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  1. Article ; Online: Clustering of systemic lupus erythematosus mortality in southwestern Spain.

    Cayuela, Lucía / Pereyra-Rodríguez, José-Juan / Hernández-Rodríguez, Juan-Carlos / Muñoz-Jiménez, Alejandro / Cayuela, Aurelio

    Lupus

    2023  Volume 32, Issue 11, Page(s) 1345–1352

    Abstract: Objective: To analyse time trends in systemic lupus erythematosus (SLE) mortality and explore possible provincial clustering of SLE mortality in Spain (2001-2020).: Methods: We conducted an ecological study using deaths registered in SLE at the ... ...

    Abstract Objective: To analyse time trends in systemic lupus erythematosus (SLE) mortality and explore possible provincial clustering of SLE mortality in Spain (2001-2020).
    Methods: We conducted an ecological study using deaths registered in SLE at the Spanish National Institute of Statistics between 2001 and 2020. Jointpoint regression models have been used to evaluate temporal trends. To analyse the spatial pattern of SLE mortality in men and women in Spain, crude rates, age-standardised mortality rates (ASMRs), smooth relative risk (RR) and posterior probabilities (PP) for RR greater than one for the period 2001-2020 were calculated. The Global Moran I index was used to assess the existence of global spatial autocorrelation. Local indicators of spatial association (LISA) and Kulldorff's spatial scan statistic were used to identify clusters.
    Results: Over the 20 years analyzed in this study, the SLE average ASMR for the period was 2.7 for women and 0.7 for men, with a sex ratio (female/male) of 3.8. In men, no province showed a RR>1. Conversely, in women, eight provinces showed values of RR> 1 with a PP greater than 0.8 (Seville, Cadiz, Huelva and Murcia in the south, Barcelona, Zaragoza, Huesca and Leon in the north). In men, neither of the two methods detected a clustering of provinces. However, in women, both methods identified a cluster of provinces located in the southwest of the country (Huelva, Cádiz, Seville and Malaga) as a cluster with significant excess mortality. In the second cluster (centred on the province of Huelva) obtained with the Kulldorff method, two more provinces were added (Badajoz and Cordoba, also located in the southwest).
    Conclusions: We detected a cluster of provinces with an excess risk of female SLE mortality in the southwest of Spain.
    MeSH term(s) Humans ; Male ; Female ; Lupus Erythematosus, Systemic ; Spain/epidemiology ; Cluster Analysis
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033231199511
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  2. Article ; Online: PROPUESTA DE USO DE ANAKINRA EN EL DISTRESS RESPIRATORIO AGUDO SECUNDARIO A COVID-19

    Muñoz-Jiménez, Alejandro / Rubio-Romero, Esteban

    Reumatología Clínica

    Abstract: Resumen El desenlace de la infección por SARS-CoV-2 (COVID-19) afecta fundamentalmente al campo pulmonar, ocasionando un cuadro de SÍNDROME DE DISTRÉS RESPIRATORIO AGUDO (SDRA). Este proceso es un cuadro inflamatorio, protagonizado por una cascada de ... ...

    Abstract Resumen El desenlace de la infección por SARS-CoV-2 (COVID-19) afecta fundamentalmente al campo pulmonar, ocasionando un cuadro de SÍNDROME DE DISTRÉS RESPIRATORIO AGUDO (SDRA). Este proceso es un cuadro inflamatorio, protagonizado por una cascada de citocinas bajo el amparo del INFLAMOSOMA NLRP3, responsable principal de la destrucción alveolar. De entre todas las citocinas que se desencadenan en este cuadro destaca la IL beta. ANAKINRA es un potente fármaco biológico, capaz de bloquear esta IL 1 beta. Proponemos su uso, de cara a controlar el SDRA secundario a la infección por COVID-19. Abstract The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS). This process is an inflammatory picture, involving an NLRP3 INFLAMOSOME-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. ANAKINRA is a potent biological drug, capable of blocking this IL 1 beta. We propose its use in controlling ARDS secondary to COVID-19 infection.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.reuma.2020.04.009
    Database COVID19

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  3. Article ; Online: Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19.

    Muñoz-Jiménez, Alejandro / Rubio-Romero, Esteban / Marenco de la Fuente, José Luis

    Reumatologia clinica

    2020  Volume 17, Issue 6, Page(s) 309–312

    Abstract: The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player ...

    Title translation Proposal for the use of anakinra in acute respiratory distress secondary to COVID-19.
    Abstract The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. Anakinra is a potent biological drug, capable of blocking this IL-1ß. We propose its use in controlling ARDS secondary to COVID-19 infection.
    Language Spanish
    Publishing date 2020-04-27
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 2231357-6
    ISSN 1885-1398 ; 1699-258X
    ISSN (online) 1885-1398
    ISSN 1699-258X
    DOI 10.1016/j.reuma.2020.04.009
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  4. Article ; Online: Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19.

    Muñoz-Jiménez, Alejandro / Rubio-Romero, Esteban / Marenco de la Fuente, José Luis

    Reumatologia clinica

    2020  Volume 17, Issue 6, Page(s) 309–312

    Abstract: The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player ...

    Title translation Proposal for the use of anakinra in acute respiratory distress secondary to COVID-19.
    Abstract The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. Anakinra is a potent biological drug, capable of blocking this IL-1ß. We propose its use in controlling ARDS secondary to COVID-19 infection.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; COVID-19/complications ; COVID-19/immunology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/virology ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/virology ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Interleukin 1 Receptor Antagonist Protein
    Keywords covid19
    Language Spanish
    Publishing date 2020-04-27
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reuma.2020.04.009
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  5. Article ; Online: Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19

    Muñoz-Jiménez, Alejandro / Rubio-Romero, Esteban / Marenco de la Fuente, José Luis

    Reumatología Clínica ; ISSN 1699-258X

    2020  

    Keywords Rheumatology ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.reuma.2020.04.009
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Trends in mortality from lupus in Spain from 1980 to 2018.

    Hernández-Rodríguez, Juan Carlos / Durán-Romero, Antonio Jose / Muñoz-Jiménez, Alejandro / Conejo-Mir, Julian / Pereyra-Rodríguez, Jose Juan

    Lupus

    2020  Volume 29, Issue 13, Page(s) 1719–1726

    Abstract: Background: Recent studies suggest that Systemic lupus erythematosus (SLE) mortality rates in Spain are decreasing. However, SLE mortality in Spain has been poorly studied. The purpose of study is to assess the temporal trends of mortality rates in the ... ...

    Abstract Background: Recent studies suggest that Systemic lupus erythematosus (SLE) mortality rates in Spain are decreasing. However, SLE mortality in Spain has been poorly studied. The purpose of study is to assess the temporal trends of mortality rates in the Spanish population with SLE from 1980 to 2018.
    Methods: Death records and mid-year population data were collected from the National Statistics Institute. Age-standardized mortality rates were calculated for overall population and for each sex and age group. Significant changes in mortality trends were identified by Joinpoint regressions. Also, an Age-period-cohort (APC) and Potential Years of Life Lost (PYLL) analysis was carried out to know the burden of SLE disease.
    Results: The overall SLE mortality rates in Spain has experimented an increased through the last 39 years. Mortality rates from the period 1980-1984 was 0.83 per 1.000.000 inhabitants, reaching the value to 1.77 cases per 1.000.000 from the period 2014-2018. A decreasing trend has been observed since 1999.
    Conclusions: SLE mortality rate has increased in Spain between 1980 and 1999, with a sustained decrease up to our days.
    MeSH term(s) Adult ; Age Distribution ; Aged ; Female ; Humans ; Incidence ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/mortality ; Male ; Middle Aged ; Regression Analysis ; Sex Distribution ; Spain/epidemiology ; Survival Rate/trends
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203320952864
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  7. Article: Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19./ Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19./ Proposal for the use of anakinra in acute respiratory distress secondary to COVID-19

    Muñoz-Jiménez, Alejandro / Rubio-Romero, Esteban / Marenco de la Fuente, José Luis

    Reumatol. clin. (Barc.)

    Abstract: The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player ...

    Abstract The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. Anakinra is a potent biological drug, capable of blocking this IL-1ß. We propose its use in controlling ARDS secondary to COVID-19 infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #539318
    Database COVID19

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  8. Article: Hydroalcoholic extract from

    Aziel Alvarado-Ojeda, Zimri / Zamilpa, Alejandro / Costet-Mejia, Alejandro / Méndez-Martínez, Marisol / Trejo-Moreno, Celeste / Jiménez-Ferrer, Jesús Enrique / Salazar-Martínez, Ana Maria / Cruz-Muñoz, Mario Ernesto / Fragoso, Gladis / Rosas-Salgado, Gabriela

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24567

    Abstract: Steatosis is characterized by fat accumulation and insulin resistance (IR) in hepatocytes, which triggers a pro-oxidant, pro-inflammatory environment that may eventually lead to cirrhosis or liver carcinoma. This work was aimed to assess the effect ... ...

    Abstract Steatosis is characterized by fat accumulation and insulin resistance (IR) in hepatocytes, which triggers a pro-oxidant, pro-inflammatory environment that may eventually lead to cirrhosis or liver carcinoma. This work was aimed to assess the effect of
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24567
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  9. Article: Reference Values of Spatial and Temporal Gait Parameters in a Contemporary Sample of Spanish Preschool Children: A Cross-Sectional Study.

    Latorre-Román, Pedro Ángel / Párraga-Montilla, Juan Antonio / Robles-Fuentes, Alejandro / Roche-Seruendo, Luis Enrique / Lucena-Zurita, Manuel / Muñoz-Jiménez, Marcos / Manjón-Pozas, Daniel / Salas-Sánchez, Jesús / da Conceição, Filipe Almeida / Consuegra González, Pedro José

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 8

    Abstract: The aim of this study was to analyze the influence of age and sex on kinematic gait parameters in preschool children, and derive reference values for this population. A total of 383 preschool children (age 3-5 years; 207 girls, 176 boys) participated in ... ...

    Abstract The aim of this study was to analyze the influence of age and sex on kinematic gait parameters in preschool children, and derive reference values for this population. A total of 383 preschool children (age 3-5 years; 207 girls, 176 boys) participated in this study. We used the OptoGait system to assess the kinematics of gait at a comfortable and self-determined speed. No significant differences between the sexes were found for the main gait parameters. Among the participants, there was a significant increase in double support, reductions in absolute cadence and the coefficient of variation (CV) of cadence, an increase in absolute step length (SL), and an increase in the walk ratio (WR) from 3 to 5 years of age. However, the normalized SL and normalized WR displayed a significant reduction in both sexes. Partial correlation indicated a significant association of age with SL and normalized SL, and WR. Additionally, WR showed a significant correlation with the CV of cadence. To summarize, no relevant differences in gait performance were found according to sex; however, age was found to influence gait maturation. The normative values established for Spanish preschool children can be used to monitor healthy gait development.
    Language English
    Publishing date 2022-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9081150
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  10. Article ; Online: Non-invasive, real-time stress measurement: Vocalization compared with thermal imaging in kittens of the domestic cat in response to social separation.

    Szenczi, Péter / Jiménez Gallardo, Alejandro / Urrutia, Andrea / Hudson, Robyn / Muñoz-Delgado, Jairo / Bánszegi, Oxána

    Behavioural processes

    2023  Volume 213, Page(s) 104955

    Abstract: Finding tools to assess the stress response which can be easily applied, are non-invasive, reliable and measured in real time is still a relevant topic in many areas of biology. Vocal characteristics and temperature of certain body areas have been ... ...

    Abstract Finding tools to assess the stress response which can be easily applied, are non-invasive, reliable and measured in real time is still a relevant topic in many areas of biology. Vocal characteristics and temperature of certain body areas have been suggested to reflect HPA axis and ANS activation. We hypothesized that changes in vocalizations and peripheral body temperature will show the magnitude of the stress response, and that the change in these will covary. Our aim was to measure the change in vocal characteristics and eye and nasal temperature of kittens (n = 43 from nine litters of seven mixed-breed mothers) during a potentially stressful event and to test how these correlated. We found change in several vocal and thermal parameters during a short social separation. Our findings indicate that arousal due to ANS activation in kittens of the domestic cat resulted in an increasing number of vocalisations of longer duration and higher intensity, and in lower and a wider range in fundamental frequency. Calls also became less tonal with more jitter. Change in temperature was generally negative in the lacrimal caruncle as well as in the rhinarium, but with great variance across individuals. Change in eye temperature positively correlated with the intensity of the calls and the change in nose temperature positively correlated with the change in call length. The results suggest the continued difficulty in interpreting both physiological and behavioural data to assess an individual´s stress response.
    MeSH term(s) Animals ; Cats ; Body Temperature ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Vocalization, Animal/physiology ; Female ; Mothers
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 196999-7
    ISSN 1872-8308 ; 0376-6357
    ISSN (online) 1872-8308
    ISSN 0376-6357
    DOI 10.1016/j.beproc.2023.104955
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