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Article ; Online: Lessons from "the 2011 off the Pacific coast of Tohoku Earthquake" through activity of Japanese Red Cross Ishinomaki Hospital (JRCIH).

Iinuma, Kazuie

2013 Volume 35, Issue 3, Page(s) 190–192

MeSH term(s)	Child ; Disaster Medicine ; Disaster Planning ; Earthquakes ; Hospitals ; Humans ; Japan ; Personnel, Hospital ; Red Cross ; Rescue Work ; Tsunamis
Language	English
Publishing date	2013-03
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	604822-5
ISSN	1872-7131 ; 0387-7604
ISSN (online)	1872-7131
ISSN	0387-7604
DOI	10.1016/j.braindev.2012.10.002
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Article: [The direction of Japanese Society of Child Neurology: a message to young doctors who aim to be child neurologists].

Iinuma, Kazuie

No to hattatsu. Brain and development

2005 Volume 37, Issue 2, Page(s) 110–113

Abstract: The bylaws of Japanese Society of Child Neurology (JSCN) declare that the purpose of this Society is to promote research activity, educational programs for child neurologists, and cooperation with other related organizations. It also has a large role to ... ...

Abstract	The bylaws of Japanese Society of Child Neurology (JSCN) declare that the purpose of this Society is to promote research activity, educational programs for child neurologists, and cooperation with other related organizations. It also has a large role to provide the results of research to the wider community. As for promotion of research, acquisition of research funding is quite important. It is necessary to increase applications for grants and to be well known by other researchers, and especially by the relevant authorities. One way to do this is to send reprints to the authorities in various research fields. Participating to the congress party to let lots of people notice his/her activity may also be effective. To promote the Impact Factor of the official journal of JSCN, Brain & Development (B & D), members should cite as many articles from B & D as possible when they submit a manuscript. The members of JSCN must respond to the demands of patients and family members as specially trained child neurologists. I am pleased that the newly founded Social Activity and Public Relations Committee has acted vigorously. I want to ask all the young members to participate positively in our activities and support the Society.
MeSH term(s)	Japan ; Neurology/standards ; Pediatrics/standards ; Societies, Medical/standards
Language	Japanese
Publishing date	2005-03
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	605615-5
ISSN	1884-7668 ; 0029-0831
ISSN (online)	1884-7668
ISSN	0029-0831
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Article: [The progress of non-invasive examination of the brain function and child neurology].

Iinuma, Kazuie

No to hattatsu. Brain and development

2003 Volume 35, Issue 2, Page(s) 97–104

Abstract: During the last 2 decades of the 20th century, various non-invasive examinations of the brain function developed strikingly with the advance of electronics. The examination procedures were tentatively classified into the following generations: the 1st ... ...

Abstract	During the last 2 decades of the 20th century, various non-invasive examinations of the brain function developed strikingly with the advance of electronics. The examination procedures were tentatively classified into the following generations: the 1st generation: EEG, the 2nd: evoked potentials using signal averaging system, the 3rd: CT and MRI using reconstruction of imaging, 4th: PET, SPECT, fMRI, MEG, MRS and DTI which are categorized in functional imaging, 5th: optic topography combining the functional imaging and time factor. In this article, the outlines of the principle and application of the 4th and 5th generation methods are described. Their application to children requires the development of less invasive and simpler methods. These examination tools still stand on the start line, and will be widely applied to the neurology field in future. Child neurologists should be concerned with the development of their application.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Brain/physiology ; Cerebrovascular Circulation ; Child ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Magnetoencephalography ; Neurology ; Spectroscopy, Near-Infrared ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2003-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605615-5
ISSN	1884-7668 ; 0029-0831
ISSN (online)	1884-7668
ISSN	0029-0831
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Article ; Online: Long-term outcome of a 26-year-old woman with West syndrome and an nuclear receptor subfamily 2 group F member 1 gene (NR2F1) mutation.

Hino-Fukuyo, Naomi / Kikuchi, Atsuo / Yokoyama, Hiroyuki / Iinuma, Kazuie / Hirose, Mieko / Haginoya, Kazuhiro / Niihori, Tetsuya / Nakayama, Keiko / Aoki, Yoko / Kure, Shigeo

Seizure

2017 Volume 50, Page(s) 144–146

Abstract: Long-term outcome of West syndrome with a NR2F1 mutation. ...

Abstract	Long-term outcome of West syndrome with a NR2F1 mutation.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2017.06.018
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Zs.A 3573: Show issues

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Article ; Online: Ketotifen overdose in infancy associated with development of epilepsy and mild mental retardation.

Yokoyama, Hiroyuki / Hirose, Mieko / Uematsu, Mitsugu / Haginoya, Kazuhiro / Iinuma, Kazuie / Kimura, Shigeru

Pediatrics international : official journal of the Japan Pediatric Society

2012 Volume 54, Issue 6, Page(s) 963

MeSH term(s)	Dermatitis, Atopic/drug therapy ; Drug Overdose ; Epilepsy/chemically induced ; Histamine H1 Antagonists/poisoning ; Humans ; Infant ; Intellectual Disability/chemically induced ; Ketotifen/poisoning ; Male
Chemical Substances	Histamine H1 Antagonists ; Ketotifen (X49220T18G)
Language	English
Publishing date	2012-12
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/j.1442-200X.2012.03718.x
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Zs.A 848: Show issues

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Article: Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey.

Iinuma, Kazuie / Haginoya, Kazuhiro

Seizure

2004 Volume 13 Suppl 1, Page(s) S34–9; discussion S40

Abstract: Postmarketing data about the effectiveness of zonisamide in childhood epilepsy was collected from 759 children with various forms of epilepsy (ages 3 months-15 years) to compare the long-term efficacy of zonisamide in the treatment of epilepsy in ... ...

Abstract	Postmarketing data about the effectiveness of zonisamide in childhood epilepsy was collected from 759 children with various forms of epilepsy (ages 3 months-15 years) to compare the long-term efficacy of zonisamide in the treatment of epilepsy in intellectually normal versus intellectually disabled children. The follow-up period was 6 months-3 years; 291 children (245 intellectually normal, 46 intellectually disabled) received zonisamide as monotherapy. The remaining patients received additional antiepilepsy drugs (AEDs); mean numbers of additional AEDs were 1.6 and 2.9 for intellectually normal and intellectually disabled groups, respectively. Effectiveness could not be evaluated in 30 of the 759 patients because of very rare or irregular seizure frequency. In the 729 patients evaluated, 78% of intellectually normal patients and 43% of intellectually disabled patients showed > or =50% reduction in the number of seizures (P < 0.001). Improvement rates seen in the intellectually normal group were almost the same for patients with generalized (82%) and partial (77%) epilepsies, whereas in the intellectually disabled group, the improvement rate was higher for partial (50%) than generalized (36%) epilepsies (P < 0.01). These results are consistent with the known phenomenon that intellectually disabled children are likely to have more intractable seizures than children with normal intelligence.
MeSH term(s)	Adolescent ; Age Factors ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Disability Evaluation ; Drug Interactions ; Drug Therapy, Combination ; Epilepsy/classification ; Epilepsy/drug therapy ; Female ; Follow-Up Studies ; Humans ; Infant ; Isoxazoles/adverse effects ; Isoxazoles/therapeutic use ; Male ; Product Surveillance, Postmarketing ; Severity of Illness Index ; Time ; Treatment Outcome
Chemical Substances	Anticonvulsants ; Isoxazoles ; zonisamide (459384H98V)
Language	English
Publishing date	2004-12
Publishing country	England
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2004.04.003
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Zs.A 3573: Show issues

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Article: [Epidemiological and clinical studies of West syndrome in Miyagi Prefecture, Japan].

Hino-Fukuyo, Naomi / Haginoya, Kazuhiro / Iinuma, Kazuie

No to hattatsu. Brain and development

2007 Volume 39, Issue 4, Page(s) 257–261

Abstract: We performed a retrospective epidemiological study of West syndrome (WS) in Miyagi prefecture over a 3-year period (2000 -2003). Twenty-two children (6 boys, 16 girls) developed WS. The incidence of WS was 3.4/10,000 live births. It agreed with the ... ...

Abstract	We performed a retrospective epidemiological study of West syndrome (WS) in Miyagi prefecture over a 3-year period (2000 -2003). Twenty-two children (6 boys, 16 girls) developed WS. The incidence of WS was 3.4/10,000 live births. It agreed with the incidence of previous report in Japan. The mean age at onset of spasms was 6.5 months (range 1 - 17 months). Thirteen patients (59%) had symptomatic WS; of these, eight patients had prenatal causes and five had perinatal causes. There were no familial cases, although four patients had family history that included neurological diseases. Periventricular leukomalacia was found in four of nine patients with abnormal magnetic resonance imagings (MRI) . Early seizure outcome was good in twenty-one patients (95%). Six patients (29%) had seizure recurrence. There were no significant differences between symptomatic WS and cryptogenic WS in terms of seizure recurrence and persistent EEG abnormalities. The Five patients (20%) with developmental quotients (DQ) more than 70 were all cryptogenic WS, while patients with DQ less than 70 were significantly frequent in symptomatic WS as compared with cryptogenic WS.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Japan/epidemiology ; Magnetic Resonance Imaging ; Male ; Retrospective Studies ; Spasms, Infantile/epidemiology ; Spasms, Infantile/physiopathology ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2007-07
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605615-5
ISSN	1884-7668 ; 0029-0831
ISSN (online)	1884-7668
ISSN	0029-0831
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Article ; Conference proceedings: Proposed diagnostic scheme for the classification of epileptic seizures and epilepsies (ILAE, 2001): proposal from Japan Epilepsy Society.

Iinuma, Kazuie / Morimoto, Kiyoshi / Akiyama, Tomoyuki / Ikeda, Akio / Kurihara, Mana

Epilepsia

2006 Volume 47, Issue 9, Page(s) 1588–9; discussion 1590–1

MeSH term(s)	Adult ; Advisory Committees/standards ; Consensus Development Conferences as Topic ; Epilepsy/classification ; Epilepsy/diagnosis ; Humans ; International Agencies/standards ; Japan ; Syndrome
Language	English
Publishing date	2006-09
Publishing country	United States
Document type	Congresses
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/j.1528-1167.2006.00843_5.x
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 475: Show issues

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Article: Abnormal primary somatosensory function in unilateral polymicrogyria: an MEG study.

Ishitobi, Mamiko / Nakasato, Nobukazu / Yoshimoto, Takashi / Iinuma, Kazuie

Brain & development

2005 Volume 27, Issue 1, Page(s) 22–29

Abstract: The purpose of this study is to investigate the primary somatosensory function in patients with unilateral polymicrogyria. Somatosensory evoked fields (SEFs) due to median and posterior tibial nerve stimulation were compared in the normal and dysplastic ... ...

Abstract	The purpose of this study is to investigate the primary somatosensory function in patients with unilateral polymicrogyria. Somatosensory evoked fields (SEFs) due to median and posterior tibial nerve stimulation were compared in the normal and dysplastic cortices of five patients with unilateral polymicrogyria. SEFs were observed in all five normal hemispheres and three dysplastic hemispheres. Latencies of N20m and P38m, the first cortical components of and SEFs for median nerve and tibial nerve stimulation, were all within the normal range in both normal and dysplastic hemispheres. The amplitudes of the N20m and P38m in the dysplastic hemispheres were smaller in one patient and larger in two patients compared to the normal hemispheres. Equivalent current dipoles of N20m and P38m were localized on the anatomical central sulcus of the normal hemispheres and over the central area of the dysplastic hemispheres. P38m dipoles were localized medial and upward to the N20m dipole in both normal and dysplastic hemispheres. N20m dipole orientation was normal in all normal hemispheres and in one dysplastic hemisphere, but abnormally inferior in two dysplastic hemispheres. P38m dipole had normal medial orientation in all hemispheres except one dysplastic hemisphere. Abnormality of the primary somatosensory function in the dysplastic cortex of patients with unilateral polymicrogyria was clearly demonstrated by magnetoencephalography with high resolution in time and space. The normal somatotopic arrangement was preserved.
MeSH term(s)	Adolescent ; Brain Mapping ; Child ; Child, Preschool ; Evoked Potentials, Somatosensory/physiology ; Female ; Functional Laterality/physiology ; Humans ; Magnetic Resonance Imaging ; Magnetoencephalography ; Male ; Nervous System Malformations/diagnosis ; Nervous System Malformations/physiopathology ; Neural Conduction/physiology ; Physical Stimulation ; Reaction Time/physiology ; Somatosensory Cortex/abnormalities ; Somatosensory Cortex/physiopathology ; Somatosensory Disorders/etiology ; Somatosensory Disorders/pathology ; Somatosensory Disorders/physiopathology
Language	English
Publishing date	2005-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604822-5
ISSN	0387-7604
ISSN	0387-7604
DOI	10.1016/j.braindev.2004.02.013
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Article: Opercular to interhemispheric source distribution of benign rolandic spikes of childhood.

Ishitobi, Mamiko / Nakasato, Nobukazu / Yamamoto, Katsuya / Iinuma, Kazuie

NeuroImage

2005 Volume 25, Issue 2, Page(s) 417–423

Abstract: We evaluated the source distribution of benign rolandic spikes of childhood along and across the central sulcus in 15 patients, aged between 7 and 15 years, who suffered from seizure disorders. Previous routine EEG showed centrotemporal spikes, but none ... ...

Abstract	We evaluated the source distribution of benign rolandic spikes of childhood along and across the central sulcus in 15 patients, aged between 7 and 15 years, who suffered from seizure disorders. Previous routine EEG showed centrotemporal spikes, but none of them had major abnormalities on brain magnetic resonance imaging or neurological deficits. The equivalent current dipoles (ECDs) of the spikes measured by whole-head magnetoencephalography (MEG) were compared to the spike distributions detected by simultaneous scalp EEG according to the international 10-20 system. Locations and orientations of the MEG spikes corresponded to the EEG spike distribution as follows: superiorly oriented spike MEG dipoles in the opercular area corresponded to T3/4 negative peaks (8 spike groups in 6 patients); anteriorly oriented spike dipoles in the rolandic area corresponded to C3/4 or P3/4 negative peaks (17 spike groups in 13 patients); laterally oriented spike dipoles in the interhemispheric area corresponded to Cz/Pz negative peaks (4 spike groups in 3 patients); and others (4 spike groups in 4 patients). Rolandic spikes include three main types according to the ECD location from the opercular to the interhemispheric areas. The functional anatomy of benign rolandic spikes was correlated with partial seizure semiology. All three rolandic spike types can be explained by a precentral origin, assuming that the surface negative potential is continuous from the gyral to fissural cortices.
MeSH term(s)	Adolescent ; Child ; Electroencephalography ; Epilepsy, Rolandic/physiopathology ; Female ; Humans ; Male ; Temporal Lobe/physiopathology
Language	English
Publishing date	2005-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2004.11.040
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