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  1. Article ; Online: Group A Streptococcal Endometritis and Toxic Shock causing Septic Pelvic Thrombophlebitis and Septic Pulmonary Emboli.

    Dharia, Sunny / Shah, Sapan / Kissinger, Meghan / Sanders, Alan / Singh, Gurpreet

    BMJ case reports

    2023  Volume 16, Issue 11

    Abstract: ... Group ... ...

    Abstract Group A
    MeSH term(s) Female ; Pregnancy ; Humans ; Shock, Septic/complications ; Endometritis/complications ; Endometritis/diagnosis ; Thrombophlebitis/diagnostic imaging ; Thrombophlebitis/drug therapy ; Thrombophlebitis/complications ; Sepsis/complications ; Streptococcus pyogenes ; Puerperal Infection ; Soft Tissue Infections/complications ; Pelvis/diagnostic imaging
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Retrofitting Light-weight Language Models for Emotions using Supervised Contrastive Learning

    Shah, Sapan / Reddy, Sreedhar / Bhattacharyya, Pushpak

    2023  

    Abstract: We present a novel retrofitting method to induce emotion aspects into pre-trained language models (PLMs) such as BERT and RoBERTa. Our method updates pre-trained network weights using contrastive learning so that the text fragments exhibiting similar ... ...

    Abstract We present a novel retrofitting method to induce emotion aspects into pre-trained language models (PLMs) such as BERT and RoBERTa. Our method updates pre-trained network weights using contrastive learning so that the text fragments exhibiting similar emotions are encoded nearby in the representation space, and the fragments with different emotion content are pushed apart. While doing so, it also ensures that the linguistic knowledge already present in PLMs is not inadvertently perturbed. The language models retrofitted by our method, i.e., BERTEmo and RoBERTaEmo, produce emotion-aware text representations, as evaluated through different clustering and retrieval metrics. For the downstream tasks on sentiment analysis and sarcasm detection, they perform better than their pre-trained counterparts (about 1% improvement in F1-score) and other existing approaches. Additionally, a more significant boost in performance is observed for the retrofitted models over pre-trained ones in few-shot learning setting.

    Comment: EMNLP 2023 Camera Ready Version
    Keywords Computer Science - Computation and Language
    Subject code 006
    Publishing date 2023-10-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Investigation of Neolamarckia cadamba phytoconstituents against SARS-CoV-2 3CL Pro

    Sumit Arora / Kalpana Tirpude / Pallavi Rushiya / Nidhi Sapkal / Subhash Yende / Abhay Ittadwar / Sapan Shah

    Orbital: The Electronic Journal of Chemistry, Vol 15, Iss

    An In-Silico Approach

    2023  Volume 1

    Abstract: In present study, the inhibitory potential of Neolamarckia cadamba phytoconstituents was investigated against SARS-CoV-2 3CL protease (3CL pro) (PDB ID: 6M2N). Molecular docking was analyzed using AutoDock Vina software by setting the grid parameter as X= ...

    Abstract In present study, the inhibitory potential of Neolamarckia cadamba phytoconstituents was investigated against SARS-CoV-2 3CL protease (3CL pro) (PDB ID: 6M2N). Molecular docking was analyzed using AutoDock Vina software by setting the grid parameter as X= -33.163, Y= -65.074 and Z= 41.434 with dimensions of the grid box 25 × 25 × 25 Å. Remdesivir was taken as the standard for comparative analysis along with inhibitor 5, 6, 7-trihydroxy-2-phenyl-4H-chromen-4-one. Furthermore, the exploration of 2 D Hydrogen-bond interactions was performed by Biovia Discovery Studio 4.5 program to identify the interactions between an amino acid of target and ligand followed by assessment of physicochemical properties using Lipinski’s rule and Swiss ADME database. The decent bonding scores of secondary metabolites owing to hydrogen bonding with catalytic residues suggest the effectiveness of these phytochemicals towards 3CLpro. The results are further consolidated positively by Lipinski’s rule and Swiss ADME prediction. Thus reasonably, observations with docking studies suggest possibility of phytochemicals from Neolamarckia cadamba to inhibit the 3CLpro and consequently would be explored further as agents for preventing COVID-19.
    Keywords 3CL Pro ; Molecular docking ; Neolamarckia cadamba ; Phytoconstituents ; SARS-CoV-2 ; Science ; Q ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Universidade Federal de Mato Grosso do Sul
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: CMS ESRD quality incentive program has not improved patient dialysis vascular access.

    Shah, Sapan / Feustel, Paul J / Manning, Christina E / Salman, Loay

    The journal of vascular access

    2021  Volume 24, Issue 2, Page(s) 246–252

    Abstract: Purpose: Over 468,000 patients in the United States use hemodialysis to manage End Stage Renal Disease (ESRD). The purpose of this study was to determine whether the dialysis access Clinical Performance Measures (CPMs) of Centers for Medicare & Medicaid ...

    Abstract Purpose: Over 468,000 patients in the United States use hemodialysis to manage End Stage Renal Disease (ESRD). The purpose of this study was to determine whether the dialysis access Clinical Performance Measures (CPMs) of Centers for Medicare & Medicaid Services (CMS) ESRD Quality Incentive Program (QIP) have increased arteriovenous fistula (AVF) rates and decreased long-term tunneled hemodialysis catheter (TDC) rates among hemodialysis patients in United States.
    Methods: Retrospective observational study: evaluated reported AVF and long-term TDC rates of 4804 dialysis facilities which reported dialysis access data as part of the ESRD QIP from Payment Year (PY) 2014-2020. Facilities were also sorted by specific additional criteria to examine disparities in dialysis access.
    Results: Mean AVF rates of included facilities increased from 63.7% in PY 2014 to 67.2% in PY 2016 (
    Conclusion: As one of the first financial QIPs in healthcare, the ESRD QIP has not achieved the stated goals of the CMS to increase AVF access rates above 68% and reduce long-term TDC clinical rates below 10%. Systemic disparities in race, geographic region, economic status, healthcare access, and education of providers and patients prevent successful attainment of goal metrics.
    MeSH term(s) Humans ; Aged ; United States ; Renal Dialysis ; Motivation ; Medicare ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/etiology ; Retrospective Studies ; Arteriovenous Shunt, Surgical/adverse effects
    Language English
    Publishing date 2021-07-05
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298211027054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In silico

    Shah, Sapan / Chaple, Dinesh / Masand, Vijay H / Zaki, Magdi E A / Al-Hussain, Sami A / Shah, Ashish / Arora, Sumit / Jawarkar, Rahul / Tauqeer, Mohammad

    Journal of biomolecular structure & dynamics

    2023  Volume 42, Issue 5, Page(s) 2211–2230

    Abstract: Cardiovascular diseases (CVD) such as heart failure, stroke, and hypertension affect 64.3 million people worldwide and are responsible for 30% of all deaths. Primary inhibition of the angiotensin-converting enzyme (ACE) is significant in the management ... ...

    Abstract Cardiovascular diseases (CVD) such as heart failure, stroke, and hypertension affect 64.3 million people worldwide and are responsible for 30% of all deaths. Primary inhibition of the angiotensin-converting enzyme (ACE) is significant in the management of CVD. In the present study, the genetic algorithm-multiple linear regressions (GA-MLR) method is used to generate highly predictive and statistically significant (
    MeSH term(s) Humans ; Molecular Docking Simulation ; Quantitative Structure-Activity Relationship ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Molecular Dynamics Simulation ; Cardiovascular Diseases ; Angiotensins
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensins
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2203261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Exploring the active constituents of

    Shah, Sapan / Chaple, Dinesh / Arora, Sumit / Yende, Subhash / Moharir, Keshav / Lohiya, Govind

    Network modeling and analysis in health informatics and bioinformatics

    2021  Volume 10, Issue 1, Page(s) 8

    Abstract: The severe acute respiratory syndrome COVID-19 declared a global pandemic by WHO has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. We report in this study a molecular docking study of ...

    Abstract The severe acute respiratory syndrome COVID-19 declared a global pandemic by WHO has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. We report in this study a molecular docking study of eighteen
    Supplementary information: The online version contains supplementary material available at 10.1007/s13721-020-00279-y.
    Language English
    Publishing date 2021-02-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2649488-7
    ISSN 2192-6670 ; 2192-6662
    ISSN (online) 2192-6670
    ISSN 2192-6662
    DOI 10.1007/s13721-020-00279-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Medical student intentions to practice internal medicine in underserved areas associated with debt, identity and extracurricular participation

    Aaron Lapidus / Sapan Shah / Meheret Mekonnen / Joseph Araj / Mytien Nguyen / Hyacinth Mason / Branden Eggan / Inginia Genao

    BMC Medical Education, Vol 23, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract Background Currently, Internal Medicine (IM) physicians do not reflect the ethno-racial diversity of the US population. Moreover, there is a shortage of IM physicians in Medically Underserved Areas (MUAs) in the US. The purpose of this study was ...

    Abstract Abstract Background Currently, Internal Medicine (IM) physicians do not reflect the ethno-racial diversity of the US population. Moreover, there is a shortage of IM physicians in Medically Underserved Areas (MUAs) in the US. The purpose of this study was to determine factors that influence medical students’ intent to practice IM in MUAs. We hypothesized students with intentions to pursue a career in IM and work in MUAs were more likely than their peers to identify as underrepresented in medicine (URiM), report greater student debt loads, and report medical school experiences in cultural competencies. Methods We analyzed de-identified data of 67,050 graduating allopathic medical students who completed the Association of American Medical Colleges’ (AAMC) Medical School annual Graduation Questionnaire (GQ) between 2012–2017 by multivariate logistic regression models, examining intent to practice IM in MUAs based on respondent characteristics. Results Of 8,363 students indicating an intent to pursue IM, 1,969 (23.54%) students also expressed an intent to practice in MUAs. Students awarded scholarships, (aOR: 1.23, [1.03–1.46]), with debt greater than $300,000 (aOR: 1.54, [1.21–1.95], and self-identified non-Hispanic Black/African American (aOR: 3.79 [2.95–4.87]) or Hispanic (aOR: 2.53, [2.05–3.11]) students were more likely than non-Hispanic White students to indicate intent to practice in MUAs. This pattern also existed for students who participated in a community-based research project (aOR: 1.55, [1.19–2.01]), had experiences related to health disparities (aOR: 2.13, [1.44–3.15]), or had experiences related to global health (aOR: 1.75, [1.34–2.28]). Conclusions We identified experiences and characteristics that associate with intention to practice IM in MUAs, which can aid future curricular redesign by medical schools to expand and deepen comprehension of health disparities, access to community-based research, and global health experiences. Loan forgiveness programs and other initiatives to increase recruitment ...
    Keywords Underserved ; Career ; Debt ; Identity ; Extracurriculars ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Medical student intentions to practice internal medicine in underserved areas associated with debt, identity and extracurricular participation.

    Lapidus, Aaron / Shah, Sapan / Mekonnen, Meheret / Araj, Joseph / Nguyen, Mytien / Mason, Hyacinth / Eggan, Branden / Genao, Inginia

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 420

    Abstract: Background: Currently, Internal Medicine (IM) physicians do not reflect the ethno-racial diversity of the US population. Moreover, there is a shortage of IM physicians in Medically Underserved Areas (MUAs) in the US. The purpose of this study was to ... ...

    Abstract Background: Currently, Internal Medicine (IM) physicians do not reflect the ethno-racial diversity of the US population. Moreover, there is a shortage of IM physicians in Medically Underserved Areas (MUAs) in the US. The purpose of this study was to determine factors that influence medical students' intent to practice IM in MUAs. We hypothesized students with intentions to pursue a career in IM and work in MUAs were more likely than their peers to identify as underrepresented in medicine (URiM), report greater student debt loads, and report medical school experiences in cultural competencies.
    Methods: We analyzed de-identified data of 67,050 graduating allopathic medical students who completed the Association of American Medical Colleges' (AAMC) Medical School annual Graduation Questionnaire (GQ) between 2012-2017 by multivariate logistic regression models, examining intent to practice IM in MUAs based on respondent characteristics.
    Results: Of 8,363 students indicating an intent to pursue IM, 1,969 (23.54%) students also expressed an intent to practice in MUAs. Students awarded scholarships, (aOR: 1.23, [1.03-1.46]), with debt greater than $300,000 (aOR: 1.54, [1.21-1.95], and self-identified non-Hispanic Black/African American (aOR: 3.79 [2.95-4.87]) or Hispanic (aOR: 2.53, [2.05-3.11]) students were more likely than non-Hispanic White students to indicate intent to practice in MUAs. This pattern also existed for students who participated in a community-based research project (aOR: 1.55, [1.19-2.01]), had experiences related to health disparities (aOR: 2.13, [1.44-3.15]), or had experiences related to global health (aOR: 1.75, [1.34-2.28]).
    Conclusions: We identified experiences and characteristics that associate with intention to practice IM in MUAs, which can aid future curricular redesign by medical schools to expand and deepen comprehension of health disparities, access to community-based research, and global health experiences. Loan forgiveness programs and other initiatives to increase recruitment and retention of future physicians should also be developed.
    MeSH term(s) Humans ; Intention ; Students, Medical ; Medically Underserved Area ; Career Choice ; Ethnicity ; Surveys and Questionnaires
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04392-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prospecting for

    Shah, Sapan / Chaple, Dinesh / Arora, Sumit / Yende, Subhash / Mehta, Chetan / Nayak, Usha

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 12, Page(s) 5643–5652

    Abstract: The severe acute respiratory syndrome COVID-19 declared as a global pandemic by the World Health Organization has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. ...

    Abstract The severe acute respiratory syndrome COVID-19 declared as a global pandemic by the World Health Organization has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications.
    MeSH term(s) Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Protease Inhibitors ; Cysteine Endopeptidases (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1872419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative Evaluation of the Efficacy of Gingival Crevicular Blood with Finger Capillary Blood and Venous Capillary Blood to Assess Blood Glucose Levels for Screening of Diabetes Mellitus in Chronic Periodontitis Patients

    Chandni Patel / Vallari Shah / Bela Dave / Sapan Patel / Shreya Gajjar / Tanvi Hirani / Gaurav Girdhar / Surabhi Joshi

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 1, Pp ZD11-ZD

    A Cross-sectional Study

    2023  Volume 15

    Abstract: Introduction: Diabetes mellitus is defined as a clinically and genetically diverse cluster of illnesses involving conflict in carbohydrate and protein metabolism. Periodontitis is a complex condition with several causes. The interaction between these two ...

    Abstract Introduction: Diabetes mellitus is defined as a clinically and genetically diverse cluster of illnesses involving conflict in carbohydrate and protein metabolism. Periodontitis is a complex condition with several causes. The interaction between these two conditions appears to be cyclical as well as bidirectional. Gingival crevicular blood obtained through routine periodontal oral assessment could be utilised for blood glucose estimation. Aim: To examine the efficacy of gingival crevicular blood elicited during routine periodontal probing, as a reliable source for screening of diabetes mellitus, and to compare it with finger capillary blood and venous capillary blood in chronic periodontitis patients. Materials and Methods: This cross-sectional, in-vivo, clinical study was conducted in the Department of Periodontology at Karnavati School of Dentistry, Gandhinagar, Gujarat, India, from January 2021 to January 2022. The study included 50 patients, who were diagnosed with chronic periodontitis in the age range ≥30 years, and met the inclusion and exclusion criteria. A prior detailed history was compiled. The clinical parameters recorded were sulcus bleeding index, plaque index, gingival index, probing pocket depth, and clinical attachment level. Each patient’s blood samples were collected from three different sites, Gingival Crevicular Blood (GCB) collected from gingival crevice, Finger Capillary Blood (FCB) collected from finger bed and and Venous Capillary Blood (VCB) collected from forearm for determining the blood glucose levels. Glucose levels were compared by one-way Analysis of Variance (ANOVA). Karl Pearson’s correlation was used for the comparison. Statistical Package for Social Sciences (SPSS) version 26.0 was used for statistical analysis and p-value ≤0.05 was considered as statistically significant. Results: The mean Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) was 5.5±0.61 mm and 6.76±0.82 mm, respectively. The mean Plaque Index (PI) and Gingival Index (GI) score was 1.41±0.25 and ...
    Keywords diagnostic aid ; glucometer ; glycated haemoglobin ; non invasive ; screening tool ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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