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Article: Development of nanostructured bioplastic material for wound healing.

Gilmutdinova, Ilmira R / Kostromina, Elena / Yakupova, Regina D / Eremin, Petr S

European journal of translational myology

2021 Volume 31, Issue 1

Abstract: The development of new biomaterials whose characteristics are as close as possible to the properties of living human tissues is one of the most promising areas of regenerative medicine. This work aimed at creating a bioplastic material based on collagen, ...

Abstract	The development of new biomaterials whose characteristics are as close as possible to the properties of living human tissues is one of the most promising areas of regenerative medicine. This work aimed at creating a bioplastic material based on collagen, elastin and hyaluronic acid and studying its structure and properties to assess the prospects for further use in clinical practice. Bioplastic material was obtained by mixing collagen, hyaluronic acid and elastin in predetermined proportions with distilled water. We treated the material with photochemical crosslinking to stabilize biofilm in a liquid medium and form a nanostructured scaffold. A commercial human skin fibroblast cell culture was used to assess the biomaterial cytotoxicity and biocompatibility. The visualization and studies of the biomaterial structure were performed using light and scanning electron microscopy. It has been shown that the obtained biomaterial is characterized by high resilience; it has also a high porosity. The co-culturing of the bioplastic material and human fibroblasts did not reveal any of its cytotoxic effects on cells in culture. It was shown that the biomaterial samples could maintain physical properties in the culture medium for more than 10 days, while the destruction of the matrix was observed 3-4 weeks after the beginning of incubation. Thus, the created biomaterial can be used on damaged skin areas due to its physical properties and structure. The use of the developed biomaterial provides effective conditions for good cell proliferation, which allows us to consider it as a promising wound cover for use in clinical practice.
Language	English
Publishing date	2021-03-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2021.9388
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Article ; Online: Mechanisms of Modulating Action of Low-Intensity Laser Radiation on the Proliferative Activity of Cells in the Stromal and Vascular Fraction of Adipose Tissue

Elena Yu. Kostromina / Petr S. Eremin / Irina S. Kudryashova / Pavel A. Markov / Ilmira R. Gilmutdinova / Tatyana V. Konchugova

Вестник восстановительной медицины, Vol 21, Iss 3, Pp 202-

2023 Volume 211

Abstract: The efficacy of low-intensity laser radiation therapy using autologous cellular products based on adipose tissue, including stromalvascularfraction, has been shown to be effective in different forms of pathology and in reconstructive and plastic surgery. ...

Abstract	The efficacy of low-intensity laser radiation therapy using autologous cellular products based on adipose tissue, including stromalvascularfraction, has been shown to be effective in different forms of pathology and in reconstructive and plastic surgery. Thereview deals with the issues related to the methodological aspects of the stromal and vascular fraction isolation from the humanadipose tissue as well as with the peculiarities of its application in experimental studies on animal models and in clinical practice.The mechanisms of low-intensity laser radiation effect on the cells of stromal-vascular fraction has been discussed. An analysis ofrecently published research results on the effects of laser radiation on mesenchymal stromal cells of adipose tissue is carried out. Theresults of experimental studies on the choice of optimal modes and parameters of low-intensity laser radiation with the aim of theirapplication in complex cell technologies are discussed. The issues related to the therapeutic effects of low-intensity physical factors inautologous transplantation of the stromal-vascular fraction and mesenchymal stromal cells in various types of pathology are viewed.Further research on the mechanisms of low-intensity laser irradiation effects on various types of cells and tissues is required to expandthe clinical application of cell-based therapy.
Keywords	regenerative medicine ; cell technologies ; adipose tissue ; stromal-vascular fraction ; low-intensity laser radiation ; Medicine (General) ; R5-920 ; Sports medicine ; RC1200-1245
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of Probiotics in Treatment and Rehabilitation of Patients after a New Coronavirus Infection

Pavel A. Markov / Irina S. Kudryashova / Petr S. Eremin / Elena Yu. Kostromina / Ilmira R. Gilmutdinova / Andrey P. Rachin

Вестник восстановительной медицины, Vol 21, Iss 3, Pp 24-

2023 Volume 29

Abstract: As of January 2022, 343 million cases of SARS-CoV-2 were reported globally. COVID-19 is a multi-faceted, multi-systemic illness in whichall age groups are susceptible. A number of research findings have shown that COVID-19 is associated with dysbiosis, ... ...

Abstract	As of January 2022, 343 million cases of SARS-CoV-2 were reported globally. COVID-19 is a multi-faceted, multi-systemic illness in whichall age groups are susceptible. A number of research findings have shown that COVID-19 is associated with dysbiosis, leading to thedevelopment of local and systemic pathologies. It was found that the use of probiotics in the complex therapy of patients with COVID-19 reduces the severity of the disease and the development of complications. According to the researchers, several mechanisms couldexplain the therapeutic effect of probiotics, including the ability to suppress pro-inflammatory cytokine formation and modulate thefunctional activity of the immune system. In Russia, probiotics in the treatment of COVID-19 patients are only used to correct diarrhea,while literature suggests that probiotics have much greater therapeutic potential. Introducing oral bacterial therapy into the treatmentand rehabilitation of COVID-19 patients requires further clinical trials.
Keywords	as of january 2022 ; 343 million cases of sars-cov-2 were reported globally. covid-19 is a multi-faceted ; multi-systemic illness in whichall age groups are susceptible. a number of research findings have shown that covid-19 is associated with dysbiosis ; leading to thedevelopment of local and systemic pathologies. it was found that the use of probiotics in the complex therapy of patients with covid-19 reduces the severity of the disease and the development of complications. according to the researchers ; several mechanisms couldexplain the therapeutic effect of probiotics ; including the ability to suppress pro-inflammatory cytokine formation and modulate thefunctional activity of the immune system. in russia ; probiotics in the treatment of covid-19 patients are only used to correct diarrhea ; while literature suggests that probiotics have much greater therapeutic potential. introducing oral bacterial therapy into the treatmentand rehabilitation of covid-19 patients requires further clinical trials ; Medicine (General) ; R5-920 ; Sports medicine ; RC1200-1245
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prospects of plasmapheresis for patients with severe COVID-19.

Gilmutdinova, Ilmira R / Yakovlev, Maksim Yu / Eremin, Petr S / Fesun, Anatoliy D

European journal of translational myology

2020 Volume 30, Issue 3, Page(s) 9165

Abstract: On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus "Coronavirus disease 2019" (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the ... ...

Abstract	On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus "Coronavirus disease 2019" (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the infectious matter "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). Emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as "cytokine storm". These complications comprise acute respiratory distress syndrome (ARDS), respiratory failure and death. Emerging data point to the logic of using extracorporeal haemocorrection to normalise cytokine levels and reduce the severity of organ disorders. The analysis of the literature indicates that to date, a certain positive experience has been accumulated in the world in the application of extracorporeal methods in clinical practice in patients with COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-09-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2020.9165
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Article ; Online: Development of nanostructured bioplastic material for wound healing

Ilmira R. Gilmutdinova / Elena Kostromina / Regina D. Yakupova / Petr S. Eremin

European Journal of Translational Myology (2021)

2021

Abstract	The development of new biomaterials whose characteristics are as close as possible to the properties of living human tissues is one of the most promising areas of regenerative medicine. This work aimed at creating a bioplastic material based on collagen, elastin and hyaluronic acid and studying its structure and properties to assess the prospects for further use in clinical practice. Bioplastic material was obtained by mixing collagen, hyaluronic acid and elastin in predetermined proportions with distilled water. We treated the material with photochemical crosslinking to stabilize biofilm in a liquid medium and form a nanostructured scaffold. A commercial human skin fibroblast cell culture was used to assess the biomaterial cytotoxicity and biocompatibility. The visualization and studies of the biomaterial structure were performed using light and scanning electron microscopy. It has been shown that the obtained biomaterial is characterized by high resilience; it has also a high porosity. The co-culturing of the bioplastic material and human fibroblasts did not reveal any of its cytotoxic effects on cells in culture. It was shown that the biomaterial samples could maintain physical properties in the culture medium for more than 10 days, while the destruction of the matrix was observed 3–4 weeks after the beginning of incubation. Thus, the created biomaterial can be used on damaged skin areas due to its physical properties and structure. The use of the developed biomaterial provides effective conditions for good cell proliferation, which allows us to consider it as a promising wound cover for use in clinical practice.
Keywords	bioplastic material ; cell technology ; tissue engineering ; collagen ; human fibroblasts ; Medicine ; R ; Human anatomy ; QM1-695
Subject code	500
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prospects of plasmapheresis for patients with severe COVID-19

Ilmira R. Gilmutdinova / Maksim Yu. Yakovlev / Petr S. Eremin / Anatoliy D. Fesun

European Journal of Translational Myology (2020)

2020

Abstract: On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus “Coronavirus disease 2019” (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the ... ...

Abstract	On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus “Coronavirus disease 2019” (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the infectious matter “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). Emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as “cytokine storm”. These complications comprise acute respiratory distress syndrome (ARDS), respiratory failure and death. Emerging data point to the logic of using extracorporeal haemocorrection to normalise cytokine levels and reduce the severity of organ disorders. The analysis of the literature indicates that to date, a certain positive experience has been accumulated in the world in the application of extracorporeal methods in clinical practice in patients with COVID-19.
Keywords	plasmapheresis ; extracorporeal haemocorrection ; COVID-19 ; coronavirus ; Medicine ; R ; Human anatomy ; QM1-695 ; covid19
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prospects of plasmapheresis for patients with severe COVID-19

Gilmutdinova, Ilmira R. / Yakovlev, Maksim Yu Eremin Petr S. / Fesun, Anatoliy D.

European Journal of Translational Myology

Abstract: On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus "Coronavirus disease 2019" (COVID-19) On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the ... ...

Abstract	On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus "Coronavirus disease 2019" (COVID-19) On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the infectious matter "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) Emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as "cytokine storm" These complications comprise acute respiratory distress syndrome (ARDS), respiratory failure and death Emerging data point to the logic of using extracorporeal haemocorrection to normalise cytokine levels and reduce the severity of organ disorders The analysis of the literature indicates that to date, a certain positive experience has been accumulated in the world in the application of extracorporeal methods in clinical practice in patients with COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #886241
Database	COVID19

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Article ; Online: Development of Wound Dressing for Regenerative Medicine

Irina S. Kudryashova / Pavel A. Markov / Elena Yu Kostromina / Petr S. Eremin / Andrey P. Rachin / Ilmira R. Gilmutdinova

Вестник восстановительной медицины, Vol 20, Iss 6, Pp 54-

2021 Volume 95

Abstract: The understanding of the pathophysiological mechanisms of the wound process deepened with the development of science. The technological base that was creating has enabled to serve the clinical needs of tissue repair. These factors, combined with the ... ...

Abstract	The understanding of the pathophysiological mechanisms of the wound process deepened with the development of science. The technological base that was creating has enabled to serve the clinical needs of tissue repair. These factors, combined with the growing need for healing of infected and chronic wounds, have led to the expansion of the market for wound dressings materials supplies. In this connection, there is a need to generalize and update information about new types of dressings. This review provides an up-to-date understanding of the wound process: cellular and signaling mechanisms of repair, characteristics of the optimal microclimate of the wound bed, morphofunctional re-arrangements of tissues during the healing process. Based on these data, the requirements for the modern wound dressings are formulated. Existing wound dressings have been classified as interacting with body tissue. The bio-functional characteristics of the synthetic and natural polymers used in the dressing are described, including their effect on regenerative processes. A classification of the active medicinal ingredients used in the manufacture of dressings is given, the characteristics of their use on the background of the pathological wound process are considered.
Keywords	wound dressing ; wound process ; interactive wound dressing ; bioactive wound dressing ; biomaterials ; wound treatment ; Medicine (General) ; R5-920 ; Sports medicine ; RC1200-1245
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Telemedicine platform COVIDREHAB for remote rehabilitation of patients after COVID-19.

Gilmutdinova, Ilmira R / Kolyshenkov, Vasiliy A / Lapickaya, Kristina A / Trepova, Anastasiya S / Vasileva, Valeriia A / Prosvirnin, Andrei N / Marchenkova, Larisa A / Terentev, Kirill V / Yakovlev, Maxim Y / Rachin, Andrey P / Fesyun, Anatoliy D / Reverchuk, Igor V

European journal of translational myology

2021 Volume 31, Issue 2

Abstract: The world's practice has shown the importance of medical rehabilitation, which allows increasing the effectiveness of treatment of patients with COVID-19, and also significantly reduce the risks of developing complications after COVID-19. Moreover, ... ...

Abstract	The world's practice has shown the importance of medical rehabilitation, which allows increasing the effectiveness of treatment of patients with COVID-19, and also significantly reduce the risks of developing complications after COVID-19. Moreover, timely medical rehabilitation reduces the frequency of disability retirement. We developed and investigated the effectiveness of the telemedicine platform "COVIDREHAB" in order to enhance the effectiveness of the recovery period during self-isolation, as well as to provide access to rehabilitation for patients residing in remote areas or unable to undergo in-person medical rehabilitation. This pilot open clinical study includes 178 patients (108 women and 70 men) aged 32 to 82 years [mean age 50 (33-56) years] who had a moderate disease of COVID-19. We used the specialised platform COVIDREHAB for remote monitoring of the rehabilitation efficiency of patients who suffered from COVID-19. During the study, the supervising doctor assigned the patient a set of specialised questionnaires, which were filled in online. The questionnaires distributed to the patient included questions specifically designed for the COVIDREHAB remote platform as well as the mMRC (Modified Medical Research Council) questionnaire. Patients who completed the remote rehabilitation programme were found to have positive dynamics of indicators of the respiratory system functional state, and complaints.Pulmonary rehabilitation is an important part of case management for patients with respiratory diseases and plays an active role in improving lung function and general well-being of patients. Patients who completed the comprehensive medical rehabilitation program using the information and analytical system COVIDREHAB, were found to have positive dynamics of indicators of the respiratory system functional state, and complaints. Hence, at the end of the course the shortness of breath severity decreased (from 34.8% to 12.4%, as well as the feeling of lack of oxygen from 32% to 17.4%, p <0.05). We anticipate the online approach to rehabilitation will improve the functioning of the respiratory and cardiovascular systems, restore physical function, reduce anxiety and depression, and restore quality of life. An essential benefit of this program is the prevention of secondary complications and reduction of serious adverse effects of COVID-19 treatment."
Language	English
Publishing date	2021-05-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2021.9783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Modern Approaches to Diagnostics and Correction of Aging Biomarkers

Ilmira R. Gilmutdinova / orcid:0000-0001-6743-2615 / Elena Yu. Kostromina / Maksim Yu. Yakovlev / Inessa Kh. Yafarova / Rinat G. Gilmutdinov / Irina A. Kaverina / Anton V. Ershov / Andrey N. Isaev / Alexey A. Moskalev

Вестник восстановительной медицины, Vol 20, Iss 6, Pp 96-

2021 Volume 102

Abstract: From the biomedicine point of, view ageing is a natural process, characterized by a gradual decrease in the physiological integrity and adaptive abilities of the body, leading to a violation of its functions and an increase in the risk of death with age. ...

Abstract	From the biomedicine point of, view ageing is a natural process, characterized by a gradual decrease in the physiological integrity and adaptive abilities of the body, leading to a violation of its functions and an increase in the risk of death with age. Demographic aging of the population is a serious socio-economic problem, both in Russia and around the world. The main cellular and molecular signs of aging include genome instability, telomere shortening, epigenetic alterations, impaired proteostasis, impaired nutrient recognition, mitochondrial dysfunction, cellular aging, the stem cell pool depletion and changes in intercellular interaction, extracellular matrix rigidity, as well as activation of retrotransposons and chronic inflammation. For these reasons, in modern healthcare, preventing premature aging and treating age-related diseases is becoming a priority task. This review presents modern approaches to the quantitative assessment of the aging process using aging biomarkers as functional parameters reflecting the biological organism age at the molecular, cellular, and organismal levels. This work also considers the actual non-drug and drug interventions allowing to slow down the development of age-associated pathological processes, allowing you to increase the quality and duration of life.
Keywords	aging biomarkers ; geroprotectors ; cellular aging therapy ; epigenetic cell reprogramming ; hemocorrection ; plasmapheresis ; Medicine (General) ; R5-920 ; Sports medicine ; RC1200-1245
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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