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Article ; Online: Antistolling zinvol bij kortdurend atriumfibrilleren?

Seelig, Jaap / Pisters, Ron / Alings, A M W Marco / Hemels, Martin E W

2023 Volume 167

Abstract: ... duration of the AF episode(s), both patients with subclinical or triggered AF are often at an inherently ...

Title translation	Anticoagulation useful in short episodes of atrial fibrillation?
Abstract	In patients with short episodes of clinical, non-triggered AF is the evidence for long-term anticoagulation based on the CHA2DS2-VASc score strong. In situations where a temporary trigger for AF is observed (e.g. after surgery or an infection), or when AF is only detected on a cardiac implantable electronic device (CIED) or smartwatch, the evidence for anticoagulation is less well established. Despite the short duration of the AF episode(s), both patients with subclinical or triggered AF are often at an inherently increased risk of stroke or thromboembolism. In some of these cases long-term anticoagulation can be considered, especially when other cardiovascular risk factors are present. Important considerations when deciding to start with long-term anticoagulation are the individually estimated risk of thrombosis and bleeding, the implementation of shared decision making, and the optimization of the overall cardiovascular risk management.
MeSH term(s)	Humans ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/complications ; Risk Factors ; Anticoagulants/adverse effects ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Hemorrhage/chemically induced ; Risk Assessment
Chemical Substances	Anticoagulants
Language	Dutch
Publishing date	2023-02-08
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: The role of thermokarst evolution in debris flow initiation (Hüttekar Rock Glacier, Austrian Alps)

S. Seelig / T. Wagner / K. Krainer / M. Avian / M. Olefs / K. Haslinger / G. Winkler

Natural Hazards and Earth System Sciences, Vol 23, Pp 2547-

2023 Volume 2568

Abstract: ... impounding a water volume of 120 000 m 3 that was partly drained by excavation to prevent a potentially catastrophic ...

Abstract	A rapid sequence of cascading events involving thermokarst lake outburst, local rock glacier front failure, debris flow development, and river blockage hit Radurschl Valley (Ötztal Alps, Tyrol) on 13 August 2019. Compounding effects from permafrost degradation and drainage network development within the rock glacier initiated the complex process chain. The debris flow dammed the main river of the valley, impounding a water volume of 120 000 m 3 that was partly drained by excavation to prevent a potentially catastrophic outburst flood. We present a systematic analysis of destabilizing factors to deduce the failure mechanism. The identification and evaluation of individual factors reveals a critical combination of topographical and sedimentological disposition, climate, and weather patterns driving the evolution of a thermokarst drainage network. Progressively changing groundwater flow and storage patterns within the frozen sediment accumulation governed the slope stability of the rock glacier front. Our results demonstrate the hazard potential of active rock glaciers due to their large amount of mobilizable sediment, dynamically changing internal structure, thermokarst lake development, and substantial water flow along a rapidly evolving channel network.
Keywords	Environmental technology. Sanitary engineering ; TD1-1066 ; Geography. Anthropology. Recreation ; G ; Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	333 ; 550
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article: Magnesium (and trace substance) deficiencies in the pathogenesis of cancer.

Seelig, M S

Biological trace element research

2013 Volume 1, Issue 4, Page(s) 273–297

Abstract: Except for a few experimental models of magnesium (Mg)-deficiency-induced neoplasms, less attention has been paid in the past quarter century in the Western world to this macromineral than to the trace elements; e.g., selenium (Se) and zinc (Zn), and to ... ...

Abstract	Except for a few experimental models of magnesium (Mg)-deficiency-induced neoplasms, less attention has been paid in the past quarter century in the Western world to this macromineral than to the trace elements; e.g., selenium (Se) and zinc (Zn), and to vitamins, deficiencies of which are each considered probable factors in oncogenesis. Although early epidemiologic studies showed an inverse correlation between the amount of Mg in soil and water and the incidence of (gastric) cancer, and several animal studies supported the premise that Mg has a prophylactic effect against induction of cancer, other studies showed that Mg supplementation increased the growth of established experimental tumors. Thus, enthusiasm for this approach subsided. The early epidemiologic findings have since been confirmed, and there have been studies demonstrating the importance of Mg in maintaining immunocompetence, and others indicating that immunodeficiencies increase susceptibility to the development of cancer. Evidence has now accrued that indicates that Mg deficiency increases susceptibility to chemical oncogens. The abnormal metabolism of tryptophan (yielding a carcinogenic metabolite) that indicates functional or absolute pyridoxine deficiency is an indirect clue to Mg deficiency. Vitamin B6-activated enzymes require Mg as a cofactor. However, the early warnings against the use of Mg as part of an antineoplastic program against established cancer were justified, since rapidly metabolizing cells (such as cancers) are dependent on Mg.There are similarities between experiences with Mg and with Se and Zn. All three are required for normal metabolism; Se also protects against free radicals in the environment. Mg and Zn have increased established tumor growth, and their depletion has been applied to antineoplastic programs, with risks comparable to those of using antimetabolic agents.
Language	English
Publishing date	2013-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/BF02778831
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Article: Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice.

Dobariya, Prakashkumar / Xie, Wei / Rao, Swetha Pavani / Xie, Jiashu / Seelig, Davis M / Vince, Robert / Lee, Michael K / More, Swati S

bioRxiv : the preprint server for biology

2023

Abstract: Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC) has a narrow therapeutic window and early treatment is essential for ... ...

Abstract	Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC) has a narrow therapeutic window and early treatment is essential for satisfactory therapeutic outcome. For more versatile therapies that can be effective even at late-presentation, the intricacies of APAP-induced hepatotoxicity must be better understood. Accumulation of advanced glycation end-products (AGEs) and consequent activation of the receptor for AGEs (RAGE) are considered one of the key mechanistic features of APAP toxicity. Glyoxalase-1 (Glo-1) regulates AGE formation by limiting the levels of methylglyoxal (MEG). In this study, we studied the relevance of Glo-1 in APAP mediated activation of RAGE and downstream cell-death cascades. Constitutive Glo-1 knockout mice (GKO) and a cofactor of Glo-1, ψ-GSH, were employed as tools. Our findings show elevated oxidative stress, activation of RAGE and hepatocyte necrosis through steatosis in GKO mice treated with high-dose APAP compared to wild type controls. A unique feature of the hepatic necrosis in GKO mice is the appearance of microvesicular steatosis as a result of centrilobular necrosis, rather than inflammation seen in wild type. The GSH surrogate and general antioxidant, ψ-GSH alleviated APAP toxicity irrespective of Glo-1 status, suggesting that oxidative stress being the primary driver of APAP toxicity. Overall, exacerbation of APAP hepatotoxicity in GKO mice suggests the importance of this enzyme system in antioxidant defense against initial stages of APAP overdose.
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.21.572856
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Article ; Online: Das Zweinutzungshuhn in der Praxis

Pluschke, Helen / Lombard, Sarah / Desaint, Brieuc / Reverchon, Maxime / Collin, Anne / Ferriz, Michel / Seelig, Sebastian / Baldinger, Lisa

Mastleistung, Schlachtkörperqualität und Tierwohl von Hähnen einer neuen Herkunft auf 2 Betrieben in Frankreich und Deutschland

2024

Abstract: Die Hähne einer neu-entwickelten Zweinutzungsherkunft mit Fokus auf der Legeleistung wurde auf zwei ökologisch zertifizierten Betrieben in Deutschland und Frankreich getestet. ...

Abstract	Die Hähne einer neu-entwickelten Zweinutzungsherkunft mit Fokus auf der Legeleistung wurde auf zwei ökologisch zertifizierten Betrieben in Deutschland und Frankreich getestet.
Keywords	Text ; abstract_or_summary ; ddc:630
Language	German
Publishing country	de
Document type	Article ; Online
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Article ; Online: Effects of a co-designed exercise and sport intervention on cardiorespiratory fitness and metabolic syndrome components among individuals living in a refugee camp in Greece: A randomized controlled trial.

Knappe, Florian / Filippou, Konstantinia / Hatzigeorgiadis, Antonis / Morres, Ioannis D / Tzormpatzakis, Emmanouil / Havas, Elsa / Seelig, Harald / Ludyga, Sebastian / Colledge, Flora / Meier, Marianne / Theodorakis, Yannis / von Känel, Roland / Pühse, Uwe / Gerber, Markus

Journal of migration and health

2024 Volume 9, Page(s) 100227

Abstract: Background: The metabolic syndrome epidemic, including in forcibly displaced individuals, requires cost-effective prevention and treatment strategies. Yet, the health needs of forcibly displaced individuals often remain underserved. Our study evaluated ... ...

Abstract	Background: The metabolic syndrome epidemic, including in forcibly displaced individuals, requires cost-effective prevention and treatment strategies. Yet, the health needs of forcibly displaced individuals often remain underserved. Our study evaluated the effect of a co-designed exercise and sport intervention on cardiorespiratory fitness and metabolic syndrome components among individuals in a refugee camp in Greece and examined the indirect effect through cardiorespiratory fitness on metabolic syndrome components. Methods: We conducted a randomized controlled trial involving an intervention and a wait-list control group with Results: In total, 62.7 % of participants presented with low cardiorespiratory fitness levels (<40th percentile), and 24.6 % met the criteria for metabolic syndrome. In the intervention group, 73.5 % attended the exercise and sport sessions at least once a week. There was evidence for a direct intervention effect on cardiorespiratory fitness, ß Conclusion: Implementing exercise and sport activities in a refugee camp in Greece effectively reaches a wider target population and improves cardiorespiratory fitness among forcibly displaced individuals. The intervention contributes to a decrease in abdominal obesity, high diastolic blood pressure and elevated triglycerides indirectly via improved cardiorespiratory fitness.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ISSN	2666-6235
ISSN (online)	2666-6235
DOI	10.1016/j.jmh.2024.100227
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Article: Inhaled fosamprenavir for laryngopharyngeal reflux: Toxicology and fluid dynamics modeling.

Lesnick, Alexandra / Samuels, Tina L / Seabloom, Donna / Wuertz, Beverly / Ojha, Abhilash / Seelig, Davis / Ondrey, Frank / Wiedmann, Timothy S / Hogan, Chris / Torii, Emma / Ouyang, Hui / Yan, Ke / Garcia, Guilherme J M / Bock, Jonathan M / Johnston, Nikki

Laryngoscope investigative otolaryngology

2024 Volume 9, Issue 1, Page(s) e1219

Abstract: Objectives: Approximately 25% of Americans suffer from laryngopharyngeal reflux (LPR), a disease for which no effective medical therapy exists. Pepsin is a predominant source of damage during LPR and a key therapeutic target. Fosamprenavir (FOS) ... ...

Abstract	Objectives: Approximately 25% of Americans suffer from laryngopharyngeal reflux (LPR), a disease for which no effective medical therapy exists. Pepsin is a predominant source of damage during LPR and a key therapeutic target. Fosamprenavir (FOS) inhibits pepsin and prevents damage in an LPR mouse model. Inhaled FOS protects at a lower dose than oral; however, the safety of inhaled FOS is unknown and there are no inhalers for laryngopharyngeal delivery. A pre-Good Lab Practice (GLP) study of inhaled FOS was performed to assess safety and computational fluid dynamics (CFD) modeling used to predict the optimal particle size for a laryngopharyngeal dry powder inhaler (DPI). Methods: Aerosolized FOS, amprenavir (APR), or air (control) were provided 5 days/week for 4 weeks ( Results: No significant increase was observed in histologic lesions, cytokines, or cardiotoxicity markers in FOS or APR groups relative to the control. CFD predicted that laryngopharyngeal deposition was maximized with aerodynamic diameters of 8.1-11.5 μm for inhalation rates of 30-60 L/min. Conclusions: A 4-week pre-GLP study supports the safety of inhaled FOS. A formal GLP assessment is underway to support a phase I clinical trial of an FOS DPI for LPR. Level of evidence: NA.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1219
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Article ; Online: Acceptability and perceived feasibility of the KaziKidz health promotion intervention among educators and caregivers in schools from South Africa: a qualitative descriptive study.

Arnaiz, Patricia / Bergman, Manfred Max / Seelig, Harald / Adams, Larissa / Dolley, Danielle / Gerber, Markus / Joubert, Nandi / Nqweniso, Siphesihle / Steinmann, Peter / Utzinger, Jürg / Randt, Rosa du / Walter, Cheryl / Pühse, Uwe / Müller, Ivan

BMC public health

2024 Volume 24, Issue 1, Page(s) 934

Abstract: Background: Despite the uncontested benefits of physical activity, its promotion lags behind in the public health agenda of low- and middle-income countries (LMICs). School-based interventions are promising strategies to foster health during childhood, ... ...

Abstract	Background: Despite the uncontested benefits of physical activity, its promotion lags behind in the public health agenda of low- and middle-income countries (LMICs). School-based interventions are promising strategies to foster health during childhood, but evidence of their effectiveness is limited and inconclusive for LMICs. Thus, further investigation is needed on contextual factors associated with intervention implementation in low-resource settings. We studied the acceptability and feasibility of the KaziKidz health promotion intervention and its implementation and make recommendations to improve future adoption and sustainability. Methods: KaziKidz was implemented in four primary schools from low-income communities in South Africa in 2019. Semi-structured interviews with four school principals, three focus group interviews with 16 educators, and another three with 16 caregivers were conducted between October and November 2021. Participants were purposively recruited. Interview transcripts were analyzed via thematic analysis using a deductive and reflexive approach. Results: Three main themes influencing intervention implementation and adoption were identified: (1) prioritizing teachers' needs (2), integrating the program into the school structure, and (3) creating opportunities in the community. Supporting recommendations included: (theme 1) adopting intervention approaches that are inclusive of educators' health and providing them with capacity development and external support; (theme 2) fostering a feeling of ownership and belonging among school stakeholders to adapt interventions to specific resources and needs; and (theme 3) raising community awareness to encourage individuals to claim power over and actively engage with the program. Conclusions: Comprehensive interventions comprising health support, adequate training, and ongoing assistance for educators combined with school-wide and community outreach actions seeking to strengthen program ownership, accountability, and engagement can enhance uptake of school-based interventions and long-term maintenance. Trial registration: ISRCTN15648510, registered on 17/04/2020.
MeSH term(s)	Humans ; South Africa ; Feasibility Studies ; Caregivers ; Health Promotion ; Schools
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18456-3
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Article ; Online: Randomized Trial to Improve Body Composition and Micronutrient Status Among South African Children.

Long, Kurt Z / Beckmann, Johanna / Lang, Christin / Seelig, Harald / Nqweniso, Siphesihle / Probst-Hensch, Nicole / Pühse, Uwe / Steinmann, Peter / Randt, Rosa du / Walter, Cheryl / Utzinger, Jürg / Gerber, Markus

American journal of preventive medicine

2024

Abstract: Introduction: Physical activity (PA) promotion combined with multimicronutrient supplementation (MMNS) among school-age children may reduce fat mass accrual and increase muscle mass through different mechanisms and so benefit child health. This study ... ...

Abstract	Introduction: Physical activity (PA) promotion combined with multimicronutrient supplementation (MMNS) among school-age children may reduce fat mass accrual and increase muscle mass through different mechanisms and so benefit child health. This study determined the efficacy of combined interventions on body composition among South African schoolchildren and determined if micronutrients mediate these effects. Study design: Longitudinal cluster randomized controlled trial of children followed from 2019 to 2021. Statistical analyses carried from 2022 to 2023. Setting/participants: A total of 1,304 children 6-12 years of age recruited from public schools in Gqeberha, South Africa. Intervention: Children were randomized by classes to either: (a) a physical activity group (PA); (b) a MMNS group; (c) a physical activity + multimicronutrient supplementation group (PA + MMNS); and (d) a placebo control group. Main outcome measures: Trajectories of overall and truncal fat free mass (FFM) and fat mass (FM) estimates in modeled at 9 and 21 months using latent growth curve models (LGCM). Changes in micronutrient concentrations at 9 months from baseline. Results: An increased FFM trajectory was found among children in the MMNS arm at 9 months (Beta 0.16, 95% CI = 0.12, 0.31). The PA and MMNS arms both had positive indirect effects on this trajectory at 9 months (Beta 0.66, 95% CI = 0.44, 0.88 and Beta 0.32 95% CI = 0.1 0.5, respectively) and similarly at 21 months when mediated by zinc concentration changes. A reduced FM trajectory was found among children in the PA promotion arm at 9 months when using this collection point as the referent intercept. This arm was inversely associated with the FM trajectory at 9 months when mediated by zinc changes. Conclusions: PA and MMNS promotion in school-based interventions directly contributed to reductions in FM and increased FFM among South African children and indirectly through changes in micronutrient status. Trial registration: ISRCTN, ISRCTN29534081. Registered on August 9, 2018 Institutional review board: Ethikkommission Nordwest- und Zentralschweiz" (EKNZ, project number: Req-2018-00608). Date of approval: 2018.
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2024.01.017
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Book ; Online: The role of thermokarst evolution in debris flow initiation (Hüttekar Rock Glacier, Austrian Alps)

Seelig, Simon / Wagner, Thomas / Krainer, Karl / Avian, Michael / Olefs, Marc / Haslinger, Klaus / Winkler, Gerfried

eISSN: 1684-9981

2023

Abstract: ... impounding a water volume of 120 000 m 3 that was partly drained by excavation to prevent a potentially catastrophic ...

Abstract	A rapid sequence of cascading events involving thermokarst lake outburst, local rock glacier front failure, debris flow development, and river blockage hit Radurschl Valley (Ötztal Alps, Tyrol) on 13 August 2019. Compounding effects from permafrost degradation and drainage network development within the rock glacier initiated the complex process chain. The debris flow dammed the main river of the valley, impounding a water volume of 120 000 m 3 that was partly drained by excavation to prevent a potentially catastrophic outburst flood. We present a systematic analysis of destabilizing factors to deduce the failure mechanism. The identification and evaluation of individual factors reveals a critical combination of topographical and sedimentological disposition, climate, and weather patterns driving the evolution of a thermokarst drainage network. Progressively changing groundwater flow and storage patterns within the frozen sediment accumulation governed the slope stability of the rock glacier front. Our results demonstrate the hazard potential of active rock glaciers due to their large amount of mobilizable sediment, dynamically changing internal structure, thermokarst lake development, and substantial water flow along a rapidly evolving channel network.
Subject code	333 ; 550
Language	English
Publishing date	2023-07-20
Publishing country	de
Document type	Book ; Online
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