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  1. Article ; Online: [Skulle vi ikke bare sende dem hjem?]

    Madsen, Anders Rørbæk

    Ugeskrift for laeger

    2021  Volume 183, Issue 14

    Language Danish
    Publishing date 2021-04-05
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intraocular pressure-related side-effects after endothelial keratoplasty.

    Madsen, Morten B M / Ivarsen, Anders / Telinius, Niklas / Hjortdal, Jesper

    Acta ophthalmologica

    2024  

    Abstract: Purpose: To investigate circumpapillary retinal nerve fibre layer (RNFL) thickness, pupillary function and diameter after phacoemulsification and lens implantation alone or combined with endothelial keratoplasty (EK).: Methods: This study was a ... ...

    Abstract Purpose: To investigate circumpapillary retinal nerve fibre layer (RNFL) thickness, pupillary function and diameter after phacoemulsification and lens implantation alone or combined with endothelial keratoplasty (EK).
    Methods: This study was a secondary analysis of data from a randomized, single-masked trial, that included 72 patients with Fuchs' endothelial dystrophy and cataract, equally allocated (1:1) to ultrathin Descemet's stripping automated endothelial keratoplasty or Descemet's membrane endothelial keratoplasty. The cataract extraction (CE) group included 40 patients undergoing cataract surgery only. All patients were treated with phacoemulsification and lens implantation.
    Results: RNFL thickness was significantly lower in the CE group than after EK for the global (p < 0.01), nasal (p = 0.04), and temporal sectors (p = 0.01) 12 months after surgery. RNFL thickness was comparable between patients treated with rebubbling and others (p ≥ 0.16 for all comparisons) after 12 months. The CE group and patients treated with EK demonstrated a comparable scotopic (p = 0.34) and photopic pupil diameter (p = 0.95) as well as a comparable maximum (p = 0.83) and average pupillary constriction velocity (p = 0.95) after 12 months. In contrast, patients treated with rebubbling had a significantly smaller scotopic pupil diameter (p = 0.04).
    Conclusion: In this study, no evidence was found indicating a negative impact on the RNFL thickness after EK when compared to CE 12 months after surgery. Iris function and pupil diameter were comparable between the CE group and patients treated with EK after 12 months.
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.16655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Biochemical identification of prepubertal boys with Klinefelter syndrome by combined reproductive hormone profiling using machine learning.

    Madsen, Andre / Juul, Anders / Aksglaede, Lise

    Endocrine connections

    2023  Volume 12, Issue 5

    Abstract: Objective: Klinefelter syndrome (KS) is the most common sex chromosome disorder and genetic cause of infertility in males. A highly variable phenotype contributes to the fact that a large proportion of cases are never diagnosed. Typical hallmarks in ... ...

    Abstract Objective: Klinefelter syndrome (KS) is the most common sex chromosome disorder and genetic cause of infertility in males. A highly variable phenotype contributes to the fact that a large proportion of cases are never diagnosed. Typical hallmarks in adults include small testes and azoospermia which may prompt biochemical evaluation that typically shows extremely high follicle-stimulating hormone and low/undetectable inhibin B serum concentrations. However, in prepubertal KS individuals, biochemical parameters are largely overlapping those of prepubertal controls. We aimed to characterize clinical profiles of prepubertal boys with KS in relation to controls and to develop a novel biochemical classification model to identify KS before puberty.
    Methods: Retrospective, longitudinal data from 15 prepubertal boys with KS and data from 1475 controls were used to calculate age- and sex-adjusted standard deviation scores (SDS) for height and serum concentrations of reproductive hormones and used to infer a decision tree classification model for KS.
    Results: Individual reproductive hormones were low but within reference ranges and did not discriminate KS from controls. Clinical and biochemical profiles including age- and sex-adjusted SDS from multiple reference curves provided input data to train a 'random forest' machine learning (ML) model for the detection of KS. Applied to unseen data, the ML model achieved a classification accuracy of 78% (95% CI, 61-94%).
    Conclusions: Supervised ML applied to clinically relevant variables enabled computational classification of control and KS profiles. The application of age- and sex-adjusted SDS provided robust predictions irrespective of age. Specialized ML models applied to combined reproductive hormone concentrations may be useful diagnostic tools to improve the identification of prepubertal boys with KS.
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-22-0537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [No title information]

    Madsen, Morten Brok Molbech / Ivarsen, Anders / Hjortdal, Jesper

    Ugeskrift for laeger

    2023  Volume 185, Issue 48

    Abstract: Corneal grafting is performed approximately 650 times a year in Denmark. A summary of these procedures is given in this review. Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy are frequent indications for transplantation. Previously, ... ...

    Title translation Corneal grafting.
    Abstract Corneal grafting is performed approximately 650 times a year in Denmark. A summary of these procedures is given in this review. Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy are frequent indications for transplantation. Previously, penetrating keratoplasty was the technique of choice but is nowadays mainly used for combined stromal and endothelial pathology. Instead, techniques specifically replacing diseased layers are more common. The Danish Cornea Bank is the only center in Denmark which undertakes preparation and distribution of tissue. The operative procedures are performed at Aarhus University Hospital or Rigshospitalet Glostrup.
    MeSH term(s) Humans ; Corneal Diseases/surgery ; Corneal Diseases/pathology ; Corneal Transplantation ; Cornea ; Fuchs' Endothelial Dystrophy/pathology ; Fuchs' Endothelial Dystrophy/surgery ; Keratoplasty, Penetrating
    Language Danish
    Publishing date 2023-11-27
    Publishing country Denmark
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  5. Article ; Online: Macular Thickness After Ultrathin Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty Combined With Cataract Surgery: A Randomized Controlled Clinical Trial.

    Molbech Madsen, Morten Brok / Ivarsen, Anders / Hjortdal, Jesper

    Cornea

    2023  Volume 42, Issue 12, Page(s) 1536–1543

    Abstract: Purpose: The aim was to investigate alterations in central retinal thickness (CRT) and their implications for visual acuity after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty ( ... ...

    Abstract Purpose: The aim was to investigate alterations in central retinal thickness (CRT) and their implications for visual acuity after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) combined with cataract surgery.
    Methods: A total of 72 eyes of 72 patients with Fuchs endothelial dystrophy and cataract were included and equally randomized to either UT-DSAEK or DMEK. A control group of 40 eyes of 40 patients with cataract were included for cataract surgery. All participants were examined preoperatively as well as 3 and 6 months postoperatively.
    Results: There was no significant difference in CRT between the study groups after surgery ( P = 0.896). A significant difference in best-corrected visual acuity (BCVA) progression over time was found between the study groups ( P < 0.0001). Average improvements of 8.03 EDTRS after UT-DSAEK ( P < 0.001) and 16.77 EDTRS after DMEK ( P < 0.001) were found 6 months postoperatively. No significant correlation was found between the change in BCVA and CRT from baseline to 3 months postoperatively (r 2 < 0.0001, P = 0.96) and from baseline to 6 months postoperatively (r 2 = 0.0053, P = 0.46).
    Conclusions: CRT was not altered by UT-DSAEK, DMEK, or cataract surgery 3 and 6 months postoperatively. BCVA significantly improved 3 and 6 months after UT-DSAEK and DMEK, respectively. No significant correlations were found between the change in BCVA and CRT postoperatively. As such CRT alterations were comparable after UT-DSAEK, DMEK, and cataract surgery.
    MeSH term(s) Humans ; Descemet Membrane/surgery ; Descemet Stripping Endothelial Keratoplasty ; Fuchs' Endothelial Dystrophy/surgery ; Visual Acuity ; Cataract ; Retrospective Studies ; Endothelium, Corneal
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000003256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Danish 20-month-olds' recognition of familiar words with and without consonant and vowel mispronunciations.

    Højen, Anders / Madsen, Thomas O / Bleses, Dorthe

    Phonetica

    2023  Volume 80, Issue 5, Page(s) 309–328

    Abstract: Although several studies initially supported the proposal by Nespor et al. (Nespor, Marina, Marcela Peña & Jacques Mehler. 2003. On the different roles of vowels and consonants in speech processing and language acquisition. ...

    Abstract Although several studies initially supported the proposal by Nespor et al. (Nespor, Marina, Marcela Peña & Jacques Mehler. 2003. On the different roles of vowels and consonants in speech processing and language acquisition.
    Language English
    Publishing date 2023-08-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208832-0
    ISSN 1423-0321 ; 0031-8388
    ISSN (online) 1423-0321
    ISSN 0031-8388
    DOI 10.1515/phon-2023-2001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Visual function after ultrathin Descemet's stripping automated endothelial keratoplasty or Descemet's membrane endothelial keratoplasty combined with cataract surgery: a randomised controlled clinical trial.

    Madsen, Morten Brok Molbech / Ivarsen, Anders / Hjortdal, Jesper

    The British journal of ophthalmology

    2023  

    Abstract: Aims: To compare best-corrected visual acuity (BCVA), contrast sensitivity and endothelial cell density (ECD) after ultrathin Descemet's stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK).: ... ...

    Abstract Aims: To compare best-corrected visual acuity (BCVA), contrast sensitivity and endothelial cell density (ECD) after ultrathin Descemet's stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK).
    Methods: A randomised, single-blinded, single-centre design was used. 72 patients with Fuchs' endothelial dystrophy and cataract were randomised to UT-DSAEK or DMEK combined with phacoemulsification and lens implantation. 27 patients with cataract were included in a control group and treated with phacoemulsification and lens implantation. The primary outcome was BCVA at 12 months.
    Results: Compared with UT-DSAEK, DMEK resulted in better BCVA with mean differences of 6.1 early treatment diabetic retinopathy study (ETDRS) (p=0.001) after 3 months, 7.4 ETDRS (p<0.001) after 6 months and 5.7 ETDRS (p<0.001) after 12 months. The control group obtained significantly better BCVA with a mean difference of 5.2 ETDRS (p<0.001) compared with DMEK 12 months postoperatively. Compared with UT-DSAEK, contrast sensitivity was significantly better 3 months after DMEK with a mean difference of 0.10 LogCS (p=0.03). However, our study found no effect after 12 months (p=0.08). ECD was significantly lower after UT-DSAEK compared with DMEK with mean differences of 332 cells/mm
    Conclusions: Compared with UT-DSAEK, DMEK resulted in better BCVA 3, 6 and 12 months postoperatively. Twelve months postoperatively, DMEK had a higher ECD than UT-DSAEK; however, no difference in contrast sensitivity was found.
    Trial registration number: NCT04417959.
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjo-2023-323304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The structure of magnesium stearate trihydrate determined from a micrometre-sized single crystal using a microfocused synchrotron X-ray beam.

    Herzberg, Mikkel / Rekis, Toms / Støttrup Larsen, Anders / Gonzalez, Ana / Rantanen, Jukka / Østergaard Madsen, Anders

    Acta crystallographica Section B, Structural science, crystal engineering and materials

    2023  Volume 79, Issue Pt 4, Page(s) 330–335

    Abstract: Crystalline magnesium stearate has been extensively used as an additive in pharmaceutical and other industries for decades. However, the lack of suitably large crystals has hindered the determination of the crystal structure and thereby a more ... ...

    Abstract Crystalline magnesium stearate has been extensively used as an additive in pharmaceutical and other industries for decades. However, the lack of suitably large crystals has hindered the determination of the crystal structure and thereby a more fundamental understanding of the structure-functionality relationship. Presented here is the structure of magnesium stearate trihydrate as determined from X-ray diffraction data of a micrometre-sized single crystal measured at a fourth-generation synchrotron facility. Despite the small size of the single crystals and the weak diffraction, it was possible to determine the positions of the non-hydrogen atoms reliably. Periodic dispersion-corrected density functional theory calculations were used to obtain the positions of the hydrogen atoms playing an important role in the overall organization of the structure via a hydrogen-bond network.
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020841-8
    ISSN 2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
    ISSN (online) 2052-5206 ; 1600-5740 ; 1600-8650
    ISSN 2052-5192
    DOI 10.1107/S2052520623005607
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  9. Article: Supporting self-regulated-learning in colonoscopy training-A comparison cohort trial.

    Jaensch, Claudia / Jensen, Rune Dall / Brydges, Ryan / Paltved, Charlotte / Madsen, Anders Husted

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28133

    Abstract: Aim: This study aimed to demonstrate that using a self-regulated learning (SRL) approach can improve colonoscopy performance skills.: Background: Colonoscopy is the gold standard for detecting colorectal cancer and removing its precursors: polyps. ... ...

    Abstract Aim: This study aimed to demonstrate that using a self-regulated learning (SRL) approach can improve colonoscopy performance skills.
    Background: Colonoscopy is the gold standard for detecting colorectal cancer and removing its precursors: polyps. Acquiring proficiency in colonoscopy is challenging, requiring completion of several hundred procedures. SRL seems to be beneficial to help trainees acquire competencies in regulating their future learning processes and enhance the outcomes of current learning situations. SRL is a learner-centred approach that refers to a trainee's ability to understand and control their learning environment, including cognitions, motivations and emotions. The key abilities include self- and situational awareness, task analysis, and strategic planning. This study is the first to use an SRL approach for workplace-based colonoscopy training.
    Methods: In this comparison cohort trial, participants used two SRL supports: a self-review of videotaped performance, and an online learning platform with procedural and conceptual knowledge about colonoscopy. In the control cohort, participants performed patient-based colonoscopy as usual in their departments. Improvement was monitored via three video-based ratings (study start, end of the study period, and follow-up) using the Gastrointestinal Endoscopy Competency Assessment Tool (GiECAT). Outcomes were analysed using two-way analysis of variance with repeated measurements.
    Results: This study recruited 21 participants (12, intervention cohort; nine, control cohort); 58 videos were recorded. The intraclass correlation coefficient was 0.88 (95% CI 0.61-0.98; p < 0.001). The global rating scale (GRS) and checklist (CL) in GiECAT were analysed separately. No statistically significant main effects of cohort (GRS: F(1,16) = 2.84, p = 0.11; CL: F(1,16) = 1.06, p = 0.32), test (GRS: F(2,32) = 2.56, p = 0.09; CL: F(2,32) = 0.76, p = 0.48), or interactions between cohort and test were observed (GRS: F(2,32) = 1.16, p = 0.33; CL: F(2,32) = 1.01, p = 0.37).
    Conclusions: SRL in patient-based colonoscopy is feasible; however, no clear effect on performance scores was observed.
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Carbon Instrumentation in Patients with Metastatic Spinal Cord Compression.

    Schmidt Morgen, Søren / Alfthan Madsen, Emma Benedikte / Skive Weiland, Anders / Dahl, Benny / Gehrchen, Martin

    Cancers

    2024  Volume 16, Issue 4

    Abstract: Recently carbon spinal implants have been introduced in the treatment of patients with metastatic spinal cord compression (MSCC). This is expected to decrease the deflection of radiation and improve diagnostic imaging and radiotherapy when compared to ... ...

    Abstract Recently carbon spinal implants have been introduced in the treatment of patients with metastatic spinal cord compression (MSCC). This is expected to decrease the deflection of radiation and improve diagnostic imaging and radiotherapy when compared to titanium implants. The aim of this study was to determine the safety and effectiveness of spinal carbon instrumentation (CI) in patients with MSCC in a large cohort study. A total of 163 patients received instrumentation between 1 January 2017 and 31 December 2021. A total of 80 were stabilized with CI and 83 with TI. The outcome measures were surgical revision, postsurgical survival, peri-operative bleeding, and surgery time. The peri-operative blood loss in the CI-group was significantly lower than that in the TI-group: 450mL vs. 630mL, (
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040736
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