathways of Tuscany, Italy.: Methods: In this prospective pre-post cohort study, we ... ...

    Abstract Objective: To explore how the COVID-19 pandemic influenced self-reported occurrence and severity of pregnancy-related urinary incontinence (UI) in the maternity pathways of Tuscany, Italy.
    Methods: In this prospective pre-post cohort study, we selected a pre-pandemic (n = 1018) and a post-pandemic (n = 3911) cohorts of women that completed, from the first trimester until 3 months postpartum, three surveys including validated patient-reported outcome measures for UI. Data were obtained from systematic surveys on the maternity pathways of Tuscany from March 2019 to June 2021. We performed panel regression models to explore how UI risk differed between COVID-19 groups.
    Results: UI occurred less frequently and less severely in post-pandemic patients-especially stress/mixed UI in women never performing pelvic floor muscle training (PFMT)-whereas no difference emerged in women performing during-pregnancy PFMT. During COVID-19, obese women had higher risk of UI, whereas women undergoing operative delivery had lower risk. The post-pandemic group reported more severe UI symptoms at the third trimester, but less severe UI postpartum in women suffering from UI during pregnancy.
    Conclusions: During the COVID-19 pandemic, women reported fewer UI symptoms because they might have lacked chances to identify UI symptoms as a result of pandemic-related sedentarism and inactivity. The risk in women performing during-pregnancy PFMT was not increased, but just six of 26 health districts organized remote PFMT sessions, thus revealing limited resilience to the pandemic in Tuscany.
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14522
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    Zs.MO 183: Show issues

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  5. Article ; Online: Evaluating Healthcare Performance in Low- and Middle-Income Countries: A Pilot Study on Selected Settings in Ethiopia, Tanzania, and Uganda.

    Belardi, Paolo / Corazza, Ilaria / Bonciani, Manila / Manenti, Fabio / Vainieri, Milena

    International journal of environmental research and public health

    2022  Volume 20, Issue 1

    Abstract: The literature reports some experiences regarding the design of integrated healthcare Performance Evaluation Systems (PES) applied in Low- and Middle-income Countries (LMIC). This study describes the design of an integrated and bottom-up PES aimed at ... ...

    Abstract The literature reports some experiences regarding the design of integrated healthcare Performance Evaluation Systems (PES) applied in Low- and Middle-income Countries (LMIC). This study describes the design of an integrated and bottom-up PES aimed at evaluating healthcare services delivery in rural settings. The analysis involved four hospitals and their relative health districts in Ethiopia, Tanzania, and Uganda. The evaluation process was undertaken for those indicators that could be evaluated using the same reference standard. The evaluation scores were determined through the international standards identified in the literature or through benchmarking assessment. Both administrative and health data were extracted from the hospitals' registers and District Health Information Systems (DHIS) from 2017 to 2020. We defined 128 indicators: 88 were calculated at the hospital level and 40 at the health district level. The evaluation process was undertaken for 48 indicators. The evaluated indicators are represented using effective graphical tools. In settings characterised by multiple healthcare providers, this framework may contribute to achieving good governance through performance evaluation, benchmarking, and accountability. It may promote evidence-based decision-making in the planning and allocation of resources, thus ultimately fostering quality improvement processes and practices, both at the hospital and health district level.
    MeSH term(s) Developing Countries ; Pilot Projects ; Uganda ; Tanzania ; Ethiopia ; Delivery of Health Care
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20010041
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  6. Article: Proposed algorithm during COVID-19 pandemic for patient management in medical retina clinic.

    Corazza, Paolo / D'Alterio, Francesco Maria / Younis, Saad

    International journal of retina and vitreous

    2020  Volume 6, Page(s) 20

    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2836254-8
    ISSN 2056-9920
    ISSN 2056-9920
    DOI 10.1186/s40942-020-00226-z
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  7. Article ; Online: Predictors of 24-month onset of macular fibrosis in type 3 macular neovascularisation.

    Forte, Paolo / Fontana, Vincenzo / Muzio, Julia / Di Cello, Luca / Corazza, Paolo / Rosa, Raffaella / Musetti, Donatella / Vagge, Aldo / Traverso, Carlo Enrico / Nicolò, Massimo

    The British journal of ophthalmology

    2024  

    Abstract: Aims: To explore prognostic multimarker models for progression to macular fibrosis (MF) over 24 months specific to type 3 macular neovascularisation (T3 MNV).: Methods: This retrospective, exploratory, single-centre, cohort study comprised 65 eyes of ...

    Abstract Aims: To explore prognostic multimarker models for progression to macular fibrosis (MF) over 24 months specific to type 3 macular neovascularisation (T3 MNV).
    Methods: This retrospective, exploratory, single-centre, cohort study comprised 65 eyes of 43 Caucasian patients with treatment naive T3 MNV, all with a 24-month follow-up post anti-VEGF therapy using a strict pro-re-nata (PRN) regimen. Data on demographic features, clinical findings, frequency of intravitreal treatments and optical coherence tomography biomarkers were collected at baseline and after 12 and 24 months of follow-up. Logistic regression models (LRM) and receiver-operating curve (C-index) analyses were performed to evaluate the prognostic ability of the studied biomarkers in discriminating between MF affected and unaffected patients.
    Results: At final follow-up, MF was present in 46.2% of eyes. Subretinal hyper-reflective material (SHRM) and subretinal pigment epithelium multilaminar hyper-reflectivity (multilaminae) emerged as significant predictors for MF, with adjusted odds ratios (OR) of 18.0 (95% CL 13.4 to 24.1) and 11.8 (95% CL 8.66 to 16.0), respectively. Additionally, the presence of multifocal lesions (OR 0.04, 95% CL 0.01 to 0.30) appeared to decrease the likelihood of MF. C-indexes for the selected LRMs ranged between 0.92 and 0.88, indicating a comparably high discriminant ability. Despite consistent treatment schedules between the two groups (MF: median intravitreal treatment (IVT) number=10.5, IQR=7; non-MF: median IVT=10, IQR=6), a decline in best-corrected visual acuity was noted in the group with MF onset over the 24-month follow-up (-13.0 ETDRS letters; 95% CL -22.1 to -3.9; p=0.006).
    Conclusion: Our study identifies SHRM and multilaminae as relevant predictors of 24-month onset of MF in patients with T3 MNV. These findings enrich our understanding of the development of MF in T3 MNV and can guide improved risk prognostication. Future research should consider larger samples and prospective designs to validate these predictors.
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjo-2023-324713
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  8. Article ; Online: Proposed algorithm during COVID-19 pandemic for patient management in medical retina clinic

    Paolo Corazza / Francesco Maria D’Alterio / Saad Younis

    International Journal of Retina and Vitreous , Vol 6, Iss 1, Pp 1-

    2020  Volume 5

    Keywords Ophthalmology ; RE1-994 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Dimethyl Fumarate Treatment in Patients with Moderate-to-Severe Psoriasis: A 52-week Real-life Study.

    Gnesotto, Laura / Mioso, Guido / Bardazzi, Federico / Filippi, Federica / Di Lernia, Vito / Motolese, Alberico / Di Nuzzo, Sergio / Conti, Andrea / Arginelli, Federica / Corazza, Monica / Odorici, Giulia / Borghi, Alessandro / Gisondi, Paolo / Naldi, Luigi / Dapavo, Paolo / Parodi, Aurora / Burlando, Martina / Piaserico, Stefano

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv4526

    MeSH term(s) Humans ; Dimethyl Fumarate/adverse effects ; Dermatologic Agents/adverse effects ; Treatment Outcome ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/chemically induced
    Chemical Substances Dimethyl Fumarate (FO2303MNI2) ; Dermatologic Agents
    Language English
    Publishing date 2023-03-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.4526
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  10. Article ; Online: Awareness of obesity among patients with psoriasis.

    Bellinato, Francesco / Gisondi, Paolo / Balato, Anna / Caldarola, Giacomo / Cammarata, Edoardo / Campione, Elena / Carugno, Andrea / Conti, Andrea / Corazza, Monica / Dapavo, Paolo / Dattola, Annunziata / Di Lernia, Vito / Gasperini, Massimo / Panduri, Salvatore / Prignano, Francesca / Satolli, Francesca / Spisni, Enzo / Girolomoni, Giampiero

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 5, Page(s) e391–e393

    MeSH term(s) Humans ; Psoriasis/complications ; Psoriasis/psychology ; Obesity/complications ; Obesity/psychology ; Female ; Male ; Middle Aged ; Adult ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2023-11-12
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19617
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