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  1. Article: Percutaneous treatment of anomalous systemic artery to pulmonary venous fistulas in children: Description of three cases and review of the literature.

    Mazza, Giuseppe Antonio / Garofalo, Mariangela / Agnoletti, Gabriella

    Annals of pediatric cardiology

    2022  Volume 14, Issue 4, Page(s) 536–540

    Abstract: In the normal lung, the only communications between the systemic and pulmonary arterial systems are the connections between the bronchial and pulmonary arteries that occur at the respiratory bronchioles, where pulmonary and bronchial capillaries freely ... ...

    Abstract In the normal lung, the only communications between the systemic and pulmonary arterial systems are the connections between the bronchial and pulmonary arteries that occur at the respiratory bronchioles, where pulmonary and bronchial capillaries freely anastomose. Rarely, anomalous connections can occur between normal or aberrant systemic arteries and pulmonary vessels. We performed a comprehensive literature review of all available manuscripts on PubMed and Google Scholar that included a case report or case series with diagnosis of systemic artery to pulmonary venous fistulas who underwent percutaneous treatment. Furthermore, we report three cases of children diagnosed and treated in our Pediatric Cardiology Center.
    Language English
    Publishing date 2022-03-25
    Publishing country India
    Document type Case Reports
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.APC_31_20
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  2. Article ; Online: Possible Risks in Taking Care of Infants During the Pandemic.

    Mazza, Giuseppe Antonio / Garofalo, Mariangela / Talarico, Valentina / Miniero, Roberto

    Journal of developmental and behavioral pediatrics : JDBP

    2021  Volume 42, Issue 3, Page(s) 255

    MeSH term(s) COVID-19 ; Humans ; Infant ; Pandemics
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 603379-9
    ISSN 1536-7312 ; 0196-206X
    ISSN (online) 1536-7312
    ISSN 0196-206X
    DOI 10.1097/DBP.0000000000000941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1582: Show issues Location:
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  3. Article ; Online: Priming with oncolytic adenovirus followed by anti-PD-1 and paclitaxel treatment leads to improved anti-cancer efficacy in the 3D TNBC model.

    Kuryk, Lukasz / Mathlouthi, Sara / Wieczorek, Magdalena / Gad, Beata / Rinner, Beate / Malfanti, Alessio / Mastrotto, Francesca / Salmaso, Stefano / Caliceti, Paolo / Garofalo, Mariangela

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2024  , Page(s) 114300

    Abstract: Triple-negative breast cancer (TNBC) is considered one of the most incurable malignancies due to its clinical characteristics, including high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Therefore, it remains a ... ...

    Abstract Triple-negative breast cancer (TNBC) is considered one of the most incurable malignancies due to its clinical characteristics, including high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Therefore, it remains a critical unmet medical need. On the other hand, poor delivery efficiency continues to reduce the efficacy of anti-cancer therapeutics developed against solid tumours using various strategies, such as genetically engineered oncolytic vectors used as nanocarriers. The study was designed to evaluate the anti-tumour efficacy of a novel combinatorial therapy based on oncolytic adenovirus AdV5/3-D24-ICOSL-CD40L with an anti-PD-1 (pembrolizumab) and paclitaxel (PTX). Here, we first tested the antineoplastic effect in two-dimensional (2D) and three-dimensional (3D) breast cancer models in MDA-MB-231, MDA-MB-468 and MCF-7 cells. Then, to further evaluate the efficacy of combinatorial therapy, including immunological aspects, we established a three-dimensional (3D) co-culture model based on MDA-MB-231 cells with peripheral blood mononuclear cells (PBMCs) to create an integrated system that more closely mimics the complexity of the tumour microenvironment and interacts with the immune system. Treatment with OV as a priming agent, followed by pembrolizumab and then paclitaxel, was the most effective in reducing the tumour volume in TNBC co-cultured spheroids. Further, T-cell phenotyping analyses revealed significantly increased infiltration of CD8+, CD4+ T and Tregs cells. Moreover, the observed anti-tumour effects positively correlated with the level of CD4+ T cell infiltrates, suggesting the development of anti-cancer immunity. Our study demonstrated that combining different immunotherapeutic agents (virus, pembrolizumab) with PTX reduced the tumour volume of the TNBC co-cultured spheroids compared to relevant controls. Importantly, sequential administration of the investigational agents (priming with the vector) further enhanced the anti-cancer efficacy in 3D culture over other groups tested. Taken together, these results support further evaluation of the virus in combination with anti-PD-1 and PTX for the treatment of triple-negative breast cancer patients. Importantly, further studies with in vivo models should be conducted to better understand the translational aspects of tested therapy.
    Language English
    Publishing date 2024-04-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2024.114300
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1651: Show issues Location:
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  4. Article ; Online: How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs.

    Garofalo, Mariangela / Grazioso, Giovanni / Cavalli, Andrea / Sgrignani, Jacopo

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 7

    Abstract: The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) ... ...

    Abstract The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems. Their combination may provide mechanistic understanding resulting in a synergy that makes possible the rational design of novel anticancer based therapies. Herein, we aim to discuss selected applications, some also from our research experience, in the fields of anticancer small organic drugs and peptides.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Computational Chemistry/methods ; Drug Delivery Systems ; Drug Design ; Drug Development/methods ; Humans ; Models, Molecular ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25071756
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs

    Mariangela Garofalo / Giovanni Grazioso / Andrea Cavalli / Jacopo Sgrignani

    Molecules, Vol 25, Iss 1756, p

    2020  Volume 1756

    Abstract: The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) ... ...

    Abstract The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems. Their combination may provide mechanistic understanding resulting in a synergy that makes possible the rational design of novel anticancer based therapies. Herein, we aim to discuss selected applications, some also from our research experience, in the fields of anticancer small organic drugs and peptides.
    Keywords drug delivery ; computational chemistry ; anticancer drug design ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Novel Insights Into Mesothelioma Therapy: Emerging Avenues and Future Prospects.

    Kuryk, Lukasz / Rodella, Giulia / Staniszewska, Monika / Pancer, Katarzyna Wanda / Wieczorek, Magdalena / Salmaso, Stefano / Caliceti, Paolo / Garofalo, Mariangela

    Frontiers in oncology

    2022  Volume 12, Page(s) 916839

    Abstract: Malignant mesothelioma is a rare and aggressive cancer that develops in the thin layer surrounding the mesothelium and is mainly caused by asbestos exposure. Despite improvements in patient prognosis with conventional cancer treatments, such as surgery, ... ...

    Abstract Malignant mesothelioma is a rare and aggressive cancer that develops in the thin layer surrounding the mesothelium and is mainly caused by asbestos exposure. Despite improvements in patient prognosis with conventional cancer treatments, such as surgery, chemotherapy, and radiotherapy, there are still no curative treatment modalities for advanced disease. In recent years, new therapeutic avenues have been explored. Improved understanding of the mechanisms underlying the dynamic tumor interaction with the immune system has led to the development of immunotherapeutic approaches. Numerous recent clinical trials have shown a desire to develop more effective treatments that can be used to fight against the disease. Immune checkpoint inhibitors, oncolytic adenoviruses, and their combination represent a promising strategy that can be used to synergistically overcome immunosuppression in the mesothelioma tumor microenvironment. This review provides a synthesized overview of the current state of knowledge on new therapeutic options for mesothelioma with a focus on the results of clinical trials conducted in the field.
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.916839
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  7. Article ; Online: Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus.

    Mori, Matteo / Cocorullo, Mario / Tresoldi, Andrea / Cazzaniga, Giulia / Gelain, Arianna / Stelitano, Giovanni / Chiarelli, Laurent R / Tomaiuolo, Martina / Delre, Pietro / Mangiatordi, Giuseppe F / Garofalo, Mariangela / Cassetta, Alberto / Covaceuszach, Sonia / Villa, Stefania / Meneghetti, Fiorella

    European journal of medicinal chemistry

    2023  Volume 265, Page(s) 116073

    Abstract: Blocking iron uptake and metabolism has been emerging as a promising therapeutic strategy for the development of novel antimicrobial compounds. Like all mycobacteria, M. abscessus (Mab) has evolved several countermeasures to scavenge iron from host ... ...

    Abstract Blocking iron uptake and metabolism has been emerging as a promising therapeutic strategy for the development of novel antimicrobial compounds. Like all mycobacteria, M. abscessus (Mab) has evolved several countermeasures to scavenge iron from host carrier proteins, including the production of siderophores, which play a crucial role in these processes. In this study, we solved, for the first time, the crystal structure of Mab-SaS, the first enzyme involved in the biosynthesis of siderophores. Moreover, we screened a small, focused library and identified a compound exhibiting a potent inhibitory effect against Mab-SaS (IC
    MeSH term(s) Humans ; Mycobacterium abscessus ; Mycobacterium Infections, Nontuberculous/microbiology ; Salicylates/pharmacology ; Siderophores/pharmacology ; Iron
    Chemical Substances Salicylates ; Siderophores ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-12-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.116073
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  8. Article ; Online: Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity.

    Fassi, Enrico Mario Alessandro / Garofalo, Mariangela / Sgrignani, Jacopo / Dei Cas, Michele / Mori, Matteo / Roda, Gabriella / Cavalli, Andrea / Grazioso, Giovanni

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: 1) Background: Disfunctions in autophagy machinery have been identified in various conditions, including neurodegenerative diseases, cancer, and inflammation. Among mammalian autophagy proteins, the Atg8 family member GABARAP has been shown to be ... ...

    Abstract (1) Background: Disfunctions in autophagy machinery have been identified in various conditions, including neurodegenerative diseases, cancer, and inflammation. Among mammalian autophagy proteins, the Atg8 family member GABARAP has been shown to be greatly involved in the autophagy process of prostate cancer cells, supporting the idea that GABARAP inhibitors could be valuable tools to fight the progression of tumors. (2) Methods: In this paper, starting from the X-ray crystal structure of GABARAP in a complex with an AnkirinB-LIR domain, we identify two new peptides by applying in silico drug design techniques. The two ligands are synthesized, biophysically assayed, and biologically evaluated to ascertain their potential anticancer profile. (3) Results: Two cyclic peptides (WC8 and WC10) displayed promising biological activity, high conformational stability (due to the presence of disulfide bridges), and K
    MeSH term(s) Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy ; Autophagy-Related Protein 8 Family/metabolism ; Mammals/metabolism ; Microtubule-Associated Proteins/metabolism ; Peptides/chemistry ; Peptides, Cyclic/pharmacology
    Chemical Substances Apoptosis Regulatory Proteins ; Autophagy-Related Protein 8 Family ; Microtubule-Associated Proteins ; Peptides ; Peptides, Cyclic
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095070
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  9. Article: From Immunosuppression to Immunomodulation - Turning Cold Tumours into Hot.

    Garofalo, Mariangela / Pancer, Katarzyna Wanda / Wieczorek, Magdalena / Staniszewska, Monika / Salmaso, Stefano / Caliceti, Paolo / Kuryk, Lukasz

    Journal of Cancer

    2022  Volume 13, Issue 9, Page(s) 2884–2892

    Abstract: Cancer cells employ various mechanisms to evade and suppress anti-cancer immune responses generating a "cold" immunosuppressive tumour microenvironment. Oncolytic viruses are a promising tool to convert tumour immunosuppression to immunomodulation and ... ...

    Abstract Cancer cells employ various mechanisms to evade and suppress anti-cancer immune responses generating a "cold" immunosuppressive tumour microenvironment. Oncolytic viruses are a promising tool to convert tumour immunosuppression to immunomodulation and improve the efficacy of cancer treatment. Emerging preclinical and clinical findings confirm that oncolytic viruses act in a multimodal scheme, triggering lyses, immunogenic cell death and finally inducing anti-cancer immune responses. In this paper, we tested the local administration of a novel oncolytic adenovirus AdV-D24-ICOSL-CD40L expressing co-stimulatory molecules ICOSL and CD40L to induce the production of tumour infiltrating lymphocytes to the site of injection. Subsequently, in immunocompetent mouse models, we studied possible correlation between tumour infiltrates and anti-cancer efficacy. Described results showed that the delivery of oncolytic viruses encoding immunomodulatory transgenes in combination with anti-PD1 resulted in synergistic inhibition of both melanoma and mesothelioma tumours. Importantly anti-cancer effect positively correlated with cytotoxic CD8+ tumour-infiltrating lymphocytes exerting a central role in the tumour volume control thus generating beneficial outcomes that will undoubtedly provide new insights into possible future treatment strategies to combat cancer. Altogether our findings highlight the importance of oncolytic vectors able to modulate anti-cancer immune responses that can correlate with efficacy in solid malignancies.
    Language English
    Publishing date 2022-07-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.71992
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  10. Article: Polymer Coated Oncolytic Adenovirus to Selectively Target Hepatocellular Carcinoma Cells.

    Garofalo, Mariangela / Bellato, Federica / Magliocca, Salvatore / Malfanti, Alessio / Kuryk, Lukasz / Rinner, Beate / Negro, Samuele / Salmaso, Stefano / Caliceti, Paolo / Mastrotto, Francesca

    Pharmaceutics

    2021  Volume 13, Issue 7

    Abstract: Despite significant advances in chemotherapy, the overall prognosis of hepatocellular carcinoma (HCC) remains extremely poor. HCC targeting strategies were combined with the tumor cell cytotoxicity of oncolytic viruses (OVs) to develop a more efficient ... ...

    Abstract Despite significant advances in chemotherapy, the overall prognosis of hepatocellular carcinoma (HCC) remains extremely poor. HCC targeting strategies were combined with the tumor cell cytotoxicity of oncolytic viruses (OVs) to develop a more efficient and selective therapeutic system. OVs were coated with a polygalactosyl-
    Language English
    Publishing date 2021-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13070949
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