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Article ; Online: Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer.

Yang, Xiaojuan / Li, Feifei / Shi, Youyang / Wu, Yuanyuan / Yang, Rui / Liu, Xiaofei / Zhang, Yang / Zhang, Guangtao / Ma, Mei / Luo, Zhanyang / Han, Xianghui / Xie, Ying / Liu, Sheng

Acta biochimica et biophysica Sinica

2024

Abstract: Traditional Chinese medicine (TCM) has been used to treat triple-negative breast cancer (TNBC), a breast cancer subtype with poor prognosis. Clinical studies have verified that the Sanyingfang formula (SYF), a TCM prescription, has obvious effects on ... ...

Abstract	Traditional Chinese medicine (TCM) has been used to treat triple-negative breast cancer (TNBC), a breast cancer subtype with poor prognosis. Clinical studies have verified that the Sanyingfang formula (SYF), a TCM prescription, has obvious effects on inhibiting breast cancer recurrence and metastasis, prolonging patient survival, and reducing clinical symptoms. However, its active ingredients and molecular mechanisms are still unclear. In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1.
Language	English
Publishing date	2024-03-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2024015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Enhanced Effect of Qing-Ying Decoction Concurrent with Secukinumab in the Treatment of Plaque Psoriasis.

Tian, Zan / Cang, Rong / Lei, Mingjun / Fan, Lifang / Wang, Hua / Shang, Mengyu / Li, Xiang / Bai, Fan

Alternative therapies in health and medicine

2022 Volume 28, Issue 6, Page(s) 96–102

Abstract: Both Qing-Ying decoction (QYD), a Traditional Chinese Medicine (TCM), and secukinumab, a fully ...

Abstract	Both Qing-Ying decoction (QYD), a Traditional Chinese Medicine (TCM), and secukinumab, a fully humanized anti-interleukin-17A monoclonal antibody, have been used to treat patients with plaque psoriasis. The combined application of TCM and biologics in the treatment of psoriasis, however, has not been investigated. We enrolled a total of 68 patients with plaque psoriasis in our prospective study, and randomly assigned them to either the study group (treated with secukinumab plus QYD), or the control group (treated with secukinumab alone). After 12- and 16-week treatment, the Psoriasis Area and Severity Index (PASI) score and the TCM score were significantly reduced in both the study and the control groups. However, the reduction in PASI and TCM scores was more significant in the study group than in the control group (12-week: PASI: 5.29 ± 0.27 vs 8.87 ± 0.38, respectively; P < .01; TCM: 5.83 ± 0.21 vs 12.39 ± 1.23, respectively; P < .01; 16-week: PASI score: 4.76 ± 0.18 vs 8.36 ± 0.31, respectively; TCM score: 4.98 ± 0.19 vs 11.27 ± 1.13, respectively; P < .01). The total treatment efficacy rate was significantly higher in the study group (97.1%) than the control group (76.5%; P = .012). The number of CD3+ and CD4+ T cells was increased, while the number of CD8+ T cells was decreased after treatment in both groups, with more significant changes in the study group (P < .01). QYD may enhance the therapeutic outcome of secukinumab in the treatment of plaque psoriasis by further suppressing chronic skin inflammation, as well as reducing adverse events and patients' psychological stress.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Prospective Studies ; Psoriasis/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; secukinumab (DLG4EML025)
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Zs.A 4504: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment.

Zhang, Shuyan / Wu, Jiajun / Wang, Leilei / Mu, Lin / Xu, Xiaoyu / Li, Jiahui / Tang, Guoyi / Chen, Guang / Zhang, Cheng / Zhang, Yinjian / Feng, Yibin

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1366020

Abstract: ... visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been ...

Abstract	Objective: Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been identified as an efficient therapy for DR with retinal vascular dysfunction for decades and has been experimentally reported to ameliorate retinal conditions in diabetic mice. This study endeavors to explore the therapeutic potential of HF with key ingredients in DR and its underlying novel mechanisms. Methods: Co-expression gene modules and hub genes were calculated by weighted gene co-expression network analysis (WGCNA) based on transcriptome sequencing data from high-glucose-treated adult retinal pigment epithelial cell line-19 (ARPE-19). The chromatographic fingerprint of HF was established by ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-Q-TOF-MS). The molecular affinity of the herbal compound was measured by molecular docking. Reactive oxygen species (ROS) was measured by a DCFDA/H2DCFDA assay. Apoptosis was detected using the TUNEL Assay Kit, while ELISA, Western blot, and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used for detecting the cytokine, protein, and mRNA expressions, respectively. Results: Key compounds in HF were identified as luteolin, paeoniflorin, and nobiletin. For WGCNA, ME-salmon ("protein deacetylation") was negatively correlated with ME-purple ("oxidative impairment") in high-glucose-treated ARPE-19. Luteolin has a high affinity for SIRT1 and P53, as indicated by molecular docking. Luteolin has a hypoglycemic effect on type I diabetic mice. Moreover, HF and luteolin suppress oxidative stress production (ROS and MDA), inflammatory factor expression (IL-6, TNF-α, IL1-β, and MCP-1), and apoptosis, as shown in the Conclusion: Using HF and its active compound luteolin as therapeutic agents offers a promising approach to diabetic retinopathy treatment. It primarily suppressed protein acetylation and oxidative stress via the SIRT1/P53 pathway in retinal pigment epithelial cells.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1366020
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Article ; Online: Effects of "Shi Ying Zi" powder and osthole on immune and antioxidant function of Eimeria tenella-infected broilers.

Cheng, Yi / Geng, Zhe / Li, Yunhe / Song, Xu / Li, Lixia / Wen, Anxiang / Yin, Zhongqiong

Experimental parasitology

2022 Volume 246, Page(s) 108451

Abstract: Shi Ying Zi" powder is a traditional Chinese herbal formula for preventing and treating ... Eimeria tenella infection. In this research, we evaluated the antioxidation and immune effect of "Shi Ying Zi ... of "Shi Ying Zi" powder and osthole alleviated the pathological changes in the cecum, spleen and bursa ...

Abstract	"Shi Ying Zi" powder is a traditional Chinese herbal formula for preventing and treating coccidiosis. In our previous studies, it showed anticoccidial effects and exhibited the potential to control Eimeria tenella infection. In this research, we evaluated the antioxidation and immune effect of "Shi Ying Zi" powder and its effective active ingredient osthole on coccidiosis-infected broilers to explore the mechanism of its anticoccidial effect. We analyzed changes in the antioxidant index, the pathological changes in cecum, immune index of serum and composition of cecal flora. The results showed that the use of "Shi Ying Zi" powder and osthole alleviated the pathological changes in the cecum, spleen and bursa of Fabricius, upregulated the spleen and bursal weigh index. "Shi Ying Zi" powder of 10 g/kg effectively rocovered the contents of interleukins and immunoglobulin in serum. Osthole increased the proportion of Firmicutes, Actino-bacteria and Lactobacillus in the cecum. In summary, "Shi Ying Zi" powder and osthole have anticoccidial effects, and they also can active the immunity, antioxidant functions and upregulate the beneficial bacteria population in Eimeria tenella-infected broilers.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Eimeria tenella ; Chickens ; Powders ; Coccidiosis/drug therapy ; Coccidiosis/veterinary ; Bacteria ; Poultry Diseases/drug therapy ; Poultry Diseases/prevention & control ; Cecum/pathology
Chemical Substances	Antioxidants ; osthol (XH1TI1759C) ; Powders
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2022.108451
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Ud II Zs.159: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Anticoccidial Effect of Herbal Powder "Shi Ying Zi" in Chickens Infected with

Song, Xu / Li, Yunhe / Chen, Shufan / Jia, Renyong / Huang, Yongyuan / Zou, Yuanfeng / Li, Lixia / Zhao, Xinxin / Yin, Zhongqiong

Animals : an open access journal from MDPI

2020 Volume 10, Issue 9

Abstract: Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an ... ...

Abstract	Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an anticoccidial herbal powder "Shi Yin Zi", which consists of
Language	English
Publishing date	2020-08-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10091484
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Article: Post-treatment With Qing-Ying-Tang, a Compound Chinese Medicine Relives Lipopolysaccharide-Induced Cerebral Microcirculation Disturbance in Mice.

Wang, Hao-Min / Huang, Ping / Li, Quan / Yan, Lu-Lu / Sun, Kai / Yan, Li / Pan, Chun-Shui / Wei, Xiao-Hong / Liu, Yu-Ying / Hu, Bai-He / Wang, Chuan-She / Fan, Jing-Yu / Han, Jing-Yan

Frontiers in physiology

2019 Volume 10, Page(s) 1320

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2019-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2019.01320
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Article ; Online: Editorial: Focus on Top-Down Proteomics: Technology Advances and Biomedical Applications, Honoring Dr. Ying Ge, Recipient of the 2020 ASMS Biemann Medal.

Brodbelt, Jenny / Li, Lingjun

Journal of the American Society for Mass Spectrometry

2021 Volume 33, Issue 9, Page(s) 1586–1589

MeSH term(s)	Awards and Prizes ; Mass Spectrometry ; Proteomics ; Technology
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Editorial
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.1c00209
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Zs.A 4618: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 241: Show issues

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Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

Zootaxa

2022 Volume 5115, Issue 4, Page(s) 600

Language	English
Publishing date	2022-03-16
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5115.4.10
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Article ; Online: Propioniciclava sinopodophylli sp. nov., isolated from leaves of Sinopodophyllum hexandrum (Royle) Ying.

Zhang, Lei / Li, Qiqi / Chen, Chaoqiong / Li, Xin / Li, Muhang / Hu, Jingjiang / Shen, Xihui

International journal of systematic and evolutionary microbiology

2017 Volume 67, Issue 10, Page(s) 4111–4115

Abstract: A Gram-reaction-positive, facultatively anaerobic, rod-shaped and non-motile bacterial strain, designated TEYR- ... ...

Abstract	A Gram-reaction-positive, facultatively anaerobic, rod-shaped and non-motile bacterial strain, designated TEYR-7
MeSH term(s)	Bacterial Typing Techniques ; Base Composition ; Berberidaceae/microbiology ; Cell Wall/chemistry ; China ; DNA, Bacterial/genetics ; Diaminopimelic Acid/chemistry ; Fatty Acids/chemistry ; Glycolipids/chemistry ; Nucleic Acid Hybridization ; Peptidoglycan/chemistry ; Phospholipids/chemistry ; Phylogeny ; Plant Leaves/microbiology ; Propionibacteriaceae/classification ; Propionibacteriaceae/genetics ; Propionibacteriaceae/isolation & purification ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/chemistry
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Glycolipids ; Peptidoglycan ; Phospholipids ; RNA, Ribosomal, 16S ; Vitamin K 2 (11032-49-8) ; menaquinone 9 (523-39-7) ; Diaminopimelic Acid (583-93-7)
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.002265
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Zs.A 409: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
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Article: [Distinguishing the "Wei Qi Ying Xue" syndrome differentiation from the "three certificates and three methods" to the diagnosis of sepsis].

Li, Zhijun / Li, Yinping

Zhonghua wei zhong bing ji jiu yi xue

2019 Volume 31, Issue 2, Page(s) 135–138

Abstract: ... emergency medicine. The "Wei Qi Ying Xue" syndrome differentiation is a dialectical theory proposed by Ye Tianshi ... storm) conversion mainly focus on the "Wei Qi Ying Xue" syndrome differentiation of the "Wei, Qi ... syndrome" to "Ying, Xue syndrome", and poison. The conversion of "toxin-heat syndrome" to "blood stasis ...

Abstract	Objective: The "three certificates and three methods" is a combination of Chinese and Western medicine for the treatment of sepsis proposed by Professor Wang Jinda, a pioneer in Chinese emergency medicine. The "Wei Qi Ying Xue" syndrome differentiation is a dialectical theory proposed by Ye Tianshi, a famous doctor in the Qing Dynasty, for the treatment of warm diseases. The "three certificates and three methods" theory of "toxin-heat syndrome" (inflammation storm) to the "blood stasis syndrome" (coagulation storm) conversion mainly focus on the "Wei Qi Ying Xue" syndrome differentiation of the "Wei, Qi syndrome" to "Ying, Xue syndrome", and poison. The conversion of "toxin-heat syndrome" to "blood stasis syndrome" is a watershed in the progression of common infections to sepsis. The timely application of Xuebijing injection can cut off this transformation, which is one of the reasons why Xuebijing injection can treat sepsis.
MeSH term(s)	Diagnosis, Differential ; Humans ; Sepsis/diagnosis ; Syndrome
Language	Chinese
Publishing date	2019-03-02
Publishing country	China
Document type	Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.issn.2095-4352.2019.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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