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  1. Book ; Online: Geochemistry of North Atlantic Igneous Province basalts, supplementary data to: Kempton, Pamela D; Fitton, J Godfrey; Saunders, Andrew D; Nowell, GM; Taylor, RN; Hardarson, BS; Pearson, Grant (2000): The Iceland plume in space and time: a Sr-Nd-Pb-Hf study of the North Atlantic rifted margin. Earth and Planetary Science Letters, 177(3-4), 255-271

    Kempton, Pamela D / Fitton, J Godfrey / Hardarson, BS / Nowell, GM / Pearson, Grant / Saunders, Andrew D / Taylor, RN

    2000  

    Abstract: ... SR; Fitton, J Godfrey; Saunders, Andrew D; Mahoney, John J; Taylor, RN (1998): High precision Hf ... JB092iB08p08089) along the MAR in the North Atlantic.

    REFERENCE:
    Nowell, GM; Kempton, Pamela D; Noble ...

    Abstract New Sr-Nd-Pb-Hf data require the existence of at least four mantle components in the genesis of basalts from the the North Atlantic Igneous Province (NAIP): (1) one (or more likely a small range of) enriched component(s) within the Iceland plume, (2) a depleted component within the Iceland plume (distinct from the shallow N-MORB source), (3) a depleted sheath surrounding the plume and (4) shallow N-MORB source mantle. These components have been available since the major phase of igneous activity associated with plume head impact during Paleogene times. In Hf-Nd isotope space, samples from Iceland, DSDP Leg 49 (Sites 407, 408 and 409), ODP Legs 152 and 163 (southeast Greenland margin), the Reykjanes Ridge, Kolbeinsey Ridge and DSDP Leg 38 (Site 348) define fields that are oblique to the main ocean island basalt array and extend toward a component with higher 176Hf/177Hf than the N-MORB source available prior to arrival of the plume, as indicated by the compositions of Cretaceous basalts from Goban Spur (~95 Ma). Aside from Goban Spur, only basalts from Hatton Bank on the oceanward side of the Rockall Plateau (DSDP Leg 81) lie consistently within the field of N-MORB, which indicates that the compositional influence of the plume did not reach this far south and east ~55 Ma ago. Thus, Hf-Nd isotope systematics are consistent with previous studies which indicate that shallow MORB-source mantle does not represent the depleted component within the Iceland plume (Thirlwall, J. Geol. Soc. London 152 (1995) 991-996; Hards et al., J. Geol. Soc. London 152 (1995) 1003-1009; Fitton et al., 1997 doi:10.1016/S0012-821X(97)00170-2). They also indicate that the depleted component is a long-lived and intrinsic feature of the Iceland plume, generated during an ancient melting event in which a mineral (such as garnet) with a high Lu/Hf was a residual phase. Collectively, these data suggest a model for the Iceland plume in which a heterogeneous core, derived from the lower mantle, consists of 'enriched' streaks or blobs dispersed in a more depleted matrix. A distinguishing feature of both the enriched and depleted components is high Nb/Y for a given Zr/Y (i.e. positive DeltaNb), but the enriched component has higher Sr and Pb isotope ratios, combined with lower epsilon-Nd and epsilon-Hf. This heterogeneous core is surrounded by a sheath of depleted material, similar to the depleted component of the Iceland plume in its epsilon-Nd and epsilon-Hf, but with lower 87Sr/86Sr, 208Pb/204Pb and negative DeltaNb; this material was probably entrained from near the 670 km discontinuity when the plume stalled at the boundary between the upper and lower mantle. The plume sheath displaced more normal MORB asthenosphere (distinguished by its lower epsilon-Hf for a given epsilon-Nd or Zr/Nb ratio), which existed in the North Atlantic prior to plume impact. Preliminary data on MORBs from near the Azores plume suggest that much of the North Atlantic may be 'polluted' not only by enriched plume material but also by depleted material similar to the Iceland plume sheath. If this hypothesis is correct, it may provide a general explanation for some of the compositional diversity and variations in inferred depth of melting (Klein and Langmuir, 1987 doi:10.1029/JB092iB08p08089) along the MAR in the North Atlantic.

    REFERENCE:
    Nowell, GM; Kempton, Pamela D; Noble, SR; Fitton, J Godfrey; Saunders, Andrew D; Mahoney, John J; Taylor, RN (1998): High precision Hf isotope measurements of MORB and OIB by thermal ionisation mass spectrometry: insights into the depleted mantle. Chemical Geology, 149(3-4), 211-233
    Language English
    Dates of publication 2000-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is cited by doi:10.1016/S0009-2541(98)00036-9 ; This dataset is supplement to doi:10.1016/S0012-821X(00)00047-9
    DOI 10.1594/PANGAEA.716921
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: Rhodiola rosea

    Tinsley, Grant M / Jagim, Andrew R / Potter, Gregory D M / Garner, Dan / Galpin, Andrew J

    The British journal of nutrition

    2023  Volume 131, Issue 3, Page(s) 461–473

    Abstract: ... Rhodiola ... ...

    Abstract Rhodiola rosea
    MeSH term(s) Male ; Adult ; Female ; Humans ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Antioxidants/pharmacology ; Rhodiola/chemistry ; Performance-Enhancing Substances/pharmacology ; Exercise/physiology
    Chemical Substances Plant Extracts ; Antioxidants ; Performance-Enhancing Substances
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114523001988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.

    Thomas, Rajan M / Pahl, Matthew C / Wang, Liqing / Grant, Struan F A / Hancock, Wayne W / Wells, Andrew D

    eLife

    2024  Volume 12

    Abstract: Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To ... ...

    Abstract Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To determine the function of Ikaros in the Treg lineage, we generated mice with Treg-specific deletion of the Ikaros gene (
    MeSH term(s) Animals ; Ikaros Transcription Factor/metabolism ; Ikaros Transcription Factor/genetics ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Forkhead Transcription Factors/metabolism ; Forkhead Transcription Factors/genetics ; Mice ; Gene Expression Regulation ; Mice, Knockout
    Chemical Substances Ikaros Transcription Factor (148971-36-2) ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Zfpn1a1 protein, mouse
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Access to a Diverse Array of Bridged Benzo[1,5]oxazocine and Benzo[1,4]diazepine Structures.

    Sherborne, Grant J / Diène, Coura / Kemmitt, Paul / Smith, Andrew D

    Organic letters

    2023  Volume 25, Issue 48, Page(s) 8585–8589

    Abstract: The preparation of bridged benzo[1,5]oxazocines and benzo[1,4]diazepines is demonstrated from simple aniline and aldehyde starting materials. A one-pot condensation/6π electrocyclization is followed by an intramolecular trapping of the 2,3- ... ...

    Abstract The preparation of bridged benzo[1,5]oxazocines and benzo[1,4]diazepines is demonstrated from simple aniline and aldehyde starting materials. A one-pot condensation/6π electrocyclization is followed by an intramolecular trapping of the 2,3-dihydroquinoline intermediate by nitrogen or oxygen nucleophiles to give bridged seven- and eight-membered products. Using 3-hydroxypyridinecarboxaldehydes results in a stable zwitterionic structure that can undergo a diastereoselective reduction under hydrogenative conditions. A similar cyclization/hydrogenation pathway with excellent diastereoselectivity is also demonstrated from 2-pyridyl-substituted 1,2,3,4-tetrahydroquinolines.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity.

    Grant, Andrew J / Gill, Dipender / Kirk, Paul D W / Burgess, Stephen

    PLoS genetics

    2022  Volume 18, Issue 1, Page(s) e1009975

    Abstract: Clustering genetic variants based on their associations with different traits can provide insight into their underlying biological mechanisms. Existing clustering approaches typically group variants based on the similarity of their association estimates ... ...

    Abstract Clustering genetic variants based on their associations with different traits can provide insight into their underlying biological mechanisms. Existing clustering approaches typically group variants based on the similarity of their association estimates for various traits. We present a new procedure for clustering variants based on their proportional associations with different traits, which is more reflective of the underlying mechanisms to which they relate. The method is based on a mixture model approach for directional clustering and includes a noise cluster that provides robustness to outliers. The procedure performs well across a range of simulation scenarios. In an applied setting, clustering genetic variants associated with body mass index generates groups reflective of distinct biological pathways. Mendelian randomization analyses support that the clusters vary in their effect on coronary heart disease, including one cluster that represents elevated body mass index with a favourable metabolic profile and reduced coronary heart disease risk. Analysis of the biological pathways underlying this cluster identifies inflammation as potentially explaining differences in the effects of increased body mass index on coronary heart disease.
    MeSH term(s) Body Mass Index ; Cluster Analysis ; Computational Biology/methods ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis ; Models, Genetic ; Obesity/genetics
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1009975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Patient With Severe Headache After IV Immunoglobulin.

    Russo, Capt Christopher / Dalton, Lt Kenneth / Grant, Loran / Enos, Noelle / Evans, D Lt Andrew

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2022  Volume 39, Issue 12, Page(s) 487–489

    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 1078-4497
    ISSN 1078-4497
    DOI 10.12788/fp.0342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Osteoporosis GWAS-implicated

    Kaur, Gurcharan / Pippin, James A / Chang, Solomon / Redmond, Justin / Chesi, Alessandra / Wells, Andrew D / Maerz, Tristan / Grant, Struan F A / Coleman, Rhima M / Hankenson, Kurt D / Wagley, Yadav

    JBMR plus

    2024  Volume 8, Issue 5, Page(s) ziae051

    Abstract: Genome wide association study (GWAS)-implicated bone mineral density (BMD) signals have been shown to localize in cis-regulatory regions of distal effector genes using 3D genomic methods. Detailed characterization of such genes can reveal novel causal ... ...

    Abstract Genome wide association study (GWAS)-implicated bone mineral density (BMD) signals have been shown to localize in cis-regulatory regions of distal effector genes using 3D genomic methods. Detailed characterization of such genes can reveal novel causal genes for BMD determination. Here, we elected to characterize the "
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1093/jbmrpl/ziae051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intrarenal Doppler Ultrasound Renal Venous Stasis Index Correlates With Acute Cardiorenal Syndrome in Patients With Acute Decompensated Heart Failure.

    Trpkov, Cvetan / Grant, Andrew D M / Fine, Nowell M

    CJC open

    2021  Volume 3, Issue 12, Page(s) 1444–1452

    Abstract: Background: Acute cardiorenal syndrome (ACRS) is associated with adverse outcomes in patients with acute decompensated heart failure (ADHF). Intrarenal venous blood flow can be assessed using Doppler ultrasound and has prognostic significance in ADHF. ... ...

    Abstract Background: Acute cardiorenal syndrome (ACRS) is associated with adverse outcomes in patients with acute decompensated heart failure (ADHF). Intrarenal venous blood flow can be assessed using Doppler ultrasound and has prognostic significance in ADHF. Although intrarenal Doppler (IRD) may be sensitive to renal congestion, an association between IRD parameters and ACRS has not been demonstrated in an ADHF population.
    Methods: Hospitalized patients with ADHF (n = 21) or acute coronary syndrome (ACS; n = 21) were prospectively enrolled. Patients underwent echocardiography, including IRD, using a standard cardiac ultrasound transducer. Intrarenal venous flow was quantified with the renal venous stasis index (RVSI), defined as the duration of absent venous flow time divided by cardiac cycle duration. The primary outcome was acute kidney injury (AKI) as assessed using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
    Results: ADHF patients had a similar cardiac index (2.0 ± 0.6 vs 2.1 ± 0.4 L/min per m
    Conclusions: RVSI is associated with AKI among ADHF patients and may be a useful diagnostic biomarker for ACRS in this setting. Further studies are needed to validate this finding and evaluate the potential efficacy of IRD-guided decongestive therapy in this setting.
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2021.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Developing a peer-led intervention to promote COVID-19 testing in low-income housing settings.

    Plunk, Andrew D / Hannon, Kapri / Carver, Alexandra / Cooper, Diane / Grant, Debra / Greene, Sudie / Morgan, Emma / Gehlert, Sarah

    Frontiers in public health

    2023  Volume 11, Page(s) 1096246

    Abstract: Background: The Housing Collaborative project at Eastern Virginia Medical School has developed a method of adapting public health guidance from public housing communities, which face tremendous health challenges in cardiometabolic health, cancer, and ... ...

    Abstract Background: The Housing Collaborative project at Eastern Virginia Medical School has developed a method of adapting public health guidance from public housing communities, which face tremendous health challenges in cardiometabolic health, cancer, and other major health conditions. In this paper, we describe how academic and community partners in the Housing Collaborative came together to do this work with a focus on COVID-19 testing in the context of the emerging pandemic.
    Methods: The academic team used virtual community engagement methods to interact with the Housing Collaborative Community Advisory Board (HCCAB) and a separate cohort of research participants (
    Results: Participants reported several important barriers to COVID-19 testing related to distrust in the tests and those administering them. Distrust in housing authorities and how they might misuse positive test results seemed to further undermine decision making about COVID-19 testing. Pain associated with testing was also a concern. To address these concerns, a peer-led testing intervention was proposed by the Housing Collaborative. A second round of focus group interviews was then conducted, in which participants reported their approval of the proposed intervention.
    Conclusion: Although the COVID-19 pandemic was not our initial focus, we were able to identify a number of barriers to COVID-19 testing in low-income housing settings that can be addressed with adapted public health guidance. We struck a balance between community input and scientific rigor and obtained high quality, honest feedback to inform evidence-based recommendations to guide decisions about health.
    MeSH term(s) Humans ; Housing ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Testing ; Poverty ; Public Health
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1096246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Long-Term Outcomes of Septoplasty With or Without Turbinoplasty: A Systematic Review.

    Fearington, Forrest W / Awadallah, Andrew S / Hamilton, Grant S / Olson, Michael D / Dey, Jacob K

    The Laryngoscope

    2023  

    Abstract: Background: Septoplasty is used to correct nasal obstruction from nasal septum deviation. However, the long-term efficacy of septoplasty is unclear, and no literature reviews have examined long-term outcomes of septoplasty with or without turbinate ... ...

    Abstract Background: Septoplasty is used to correct nasal obstruction from nasal septum deviation. However, the long-term efficacy of septoplasty is unclear, and no literature reviews have examined long-term outcomes of septoplasty with or without turbinate modification. This systematic review aimed to evaluate the long-term efficacy of septoplasty with or without turbinate modification in improving nasal obstruction.
    Data sources: PubMed, EMBASE, Cochrane CENTRAL.
    Methods: A systematic review of the literature was conducted using the aforementioned databases. Studies reporting outcomes 12+ months after functional septoplasty with or without turbinate surgery for nasal obstruction were included. Septorhinoplasties, concurrent sinus surgery, pediatric studies, and studies where septoplasty was performed for indications other than nasal obstruction were excluded.
    Results: After screening, 35 studies with 4,432 patients were included. Mean weighted post-operative follow-up time was 29.1 months (range 12-120 months). All studies reported significant improvement in subjective and objective outcomes at long-term follow-up compared to baseline. When comparing short-term (<12 months) to long-term (≥12 months) outcomes, four studies noticed that subjective outcomes worsened slightly over time, but no study found a significant change in objective outcomes over time. In addition, 23 studies reported patient satisfaction and/or improvement rates, with 75.4% (2,348/3,113) of patients expressing satisfaction/improvement at an average of 27.0 months after surgery.
    Conclusions: Overall, septoplasty with or without turbinate modification shows significant improvement in obstructive symptoms at long-term follow-up per both objective and subjective measures. Whether outcomes may worsen slightly over time remains indeterminate based on mixed results in the literature.
    Level of evidence: N/A Laryngoscope, 2023.
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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