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Article ; Online: Influence of Ag nanoparticles anchored on protonated g-C

Govinda Raj, Muniyandi / Vijayakumar, Elayaperumal / Neppolian, Bernaurdshaw / Lakhera, Sandeep Kumar / Bosco, Aruljothy John

RSC advances

2021 Volume 11, Issue 41, Page(s) 25511–25523

Abstract: ... we report novel Ag@p-g-C ...

Abstract	The development of noble metal-anchored semiconductors for photocatalytic processes is now garnering interest for potential application to toxic pollutants as well as antibiotic degradation. Herein, we report novel Ag@p-g-C
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra02800f
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Article: Insights into g-C₃N₄ as a chemi-resistive gas sensor for VOCs and humidity – a review of the state of the art and recent advancements

Srinivasan, Parthasarathy / Samanta, Soumadri / Krishnakumar, Akshay / Rayappan, John Bosco Balaguru / Kailasam, Kamalakannan

Journal of materials chemistry A. 2021 May 4, v. 9, no. 17

2021

Abstract: ... in recent years is graphitic polymeric carbon nitride, g-CN (so-called g-C₃N₄). It has emerged ... other sensing principles of g-C₃N₄, such as photo-electrochemical, electrochemiluminescence, electrochemical and ... on the chemi-resistive gas sensing signatures of g-C₃N₄. This stood out as our first and foremost inspiration ...

Abstract	Over the past decades, many materials like metal oxides, conducting polymers, carbon nanotubes, 2D materials, graphene, zeolites and porous organic frameworks (MOFs and COFs) have been explored for chemo-sensing applications owing to their unique properties. One such 2D material in the center of attraction in recent years is graphitic polymeric carbon nitride, g-CN (so-called g-C₃N₄). It has emerged as a potential candidate for chemo-sensing applications due to its facile synthesis, physicochemical properties, and tunable electronic structures. Though there are a few reports and reviews available for various other sensing principles of g-C₃N₄, such as photo-electrochemical, electrochemiluminescence, electrochemical and fluorescence-based ion-sensing and bio-sensing, it is difficult to find a comprehensive review solely on the chemi-resistive gas sensing signatures of g-C₃N₄. This stood out as our first and foremost inspiration to compile this review by focusing on chemi-resistive sensors reported using g-C₃N₄ and its composites. In this review, the humidity and VOC sensing applications of g-C₃N₄ & its composites have been accentuated. A detailed sensing mechanism, along with the specific rationales for selective detection, has been presented. Along with the specific figures of merit of the g-C₃N₄ based chemo-sensors, a futuristic perspective of carbon nitride-based hybrid materials and key strategies to improve the sensing characteristics are presented. Thus, this progress in the recently booming g-C₃N₄ and its hybrid-based chemo-sensors paves a way to further fabricate different forms of g-C₃N₄ based sensors for the challenges ahead in the field of energy and environment, especially IoT based futuristic sensing platforms.
Keywords	carbon nanotubes ; carbon nitride ; electrochemiluminescence ; electrochemistry ; energy ; graphene ; humidity ; polymers ; zeolites
Language	English
Dates of publication	2021-0504
Size	p. 10612-10651.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d0ta12500h
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Article: Influence of Ag nanoparticles anchored on protonated g-C₃N₄–Bi₂MoO₆ nanocomposites for effective antibiotic and organic pollutant degradation

Govinda raj, Muniyandi / Vijayakumar, Elayaperumal / Neppolian, Bernaurdshaw / Lakhera, Sandeep Kumar / Bosco, Aruljothy John

RSC advances. 2021 July 22, v. 11, no. 41

2021

Abstract: ... we report novel Ag@p-g-C₃N₄–Bi₂MoO₆ nanocomposites synthesized by facile hydrothermal and calcination ... nanoparticles over p-g-C₃N₄/Bi₂MoO₆ decreased the band gap energy from 2.67 to 2.48 eV, to exhibit an abnormal ... the heterostructure mechanism. Moreover, this work features the feasible applications of Ag@p-g-C₃N₄–Bi₂MoO₆ ...

Abstract	The development of noble metal-anchored semiconductors for photocatalytic processes is now garnering interest for potential application to toxic pollutants as well as antibiotic degradation. Herein, we report novel Ag@p-g-C₃N₄–Bi₂MoO₆ nanocomposites synthesized by facile hydrothermal and calcination methods with a size of about 50 nm, exhibiting superior photocatalytic activity for charge separation. The resulting nanocomposites were evaluated by various physiochemical techniques such as X-ray diffraction, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, and high-resolution transmission electron microscopy. The charge transfer photogenerated carriers were confirmed by photoluminescence spectra and electrochemical impedance spectroscopy. The anchoring of Ag nanoparticles over p-g-C₃N₄/Bi₂MoO₆ decreased the band gap energy from 2.67 to 2.48 eV, to exhibit an abnormal increase in absorption of light towards the visible light region. The degradation performance of the nanocomposites in terms of antibiotic ciprofloxacin and rhodamine B degradation efficiency was measured 85 and 99.7% respectively. The superoxide radical anion ˙O₂⁻ played a significant role throughout the entire degradation process. Focusing on the probable mechanism based on the desirable results, the present work follows the heterostructure mechanism. Moreover, this work features the feasible applications of Ag@p-g-C₃N₄–Bi₂MoO₆ as a modified photocatalyst in the treatment of both domestic and industrial waste water.
Keywords	Fourier transform infrared spectroscopy ; X-ray diffraction ; X-ray photoelectron spectroscopy ; absorption ; antibiotics ; ciprofloxacin ; dielectric spectroscopy ; energy ; industrial wastewater ; nanocomposites ; nanosilver ; photocatalysis ; photocatalysts ; photoluminescence ; pollutants ; rhodamines ; superoxide anion ; toxicity ; transmission electron microscopy
Language	English
Dates of publication	2021-0722
Size	p. 25511-25523.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra02800f
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.

Coppedè, Fabio / Bosco, Paolo / Lorenzoni, Valentina / Denaro, Maria / Anello, Guido / Antonucci, Ivana / Barone, Concetta / Stuppia, Liborio / Romano, Corrado / Migliore, Lucia

Molecular biology reports

2014 Volume 41, Issue 9, Page(s) 5571–5583

Abstract: ... of the methionine synthase reductase (MTRR) c.66A>G polymorphism as a maternal risk factor for the birth of a child ... Results from the meta-analysis indicated overall a positive significant association between MTRR c.66A>G ... with the methionine synthase (MTR) c.2756A>G one, that resulted in a borderline significant maternal risk of birth of a child ...

Abstract	We performed a large case-control study and a meta-analysis of the literature to address the role of the methionine synthase reductase (MTRR) c.66A>G polymorphism as a maternal risk factor for the birth of a child with Down Syndrome (DS) among Caucasian women. A total of 253 mothers of a DS child (MDS) and 298 control mothers of Italian origin were included in the case-control study. The meta-analysis of previous and present data involved a total of seven studies performed in Caucasian populations (971 MDS and 1,387 control mothers). Results from the meta-analysis indicated overall a positive significant association between MTRR c.66A>G genotype [OR 1.36 (95 % CI 1.10-1.68), dominant model] and allele frequencies [OR 1.26 (95 % CI 1.04-1.51), allele contrast model] and maternal risk of birth of a child with DS. A sensitivity analysis revealed some interesting differences between Europeans, Caucasians of European descent, and inhabitants of Mediterranean regions, suggesting the possibility of population-specific modifying factors. The case-control study revealed association of the polymorphism with increased folate levels, and a possible interaction with the methionine synthase (MTR) c.2756A>G one, that resulted in a borderline significant maternal risk of birth of a child with DS for the double heterozygous MTR 2756AG/MTRR 66AG genotype [OR 1.79 (95 % CI 1.00-3.18)]. Overall, present data suggest that the MTRR c.66A>G polymorphism represents a risk factor for the birth of a child with DS among white Caucasian women. However, the combined presence of other genetic factors and interactions with geographic and environmental ones, can modify the effect of the single polymorphism alone, leading to population specific effect sizes.
MeSH term(s)	Adult ; Aged ; Alleles ; Biomarkers/blood ; Case-Control Studies ; Down Syndrome/genetics ; European Continental Ancestry Group/genetics ; Female ; Ferredoxin-NADP Reductase/genetics ; Folic Acid/blood ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Genotyping Techniques ; Heterozygote ; Homocysteine/blood ; Humans ; Logistic Models ; Middle Aged ; Mothers ; Polymorphism, Single Nucleotide ; Risk Factors ; Vitamin B 12/blood
Chemical Substances	Biomarkers ; Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2014-06-26
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-014-3462-5
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Article: Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.

Bosco, Paolo / Guéant-Rodriguez, Rosa-Maria / Anello, Guido / Spada, Rosario / Romano, Antonino / Fajardo, Adrian / Caraci, Filippo / Ferri, Raffaele / Guéant, Jean-Louis

Thrombosis and haemostasis

2006 Volume 96, Issue 2, Page(s) 154–159

Abstract: ... neutral in North Europe and North America. The association of 2756 A>G of methionine synthase (MTR), 66 ... A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin ( TCN2 ) needs to be ...

Abstract	Association between methylenetetrahydrofolate reductase polymorphism (MTHFR 677 C>T ), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America. The association of 2756 A>G of methionine synthase (MTR), 66 A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin ( TCN2 ) needs to be evaluated further. It was the objective of this study to evaluate the association of these polymorphisms, t-Hcys, vitamin B12 and folate levels with iCVD, in an Italian population from Sicily. We investigated the association of these polymorphisms, t-Hcys, vitamin B12 and folate with iCVD in 252 subjects, including 131 cases and 121 sex- and age-matched healthy controls. t-Hcys was higher in the iCVD group than in controls [15.3 (11.5 - 17.9) vs. 11.6 (9.4 - 14.5) microM; P = 0.0007] and also in subjects with TCN2 776CG genotype, compared to homozygous genotypes [13.5 (9.9 +/- 16.9) vs. 11.7 (9.6 +/- 14.4) microM; P = 0.0327]. The folate level in cases and controls was consistent with an adequate dietary intake [12.7 (9.0 - 15.3) vs. 12.5 (9.6 - 16.9) nM; P = 0.7203]. In multivariate analysis, t-Hcys was a significant independent predictor of iCVD with an odds ratio of 1.14 (95 % C.I.: 1.06 - 1.24; P = 0.0006). No association was found between MTHFR, MTR, MTRR and TCN2 polymorphisms and iCVD risk. We have found an influence of t-Hcys and a neutral effect of MTHFR, MTR, MTRR and TCN2 on iCVD risk in Sicily. The neutral influence of these polymorphisms may be explained by adequate status in folate and vitamin B12. Other factors underlying the increased t-Hcys need further investigations.
MeSH term(s)	Aged ; Cerebrovascular Disorders/genetics ; Female ; Ferredoxin-NADP Reductase/genetics ; Homocysteine/chemistry ; Homocysteine/genetics ; Humans ; Ischemia/pathology ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Polymorphism, Genetic ; Sicily ; Transcobalamins/metabolism
Chemical Substances	Transcobalamins ; Homocysteine (0LVT1QZ0BA) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	English
Publishing date	2006-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	0340-6245
ISSN	0340-6245
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Article ; Online: Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

Journal of medical genetics

2007 Volume 44, Issue 6, Page(s) 363–367

Abstract: Background: A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350 ...

Abstract	Background: A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350) decreases the cellular and plasma concentration of transcobalamin and thereby influences the cellular availability of vitamin B(12). Objective: To evaluate the worldwide prevalence of this variant and its association with homocysteine plasma level. Methods: The study was performed in 1433 apparently healthy subjects, including Afro-Americans and Afro-Africans and in 251 Afro-Africans participants with severe malaria. Results: The frequencies of the 776G allele were the highest in China (0.607; 95% CI 0.554 to 0.659), low in West Africa (Bénin and Togo, 0.178; 0.154 to 0.206), and intermediate in France (0.445; 0.408 to 0.481), Italy (0.352; 0.299 to 0.409), Morocco (0.370; 0.300 to 0.447) and Mexico (0.374; 0.392 to 0.419). The 776G genotype was more frequent in Afro-Americans from New York (16.7; 8.4 to 30.7) and in Afro-African patients with severe malaria (6.0%; 95% CI 3.7 to 9.6) than in healthy Afro-African volunteers (p = 0.0004 and p = 0.033, respectively), while no difference was observed for MTHFR 677TT and 677T alleles. A disequilibrium of TCN2 genotype distribution was recorded in patients with severe malaria, with a twofold higher GG genotype than expected (p = 0.010). An association between the TCN2 polymorphism and homocysteine was observed only in Mexico and France, the two countries with the highest rate of low plasma concentration of vitamin B(12) (<100 pmol/l). Conclusion: Given the dramatic heterogeneity of the 776G allele frequency worldwide, this polymorphism may be prone to a selective pressure or confers an evolutionary advantage in confronting environmental factors, one of which is malaria.
MeSH term(s)	Adult ; Cytosine ; Environment ; Gene Frequency/genetics ; Genotype ; Guanine ; Homocysteine/blood ; Humans ; Linkage Disequilibrium/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Mutation/genetics ; Transcobalamins/genetics
Chemical Substances	Transcobalamins ; Homocysteine (0LVT1QZ0BA) ; Guanine (5Z93L87A1R) ; Cytosine (8J337D1HZY) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	English
Publishing date	2007-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmg.2006.048041
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Article: Association study of COX-2 (PTGS2) -765 G/C promoter polymorphism by pyrosequencing in Sicilian patients with Alzheimer's disease.

Michele, Salemi / Salluzzo, Maria Grazia / Calogero, Aldo E / Raffaele, Ferri / Bosco, Paolo

Archives of medical science : AMS

2014 Volume 10, Issue 6, Page(s) 1235–1238

Abstract: ... polymorphism (-765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD ... patients and in 80 controls.: Results: No significant statistical difference in PTGS2 -765 G/C genotype ... These findings suggest that the PTGS2 -765 G/C polymorphism may not be associated with AD in the Sicilian ...

Abstract	Introduction: Alzheimer's disease (AD) is characterized by progression of memory problems to a slow global decline of cognitive function. Inflammation when left unregulated becomes a major cofactor in the pathogenesis of AD. PTGS2 is of crucial relevance in the inflammatory response, and it has been shown to play a considerable role in AD pathogenesis. Material and methods: To assess the possible putative role of a PTGS2 polymorphism (-765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD patients and in 80 controls. Results: No significant statistical difference in PTGS2 -765 G/C genotype distribution was found comparing patients with AD and controls. In addition, no significant difference was observed in the distribution of the PTGS2 -765 alleles between AD patients and controls. Conclusions: These findings suggest that the PTGS2 -765 G/C polymorphism may not be associated with AD in the Sicilian population.
Language	English
Publishing date	2014-09-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2014.47832
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Article ; Online: Mycobacterium tuberculosis epitope-specific interferon-g production in healthy Brazilians reactive and non-reactive to tuberculin skin test.

Silva, Bosco Christiano Maciel da / Grassi, Maria Fernanda Rios / Coutinho, Raimundo / Mascarenhas, Rita Elizabeth Moreira / Olavarria, Viviana Nilla / Coutinho-Borgo, Adriana / Kalil, Jorge / Cunha Neto, Edecio / Fonseca, Simone Gonçalves

Memorias do Instituto Oswaldo Cruz

2014 Volume 109, Issue 8, Page(s) 999–1004

Abstract: The interferon (IFN)-γ response to peptides can be a useful diagnostic marker of Mycobacterium tuberculosis (MTB) latent infection. We identified promiscuous and potentially protective CD4+ T-cell epitopes from the most conserved regions of MTB antigenic ...

Abstract	The interferon (IFN)-γ response to peptides can be a useful diagnostic marker of Mycobacterium tuberculosis (MTB) latent infection. We identified promiscuous and potentially protective CD4+ T-cell epitopes from the most conserved regions of MTB antigenic proteins by scanning the MTB antigenic proteins GroEL2, phosphate-binding protein 1 precursor and 19 kDa antigen with the TEPITOPE algorithm. Seven peptide sequences predicted to bind to multiple human leukocyte antigen (HLA)-DR molecules were synthesised and tested with IFN-γ enzyme-linked immunospot (ELISPOT) assays using peripheral blood mononuclear cells (PBMCs) from 16 Mantoux tuberculin skin test (TST)-positive and 16 TST-negative healthy donors. Eighty-eight percent of TST-positive donors responded to at least one of the peptides, compared to 25% of TST-negative donors. Each individual peptide induced IFN-γ production by PBMCs from at least 31% of the TST-positive donors. The magnitude of the response against all peptides was 182 ± 230 x 106 IFN-γ spot forming cells (SFC) among TST-positive donors and 36 ± 62 x 106 SFC among TST-negative donors (p = 0.007). The response to GroEL2 (463-477) was only observed in the TST-positive group. This combination of novel MTB CD4 T-cell epitopes should be tested in a larger cohort of individuals with latent tuberculosis (TB) to evaluate its potential to diagnose latent TB and it may be included in ELISPOT-based IFN-γ assays to identify individuals with this condition.
MeSH term(s)	Adult ; Algorithms ; Antigens, Bacterial/analysis ; Bacterial Proteins/blood ; Biomarkers/analysis ; Brazil ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Chaperonins/blood ; Enzyme-Linked Immunospot Assay ; Epitope Mapping ; Epitopes/immunology ; HLA-DR Antigens/immunology ; Healthy Volunteers ; Humans ; Interferon-gamma/metabolism ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/immunology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Middle Aged ; Mycobacterium tuberculosis/immunology ; Phosphate-Binding Proteins/blood ; Tuberculin Test
Chemical Substances	Antigens, Bacterial ; Bacterial Proteins ; Biomarkers ; Epitopes ; GroESL protein, Bacteria ; HLA-DR Antigens ; Phosphate-Binding Proteins ; Interferon-gamma (82115-62-6) ; Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2014-12
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-0276140193
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Article ; Online: Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa.

Oussalah, Abderrahim / Besseau, Cyril / Chery, Céline / Jeannesson, Elise / Guéant-Rodriguez, Rosa-Maria / Anello, Guido / Bosco, Paolo / Elia, Maurizzio / Romano, Antonino / Bronowicki, Jean-Pierre / Gerard, Philippe / Paoli, Justine / Avogbe, Patrice Hodonou / Chabi, Nicodème / Sanni, Ambaliou / Amouzou, Emile / Peyrin-Biroulet, Laurent / Guéant, Jean-Louis

The American journal of clinical nutrition

2012 Volume 95, Issue 2, Page(s) 514–521

Abstract: Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection.: Objective: ...

Abstract	Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P < 0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa.
MeSH term(s)	Africa ; Analysis of Variance ; Enzyme-Linked Immunosorbent Assay ; Europe ; Female ; Fucosyltransferases/genetics ; Genotype ; Helicobacter Infections/blood ; Helicobacter Infections/genetics ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prevalence ; Vitamin B 12/blood ; Galactoside 2-alpha-L-fucosyltransferase
Chemical Substances	Fucosyltransferases (EC 2.4.1.-) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2012-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.111.016410
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Article: Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily

Bosco, Paolo / Guéant-Rodriguez, Rosa-Maria / Anello, Guido / Spada, Rosario / Romano, Antonino / Fajardo, Adrian / Caraci, Filippo / Ferri, Raffaele / Guéant, Jean-Louis

Thrombosis and Haemostasis

2006 Volume 95, Issue 02, Page(s) 154–159

Abstract: ... neutral in North Europe and North America. The association of 2756 A>G of methionine synthase (MTR) 66 ... A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin TCN2 ) needs to be ...

Abstract	Association between methylenetetrahydrofolate reductase polymorphism ( MTHFR 677 C>T ), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America. The association of 2756 A>G of methionine synthase (MTR) 66 A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin TCN2 ) needs to be evaluated further. It was the objective of this study to evaluate the association of these polymorphisms, t-Hcys, vitamin B 12 and folate levels with iCVD, in an Italian population from Sicily. We investigated the association of these polymorphisms, t-Hcys, vitamin B 12 and folate with iCVD in 252 subjects, including 131 cases and 121 sexand agematched healthy controls. t-Hcys was higher in the iCVD group than in controls [15.3 (11.5–17.9) vs. 11.6 (9.4–14.5) µM; P=0. 0007] and also in subjects with TCN2 776CG genotype, compared to homozygous genotypes [13.5 (9.9± 16.9) vs. 11.7 (9.6 ± 14.4) µM; P=0. 0327]. The folate level in cases and controls was consistent with an adequate dietary intake [12.7 (9.0–15.3) vs. 12.5 (9.6–16.9) nM; P=0. 7203]. In multivariate analysis, t-Hcys was a significant independent predictor of iCVD with an odds ratio of 1.14 (95% C.I. : 1.06–1.24; P=0. 0006). No association was found between MTHFR MTR MTRR and TCN2 polymorphisms and iCVD risk. We have found an influence of t-Hcys and a neutral effect of MTHFR, MTR, MTRR and TCN2 on iCVD risk in Sicily. The neutral influence of these polymorphisms may be explained by adequate status in folate and vitamin B12. Other factors underlying the increased t-Hcys need further investigations.
Keywords	Cerebrovascular disease ; folate ; homocysteine ; methionine synthase reductase ; methylenetetrahydrofolate reductase ; transcobalamin
Language	English
Publishing date	2006-01-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH06-02-0082
Database	Thieme publisher's database

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