LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 53

Search options

  1. Article ; Online: Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection.

    Okano, Motohiko

    Current pediatric reviews

    2015  Volume 11, Issue 1, Page(s) 5–9

    Abstract: Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. Patients with CAEBV also may have various life- ... ...

    Abstract Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. Patients with CAEBV also may have various life-threatening conditions including hematological, neurological, pulmonary, cardiac, digestive tract, ocular and/or dermal disorders. Additionally, during the course of illness, they often develop hematological malignancies such as T cell, NK cell or B cell lymphoproliferative disorder (LPD) and/or lymphoma. No causative pathogenetic mechanisms have been sufficiently clarified, and additionally no promising efficacious treatment was demonstrated except for the hematopoietic stem cell transplantation (HSCT) in cases who develop T cell or NK cell LPD or lymphoma. This minireview outlines the recent development for the comprehensive viewpoints of CAEBV mainly regarding to virological, immunological, pathological and therapeutical progresses.
    MeSH term(s) Child ; Child, Preschool ; Chronic Disease ; DNA, Viral ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/physiopathology ; Epstein-Barr Virus Infections/therapy ; Hematopoietic Stem Cell Transplantation/methods ; Herpesvirus 4, Human/pathogenicity ; Humans ; Killer Cells, Natural/pathology ; Killer Cells, Natural/virology ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/physiopathology ; Lymphoproliferative Disorders/virology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/virology ; Treatment Outcome
    Chemical Substances DNA, Viral ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2015-05-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1875-6336
    ISSN (online) 1875-6336
    DOI 10.2174/1573396311666150501002809
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: [Successful treatment with cyclosporine in a patient with rituximab-refractory thrombocytopenic purpura].

    Nato, Yuma / Nagaharu, Keiki / Okano, Motohiko / Suzuki, Kei / Matsumoto, Takeshi / Tawara, Isao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2021  Volume 62, Issue 3, Page(s) 176–179

    Abstract: Acquired thrombotic thrombocytopenic purpura (aTTP) is a life-threatening systemic thrombotic microangiopathy characterized by the presence of anti-ADAMTS13 antibodies (inhibitor). Here we report the case of a patient with refractory aTTP successfully ... ...

    Abstract Acquired thrombotic thrombocytopenic purpura (aTTP) is a life-threatening systemic thrombotic microangiopathy characterized by the presence of anti-ADAMTS13 antibodies (inhibitor). Here we report the case of a patient with refractory aTTP successfully treated with cyclosporine. A 69-year-old man presenting with hematuria and petechiae was referred to our hospital; he was disoriented and febrile. Laboratory results revealed Coombs-negative hemolytic anemia, thrombocytopenia, and renal failure. Undetectable ADAMTS13 activity and presence of anti-ADAMTS13 antibodies (inhibitor) confirmed the diagnosis of aTTP. Despite performing plasma exchange and administering prednisolone and rituximab (375 mg/m
    MeSH term(s) ADAMTS13 Protein ; Aged ; Cyclosporine/therapeutic use ; Humans ; Male ; Plasma Exchange ; Plasmapheresis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Rituximab/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6) ; Cyclosporine (83HN0GTJ6D) ; ADAMTS13 Protein (EC 3.4.24.87)
    Language Japanese
    Publishing date 2021-04-07
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.62.176
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 535: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Taurine induces upregulation of p53 and Beclin1 and has antitumor effect in human nasopharyngeal carcinoma cells in vitro and in vivo.

    Okano, Motohiko / He, Feng / Ma, Ning / Kobayashi, Hatasu / Oikawa, Shinji / Nishimura, Komei / Tawara, Isao / Murata, Mariko

    Acta histochemica

    2022  Volume 125, Issue 1, Page(s) 151978

    Abstract: Taurine is an amino acid that has several physiological functions. Previously, we reported the apoptosis-inducing effect of taurine in human nasopharyngeal carcinoma (NPC) cells in vitro. However, the effect of taurine on NPC cell growth in vivo has not ... ...

    Abstract Taurine is an amino acid that has several physiological functions. Previously, we reported the apoptosis-inducing effect of taurine in human nasopharyngeal carcinoma (NPC) cells in vitro. However, the effect of taurine on NPC cell growth in vivo has not been elucidated. Autophagy plays an important role in cell metabolism and exhibits antitumor effects under certain conditions. In this study, we investigated the effects of taurine on apoptosis- and autophagy-related molecules in NPC cells in vitro and in vivo. In our in vitro study, NPC cells (HK1-EBV) were treated with taurine, and Western blot and immunocytochemical analyses revealed that taurine co-upregulated Beclin 1 and p53, with autophagy upregulation. In the in vivo study, we used a nude mouse model with subcutaneous xenografts of HK1-EBV cells. Once the tumors reached 2-3 mm in diameter, the mice were provided with distilled water (control group) or taurine dissolved in distilled water (taurine-treated group) ad libitum (day 1) and sacrificed on day 13. The volume and weight of the tumors were significantly lower in the taurine-treated group. Using immunohistochemistry (IHC), we confirmed that taurine treatment reduced the distinct cancer nest areas. IHC analyses also revealed that taurine promoted apoptosis, as evidenced by an increase in cleaved caspase-3, accompanied by upregulation of p53. Additionally, taurine increased LC3B and Beclin 1 expression, which are typical autophagy markers. The present study demonstrated taurine-mediated tumor growth suppression. Therefore, taurine may be a novel preventive strategy for NPC.
    MeSH term(s) Animals ; Humans ; Mice ; Apoptosis ; Beclin-1/metabolism ; Beclin-1/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/metabolism ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Taurine/pharmacology ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation ; Water
    Chemical Substances Beclin-1 ; Taurine (1EQV5MLY3D) ; Tumor Suppressor Protein p53 ; Water (059QF0KO0R) ; TP53 protein, human
    Language English
    Publishing date 2022-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 77-2
    ISSN 1618-0372 ; 0065-1281
    ISSN (online) 1618-0372
    ISSN 0065-1281
    DOI 10.1016/j.acthis.2022.151978
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.185: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Impact of lenvatinib-induced proteinuria and renal dysfunction in patients with thyroid cancer.

    Shibutani, Yuma / Suzuki, Shinya / Sagara, Atsunobu / Enokida, Tomohiro / Okano, Susumu / Fujisawa, Takao / Sato, Fumiaki / Yumoto, Tetsuro / Sano, Motohiko / Kawasaki, Toshikatsu / Tahara, Makoto

    Frontiers in oncology

    2023  Volume 13, Page(s) 1154771

    Abstract: Background: Proteinuria is the most frequent adverse event of lenvatinib use. However, the association between lenvatinib-induced proteinuria and renal dysfunction remains unclear.: Methods: We retrospectively reviewed medical records of patients ... ...

    Abstract Background: Proteinuria is the most frequent adverse event of lenvatinib use. However, the association between lenvatinib-induced proteinuria and renal dysfunction remains unclear.
    Methods: We retrospectively reviewed medical records of patients with thyroid cancer without proteinuria treated with lenvatinib as a first-line systemic therapy at the initiation of treatment to assess the association between lenvatinib-induced proteinuria and renal function and the risk factors for the development of ≥3+ proteinuria on a dipstick test. Proteinuria was assessed by the dipstick test throughout the treatment in all cases.
    Results: Of the 76 patients, 39 developed ≤2+ proteinuria (low proteinuria group) and 37 developed ≥3+ proteinuria (high proteinuria group). There was no significant difference in estimated glomerular filtration rate (eGFR) between high and low proteinuria groups at each time point, but there was a trend toward a significant decrease in eGFR of -9.3 ml/min/1.73 m
    Conclusions: There was no association between the degree of lenvatinib-induced proteinuria and renal function. Therefore, treatment should be continued with attention to renal function, regardless of the degree of proteinuria.
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1154771
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Association between baseline blood pressure and the incidence of lenvatinib-induced hypertension in patients with thyroid cancer.

    Shibutani, Yuma / Tajiri, Kazuko / Suzuki, Shinya / Enokida, Tomohiro / Sagara, Atsunobu / Okano, Susumu / Fujisawa, Takao / Sato, Fumiaki / Yumoto, Tetsuro / Sano, Motohiko / Kawasaki, Toshikatsu / Tahara, Makoto

    Cancer medicine

    2023  Volume 12, Issue 22, Page(s) 20773–20782

    Abstract: Background: Hypertension is the most frequently occurring adverse event of lenvatinib, recognized relatively early in its course. However, the trend in blood pressure after the initiation of lenvatinib and the outcomes with antihypertensive treatment ... ...

    Abstract Background: Hypertension is the most frequently occurring adverse event of lenvatinib, recognized relatively early in its course. However, the trend in blood pressure after the initiation of lenvatinib and the outcomes with antihypertensive treatment are unclear. This study aimed to clarify the association between baseline blood pressure and the incidence of lenvatinib-induced hypertension in patients with thyroid cancer.
    Methods: This retrospective study included 65 patients without hypertension at the time of lenvatinib initiation. Patients were divided into two groups: those who developed hypertension grade ≥3 (HTN group) and those who did not develop hypertension grade ≥3 (non-HTN group).
    Results: Of the 65 patients, 46 (71%) developed hypertension grade ≥3. In both HTN and non-HTN groups, blood pressure significantly increased the day after lenvatinib initiation. There was no significant difference in the elevated values of both the changes in systolic blood pressure (ΔSBP) and diastolic blood pressure (ΔDBP) between the two groups, with an average increase of 20 mmHg in SBP and 13 mmHg in DBP from baseline. The median (range) time to the onset of hypertension grade ≥3 was 2 days (1-12 days). In the multivariable analysis, patients with normal (SBP 120-129 mmHg and/or DBP 80-84 mmHg) or high-normal baseline blood pressure (SBP 130-139 mmHg and/or DBP 85-89 mmHg) were at higher risk of developing hypertension grade ≥3 than those with optimal baseline blood pressure (SBP <120 mmHg and DBP <80 mmHg) (odds ratio [OR], 5.07; 95% confidential interval [CI] 1.09-23.54 and OR, 7.48; 95% CI, 1.67-33.51, respectively).
    Conclusions: Lenvatinib-induced hypertension appears the day after administration, and higher baseline blood pressure is a significant risk factor for developing hypertension grade ≥3. In cases of increased blood pressure with lenvatinib, early initiation of antihypertensives may prevent treatment interruption due to hypertension and maintain the therapeutic intensity of lenvatinib.
    MeSH term(s) Humans ; Blood Pressure ; Incidence ; Retrospective Studies ; Hypertension/chemically induced ; Hypertension/epidemiology ; Antihypertensive Agents/adverse effects ; Thyroid Neoplasms/drug therapy
    Chemical Substances lenvatinib (EE083865G2) ; Antihypertensive Agents
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6644
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Isolated thrombocytosis in chronic myeloid leukemia without significant leukocytosis.

    Okano, Motohiko / Sugimoto, Yuka / Ohishi, Koshi / Miyazaki, Kana / Monma, Fumihiko / Katayama, Naoyuki

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2017  Volume 58, Issue 7, Page(s) 766–771

    Abstract: Chronic myeloid leukemia (CML) typically causes leukocytosis rather than thrombocytosis. We encountered two women in their thirties with remarkable thrombocytosis, whose platelet counts were over 3,000× ... ...

    Abstract Chronic myeloid leukemia (CML) typically causes leukocytosis rather than thrombocytosis. We encountered two women in their thirties with remarkable thrombocytosis, whose platelet counts were over 3,000×10
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.58.766
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 535: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: The evolving therapeutic approaches for Epstein-Barr virus infection in immunocompetent and immunocompromised individuals.

    Okano, Motohiko

    Current drug targets. Immune, endocrine and metabolic disorders

    2003  Volume 3, Issue 2, Page(s) 137–142

    Abstract: Epstein-Barr virus (EBV) is one of eight known human herpesviruses (HHVs). A primary EBV infection is generally subclinical in immunocompetent individuals, but often causes infectious mononucleosis (IM) in adolescents and adults, which is generally a ... ...

    Abstract Epstein-Barr virus (EBV) is one of eight known human herpesviruses (HHVs). A primary EBV infection is generally subclinical in immunocompetent individuals, but often causes infectious mononucleosis (IM) in adolescents and adults, which is generally a benign and self-limiting disease. Therefore, in immunocompetent individuals only symptomatic treatment is recommended, although fatal or malignant diseases such as fatal IM, Burkitt's lymphoma (BL) and nasopharyngeal carcinoma (NPC) may develop without obvious preceding immunodeficiency. However, in certain circumstances such as in patients with hereditary immunodeficiencies, in recipients receiving a potent immunosuppressant or in patients with acquired immunodeficiency syndrome (AIDS), this virus strongly links to the development of lethal lymphoproliferative diseases (LPD). These LPD range from IM-like illness associated with polyclonal proliferation to malignant lymphoma in monoclonal fashion. To date, no specific therapy has been available for latent EBV infection itself, but understanding the underlying pathogenetic mechanisms in each condition provides the possible treatment including anti-viral agents, immune modulators and chemotherapeutic drugs. Furthermore, severe combined immunodeficiency (SCID) mouse engrafted with human peripheral blood mononuclear cells is a suitable model for EBV-associated LPD which occur in human beings. Using this, several therapeutic trials have been investigated, and some are possibly beneficial. This concise review focuses on recent understanding of the pathogenetic mechanisms in various EBV-associated diseases in immunocompetent and immunocompromised individuals, and discusses potent therapeutic approaches in each condition.
    MeSH term(s) Animals ; Disease Models, Animal ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/immunology ; Humans ; Immunocompetence/drug effects ; Immunocompetence/immunology ; Immunocompromised Host/drug effects ; Immunocompromised Host/immunology
    Language English
    Publishing date 2003-04-24
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112549-1
    ISSN 1568-0088
    ISSN 1568-0088
    DOI 10.2174/1568008033340270
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Overview and problematic standpoints of severe chronic active Epstein-Barr virus infection syndrome.

    Okano, Motohiko

    Critical reviews in oncology/hematology

    2002  Volume 44, Issue 3, Page(s) 273–282

    Abstract: Epstein-Barr virus (EBV) is an ubiquitous human herpesvirus. Its infection is generally subclinical. However, in certain circumstances, EBV causes infectious mononucleosis (IM) and lymphoproliferative disorders (LPD) in immunologically compromised ... ...

    Abstract Epstein-Barr virus (EBV) is an ubiquitous human herpesvirus. Its infection is generally subclinical. However, in certain circumstances, EBV causes infectious mononucleosis (IM) and lymphoproliferative disorders (LPD) in immunologically compromised individuals. Furthermore, EBV infection is etiologically linked to human malignancies such as Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC) and miscellaneous malignant diseases because of the presence of viral genome in their tumor tissues. Since the late 1970s, a chronic undefined illness possibly associated with EBV infection, named such as severe chronic active EBV infection syndrome (SCAEBV), has been of interest due to its unique manifestations that often result in a poor prognosis. This review is an overview of SCAEBV with respect to its; history, diagnosis, pathogenesis, therapeutic approaches, and ideas on how to further recognize this enigmatic disease.
    MeSH term(s) Chronic Disease ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/therapy ; Humans ; Syndrome
    Language English
    Publishing date 2002-12-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1040-8428 ; 0737-9587
    ISSN 1040-8428 ; 0737-9587
    DOI 10.1016/s1040-8428(02)00118-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006-2015.

    Miyoshi, Masahiro / Komagome, Rika / Yamaguchi, Hiroki / Ishida, Setsuko / Nagano, Hideki / Okano, Motohiko

    Microbiology and immunology

    2018  Volume 62, Issue 6, Page(s) 411–417

    Abstract: Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, their antigenic features were evaluated by ... ...

    Abstract Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.
    MeSH term(s) Amino Acid Sequence ; Antibodies, Neutralizing ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Evolution, Molecular ; Genetic Variation/genetics ; Genotype ; Hemagglutinins, Viral/genetics ; Hemagglutinins, Viral/immunology ; Humans ; Japan/epidemiology ; Measles/epidemiology ; Measles/immunology ; Measles/virology ; Measles virus/classification ; Measles virus/genetics ; Molecular Epidemiology ; Neutralization Tests ; Nucleocapsid Proteins/genetics ; Nucleocapsid Proteins/immunology ; Phylogeny ; Sequence Analysis, DNA ; Viral Proteins/genetics
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Antigens, Viral ; Hemagglutinins, Viral ; Nucleocapsid Proteins ; Viral Proteins
    Language English
    Publishing date 2018-04-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 224792-6
    ISSN 1348-0421 ; 0385-5600
    ISSN (online) 1348-0421
    ISSN 0385-5600
    DOI 10.1111/1348-0421.12594
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Hepatitis E outbreak at a nursing home for aged people in Hokkaido, Japan, between February and March 2016.

    Ishida, Setsuko / Matsuura, Kaori / Yoshizumi, Shima / Miyoshi, Masahiro / Sugisawa, Takahisa / Tanida, Mitsuhiro / Okano, Motohiko

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2018  Volume 101, Page(s) 23–28

    Abstract: Background: Infection with hepatitis E virus (HEV) genotypes 3 and 4 are usually asymptomatic but can occasionally result in life-threatening acute hepatitis. To date, only sporadic cases together with a few outbreaks have been documented. ... ...

    Abstract Background: Infection with hepatitis E virus (HEV) genotypes 3 and 4 are usually asymptomatic but can occasionally result in life-threatening acute hepatitis. To date, only sporadic cases together with a few outbreaks have been documented. Seroprevalence studies with assays for the detection of HEV IgG antibodies, suggest that HEV is more prevalent than previously thought, even in non-endemic regions.
    Objectives: The aim of this study was to characterize an outbreak of hepatitis E (HE) in a nursing home for aged people between February and March 2016.
    Study design: After the identification of two cases living in the same nursing home, the presence of antibodies against HEV and HEV RNA were examined in serum samples collected from the other residents and staff members to identify any additional cases. An epidemiological investigation was also carried out.
    Results: Only 4 patients showed mild symptoms such as anorexia, abdominal pain and fatigue. Among the 125 persons tested, 28 residents and one dietitian were confirmed positive for anti-HEV IgA or IgM antibodies, and/or HEV RNA. Eight samples had only IgG antibodies. Finally, 22 cases were notified with HE on the basis of the presence of IgA antibodies. All HEV isolates obtained were 99.8-100% identical and belonged to genotype 3.
    Conclusion: HEV infections seem to be under-reported or underestimated possibly due to cases being generally asymptomatic. Testing for the presence of both anti-HEV antibodies and HEV RNA would be beneficial for both the comprehensive diagnosis of HE infections and the prevention of further infections.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Disease Notification ; Disease Outbreaks ; Female ; Genotype ; Hepatitis Antibodies/blood ; Hepatitis E/diagnosis ; Hepatitis E/epidemiology ; Hepatitis E virus/classification ; Hepatitis E virus/genetics ; Hepatitis E virus/immunology ; Hepatitis E virus/isolation & purification ; Homes for the Aged/statistics & numerical data ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Japan/epidemiology ; Male ; Nursing Homes/statistics & numerical data ; Prevalence ; RNA, Viral/blood ; RNA, Viral/genetics ; Seroepidemiologic Studies
    Chemical Substances Hepatitis Antibodies ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2018.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top