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Article ; Online: Genomic Tests Should be Used to Help Guide Treatment of Prostate Cancer: Yes.

Palapattu, Ganesh S

2017 Volume 198, Issue 2, Page(s) 265–266

MeSH term(s)	Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/urine ; Biopsy ; Clinical Decision-Making/methods ; Genetic Testing/methods ; Humans ; Male ; Practice Guidelines as Topic ; Precision Medicine/methods ; Prostate/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Risk Assessment/methods ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2017-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2017.05.039
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

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Article ; Online: Parsing Multi-omic Data to Understand Urothelial Cell Carcinoma Progression.

Palapattu, Ganesh S

The Journal of urology

2016 Volume 195, Issue 6, Page(s) 1645

MeSH term(s)	Carcinoma, Transitional Cell ; Disease Progression ; Humans ; Urinary Bladder Neoplasms
Language	English
Publishing date	2016
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2016.02.2965
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Commentary on "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer." Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, Chen Y, Mohammad TA, Chen Y, Fedor HL, Lotan TL, Zheng Q, De Marzo AM, Isaacs JT, Isaacs WB, Nadal R, Paller CJ, Denmeade SR, Carducci MA, Eisenberger MA, Luo J, Division of Urologic Oncology, Department of Urology, University of Michigan, MI. N Engl J Med 2014; 371(11):1028-38.

Palapattu, Ganesh S

Urologic oncology

2016 Volume 34, Issue 11, Page(s) 520

MeSH term(s)	Androstenes ; Humans ; Male ; Phenylthiohydantoin/analogs & derivatives ; Prostatic Neoplasms ; Urology
Chemical Substances	Androstenes ; Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; abiraterone (G819A456D0)
Language	English
Publishing date	2016-03-07
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2015.12.011
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Zs.A 4817: Show issues

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Article ; Online: Michigan Urology Academy-Our Role in Diversifying the Urology Workforce.

Zebib, Laura / Irani, Sarosh / Salami, Simpa S / Kraft, Kate / Palapattu, Ganesh / Goh, Keow Mei

Urology

2023 Volume 181, Page(s) 18–23

Abstract: Objective: To evaluate the value/utility of developing an online mentorship program for underrepresented in medicine (URiM) students interested in urology. The Michigan Urology Academy (MUA) was launched in 2020 to increase exposure and provide ... ...

Abstract	Objective: To evaluate the value/utility of developing an online mentorship program for underrepresented in medicine (URiM) students interested in urology. The Michigan Urology Academy (MUA) was launched in 2020 to increase exposure and provide mentorship to URiM students interested in urology, in an effort to address the continued low numbers of Black and LatinX urologists in the workforce. Methods: The 2-day virtual mentorship program was launched in June 2020 and held annually thereafter. Demographic information was collected, and surveys were distributed at 1week and 3months after the events. Surveys assessed participants' perception of the utility and effectiveness of the sessions. Thematic analysis was performed on qualitative data. Fourth-year med students were followed longitudinally to determine urology match results. Results: Over the last 3years, MUA hosted 208 students from 104 medical schools. Participants self-identified as 42.3% (n = 88) identified as African American/Black, 14.9% (n = 31) Hispanic/LatinX, 12.98% (n = 27) white, 18.75% (n = 39) as Asian/Indian 7.7% (n = 16) as Middle Eastern/North African, and 0.48% Native Hawaiian/Pacific Islander (n = 1). Overall, fourth-year MUA participants matched at a higher rate than the national average (80.2% vs 71.4%; P = .0486). Narrative feedback revealed five themes: (1) the importance of community support within urology, (2) the utility of vulnerability and storytelling, (3) the importance of representation of diverse backgrounds, (4) the desire for in-person mentorship opportunities, and (5) the need for transparency in application logistics. Conclusion: Mentorship programs such as MUA allow URiM students to have greater exposure to the field of urology and to networking opportunities.
MeSH term(s)	Humans ; Michigan ; Students, Medical ; Urology/education ; Workforce ; Mentoring ; Diversity, Equity, Inclusion
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2023.07.031
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: Analyzing the Current State and Visibility of Diversity, Equity, and Inclusion Initiatives at Urology Residency Programs.

Irani, Sarosh / Zebib, Laura / Simons, Efe Chantal Ghanney / Andino, Juan J / Palapattu, Ganesh / Goh, Keow Mei

Urology

2024

Abstract: Objective: To analyze AUA urology residency program websites to determine visibility of diversity, equity, and inclusion (DEI) initiatives. There is growing interest in DEI initiatives by urology applicants, and in recent years, urology programs have ... ...

Abstract	Objective: To analyze AUA urology residency program websites to determine visibility of diversity, equity, and inclusion (DEI) initiatives. There is growing interest in DEI initiatives by urology applicants, and in recent years, urology programs have invested in efforts to promote DEI. Methods: All ACGME-accredited urology residency program with a website were assessed. Military programs were excluded. A DEI Score Card was developed using published pillars of DEI, including five domains: departmental inclusion, pipeline growth, departmental education, community engagement, and faculty demographics. Program Doximity rank, address, and surrounding demographics were collected to determine predictors of investing in DEI. Results: One hundred forty-one urology residency websites were included for analysis. Only 40.7% of programs referenced DEI on their webpage, and 21.4% offered funded mentorship opportunities. Department education and community engagement were the least popular initiatives. The Western, Northeastern, and North Central sections had the highest DEI total score with wide variation across domains. Mention of DEI was not associated with program's county-level social vulnerability or percent minority but was associated with being a top 50 program (OR=4.0; 95% CI 1.8, 8.9; P = .0007). Conclusion: Less than half of academic urology programs' websites referenced DEI initiatives. Using a DEI score card, our study shows that investment in DEI varies widely by AUA section, and greater investment is positively correlated with program rank. Our DEI score card serves as a tool that programs can use to assess their current DEI investment, identify areas for improvement, and ensure existing initiatives are visible to applicants.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2024.03.013
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Spatial Heterogeneity of Glomerular Phenotypes Affects Kidney Biopsy Findings.

Schaub, Jennifer A / O'Connor, Christopher L / Dailey, Meghan / Hlynka, Andrew W / Chang, Yurui / Postiff, Deborah / Kaffenberger, Samuel D / Palapattu, Ganesh S / Gillespie, Brenda W / Hodgin, Jeffrey B / Shedden, Kerby / Bitzer, Markus

Kidney360

2023 Volume 4, Issue 11, Page(s) 1598–1607

MeSH term(s)	Humans ; Kidney ; Kidney Glomerulus/pathology ; Kidney Diseases/diagnosis ; Nephrectomy ; Biopsy
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000283
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Article: Analysis of the Tumor Immune Microenvironment (TIME) in Clear Cell Renal Cell Carcinoma (ccRCC) Reveals an M0 Macrophage-Enriched Subtype: An Exploration of Prognostic and Biological Characteristics of This Immune Phenotype.

Farha, Mark / Nallandhighal, Srinivas / Vince, Randy / Cotta, Brittney / Stangl-Kremser, Judith / Triner, Daniel / Morgan, Todd M / Palapattu, Ganesh S / Cieslik, Marcin / Vaishampayan, Ulka / Udager, Aaron M / Salami, Simpa S

Cancers

2023 Volume 15, Issue 23

Abstract: There is a need to optimize the treatment of clear cell renal cell carcinoma (ccRCC) patients at high recurrence risk after nephrectomy. We sought to elucidate the tumor immune microenvironment (TIME) of localized ccRCC and understand the prognostic and ... ...

Abstract	There is a need to optimize the treatment of clear cell renal cell carcinoma (ccRCC) patients at high recurrence risk after nephrectomy. We sought to elucidate the tumor immune microenvironment (TIME) of localized ccRCC and understand the prognostic and predictive characteristics of certain features. The discovery cohort was clinically localized patients in the TCGA-Kidney Renal Clear Cell Carcinoma (KIRC) project (
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15235530
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Article ; Online: Current Landscape of Genomic Biomarkers in Clear Cell Renal Cell Carcinoma.

Cotta, Brittney H / Choueiri, Toni K / Cieslik, Marcin / Ghatalia, Pooja / Mehra, Rohit / Morgan, Todd M / Palapattu, Ganesh S / Shuch, Brian / Vaishampayan, Ulka / Van Allen, Eliezer / Ari Hakimi, A / Salami, Simpa S

European urology

2023 Volume 84, Issue 2, Page(s) 166–175

Abstract: Context: Dramatic gains in our understanding of the molecular biology of clear cell renal cell carcinoma (ccRCC) have created a foundation for clinical translation to improve patient care.: Objective: To review and contextualize clinically impactful ... ...

Abstract	Context: Dramatic gains in our understanding of the molecular biology of clear cell renal cell carcinoma (ccRCC) have created a foundation for clinical translation to improve patient care. Objective: To review and contextualize clinically impactful data surrounding genomic biomarkers in ccRCC. Evidence acquisition: A systematic literature search was conducted focusing on genomic-based biomarkers with an emphasis on studies assessing clinical outcomes. Evidence synthesis: The advancement of tumor sequencing techniques has led to a rapid increase in the knowledge of the molecular underpinnings of ccRCC and with that the discovery of multiple candidate genomic biomarkers. These include somatic gene mutations such as VHL, PBRM1, SETD2, and BAP1; copy number variations; transcriptomic multigene signatures; and specific immune cell populations. Many of these biomarkers have been assessed for their association with survival and a smaller number as potential predictors of a response to systemic therapy. In this scoping review, we discuss many of these biomarkers in detail. Further studies are needed to continue to refine and validate these molecular tools for risk stratification, with the ultimate goal of improving clinical decision-making and patient outcomes. Conclusions: While no tissue or blood-based biomarkers for ccRCC have been incorporated into routine clinical practice to date, the field continues to expand rapidly. There remains a critical need to develop and validate these tools in order to improve the care for patients with kidney cancer. Patient summary: Genomic biomarkers have the potential to better predict outcome and select the most appropriate treatment for patients with kidney cancer; however, further research is needed before any of these currently developed biomarkers are adopted into clinical practice.
MeSH term(s)	Humans ; Biomarkers, Tumor/genetics ; Carcinoma, Renal Cell/drug therapy ; DNA Copy Number Variations ; Genomics ; Kidney Neoplasms/pathology ; Mutation
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2023.04.003
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations.

Rajwa, Pawel / Quhal, Fahad / Pradere, Benjamin / Gandaglia, Giorgio / Ploussard, Guillaume / Leapman, Michael S / Gore, John L / Paradysz, Andrzej / Tilki, Derya / Merseburger, Axel S / Morgan, Todd M / Briganti, Alberto / Palapattu, Ganesh S / Shariat, Shahrokh F

Nature reviews. Urology

2023 Volume 20, Issue 4, Page(s) 205–216

Abstract: Mutations in the BRCA1 and BRCA2 tumour suppressor genes are associated with prostate cancer risk; however, optimal screening protocols for individuals with these mutations have been a subject of debate. Several prospective studies of prostate cancer ... ...

Abstract	Mutations in the BRCA1 and BRCA2 tumour suppressor genes are associated with prostate cancer risk; however, optimal screening protocols for individuals with these mutations have been a subject of debate. Several prospective studies of prostate cancer incidence and screening among BRCA1/2 mutation carriers have indicated at least a twofold to fourfold increase in prostate cancer risk among carriers of BRCA2 mutations compared with the general population. Moreover, BRCA2 mutations are associated with more aggressive, high-grade disease characteristics at diagnosis, more aggressive clinical behaviour and greater prostate cancer-specific mortality. The risk for BRCA1 mutations seems to be attenuated compared with BRCA2. Prostate-specific antigen (PSA) measurement or prostate magnetic resonance imaging (MRI) alone is an imperfect indicator of clinically significant prostate cancer; therefore, BRCA1/2 mutation carriers might benefit from refined risk stratification strategies. However, the long-term impact of prostate cancer screening is unknown, and the optimal management of BRCA1/2 carriers with prostate cancer has not been defined. Whether timely localized therapy can improve overall survival in the screened population is uncertain. Long-term results of prospective studies are awaited to confirm the optimal screening strategies and benefits of prostate cancer screening among BRCA1/2 mutation carriers, and whether these approaches ultimately have a positive impact on survival and quality of life in these patients.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy ; Prostate-Specific Antigen/genetics ; Early Detection of Cancer/methods ; Prospective Studies ; Quality of Life ; Genes, BRCA1 ; BRCA2 Protein/genetics ; Mutation ; Germ Cells/pathology ; Genetic Predisposition to Disease ; BRCA1 Protein/genetics
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77) ; BRCA2 Protein ; BRCA1 protein, human ; BRCA1 Protein
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-022-00680-4
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Zs.A 6030: Show issues

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Article ; Online: Comparing Patient-reported Functional Outcomes After Radical Prostatectomy in Historical and Contemporary Practice.

Singhal, Udit / Hollenbeck, Brent K / Kaffenberger, Samuel D / Salami, Simpa S / George, Arvin K / Skolarus, Ted A / Montgomery, Jeffrey S / Wittmann, Daniela A / Miller, David C / Wei, John T / Palapattu, Ganesh S / Montie, James E / Dunn, Rodney L / Morgan, Todd M

The Journal of urology

2023 Volume 210, Issue 5, Page(s) 771–777

Abstract: Purpose: Modifications to surgical technique, particularly the widespread adoption of robotic surgery, have been proposed to improve functional recovery after prostate cancer surgery. However, rigorous comparison of men in historical vs contemporary ... ...

Abstract	Purpose: Modifications to surgical technique, particularly the widespread adoption of robotic surgery, have been proposed to improve functional recovery after prostate cancer surgery. However, rigorous comparison of men in historical vs contemporary practice to evaluate the cumulative effect of these changes on urinary and sexual function after radical prostatectomy is lacking. Materials and methods: We compared prospectively collected patient-reported urinary and sexual function from historical (PROSTQA [Prostate Cancer Outcomes and Satisfaction With Treatment Quality Assessment study], n=235) and contemporary (MUSIC-PRO [Michigan Urological Surgery Improvement Collaborative Patient Reported Outcome] registry, n=1,215) cohorts at the University of Michigan to understand whether modern techniques have resulted in functional improvements for men undergoing prostate cancer surgery. Results: We found significant differences in baseline function, with better urinary (median [IQR]; 100 [93.8-100] vs 93.8 [85.5-100], Conclusions: Our results demonstrate that the widespread alterations in prostate cancer surgery over the past 2 decades have yielded improvements in sexual, but not urinary, function recovery.
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000003646
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