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  1. Article ; Online: Activation Mechanism of Fe

    Song, Qiang / Tong, Xiong / Dai, Pulin / Xie, Xian / Xie, Ruiqi / Fan, Peiqiang / Ma, Yuanlin / Chen, Hang

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: In industrial manufacturing, pyrrhotite( ... ...

    Abstract In industrial manufacturing, pyrrhotite(Fe
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071490
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    Zs.MO 81: Show issues

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  2. Article ; Online: Electrolysis of water is an effective source of oxygen at high altitude.

    Tang, Xinjun / Liang, Li / Hu, Lijuan / Song, Yuanlin

    Journal of translational medicine

    2022  Volume 20, Issue 1, Page(s) 242

    MeSH term(s) Altitude ; Electrolysis ; Oxygen ; Water
    Chemical Substances Water (059QF0KO0R) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-022-03443-2
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  3. Article ; Online: Inhalable antibodies for the treatment of COVID-19.

    Yang, Zhenlin / Li, Cheng / Song, Yuanlin / Ying, Tianlei / Wu, Yanling

    Innovation (Cambridge (Mass.))

    2022  Volume 3, Issue 6, Page(s) 100328

    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type News
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2022.100328
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  4. Article ; Online: Preparation for the challenge of heavily mutated Omicron variant.

    Song, Yuanlin / Masaki, Fujita

    Clinical and translational medicine

    2021  Volume 11, Issue 12, Page(s) e679

    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; Humans ; Mutation/immunology ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.679
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  5. Article ; Online: Electrolysis of water is an effective source of oxygen at high altitude

    Xinjun Tang / Li Liang / Lijuan Hu / Yuanlin Song

    Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-

    2022  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Internet of things-based home noninvasive ventilation in COPD patients with hypercapnic chronic respiratory failure

    Weipeng Jiang / Yuanlin Song

    Trials, Vol 23, Iss 1, Pp 1-

    study protocol for a randomized controlled trial

    2022  Volume 10

    Abstract: Abstract Background Home noninvasive positive pressure ventilation (NIPPV) has become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including appropriate follow-up, ... ...

    Abstract Abstract Background Home noninvasive positive pressure ventilation (NIPPV) has become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including appropriate follow-up, telemonitor, and management to ensure treatment effectiveness, compliance, and security and to improve quality of life. The Internet of things (IOT) is the name given to the network of devices and other “things” with built-in sensors, software, electronics, and network connectivity, communicating these objects over wireless networks and sending data to a cloud platform. The study aims to evaluate the effectiveness and safety of the IOT-based management of NIPPV for the COPD patients with hypercapnic chronic respiratory failure. Methods This multicenter, prospective, randomized controlled trial was conducted with a total of 200 COPD patients with chronic hypercapnic respiratory failure. Using a computer-generated randomization process, patients were randomized (in a 1:1 ratio) into the usual NIPPV (control group) or to receive additional IOT-based management (intervention group) for 12 months. The primary outcome was the Severe Respiratory Insufficiency (SRI) questionnaire. Secondary outcomes included compliance with the ventilator, gas exchange, lung function, health-related quality of life, hospitalization frequency, time to death within 1-year, all-cause mortality, safety analysis, and cost-effectiveness analysis. Discussion This study will be the first and largest randomized trial in China to evaluate the effectiveness and safety of the IOT-based management of NIPPV for COPD patients with chronic hypercapnic respiratory failure. The results will help to understand the current situation of IOT-based home ventilation and may provide new evidence for home NIPPV treatment and management in the future. Trial registration Chinese Clinical Trials Registry ChiCTR1800019536 . Registered on 17 November 2018.
    Keywords Chronic obstructive pulmonary disease ; Noninvasive positive pressure ventilation ; Hypercapnia respiratory failure ; Internet of things ; Tele-monitoring ; Follow-up ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Obesity and COVID-19 Pandemics: Epidemiology, Mechanisms, and Management.

    Yang, Yanping / Song, Yuanlin / Hou, Dongni

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 4147–4156

    Abstract: Obesity is a principle causative factor of various metabolic dysfunctions, chronic inflammation, and multi-organ impairment. The global epidemic of obesity has constituted the greatest threat to global health. Emerging evidence has associated obesity ... ...

    Abstract Obesity is a principle causative factor of various metabolic dysfunctions, chronic inflammation, and multi-organ impairment. The global epidemic of obesity has constituted the greatest threat to global health. Emerging evidence has associated obesity with an increased risk of severe infection and poor outcomes from coronavirus disease 2019 (COVID-19). During current COVID-19 pandemic, the interaction between COVID-19 and obesity has exaggerated the disease burden of obesity more than ever before. Thus, there is an urgent need for consideration of universal measures to reduce the risk of complications and severe illness from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in obesity population. In this review, we first summarized the clinical evidence on the effect of obesity on susceptibility, severity, and prognosis of COVID-19. Then we discussed and the underlying mechanisms, including respiratory pathophysiology of obesity, dysregulated inflammation, upregulated angiotensin-converting enzyme 2 (ACE2) expression, hyperglycemia, and adipokines. Finally, we proposed recommendations on how to reduce the spread and pandemic of SARS-CoV-2 infection by prevention and treatment of obesity.
    Language English
    Publishing date 2023-12-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S441762
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  8. Article ; Online: Internet of things-based home noninvasive ventilation in COPD patients with hypercapnic chronic respiratory failure: study protocol for a randomized controlled trial.

    Jiang, Weipeng / Song, Yuanlin

    Trials

    2022  Volume 23, Issue 1, Page(s) 393

    Abstract: Background: Home noninvasive positive pressure ventilation (NIPPV) has become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including appropriate follow-up, telemonitor, ...

    Abstract Background: Home noninvasive positive pressure ventilation (NIPPV) has become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including appropriate follow-up, telemonitor, and management to ensure treatment effectiveness, compliance, and security and to improve quality of life. The Internet of things (IOT) is the name given to the network of devices and other "things" with built-in sensors, software, electronics, and network connectivity, communicating these objects over wireless networks and sending data to a cloud platform. The study aims to evaluate the effectiveness and safety of the IOT-based management of NIPPV for the COPD patients with hypercapnic chronic respiratory failure.
    Methods: This multicenter, prospective, randomized controlled trial was conducted with a total of 200 COPD patients with chronic hypercapnic respiratory failure. Using a computer-generated randomization process, patients were randomized (in a 1:1 ratio) into the usual NIPPV (control group) or to receive additional IOT-based management (intervention group) for 12 months. The primary outcome was the Severe Respiratory Insufficiency (SRI) questionnaire. Secondary outcomes included compliance with the ventilator, gas exchange, lung function, health-related quality of life, hospitalization frequency, time to death within 1-year, all-cause mortality, safety analysis, and cost-effectiveness analysis.
    Discussion: This study will be the first and largest randomized trial in China to evaluate the effectiveness and safety of the IOT-based management of NIPPV for COPD patients with chronic hypercapnic respiratory failure. The results will help to understand the current situation of IOT-based home ventilation and may provide new evidence for home NIPPV treatment and management in the future.
    Trial registration: Chinese Clinical Trials Registry ChiCTR1800019536 . Registered on 17 November 2018.
    MeSH term(s) Humans ; Hypercapnia/diagnosis ; Hypercapnia/therapy ; Internet of Things ; Multicenter Studies as Topic ; Noninvasive Ventilation/adverse effects ; Noninvasive Ventilation/methods ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06372-z
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  9. Article: Comparison of the efficacy and safety of rivaroxaban and low-molecular-weight heparin in Chinese lung cancer patients with nonhigh-risk pulmonary embolism.

    Song, Yijun / Yang, Dawei / Hou, Dongni / She, Jun / Song, Yuanlin

    Thrombosis journal

    2023  Volume 21, Issue 1, Page(s) 16

    Abstract: Background: Data that guide selection of differing anticoagulant regimens for specific cancer-associated venous thromboembolism (VTE) are lacking. We aimed to compare the efficacy and safety of rivaroxaban and low-molecular-weight heparin (LMWH) against ...

    Abstract Background: Data that guide selection of differing anticoagulant regimens for specific cancer-associated venous thromboembolism (VTE) are lacking. We aimed to compare the efficacy and safety of rivaroxaban and low-molecular-weight heparin (LMWH) against nonhigh-risk pulmonary embolism (PE) in Chinese lung cancer patients.
    Methods: Four hundred forty-six Chinese lung cancer patients with nonhigh-risk PE who initiated treatment with rivaroxaban or LMWH were identified from Zhongshan Hospital database from 2016 to 2020. The primary outcomes were the composite event of VTE recurrence or major bleeding, and all-cause mortality. The secondary outcomes were VTE recurrence, major bleeding and clinically relevant non-major bleeding (CRNMB). Propensity score matching was used to balance baseline covariates. We conducted sensitivity analysis by stabilized inverse probability of treatment weighting and competing risk analysis by a Fine and Gray subdistribution hazard model.
    Results: In propensity score-matched cohorts, rivaroxaban was similar to LMWH in the risks of the composite outcome (hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.45-1.21; P = 0.22), VTE recurrence (HR, 0.69; 95% CI, 0.36-1.34; P = 0.28), major bleeding (HR, 0.79; 95% CI, 0.37-1.68; P = 0.54) and CRNMB (HR, 1.13; 95% CI, 0.62-2.09; P = 0.69). All-cause mortality was significantly lower in rivaroxaban group than LMWH group (HR, 0.52; 95% CI, 0.36-0.75; P < 0.001). The primary and secondary outcomes favored rivaroxaban over LMWH in all the subgroups expect for central PE and intermediate-risk PE. The sensitivity analysis yielded similar results, and competing risk analysis was in accordance with the primary findings.
    Conclusions: Rivaroxaban might be a promising alternative to LMWH as initial treatment for nonhigh-risk PE in lung cancer patients.
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-023-00453-y
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  10. Article: Aquaporins in Respiratory System.

    Wang, Linlin / Wang, Jian / Zhu, Xiaodan / Bai, Chunxue / Song, Yuanlin

    Advances in experimental medicine and biology

    2023  Volume 1398, Page(s) 137–144

    Abstract: Aquaporins (AQPs) are water channel proteins facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion. In this chapter, we mainly focus on the expression of four AQPs in the lungs, ... ...

    Abstract Aquaporins (AQPs) are water channel proteins facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion. In this chapter, we mainly focus on the expression of four AQPs in the lungs, which include AQP1, AQP2, AQP4, and AQP5 in normal and disease status, and the experience of AQPs function from various model and transgenic mice were summarized in detail to improve our understanding of the role of AQPs in fluid balance of respiratory system. It has been suggested that AQPs play important roles in various physiology and pathophysiology conditions of different lung diseases. There still remains unclear the exact role of AQPs in lung diseases, and thus continuous efforts on elucidating the roles of AQPs in lung physiological and pathophysiological processes are warranted.
    MeSH term(s) Mice ; Animals ; Aquaporin 2/metabolism ; Aquaporins/genetics ; Aquaporins/metabolism ; Lung/metabolism ; Mice, Transgenic ; Biological Transport ; Lung Diseases/metabolism
    Chemical Substances Aquaporin 2 ; Aquaporins
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-981-19-7415-1_9
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