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  1. Article: Babesia, Theileria, Plasmodium and Hemoglobin.

    Sojka, Daniel / Jalovecká, Marie / Perner, Jan

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: The Propagation ... ...

    Abstract The Propagation of
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081651
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  2. Article: Babesia, Theileria, Plasmodium and Hemoglobin

    Sojka, Daniel / Jalovecká, Marie / Perner, Jan

    Microorganisms. 2022 Aug. 15, v. 10, no. 8

    2022  

    Abstract: The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages relies on the mediated acquisition of nutrients available within the host’s red blood cell (RBC). The cellular processes of uptake, trafficking and metabolic processing ...

    Abstract The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages relies on the mediated acquisition of nutrients available within the host’s red blood cell (RBC). The cellular processes of uptake, trafficking and metabolic processing of host RBC proteins are thus crucial for the intraerythrocytic development of these parasites. In contrast to malarial Plasmodia, the molecular mechanisms of uptake and processing of the major RBC cytoplasmic protein hemoglobin remain widely unexplored in intraerythrocytic Babesia/Theileria species. In the paper, we thus provide an updated comparison of the intraerythrocytic stage feeding mechanisms of these two distantly related groups of parasitic Apicomplexa. As the associated metabolic pathways including proteolytic degradation and networks facilitating heme homeostasis represent attractive targets for diverse antimalarials, and alterations in these pathways underpin several mechanisms of malaria drug resistance, our ambition is to highlight some fundamental differences resulting in different implications for parasite management with the potential for novel interventions against Babesia/Theileria infections.
    Keywords Babesia ; Plasmodium ; Theileria ; antimalarials ; drug resistance ; erythrocytes ; heme ; hemoglobin ; homeostasis ; malaria ; parasites ; proteolysis ; vertebrates
    Language English
    Dates of publication 2022-0815
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081651
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Degrade to survive: the intricate world of piroplasmid proteases.

    Florin-Christensen, Monica / Sojka, Daniel / Ganzinelli, Sabrina / Šnebergerová, Pavla / Suarez, Carlos E / Schnittger, Leonhard

    Trends in parasitology

    2023  Volume 39, Issue 7, Page(s) 532–546

    Abstract: Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous ... ...

    Abstract Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.
    MeSH term(s) Animals ; Humans ; Peptide Hydrolases ; Babesia/genetics ; Piroplasmida ; Theileria ; Ticks/parasitology ; Babesiosis/parasitology
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.04.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
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    Zs.MO 251: Show issues

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  4. Article ; Online: Protease Inhibition-An Established Strategy to Combat Infectious Diseases.

    Sojka, Daniel / Šnebergerová, Pavla / Robbertse, Luïse

    International journal of molecular sciences

    2021  Volume 22, Issue 11

    Abstract: Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. ...

    Abstract Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. Among them are the three recently validated proteolytic targets: proteasomes of the malarial parasite
    MeSH term(s) Aspartic Acid Endopeptidases/metabolism ; COVID-19/enzymology ; COVID-19/metabolism ; Drug Development/methods ; Humans ; Malaria/drug therapy ; Malaria/enzymology ; Malaria/metabolism ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/pathogenicity ; Protease Inhibitors/pharmacology ; Proteasome Endopeptidase Complex/drug effects ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; COVID-19 Drug Treatment
    Chemical Substances Protease Inhibitors ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; plasmepsin (EC 3.4.23.38) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22115762
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  5. Article: Plasmepsin-like Aspartyl Proteases in

    Šnebergerová, Pavla / Bartošová-Sojková, Pavla / Jalovecká, Marie / Sojka, Daniel

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: Apicomplexan genomes encode multiple pepsin-family aspartyl proteases (APs) that phylogenetically cluster to six independent clades (A to F). Such diversification has been powered by the function-driven evolution of the ancestral apicomplexan AP gene and ...

    Abstract Apicomplexan genomes encode multiple pepsin-family aspartyl proteases (APs) that phylogenetically cluster to six independent clades (A to F). Such diversification has been powered by the function-driven evolution of the ancestral apicomplexan AP gene and is associated with the adaptation of various apicomplexan species to different strategies of host infection and transmission through various invertebrate vectors. To estimate the potential roles of
    Language English
    Publishing date 2021-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10101241
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  6. Article ; Online: Establishment of a stable transfection and gene targeting system in

    Cubillos, Eliana F G / Snebergerova, Pavla / Borsodi, Sarka / Reichensdorferova, Dominika / Levytska, Viktoriya / Asada, Masahito / Sojka, Daniel / Jalovecka, Marie

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1278041

    Abstract: ... Babesia ... ...

    Abstract Babesia divergens
    MeSH term(s) Humans ; Babesia/genetics ; Babesiosis/parasitology ; Transfection ; Gene Targeting ; Erythrocytes/parasitology
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1278041
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  7. Article ; Online: Protease Inhibition—An Established Strategy to Combat Infectious Diseases

    Daniel Sojka / Pavla Šnebergerová / Luïse Robbertse

    International Journal of Molecular Sciences, Vol 22, Iss 5762, p

    2021  Volume 5762

    Abstract: Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. ...

    Abstract Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. Among them are the three recently validated proteolytic targets: proteasomes of the malarial parasite Plasmodium falciparum, aspartyl proteases of P. falciparum (plasmepsins) and the Sars-CoV-2 viral proteases. Despite some unfulfilled expectations over previous decades, the three reviewed targets clearly demonstrate that selective protease inhibitors provide effective therapeutic solutions for the two most impacting infectious diseases nowadays—malaria and COVID-19.
    Keywords protease ; parasites ; inhibition ; therapy ; infectious diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome.

    Kozelková, Tereza / Dyčka, Filip / Lu, Stephen / Urbanová, Veronika / Frantová, Helena / Sojka, Daniel / Šíma, Radek / Horn, Martin / Perner, Jan / Kopáček, Petr

    Molecular & cellular proteomics : MCP

    2023  Volume 22, Issue 11, Page(s) 100663

    Abstract: Ticks are ectoparasites that feed on blood and have an impressive ability to consume and process enormous amounts of host blood, allowing extremely long periods of starvation between blood meals. The central role in the parasitic lifestyle of ticks is ... ...

    Abstract Ticks are ectoparasites that feed on blood and have an impressive ability to consume and process enormous amounts of host blood, allowing extremely long periods of starvation between blood meals. The central role in the parasitic lifestyle of ticks is played by the midgut. This organ efficiently stores and digests ingested blood and serves as the primary interface for the transmission of tick-borne pathogens. In this study, we used a label-free quantitative approach to perform a novel dynamic proteomic analysis of the midgut of Ixodesricinus nymphs, covering their development from unfed to pre-molt stages. We identified 1534 I. ricinus-specific proteins with a relatively low proportion of host proteins. This proteome dataset, which was carefully examined by manual scrutiny, allowed precise annotation of proteins important for blood meal processing and their dynamic changes during nymphal ontogeny. We focused on midgut molecules related to lipid hydrolysis, storage, and transport, opening a yet unexplored avenue for studying lipid metabolism in ticks. Further dynamic profiling of the tick's multi-enzyme digestive network, protease inhibitors, enzymes involved in redox homeostasis and detoxification, antimicrobial peptides, and proteins responsible for midgut colonization by Borrelia spirochetes promises to uncover new targets for targeting tick nymphs, the most critical life stage for transmission the pathogens that cause tick-borne diseases.
    MeSH term(s) Animals ; Ixodes/parasitology ; Proteome ; Proteomics ; Digestive System
    Chemical Substances Proteome
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1016/j.mcpro.2023.100663
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5599: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Chelation of Mitochondrial Iron as an Antiparasitic Strategy.

    Arbon, Dominik / Mach, Jan / Čadková, Aneta / Sipkova, Anna / Stursa, Jan / Klanicová, Kristýna / Machado, Marta / Ganter, Markus / Levytska, Viktoriya / Sojka, Daniel / Truksa, Jaroslav / Werner, Lukáš / Sutak, Robert

    ACS infectious diseases

    2024  Volume 10, Issue 2, Page(s) 676–687

    Abstract: Iron, as an essential micronutrient, plays a crucial role in host-pathogen interactions. In order to limit the growth of the pathogen, a common strategy of innate immunity includes withdrawing available iron to interfere with the cellular processes of ... ...

    Abstract Iron, as an essential micronutrient, plays a crucial role in host-pathogen interactions. In order to limit the growth of the pathogen, a common strategy of innate immunity includes withdrawing available iron to interfere with the cellular processes of the microorganism. Against that, unicellular parasites have developed powerful strategies to scavenge iron, despite the effort of the host. Iron-sequestering compounds, such as the approved and potent chelator deferoxamine (DFO), are considered a viable option for therapeutic intervention. Since iron is heavily utilized in the mitochondrion, targeting iron chelators in this organelle could constitute an effective therapeutic strategy. This work presents mitochondrially targeted DFO, mitoDFO, as a candidate against a range of unicellular parasites with promising in vitro efficiency. Intracellular
    MeSH term(s) Iron ; Deferoxamine/chemistry ; Antiparasitic Agents/pharmacology ; Iron Chelating Agents/pharmacology ; Iron Chelating Agents/therapeutic use ; Mitochondria ; Anti-Infective Agents
    Chemical Substances Iron (E1UOL152H7) ; Deferoxamine (J06Y7MXW4D) ; Antiparasitic Agents ; Iron Chelating Agents ; Anti-Infective Agents
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00529
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  10. Article ; Online: Mechanoluminescence and Photoluminescence Heterojunction for Superior Multimode Sensing Platform of Friction, Force, Pressure, and Temperature in Fibers and 3D-Printed Polymers.

    Zheng, Teng / Runowski, Marcin / Martín, Inocencio R / Soler-Carracedo, Kevin / Peng, Liang / Skwierczyńska, Małgorzata / Sójka, Małgorzata / Barzowska, Justyna / Mahlik, Sebastian / Hemmerich, Hanoch / Rivera-López, Fernando / Kulpiński, Piotr / Lavín, Víctor / Alonso, Daniel / Peng, Dengfeng

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 40, Page(s) e2304140

    Abstract: Endowing a single material with various types of luminescence, that is, exhibiting a simultaneous optical response to different stimuli, is vital in various fields. A photoluminescence (PL)- and mechanoluminescence (ML)-based multifunctional sensing ... ...

    Abstract Endowing a single material with various types of luminescence, that is, exhibiting a simultaneous optical response to different stimuli, is vital in various fields. A photoluminescence (PL)- and mechanoluminescence (ML)-based multifunctional sensing platform is built by combining heterojunctioned ZnS/CaZnOS:Mn
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202304140
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