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Article: [Effects of mucolytic agents and macrolides in the treatment of COPD].

Yamaya, Mutsuo

Nihon rinsho. Japanese journal of clinical medicine

2016 Volume 74, Issue 5, Page(s) 833–838

Abstract: Mucolytic agents and macrolides have been used in the treatment of patients with chronic obstructive pulmonary disease (COPD). These drugs improve symptoms, such as sputum, and quality of life in COPD patients and reduce the frequency of COPD ... ...

Abstract	Mucolytic agents and macrolides have been used in the treatment of patients with chronic obstructive pulmonary disease (COPD). These drugs improve symptoms, such as sputum, and quality of life in COPD patients and reduce the frequency of COPD exacerbation. Mucolytic agents have various biological effects, such as reduction of mucin production, improvement of goblet cell hyperplasia and mucociliary transport, reduction of airway inflammation, and anti-oxidant and anti-viral effects. Similarly, in addition to antimicrobial effects, macrolides have biological effects, including reduction of mucin production and airway inflammation induced by airway infection, improvement of mucociliary transport, and anti-bacterial and anti-viral effects. These biological effects may be associated with clinical benefits of mucolvtic agents and macrolides in the treatment of COPD patients.
MeSH term(s)	Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Antiviral Agents ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Disease Progression ; Drug Therapy, Combination ; Erythromycin/pharmacology ; Erythromycin/therapeutic use ; Expectorants/pharmacology ; Expectorants/therapeutic use ; Goblet Cells/pathology ; Humans ; Hyperplasia/drug therapy ; Macrolides/pharmacology ; Macrolides/therapeutic use ; Mucins/metabolism ; Mucociliary Clearance/drug effects ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quality of Life ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Antiviral Agents ; Expectorants ; Macrolides ; Mucins ; Erythromycin (63937KV33D) ; Clarithromycin (H1250JIK0A)
Language	Japanese
Publishing date	2016-05
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 429: Show issues

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Article ; Online: Anti-inflammatory effects of medications used for viral infection-induced respiratory diseases.

Yamaya, Mutsuo / Kikuchi, Akiko / Sugawara, Mitsuru / Nishimura, Hidekazu

Respiratory investigation

2022 Volume 61, Issue 2, Page(s) 270–283

Abstract: Respiratory viruses like rhinovirus, influenza virus, respiratory syncytial virus, and coronavirus cause several respiratory diseases, such as bronchitis, pneumonia, pulmonary fibrosis, and coronavirus disease 2019, and exacerbate bronchial asthma, ... ...

Abstract	Respiratory viruses like rhinovirus, influenza virus, respiratory syncytial virus, and coronavirus cause several respiratory diseases, such as bronchitis, pneumonia, pulmonary fibrosis, and coronavirus disease 2019, and exacerbate bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis, and diffuse panbronchiolitis. The production of inflammatory mediators and mucin and the accumulation of inflammatory cells have been reported in patients with viral infection-induced respiratory diseases. Interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, granulocyte-macrophage colony-stimulating factor, and regulated on activation normal T-cell expressed and secreted are produced in the cells, including human airway and alveolar epithelial cells, partly through the activation of toll-like receptors, nuclear factor kappa B and p44/42 mitogen-activated protein kinase. These mediators are associated with the development of viral infection-induced respiratory diseases through the induction of inflammation and injury in the airway and lung, airway remodeling and hyperresponsiveness, and mucus secretion. Medications used to treat respiratory diseases, including corticosteroids, long-acting β
MeSH term(s)	Humans ; Quality of Life ; COVID-19 ; Asthma/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Virus Diseases/drug therapy ; Anti-Inflammatory Agents/therapeutic use ; Bronchiectasis ; Mucins/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Mucins
Language	English
Publishing date	2022-12-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2022.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chronic obstructive pulmonary disease and severe pneumonia.

Yamaya, Mutsuo

Geriatrics & gerontology international

2012 Volume 12, Issue 2, Page(s) 177–179

MeSH term(s)	Female ; Humans ; Male ; Pneumonia, Bacterial/therapy ; Respiration, Artificial ; Ventilator Weaning
Language	English
Publishing date	2012-04
Publishing country	Japan
Document type	Comment ; Editorial
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/j.1447-0594.2011.00832.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5801: Show issues

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Article: [Prevention and management of geriatric syndrome; aspiration and pneumonia].

Yamaya, Mutsuo

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

2011 Volume 48, Issue 6, Page(s) 662–664

MeSH term(s)	Aged ; Humans ; Pneumonia/etiology ; Pneumonia/prevention & control ; Pneumonia, Aspiration
Language	Japanese
Publishing date	2011-03-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604107-3
ISSN	0300-9173
ISSN	0300-9173
DOI	10.3143/geriatrics.48.662
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Zs.A 1039: Show issues

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Article ; Online: Virus infection-induced bronchial asthma exacerbation.

Yamaya, Mutsuo

Pulmonary medicine

2012 Volume 2012, Page(s) 834826

Abstract: Infection with respiratory viruses, including rhinoviruses, influenza virus, and respiratory syncytial virus, exacerbates asthma, which is associated with processes such as airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. In ... ...

Abstract	Infection with respiratory viruses, including rhinoviruses, influenza virus, and respiratory syncytial virus, exacerbates asthma, which is associated with processes such as airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. In patients with viral infections and with infection-induced asthma exacerbation, inflammatory mediators and substances, including interleukins (ILs), leukotrienes and histamine, have been identified in the airway secretions, serum, plasma, and urine. Viral infections induce an accumulation of inflammatory cells in the airway mucosa and submucosa, including neutrophils, lymphocytes and eosinophils. Viral infections also enhance the production of inflammatory mediators and substances in airway epithelial cells, mast cells, and other inflammatory cells, such as IL-1, IL-6, IL-8, GM-CSF, RANTES, histamine, and intercellular adhesion molecule-1. Viral infections affect the barrier function of the airway epithelial cells and vascular endothelial cells. Recent reports have demonstrated augmented viral production mediated by an impaired interferon response in the airway epithelial cells of asthma patients. Several drugs used for the treatment of bronchial asthma reduce viral and pro-inflammatory cytokine release from airway epithelial cells infected with viruses. Here, I review the literature on the pathogenesis of the viral infection-induced exacerbation of asthma and on the modulation of viral infection-induced airway inflammation.
Language	English
Publishing date	2012-08-23
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2603580-7
ISSN	2090-1844 ; 2090-1844
ISSN (online)	2090-1844
ISSN	2090-1844
DOI	10.1155/2012/834826
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Pharmacologic treatments of COPD depending on disease severity].

Yamaya, Mutsuo

Nihon rinsho. Japanese journal of clinical medicine

2011 Volume 69, Issue 10, Page(s) 1821–1825

Abstract: Depending on decreases in lung function and severity of symptoms, treatment with bronchodilators, including beta2-agonists and anticholinergics, is performed in pharmacologic treatments of COPD. Methylxanthines are also frequently used in Japan. As- ... ...

Abstract	Depending on decreases in lung function and severity of symptoms, treatment with bronchodilators, including beta2-agonists and anticholinergics, is performed in pharmacologic treatments of COPD. Methylxanthines are also frequently used in Japan. As-needed use of short-acting bronchodilators is recommended for patients with mild COPD for relief of symptoms. Regular treatment with long-acting bronchodilators is more effective than treatment with short-acting bronchodilators. Inhaled beta2-agonists and anticholinergics in combination are more effective than either agent alone. Combining bronchodilators with different mechanisms of action may increase the effects of bronchodilation, may improve symptoms and quality of life, and reduce the frequency of exacerbations. Inhaled corticosteroids reduce the frequency of exacerbations and improve symptoms in severe COPD.
MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Aged ; Aged, 80 and over ; Cholinergic Antagonists/therapeutic use ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology
Chemical Substances	Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Cholinergic Antagonists
Language	Japanese
Publishing date	2011-10
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 429: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Book: Kōreisha no haien

Yamaya, Mutsuo

chiryō, rihabiritēshon, yobō

2011

Author's details	Matsumoto Keizō sōkanshū ; Sasaki Hidetada, Fukuchi Yoshinosuke kanshū ; Yamaya Mutsuo hen
MeSH term(s)	Pneumonia ; Aged
Language	Japanese
Size	271 pages :, illustrations
Edition	Shohan.
Document type	Book
ISBN	9784753224821 ; 4753224821
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: [Effects of macrolides in preventing influenza and airway inflammation].

Yamaya, Mutsuo

The Japanese journal of antibiotics

2009 Volume 62 Suppl A, Page(s) 78–82

MeSH term(s)	Clarithromycin/therapeutic use ; Erythromycin/therapeutic use ; Humans ; In Vitro Techniques ; Inflammation ; Influenza A virus ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Macrolides/therapeutic use ; Respiratory Mucosa/pathology ; Respiratory Mucosa/virology
Chemical Substances	Macrolides ; Erythromycin (63937KV33D) ; Clarithromycin (H1250JIK0A)
Language	Japanese
Publishing date	2009-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390804-5
ISSN	0368-2781
ISSN	0368-2781
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 811: Show issues

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Article ; Online: Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells.

Deng, Xue / Yasuda, Hiroyasu / Sasaki, Takahiko / Yamaya, Mutsuo

The Tohoku journal of experimental medicine

2019 Volume 247, Issue 4, Page(s) 215–222

Abstract: Carbon monoxide (CO) and nitric oxide (NO) exhibit physiological properties that include the activation of guanylate cyclase. NO inhibits replication of rhinovirus (RV), a major cause of the common cold and exacerbation of bronchial asthma and chronic ... ...

Abstract	Carbon monoxide (CO) and nitric oxide (NO) exhibit physiological properties that include the activation of guanylate cyclase. NO inhibits replication of rhinovirus (RV), a major cause of the common cold and exacerbation of bronchial asthma and chronic obstructive pulmonary disease. However, the anti-rhinoviral effects of CO remain unclear. This study investigated whether the exogenous application of low-dose CO could inhibit RV replication in human alveolar and airway epithelial cells. A549 human lung carcinoma cells with alveolar epithelial features and primary cultures of human tracheal epithelial (HTE) cells were pretreated with CO (100 ppm) and infected with a major group RV, type 14 RV (RV14). CO exposure reduced RV14 titers in the supernatants and RV RNA levels in A549 and HTE cells. The treatment with a guanylate cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, reversed the inhibitory effects of CO exposure on RV14 replication in A549 cells. Pretreatment of A549 cells with 8-Br-cGMP, a cell-permeable cGMP analog, caused the decrease in RV14 replication, while CO exposure increased cGMP production. CO exposure also increased the expression levels of interferon (IFN)-γ mRNA and protein. In contrast, pretreatment with CO did not increase DNA fragmentation and did not reduce the expression of intercellular adhesion molecule-1, the RV14 receptor, or the number of acidic endosomes, through which RV RNA enters the cytoplasm. These findings suggest that low-dose CO may decrease RV14 replication in alveolar and airway epithelial cells. IFN-γ production, which is induced by CO exposure via guanylate cyclase activation-mediated cGMP production, may be involved in RV14 replication inhibition.
MeSH term(s)	A549 Cells ; Acids ; Carbon Monoxide/pharmacology ; Cyclic GMP/antagonists & inhibitors ; Cyclic GMP/biosynthesis ; DNA Fragmentation/drug effects ; Dose-Response Relationship, Drug ; Endosomes/drug effects ; Endosomes/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/virology ; Guanylate Cyclase/metabolism ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Interferon-gamma/biosynthesis ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/virology ; Rhinovirus/drug effects ; Rhinovirus/physiology ; Virus Replication/drug effects
Chemical Substances	Acids ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Carbon Monoxide (7U1EE4V452) ; Interferon-gamma (82115-62-6) ; Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2019-04-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.247.215
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Ua VI Zs.155: Show issues

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Article ; Online: Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.

Yamaya, Mutsuo / Nishimura, Hidekazu / Deng, Xue / Kikuchi, Akiko / Nagatomi, Ryoichi

The Tohoku journal of experimental medicine

2020 Volume 251, Issue 1, Page(s) 27–30

Abstract: The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been ... ...

Abstract	The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pretreated primary cultures of human nasal epithelial (HNE) cells with camostat or nafamostat, each of which has been used for the treatment of pancreatitis and/or disseminated intravascular coagulation. HNE cells were then infected with coronavirus 229E, and viral titers in the airway surface liquid of the cells were examined. Pretreatment with camostat (0.1-10 μg/mL) or nafamostat (0.01-1 μg/mL) reduced the titers of coronavirus 229E. Furthermore, a significant amount of type II transmembrane protease protein was detected in the airway surface liquid of HNE cells. Additionally, interferons have been reported to have antiviral effects against SARS coronavirus. The additive effects of interferons on the inhibitory effects of other candidate drugs to treat SARS-CoV-2 infection, such as lopinavir, ritonavir and favipiravir, have also been studied. These findings suggest that protease inhibitors of this type may inhibit coronavirus 229E replication in human airway epithelial cells at clinical concentrations. Protease inhibitors, interferons or the combination of these drugs may become candidate drugs to inhibit the replication of SARS-CoV-2.
MeSH term(s)	Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Cells, Cultured ; Coronavirus 229E, Human/drug effects ; Coronavirus 229E, Human/enzymology ; Coronavirus 229E, Human/physiology ; Coronavirus Infections/drug therapy ; Culture Media, Conditioned ; Epithelial Cells/virology ; Gabexate/analogs & derivatives ; Gabexate/pharmacology ; Guanidines/pharmacology ; Humans ; Nasal Mucosa/cytology ; Pandemics ; Pneumonia, Viral/drug therapy ; Primary Cell Culture ; Protease Inhibitors/pharmacology ; SARS-CoV-2 ; Serine Endopeptidases/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Load ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Culture Media, Conditioned ; Guanidines ; Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; camostat (0FD207WKDU) ; Gabexate (4V7M9137X9) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; nafamostat (Y25LQ0H97D)
Keywords	covid19
Language	English
Publishing date	2020-04-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.251.27
Database	MEDical Literature Analysis and Retrieval System OnLINE

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