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Book ; Online ; Thesis: Mechanismen der innaten Immunantwort im Rahmen kardiovaskulärer Erkrankungen

Weinberger, Tobias [Verfasser]

2023

Author's details	Tobias Weinberger
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: The Allium Ureteral Stent for the Treatment of Ureteral Complications Following Renal Transplantation-A Single-Center, Single-Surgeon Series.

Weinberger, Sarah / Hubatsch, Mandy / Klatte, Tobias / Neymeyer, Jörg / Friedersdorff, Frank

Journal of clinical medicine

2023 Volume 12, Issue 9

Abstract: Ureteral complications such as urinary leak, ureteral necrosis or ureteral stenosis are common complications after renal transplantation with major short- and long-term issues, including graft impairment and graft loss. At present, there is no agreement ... ...

Abstract	Ureteral complications such as urinary leak, ureteral necrosis or ureteral stenosis are common complications after renal transplantation with major short- and long-term issues, including graft impairment and graft loss. At present, there is no agreement on the optimal management of ureteral complications. The aim of the current study was to evaluate the safety and efficacy of the self-expanding, large-caliber Allium ureteral stent in patients with ureteral complications following renal transplantation. In this retrospective study, the electronic database of Charité University Hospital was screened for patients receiving the self-expandable Allium ureteral stent in the transplant ureter after kidney transplantation between January 2016 and March 2022. Descriptive statistics were used to describe the outcomes. There were six men and four women with a median age of 61 years (interquartile range, 55 to 68 years). Nine out of 10 patients had ureteric stenosis, which was diagnosed at a median of two years (interquartile range 10 months to 9 years) following renal transplantation. The median operating time was 49 min (interquartile range, 30 to 60 min). Endoscopic Allium stent placement was successful in all patients with ureteric stenosis. The median length of stay in the hospital was four days (interquartile range 2 to 7 days). Only one patient (#5) had a postoperative grade IIIb Clavien-Dindo complication. Patients had follow-ups every 3 months with ultrasound and serum creatinine. Dislocation of the Allium stent was seen in four patients; all occurred within three months. Ultimately, three patients required ureteric re-implantation, two of which had early dislocation of the stent. Six patients are managed with a permanent Allium stent. The median dwell time was 11 months (interquartile range 3 to 20 months) and maximum dwell time was 23 months. The overall success rate was 60% (6 out of 10). According to our data, the Allium stent represents a safe and minimally invasive option with a success rate of 60%. It might, therefore, represent an alternative to DJ stents, nephrostomies or immediate re-implantation. As all dislocations occurred within three months, frequent early postoperative follow-up is required.
Language	English
Publishing date	2023-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12093317
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Images in Vascular Medicine: Vena cava syndrome mimicking caput medusae.

von Bismarck, Amanda / Weinberger, Tobias / Steffen, Julius

Vascular medicine (London, England)

2021 Volume 26, Issue 6, Page(s) 672–673

MeSH term(s)	Cardiology ; Humans ; Varicose Veins ; Vena Cava, Inferior/diagnostic imaging
Language	English
Publishing date	2021-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X211028296
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Zs.A 4409: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Spatially Guided Distractor Suppression during Visual Search.

Feldmann-Wüstefeld, Tobias / Weinberger, Marina / Awh, Edward

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 14, Page(s) 3180–3191

Abstract: Past work has demonstrated that active suppression of salient distractors is a critical part of visual selection. Evidence for goal-driven suppression includes below-baseline visual encoding at the position of salient distractors (Gaspelin and Luck, 2018) ...

Abstract	Past work has demonstrated that active suppression of salient distractors is a critical part of visual selection. Evidence for goal-driven suppression includes below-baseline visual encoding at the position of salient distractors (Gaspelin and Luck, 2018) and neural signals such as the distractor positivity (Pd) that track how many distractors are presented in a given hemifield (Feldmann-Wüstefeld and Vogel, 2019). One basic question regarding distractor suppression is whether it is inherently spatial or nonspatial in character. Indeed, past work has shown that distractors evoke both spatial (Theeuwes, 1992) and nonspatial forms of interference (Folk and Remington, 1998), motivating a direct examination of whether space is integral to goal-driven distractor suppression. Here, we use behavioral and EEG data from adult humans (male and female) to provide clear evidence for a spatial gradient of suppression surrounding salient singleton distractors. Replicating past work, both reaction time and neural indices of target selection improved monotonically as the distance between target and distractor increased. Importantly, these target selection effects were paralleled by a monotonic decline in the amplitude of the Pd, an electrophysiological index of distractor suppression. Moreover, multivariate analyses revealed spatially selective activity in the θ-band that tracked the position of the target and, critically, revealed suppressed activity at spatial channels centered on distractor positions. Thus, goal-driven selection of relevant over irrelevant information benefits from a spatial gradient of suppression surrounding salient distractors.
MeSH term(s)	Adolescent ; Adult ; Attention/physiology ; Electroencephalography/methods ; Evoked Potentials, Visual/physiology ; Female ; Humans ; Male ; Photic Stimulation/methods ; Reaction Time/physiology ; Space Perception/physiology ; Visual Perception/physiology ; Young Adult
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2418-20.2021
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Zs.A 1668: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sulfonated halloysite nanotubes as a novel cation exchange material for solid phase extraction of toxic pyrrolizidine alkaloids.

Schlappack, Tobias / Rainer, Matthias / Weinberger, Nikolaus / Bonn, Günther K

Analytical methods : advancing methods and applications

2022 Volume 14, Issue 27, Page(s) 2689–2697

Abstract: Pyrrolizidine alkaloids are phytochemicals, which present a highly toxic class of compounds in multiple food resources and are therefore a late-breaking topic in food safety. This study describes the first use of modified halloysite nanotubes as a novel ... ...

Abstract	Pyrrolizidine alkaloids are phytochemicals, which present a highly toxic class of compounds in multiple food resources and are therefore a late-breaking topic in food safety. This study describes the first use of modified halloysite nanotubes as a novel solid material for solid phase extraction. As a result of a fast one-pot sulfonation of the cheap and non-toxic halloysite nanotubes, an efficient cation exchange phase has been prepared. After optimization of the solid phase extraction protocol, high extraction efficiencies and overall recoveries were obtained for a mixture of four pyrrolizidine alkaloid structures through UHPLC-MS/MS analysis with caffeine as the internal standard. Furthermore, the novel solid phase was used for the selective binding of the toxic pyrrolizidine alkaloids in a real-life honey sample, which itself is often contaminated with these compounds. In-house validation showed great extraction efficiencies up to 99.9% for senecionine with a lower limit for lycopsamine with 59.3%, which indicated high selectivity even in the presence of potential interfering compounds. Subsequently, overall recoveries up to 91.5% could be obtained for senecionine while the lowest value was reached for lycopsamine with 55.1%. Comparison with a commercial strong cation exchange tube procedure showed the high competitiveness of the novel solid phase with respect to overall performance. Only slight disadvantages regarding precision and repeatability with values under 5.7% and 11.6% could be observed. Therefore, sulfonated halloysite nanotubes present themselves as an easy to prepare, cheap and highly efficient novel cation exchange material for the selective solid phase extraction of toxic pyrrolizidine alkaloids in frequently contaminated real-life samples like honey.
MeSH term(s)	Cations ; Chromatography, High Pressure Liquid ; Clay ; Nanotubes/analysis ; Pyrrolizidine Alkaloids/analysis ; Pyrrolizidine Alkaloids/chemistry ; Solid Phase Extraction/methods ; Tandem Mass Spectrometry
Chemical Substances	Cations ; Pyrrolizidine Alkaloids ; Clay (T1FAD4SS2M)
Language	English
Publishing date	2022-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d2ay00614f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interventional Closure of a Large Pseudoaneurysm of the Ascending Aorta in a Patient after Lung Transplantation.

Weinberger, Tobias / Nabauer, Michael / Massberg, Steffen / Hausleiter, Joerg

CASE (Philadelphia, Pa.)

2019 Volume 3, Issue 6, Page(s) 263–266

Language	English
Publishing date	2019-09-20
Publishing country	United States
Document type	Journal Article
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2019.08.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The immunomodulatory role of Regnase family RNA-binding proteins.

Fischer, Maximilian / Weinberger, Tobias / Schulz, Christian

RNA biology

2020 Volume 17, Issue 12, Page(s) 1721–1726

Abstract: RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune ... ...

Abstract	RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.
MeSH term(s)	Adaptive Immunity ; Animals ; Disease Susceptibility ; Homeostasis/immunology ; Humans ; Immunity, Innate ; Immunomodulation ; Inflammation/etiology ; Inflammation/metabolism ; Multigene Family ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonucleases/genetics ; Ribonucleases/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	RNA-Binding Proteins ; Transcription Factors ; Ribonucleases (EC 3.1.-)
Language	English
Publishing date	2020-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1555-8584
ISSN (online)	1555-8584
DOI	10.1080/15476286.2020.1795584
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic.

Biener, Ingeborg / Mueller, Tonina T / Lin, Jin / Bao, Han / Steffen, Julius / Hoerl, Marion / Biere, Katharina / Matzel, Sandra / Woehrle, Tobias / König, Simon / Keiler, Annekathrin M / Thieme, Detlef / Keppler, Oliver / Klein, Matthias / Weinberger, Tobias / Osterman, Andreas / Adorjan, Kristina / Choukér, Alexander

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 71

Abstract: The pandemic caused by SARS-CoV-2 impacted health systems globally, creating increased workload and mental stress upon health care workers (HCW). During the first pandemic wave (March to May 2020) in southern Germany, we investigated the impact of stress ...

Abstract	The pandemic caused by SARS-CoV-2 impacted health systems globally, creating increased workload and mental stress upon health care workers (HCW). During the first pandemic wave (March to May 2020) in southern Germany, we investigated the impact of stress and the resilience to stress in HCW by measuring changes in hair concentrations of endocannabinoids, endocannabinoid-like compounds and cortisone. HCW (n = 178) recruited from multiple occupation and worksites in the LMU-University-Hospital in Munich were interviewed at four interval visits to evaluate mental stress associated with the COVID-19 pandemic. A strand of hair of up to 6 cm in length was sampled once in May 2020, which enabled retrospective individual stress hormone quantifications during that aforementioned time period. Perceived anxiety and impact on mental health were demonstrated to be higher at the beginning of the COVID-19 pandemic and decreased significantly thereafter. Resilience was stable over time, but noted to be lower in women than in men. The concentrations of the endocannabinoid anandamide (AEA) and the structural congeners N-palmitoylethanolamide (PEA), N-oleoylethanolamide (OEA) and N-stearoylethanolamide (SEA) were noted to have decreased significantly over the course of the pandemic. In contrast, the endocannabinoid 2-arachidonoylglycerol (2-AG) levels increased significantly and were found to be higher in nurses, laboratory staff and hospital administration than in physicians. PEA was significantly higher in subjects with a higher resilience but lower in subjects with anxiety. SEA was also noted to be reduced in subjects with anxiety. Nurses had significantly higher cortisone levels than physicians, while female subjects had significant lower cortisone levels than males. Hair samples provided temporal and measurable objective psychophysiological-hormonal information. The hair endocannabinoids/endocannabinoid-like compounds and cortisone correlated to each other and to professions, age and sex quite differentially, relative to specific periods of the COVID-19 pandemic.
MeSH term(s)	Male ; Humans ; Female ; Endocannabinoids ; Cortisone/analysis ; Pandemics ; Retrospective Studies ; Resilience, Psychological ; COVID-19 ; SARS-CoV-2 ; Hair/chemistry ; Health Personnel
Chemical Substances	Endocannabinoids ; Cortisone (V27W9254FZ)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-024-02771-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of time to surgery on oncological outcomes in stage I-III dMMR colon cancer - A nationwide cohort study.

Justesen, Tobias Freyberg / Gögenur, Mikail / Clausen, Johan Stub Rønø / Mashkoor, Maliha / Rosen, Andreas Weinberger / Gögenur, Ismail

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 9, Page(s) 106887

Abstract: Introduction: One of the considerations when investigating neoadjuvant interventions is the prolonging of time from diagnosis to curative surgery (i.e. the treatment interval [TI]). The aim of this study was to investigate the association between the ... ...

Abstract	Introduction: One of the considerations when investigating neoadjuvant interventions is the prolonging of time from diagnosis to curative surgery (i.e. the treatment interval [TI]). The aim of this study was to investigate the association between the length of TI and overall survival and disease-free survival in patients with deficient mismatch repair (dMMR) colon cancer. Materials and methods: This retrospective propensity score-adjusted study included all patients of ≥18 years of age undergoing elective curative surgery for stage I-III, dMMR colon cancer. Data were extracted from four Danish patient databases. Outcomes were investigated in groups with TIs of ≤14 days versus >14 days. Propensity scores were computed using all demographics, diagnoses and measurements. Matching was done in a 1:1 ratio. Results: A total of 4130 patients were included in the study with a mean age of 73.8 years and a median follow-up time of 43.9 months. After matching, 2794 patients were included in the analysis of overall survival. No significant difference in overall survival was seen between patients with TIs of ≤14 days versus >14 days (hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.81-1.17; p = 0.78). In the analysis of disease-free survival, 1798 patients were included after matching. This showed no significant difference between patients with TIs of ≤14 days versus >14 days (HR, 0.85; 95% CI, 0.69-1.06; p = 0.14). Conclusion: No associations were found between TI and overall survival and disease-free survival in patients with stage I-III, dMMR colon cancer undergoing elective curative surgery.
MeSH term(s)	Humans ; Aged ; Cohort Studies ; Retrospective Studies ; DNA Mismatch Repair ; Neoplasm Staging ; Colonic Neoplasms/pathology
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.03.223
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article ; Online: The periacetabular osteotomy: angulation of the supraacetabular osteotomy for quantification of correction.

Hoch, Armando / Grossenbacher, Geraldine / Jungwirth-Weinberger, Anna / Götschi, Tobias / Fürnstahl, Philipp / Zingg, Patrick O

Hip international : the journal of clinical and experimental research on hip pathology and therapy

2022 Volume 33, Issue 5, Page(s) 934–940

Abstract: Background: Malcorrection of the acetabular fragment in periacetabular osteotomy (PAO) is associated with inferior outcomes. 2-dimensional radiographic parameters are being used for intraoperative verification of a satisfactory result. After ... ...

Abstract	Background: Malcorrection of the acetabular fragment in periacetabular osteotomy (PAO) is associated with inferior outcomes. 2-dimensional radiographic parameters are being used for intraoperative verification of a satisfactory result. After reorientation of the fragment, the acetabular version must be verified with an intraoperative radiograph. In the case of an unsatisfactory correction, a reorientation would be required. A slim and radiation-free intraoperative navigation method to directly quantify the correction is highly desirable. Aim: To find out whether the measurable angulation of the supraacetabular osteotomy can be used for this purpose. Methods: To determine the angulation, 13 consecutive patients who underwent a PAO were investigated. The preoperative and postoperative standard radiographs as well as CT scans were available. The surgically produced alteration of radiographic parameters was correlated to tilting and spreading of the supraacetabular osteotomy planes. Results: Tilting of the supraacetabular osteotomy planes correlates strongly to alteration of the lateral centre-edge angle (LCEA) and the acetabular index (ACI), whereas spreading of the same planes showed also a strong correlation, but to the LCEA only. 1° of tilting resulted in a 0.2° alteration of the LCEA and a 0.5° alteration of the ACI, whereas 1° of spreading resulted in a 0.5° alteration of the LCEA. Conclusions: This study shows that the measurable angulation of the supraacetabular osteotomy planes can be used to monitor the three-dimensional reorientation of the acetabular fragment in PAO. As long as sophisticated modalities are lacking, this technique offers an easy way to intraoperatively navigate the correction in PAO.
MeSH term(s)	Humans ; Retrospective Studies ; Treatment Outcome ; Arthroplasty, Replacement, Hip ; Acetabulum/diagnostic imaging ; Acetabulum/surgery ; Osteotomy/methods
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1162513-2
ISSN	1724-6067 ; 1120-7000
ISSN (online)	1724-6067
ISSN	1120-7000
DOI	10.1177/11207000221103079
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Zs.A 3810: Show issues

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