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Article ; Online: Patella related problems as common reason for revision of NexGen PS® total knee arthroplasty without patella resurfacing: An analysis of 5911 primary total knee arthroplasties registered in the Dutch Arthroplasty Register.

Huitema, Gerian C / de Vries, Lieke M A / Verboom, Tom W / Spekenbrink-Spooren, Anneke / Steens, Jeroen

2022 Volume 34, Page(s) 217–222

Abstract: Background: Patella resurfacing remains controversial in primary total knee arthroplasty (TKA).The aim of this study was to investigate if there was a difference in revision rate and reason for revision within 8 years after single brand primary cemented ...

Abstract	Background: Patella resurfacing remains controversial in primary total knee arthroplasty (TKA).The aim of this study was to investigate if there was a difference in revision rate and reason for revision within 8 years after single brand primary cemented TKA with or without patella resurfacing, using data from the Dutch Arthroplasty Register. Methods: All primary TKA surgeries with a posterior stabilized cemented primary NexGen®, between 2010 and 2013 with diagnosis osteoarthritis were analyzed (n = 5911). Multivariate cox regression analyses were performed to analyze differences in revision rate between TKA with or without patella component, and was adjusted for age and previous surgery. Results: Of 5911 TKA surgeries, 4795 were performed without patella resurfacing (81.1%) and 1116 with patella resurfacing (18.9%). There was a significant difference in patellar problems as reason for revision between patients after primary TKA with patella resurfacing (9.3%) and without patella resurfacing (29.9%) (p = 0.01). This was mostly caused by patellar pain (28.0%). There was no significant difference in cumulative revision rate within between TKA with patella resurfacing and without patella resurfacing. Conclusion: In conclusion, 30% of patients who need revision surgery after TKA using NexGen® PS without patella resurfacing the reason for revision is patella related problems, compared to 9% after TKA NexGen® PS with patella resurfacing. There was no difference in cumulative incidence of revision after primary surgery of all TKA's using NexGen® PS with or without patella. To reduce the probability of reoperation for patella related problems, our data suggest the patella should be resurface during primary TKA.
MeSH term(s)	Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Knee Prosthesis/adverse effects ; Osteoarthritis, Knee/surgery ; Patella/surgery ; Registries ; Reoperation ; Treatment Outcome
Language	English
Publishing date	2022-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2021.12.008
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Article: Prosthesis retention after an infected hip prosthesis: hip fractures versus primary total hip prosthesis, data from 1998 - 2015.

de Vries, Lieke M A / Neve, William C / Steens, Jeroen

Journal of bone and joint infection

2018 Volume 3, Issue 3, Page(s) 118–122

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2018-06-10
Publishing country	Germany
Document type	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.7150/jbji.23952
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Article ; Online: Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment.

Gorris, Mark A J / Martynova, Evgenia / Sweep, Mark W D / van der Hoorn, Iris A E / Sultan, Shabaz / Claassens, Mike J D E / van der Woude, Lieke L / Verrijp, Kiek / Figdor, Carl G / Textor, Johannes / de Vries, I Jolanda M

Journal of visualized experiments : JoVE

2023 , Issue 198

Abstract: The immune cell landscape of the tumor microenvironment potentially contains information for the discovery of prognostic and predictive biomarkers. Multiplex immunohistochemistry is a valuable tool to visualize and identify different types of immune ... ...

Abstract	The immune cell landscape of the tumor microenvironment potentially contains information for the discovery of prognostic and predictive biomarkers. Multiplex immunohistochemistry is a valuable tool to visualize and identify different types of immune cells in tumor tissues while retaining its spatial information. Here we provide detailed protocols to analyze lymphocyte, myeloid, and dendritic cell populations in tissue sections. Starting from cutting formalin-fixed paraffin-embedded sections, automatic multiplex staining procedures on an automated platform, scanning of the slides on a multispectral imaging microscope, to the analysis of images using an in-house-developed machine learning algorithm ImmuNet. These protocols can be applied to a variety of tumor specimens by simply switching tumor markers to analyze immune cells in different compartments of the sample (tumor versus invasive margin) and apply nearest-neighbor analysis. This analysis is not limited to tumor samples but can also be applied to other (non-)pathogenic tissues. Improvements to the equipment and workflow over the past few years have significantly shortened throughput times, which facilitates the future application of this procedure in the diagnostic setting.
MeSH term(s)	Tumor Microenvironment ; Algorithms ; Biomarkers, Tumor ; Cluster Analysis ; Histological Techniques
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/65717
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Article ; Online: Infectie van een heupprothese na 'dry needling'.

Steentjes, Koen / de Vries, Lieke M A / Ridwan, Ben U / Wijgman, A J Jurgen

Nederlands tijdschrift voor geneeskunde

2016 Volume 160, Page(s) A9364

Abstract: A 57-year-old patient presented to the orthopaedic department with hip pain 7 months after hip replacement and two weeks after dry needling by a physiotherapist. Dry needling is used by physiotherapists to treat pain and stiffness. In the Netherlands, ... ...

Title translation	Infection of a hip prosthesis after dry needling.
Abstract	A 57-year-old patient presented to the orthopaedic department with hip pain 7 months after hip replacement and two weeks after dry needling by a physiotherapist. Dry needling is used by physiotherapists to treat pain and stiffness. In the Netherlands, there are no clear guidelines or contra-indications described for this treatment. The surgical scar of our patient showed signs of inflammation for which debridement and irrigation were performed. Tissue samples showed positive bacterial cultures and the patient was treated with antibiotics. One week after completing this treatment, the infection returned. Debridement and irrigation were repeated and antibiotic treatment was recommenced. Three months later, the patient showed no signs of infection with the prosthesis still in situ. Although there is no strong evidence for a causal relationship between dry needling and the infection, dry needling should be used carefully in patients with a joint replacement, due to the increased risk of infection.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Hip/adverse effects ; Debridement ; Hip Prosthesis/microbiology ; Humans ; Male ; Middle Aged ; Netherlands ; Physical Therapy Modalities/adverse effects ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/therapy ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	Dutch
Publishing date	2016
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: CSTB null mutation associated with microcephaly, early developmental delay, and severe dyskinesia.

Mancini, Grazia M S / Schot, Rachel / de Wit, Marie Claire Y / de Coo, René F / Oostenbrink, Rianne / Bindels-de Heus, Karen / Berger, Lieke P V / Lequin, Maarten H / de Vries, Femke A T / Wilke, Martina / van Slegtenhorst, Marjon A

Neurology

2016 Volume 86, Issue 9, Page(s) 877–878

MeSH term(s)	Child, Preschool ; Comorbidity ; Cystatin B/genetics ; Developmental Disabilities/diagnosis ; Developmental Disabilities/genetics ; Dyskinesias/diagnosis ; Dyskinesias/genetics ; Genetic Association Studies ; Genetic Markers/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Incidence ; Infant ; Male ; Microcephaly/diagnosis ; Microcephaly/genetics ; Mutation/genetics ; Polymorphism, Single Nucleotide/genetics ; Risk Assessment
Chemical Substances	CSTB protein, human ; Genetic Markers ; Cystatin B (88844-95-5)
Language	English
Publishing date	2016-03-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000002422
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Article ; Online: Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial.

Cancer immunology, immunotherapy : CII

2020 Volume 69, Issue 3, Page(s) 477–488

Abstract: Background: Autologous dendritic cell (DC) vaccines can induce tumor-specific T cells, but their effect can be counteracted by immunosuppressive mechanisms. Cisplatin has shown immunomodulatory effects in vivo which may enhance efficacy of DC ... ...

Abstract	Background: Autologous dendritic cell (DC) vaccines can induce tumor-specific T cells, but their effect can be counteracted by immunosuppressive mechanisms. Cisplatin has shown immunomodulatory effects in vivo which may enhance efficacy of DC vaccination. Methods: This is a prospective, randomized, open-label phase 2 study (NCT02285413) including stage III and IV melanoma patients receiving 3 biweekly vaccinations of gp100 and tyrosinase mRNA-loaded monocyte-derived DCs with or without cisplatin. Primary objectives were to study immunogenicity and feasibility, and secondary objectives were to assess toxicity and survival. Results: Twenty-two stage III and 32 stage IV melanoma patients were analyzed. Antigen-specific CD8 Conclusions: Combination of DC vaccination and cisplatin in melanoma patients is feasible and safe, but does not seem to result in more tumor-specific T cell responses or improved clinical outcome, when compared to DC vaccination monotherapy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cancer Vaccines/pharmacology ; Cancer Vaccines/therapeutic use ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Dendritic Cells/immunology ; Female ; Humans ; Male ; Melanoma/drug therapy ; Melanoma/pathology ; Middle Aged ; Monocytes/immunology ; Neoplasm Staging ; Prospective Studies ; Vaccination ; Young Adult
Chemical Substances	Cancer Vaccines ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2020-01-24
Publishing country	Germany
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-019-02466-x
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Article ; Online: The predictive value of radiostereometric analysis for stem survival in total hip arthroplasty. A systematic review.

de Vries, Lieke M A / van der Weegen, Walter / Pilot, Peter / Stolarczyk, Piotr A / Sijbesma, Thea / Hoffman, Erik L

Hip international : the journal of clinical and experimental research on hip pathology and therapy

2014 Volume 24, Issue 3, Page(s) 215–222

Abstract: Background: The high precision of radiostereometric analysis (RSA) has enabled us to predict long-term implant survival with a small sample of patients followed for a relatively short period of time. The purpose of our systematic review was to validate ... ...

Abstract	Background: The high precision of radiostereometric analysis (RSA) has enabled us to predict long-term implant survival with a small sample of patients followed for a relatively short period of time. The purpose of our systematic review was to validate the predictive value of two-year RSA results on long-term survival of different types of primary total hip arthroplasty stems. Methods: We systematically reviewed literature to determine the maximum total point motion (MTPM), distal migration and rotation of stem designs and correlated these values to survival rates for aseptic loosening of these specific stems in arthroplasty registries. Results: We included 32 studies describing migration of 15 different stem designs. The mean MTPM for straight polished cemented stems was 1.35 mm, for other cemented stems 0.83 mm and for other uncemented stems 1.50 mm. No data were available for the uncemented collared stem. Mean distal migration for straight polished cemented stems was 1.24 mm, for other cemented stems 0.26 mm, the uncemented collared stem 0.40 mm and for other uncemented stems 0.66 mm. Internal rotation was presented for 13 stems and all stems rotated into retroversion. All stems showed 10-year survival rates of >97% corrected for aseptic loosening. Discussion: Reporting RSA results in a universal way including interpretation of outliers could improve the predictive value of RSA, allowing this technique to be an important tool during the phased introduction of new implant designs. However, a quality assessment of the data by an experienced reviewer is essential.
MeSH term(s)	Arthroplasty, Replacement, Hip ; Equipment Failure Analysis ; Hip Prosthesis ; Humans ; Prosthesis Design ; Prosthesis Failure ; Radiostereometric Analysis
Language	English
Publishing date	2014-05
Publishing country	Italy
Document type	Journal Article ; Review ; Validation Studies
ZDB-ID	1162513-2
ISSN	1724-6067 ; 1120-7000
ISSN (online)	1724-6067
ISSN	1120-7000
DOI	10.5301/hipint.5000102
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Article ; Online: Dealing with Moral Challenges in Treatment of Transgender Children and Adolescents: Evaluating the Role of Moral Case Deliberation.

Vrouenraets, Lieke Josephina Jeanne Johanna / Hartman, Laura A / Hein, Irma M / de Vries, Annelou L C / de Vries, Martine C / Molewijk, Bert A C

Archives of sexual behavior

2020 Volume 49, Issue 7, Page(s) 2619–2634

Abstract: Treatment teams providing affirmative medical transgender care to young people frequently face moral challenges arising from the care they provide. An adolescent's capacity to consent, for example, could raise several issues and challenges. To deal with ... ...

Abstract	Treatment teams providing affirmative medical transgender care to young people frequently face moral challenges arising from the care they provide. An adolescent's capacity to consent, for example, could raise several issues and challenges. To deal with these challenges more effectively, several Dutch treatment teams started using a relatively well-established form of clinical ethics support (CES) called Moral Case Deliberation (MCD). MCD is a facilitator-led, collective moral inquiry based on a real case. This study's purpose is to describe the teams' perceived value and effectiveness of MCD. We conducted a mixed methods evaluation study using MCD session reports, individual interviews, focus groups, and MCD evaluation questionnaires. Our results show that Dutch transgender care providers rated MCD as highly valuable in situations where participants were confronted with moral challenges. The health care providers reported that MCD increased mutual understanding and open communication among team members and strengthened their ability to make decisions and take action when managing ethically difficult circumstances. However, the health care providers also expressed criticisms of MCD: some felt that the amount of time spent discussing individual cases was excessive, that MCD should lead to more practical and concrete results, and that MCD needed better integration and follow-up in the regular work process. We recommend future research on three matters: studying how MCD contributes to the quality of care, involvement of transgender people themselves in MCD, and integration of CES into daily work processes.
MeSH term(s)	Adolescent ; Child ; Ethics Consultation/standards ; Female ; Humans ; Male ; Morals ; Surveys and Questionnaires ; Transgender Persons/psychology
Language	English
Publishing date	2020-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-020-01762-3
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Article ; Online: Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study.

Leerink, Jan M / Feijen, E Lieke A M / van der Pal, Helena J H / Kok, Wouter E M / Mavinkurve-Groothuis, Annelies M C / Kapusta, Livia / Pinto, Yigal M / Maas, Angela H E M / Bellersen, Louise / Teske, Arco J / Ronckers, Cécile M / Louwerens, Marloes / van Dalen, Elvira C / van Dulmen-den Broeder, Eline / Batenburg, Lilian / van der Heiden-van der Loo, Margriet / van den Heuvel-Eibrink, Marry M / van Leeuwen, Flora E / de Vries, Andrica C H /

Weijers, Gert / de Korte, Chris L / Loonen, Jacqueline J / Neggers, Sebastian J C M M / Versluys, A B Birgitta / Tissing, Wim J E / Kremer, Leontien C M

American heart journal

2019 Volume 219, Page(s) 89–98

Abstract: Background: Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers ... ...

Abstract	Background: Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. Objective: To describe the methodology of the Dutch LATER cardiology study (LATER CARD). Methods: The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. Conclusions: The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
MeSH term(s)	Adolescent ; Apoptosis ; Biomarkers/blood ; Cancer Survivors ; Child ; Child, Preschool ; Cross-Sectional Studies ; Early Diagnosis ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases/blood ; Heart Diseases/diagnosis ; Heart Failure ; Humans ; Infant ; Infant, Newborn ; Inflammation ; Male ; Myocytes, Cardiac/physiology ; Neoplasms/therapy ; Netherlands ; Oxidative Stress ; Risk Factors ; Ventricular Dysfunction, Left/blood ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Remodeling
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2019.10.010
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Article: Adventitial adaptive immune cells are associated with ascending aortic dilatation in patients with a bicuspid aortic valve.

Staal, Alexander H J / Cortenbach, Kimberley R G / Gorris, Mark A J / van der Woude, Lieke L / Srinivas, Mangala / Heijmen, Robin H / Geuzebroek, Guillaume S C / Grewal, Nimrat / Hebeda, Konnie M / de Vries, I Jolanda M / DeRuiter, Marco C / van Kimmenade, Roland R J

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1127685

Abstract: Background: Bicuspid aortic valve (BAV) is associated with ascending aorta aneurysms and dissections. Presently, genetic factors and pathological flow patterns are considered responsible for aneurysm formation in BAV while the exact role of inflammatory ...

Abstract	Background: Bicuspid aortic valve (BAV) is associated with ascending aorta aneurysms and dissections. Presently, genetic factors and pathological flow patterns are considered responsible for aneurysm formation in BAV while the exact role of inflammatory processes remains unknown. Methods: In order to objectify inflammation, we employ a highly sensitive, quantitative immunohistochemistry approach. Whole slides of dissected, dilated and non-dilated ascending aortas from BAV patients were quantitatively analyzed. Results: Dilated aortas show a 4-fold increase of lymphocytes and a 25-fold increase in B lymphocytes in the adventitia compared to non-dilated aortas. Tertiary lymphoid structures with B cell follicles and helper T cell expansion were identified in dilated and dissected aortas. Dilated aortas were associated with an increase in M1-like macrophages in the aorta media, in contrast the number of M2-like macrophages did not change significantly. Conclusion: This study finds unexpected large numbers of immune cells in dilating aortas of BAV patients. These findings raise the question whether immune cells in BAV aortopathy are innocent bystanders or contribute to the deterioration of the aortic wall.
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1127685
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