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  1. Article ; Online: Geographical variation in Black Redstart Phoenicurus ochruros (S. G. Gmelin, 1774) calls

    Martinez, Nicolas / van der Spek, Vincent

    Bulletin of the British Ornithologists’ Club. 2022 Dec. 7, v. 142, no. 4 p.466-477

    2022  

    Abstract: Black Redstart Phoenicurus ochruros occurs over a broad range from Western Europe and north-west Africa to Central Asia. Seven subspecies are usually recognised, which can be divided morphologically into a grey-and-white-bellied western group (‘Western ... ...

    Abstract Black Redstart Phoenicurus ochruros occurs over a broad range from Western Europe and north-west Africa to Central Asia. Seven subspecies are usually recognised, which can be divided morphologically into a grey-and-white-bellied western group (‘Western Black Redstart’; two subspecies) and an orange-bellied eastern group (‘Eastern Black Redstart’; five subspecies). Because vocalisations might help to understand relationships between these taxa, we analysed the calls of six of the seven subspecies. We demonstrate that calls can be grouped into one of three geographical variants. One is formed by the western subspecies breeding in Europe, the morphologically intermediate subspecies ochruros and Eastern Black Redstarts from the Altai and Mongolia. Further south-east, birds call at lower frequencies on average and within a smaller frequency range (group 2). The third group is formed by the eastern subspecies rufiventris which differs from all other taxa, with a descending instead of a rising call, given at much lower frequencies.
    Keywords geographical variation ; Africa ; Central Asia ; Europe ; Mongolia ; Western European region
    Language English
    Dates of publication 2022-1207
    Size p. 466-477.
    Publishing place British Ornithologists’ Club
    Document type Article ; Online
    ZDB-ID 2927179-4
    ISSN 2513-9894 ; 0007-1595
    ISSN (online) 2513-9894
    ISSN 0007-1595
    DOI 10.25226/bboc.v142i4.2022.a5
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease

    Rocío Alfaro-Ruiz / Alejandro Martín-Belmonte / Carolina Aguado / Félix Hernández / Ana Esther Moreno-Martínez / Jesús Ávila / Rafael Luján

    International Journal of Molecular Sciences, Vol 22, Iss 11106, p

    2021  Volume 11106

    Abstract: G protein-gated inwardly rectifying K + (GIRK) channels are the main targets controlling ...

    Abstract G protein-gated inwardly rectifying K + (GIRK) channels are the main targets controlling excitability and synaptic plasticity on hippocampal neurons. Consequently, dysfunction of GIRK-mediated signalling has been implicated in the pathophysiology of Alzheimer´s disease (AD). Here, we provide a quantitative description on the expression and localisation patterns of GIRK2 in two transgenic mice models of AD (P301S and APP/PS1 mice), combining histoblots and immunoelectron microscopic approaches. The histoblot technique revealed differences in the expression of GIRK2 in the two transgenic mice models. The expression of GIRK2 was significantly reduced in the hippocampus of P301S mice in a laminar-specific manner at 10 months of age but was unaltered in APP/PS1 mice at 12 months compared to age-matched wild type mice. Ultrastructural approaches using the pre-embedding immunogold technique, demonstrated that the subcellular localisation of GIRK2 was significantly reduced along the neuronal surface of CA1 pyramidal cells, but increased in its frequency at cytoplasmic sites, in both P301S and APP/PS1 mice. We also found a decrease in plasma membrane GIRK2 channels in axon terminals contacting dendritic spines of CA1 pyramidal cells in P301S and APP/PS1 mice. These data demonstrate for the first time a redistribution of GIRK channels from the plasma membrane to intracellular sites in different compartments of CA1 pyramidal cells. Altogether, the pre- and post-synaptic reduction of GIRK2 channels suggest that GIRK-mediated alteration of the excitability in pyramidal cells could contribute to the cognitive dysfunctions as described in the two AD animal models.
    Keywords Alzheimer´s disease ; hippocampus ; GIRK channels ; immunohistochemistry ; electron microscopy ; histoblot ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Loss of androgen receptor transcriptional activity at the G(1)/S transition.

    Martinez, Elisabeth D / Danielsen, Mark

    The Journal of biological chemistry

    2002  Volume 277, Issue 33, Page(s) 29719–29729

    Abstract: ... specific probasin promoter. This activity is strongly reduced or abolished at the G(1)/S boundary. In S ... that inactivates the AR at the G(1)/S transition. This regulation is specific for the AR, since the related ... glucocorticoid receptor is transcriptionally active at the G(1)/S boundary. Not all of the effects of androgens are ...

    Abstract Androgens are essential for the differentiation, growth, and maintenance of male-specific organs. The effects of androgens in cells are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily of transcription factors. Recently, transient transfection studies have shown that overexpression of cell cycle regulatory proteins affects the transcriptional activity of the AR. In this report, we characterize the transcriptional activity of endogenous AR through the cell cycle. We demonstrate that in G0, AR enhances transcription from an integrated steroid-responsive mouse mammary tumor virus promoter and also from an integrated androgen-specific probasin promoter. This activity is strongly reduced or abolished at the G(1)/S boundary. In S phase, the receptor regains activity, indicating that there is a transient regulatory event that inactivates the AR at the G(1)/S transition. This regulation is specific for the AR, since the related glucocorticoid receptor is transcriptionally active at the G(1)/S boundary. Not all of the effects of androgens are blocked, however, since androgens retain the ability to increase AR protein levels. The transcriptional inactivity of the AR at the G(1)/S junction coincides with a decrease in AR protein level, although activity can be partly rescued without an increase in receptor. Inhibition of histone deacetylases brings about this partial restoration of AR activity at the G(1)/S boundary, demonstrating the involvement of acetylation pathways in the cell cycle regulation of AR transcriptional activity. Finally, a model is proposed that explains the inactivity of the AR at the G(1)/S transition by integrating receptor levels, the action of cell cycle regulators, and the contribution of histone acetyltransferase-containing coactivators.
    MeSH term(s) Acetylation ; Androgens/pharmacology ; Cell Line ; G1 Phase ; Glucocorticoids/pharmacology ; Histones/metabolism ; Receptors, Androgen/metabolism ; Receptors, Androgen/physiology ; S Phase ; Transcription, Genetic/physiology
    Chemical Substances Androgens ; Glucocorticoids ; Histones ; Receptors, Androgen
    Language English
    Publishing date 2002-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M112134200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hemoglobinopatía S con interacción de la HbS y la Hb G-Ferrara.

    Cañizares, M E / Martínez, G / Hernández, S / Raymond, P / Colombo, B

    Sangre

    1983  Volume 28, Issue 6, Page(s) 770–774

    Title translation Hemoglobinopathy S with an interaction of HbS and Hb G-Ferrara.
    MeSH term(s) Adult ; Anemia, Sickle Cell/complications ; Female ; Hemoglobin, Sickle/metabolism ; Hemoglobinopathies/complications ; Hemoglobinopathies/genetics ; Hemoglobins, Abnormal/genetics ; Hemoglobins, Abnormal/metabolism ; Humans ; Infant ; Protein Conformation ; Sickle Cell Trait/complications ; Sickle Cell Trait/genetics
    Chemical Substances Hemoglobin, Sickle ; Hemoglobins, Abnormal ; hemoglobin G Ferrara (54577-93-4)
    Language Spanish
    Publishing date 1983
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 128404-6
    ISSN 0036-4355
    ISSN 0036-4355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Temperature and salinity profiles at 10 m depth resolution from time series station E1 in the western English Channel from 1903 to 2010, supplementary data to: Smyth, Timothy J; Fishwick, James R; Al-Moosawi, Lisa; Cummings, Denise G; Harris, Carolyn; Kitidis, Vasillis; Rees, Andrew; Martinez-Vicente, Victor; Woodward, E Malcolm S (2010): A broad spatio-temporal view of the Western English Channel observatory. Journal of Plankton Research, 32(5), 585-601

    Smyth, Timothy J / Al-Moosawi, Lisa / Cummings, Denise G / Fishwick, James R / Harris, Carolyn / Kitidis, Vasillis / Martinez-Vicente, Victor / Rees, Andrew / Woodward, E Malcolm S

    2010  

    Abstract: The marine laboratories in Plymouth have sampled at two principle sites in the Western English Channel for over a century in open-shelf (station E1; 50? 02'N, 4? 22'W) and coastal (station L4; 50? 15'N, 4? 13'W) waters. These stations are seasonally ... ...

    Abstract The marine laboratories in Plymouth have sampled at two principle sites in the Western English Channel for over a century in open-shelf (station E1; 50? 02'N, 4? 22'W) and coastal (station L4; 50? 15'N, 4? 13'W) waters. These stations are seasonally stratified from late-April until September, and the variable biological response is regulated by subtle variations in temperature, light, nutrients and meteorology. Station L4 is characterized by summer nutrient depletion, although intense summer precipitation, increasing riverine input to the system, results in pulses of increased nitrate concentration and surface freshening. The winter nutrient concentrations at E1 are consistent with an open-shelf site. Both stations have a spring and autumn phytoplankton bloom; at station E1, the autumn bloom tends to dominate in terms of chlorophyll concentration. The last two decades have seen a warming of around 0.6?C per decade, and this is superimposed on several periods of warming and cooling over the past century. In general, over the Western English Channel domain, the end of the 20th century was around 0.5?C warmer than the first half of the century. The warming magnitude and trend is consistent with other stations across the north-west European Shelf and occurred during a period of reduced wind stress and increased levels of insolation (+20%); these are both correlated with the larger scale climatic forcing of the North Atlantic Oscillation.
    Language English
    Dates of publication 2010-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1093/plankt/fbp128
    DOI 10.1594/PANGAEA.742659
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article: Ab initio analytical potential energy surface and quasiclassical trajectory study of the O(+)((4)S)+H(2)(X (1)Sigma(g) (+))-->OH(+)(X (3)Sigma(-))+H((2)S) reaction and isotopic variants.

    Martínez, Rodrigo / Millán, Judith / Gonzalez, Miguel

    The Journal of chemical physics

    2004  Volume 120, Issue 10, Page(s) 4705–4714

    Abstract: An analytical potential energy surface (PES) representation of the O(+)((4)S)+H(2)(X (1)Sigma(g ...

    Abstract An analytical potential energy surface (PES) representation of the O(+)((4)S)+H(2)(X (1)Sigma(g) (+)) system was developed by fitting around 600 CCSD(T)/cc-pVQZ ab initio points. Rate constant calculations for this reaction and its isotopic variants (D(2) and HD) were performed using the quasiclassical trajectory (QCT) method, obtaining a good agreement with experimental data. Calculations conducted to determine the cross section of the title reaction, considering collision energies (E(T)) below 0.3 eV, also led to good accord with experiments. This PES appears to be suitable for kinetics and dynamics studies. Moreover, the QCT results show that, although the hypotheses of a widely used capture model are not satisfied, the resulting expression for the cross section can be applied within a suitable E(T) interval, due to errors cancellation. This could be a general situation regarding the application of this simple model to ion-molecule processes.
    Language English
    Publishing date 2004-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.1638735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: In response to Milano A. Pratali S, De Carlo M, Borzoni G, Tartarini G, Bortolotti U. Ascending aorta dissection after aortic valve replacement. J Heart Valve Dis 1998; 7:75-80.

    Fernandez Gonzalez, A L / Martinez Monzonis, A

    The Journal of heart valve disease

    1998  Volume 7, Issue 4, Page(s) 471; author reply 472–3

    MeSH term(s) Aneurysm, Dissecting/etiology ; Aorta ; Aortic Aneurysm/etiology ; Aortic Valve ; Heart Valve Prosthesis Implantation ; Humans ; Postoperative Complications
    Language English
    Publishing date 1998-07
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1205265-6
    ISSN 2053-2644 ; 0966-8519
    ISSN (online) 2053-2644
    ISSN 0966-8519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: New records of Orthotrichum alpestre B., S. & G. from Spain

    Martinez-Abaigar, J / Lewinsky-Haapasaari, J / Nunez-Olivera, E

    Lindbergia. 1995/1996. v. 20 (2/3)

    1995  

    Keywords epiphytes ; Fagus sylvatica ; geographical distribution ; new geographic records ; taxonomy ; Quercus pyrenaica ; flora ; Bryopsida ; Spain
    Language English
    Dates of publication 1995-1996
    Size p. 106-108.
    Document type Article
    ZDB-ID 2495025-7
    ISSN 2001-5909 ; 0105-0761
    ISSN (online) 2001-5909
    ISSN 0105-0761
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: The GTP-binding protein G alpha s is present in dormant spores and expressed differentially during spore germination of the fungus Phycomyces blakesleeanus.

    Martínez-Cadena, G / Novoa-Martínez, G / González-Hernández, A / García-Soto, J

    Microbiology (Reading, England)

    1995  Volume 141 Pt 12, Page(s) 3149–3154

    Abstract: A DNA sequence homologous to a G alpha s DNA probe, and the corresponding G alpha s protein ... a 56 kDa protein was detected by Western blotting with a specific antibody against mammalian G alpha s ... These results indicate that G alpha s (56 kDa) is present in dormant spores of P. blakesleeanus. Using the ADP ...

    Abstract A DNA sequence homologous to a G alpha s DNA probe, and the corresponding G alpha s protein (stimulatory alpha-subunit of GTP-binding protein) were detected in Phycomyces blakesleeanus. The protein was demonstrated in membrane fractions of dormant spores of this fungus using three different experimental approaches. Photoaffinity-labelling experiments with [alpha-32P]GTP of the membrane fraction revealed two bands, of 56 and 32 kDa. The 56 kDa GTP-binding protein was detected by this method in all the stages of early development and growth investigated. Also, a spore protein of 56 kDa was ADP-ribosylated by cholera toxin, and a 56 kDa protein was detected by Western blotting with a specific antibody against mammalian G alpha s. These results indicate that G alpha s (56 kDa) is present in dormant spores of P. blakesleeanus. Using the ADP-ribosylation and Western blotting assays, G alpha s was detected during all stages of spore germination before the hyphae became highly branched, but it was not detected in the branched hyphae that formed 18 h after the initiation of spore germination. Therefore, G alpha s is expressed differentially during Phycomyces development.
    MeSH term(s) Adenosine Diphosphate Ribose/metabolism ; Affinity Labels ; Cholera Toxin/pharmacology ; DNA, Fungal/genetics ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Fungal ; Genes, Fungal ; Guanosine Triphosphate ; Phycomyces/genetics ; Phycomyces/growth & development ; Phycomyces/physiology ; Spores, Fungal/genetics ; Spores, Fungal/physiology
    Chemical Substances Affinity Labels ; DNA, Fungal ; Adenosine Diphosphate Ribose (20762-30-5) ; Guanosine Triphosphate (86-01-1) ; Cholera Toxin (9012-63-9) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1995-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/13500872-141-12-3149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Brown-McLean syndrome in the peripheral cornea.

    Rodríguez-Iranzo, G / Montolío-Marzo, S / Fernández-López, E / Peris-Martínez, C

    Journal francais d'ophtalmologie

    2024  Volume 47, Issue 6, Page(s) 104146

    Language English
    Publishing date 2024-03-14
    Publishing country France
    Document type Journal Article
    ZDB-ID 426662-6
    ISSN 1773-0597 ; 0181-5512
    ISSN (online) 1773-0597
    ISSN 0181-5512
    DOI 10.1016/j.jfo.2024.104146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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