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Article: Integrin

Yuan, Zihui / Tan, Juan / Wang, Jian

2023 Volume 17, Issue 1, Page(s) 70–79

Abstract: The efficacy of adipose-derived stem cells (ASCs) on myocardial infarction is limited due to poor survival and engraftment. Integrin-mediated cell adhesion is a prerequisite for its survival and homing. ASCs expressed insufficient ... ...

Abstract	The efficacy of adipose-derived stem cells (ASCs) on myocardial infarction is limited due to poor survival and engraftment. Integrin-mediated cell adhesion is a prerequisite for its survival and homing. ASCs expressed insufficient integrin
Language	English
Publishing date	2023-10-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2914134-5
ISSN	2005-5447 ; 2005-3606
ISSN (online)	2005-5447
ISSN	2005-3606
DOI	10.15283/ijsc22209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dynamic pruning group equivariant network for motor imagery EEG recognition.

Tang, Xianlun / Zhang, Wei / Wang, Huiming / Wang, Tianzhu / Tan, Cong / Zou, Mi / Xu, Zihui

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 917328

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.917328
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Article ; Online: Short Physical Performance Battery Cutoff Points Using Clinical Outcomes for At-Risk Older Adults in Singapore: An Exploratory Study.

Hernandez, Herb Howard C / Yang, Daphne Zihui / Tan, Cai Ning / Kua, Joanne / Ismail, Noor Hafizah / Lim, Wee Shiong

Annals of geriatric medicine and research

2023 Volume 27, Issue 4, Page(s) 358–360

Language	English
Publishing date	2023-11-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3035056-6
ISSN	2508-4909 ; 2508-4798
ISSN (online)	2508-4909
ISSN	2508-4798
DOI	10.4235/agmr.23.0164
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Article ; Online: Association between a high triglyceride-glucose index and chronic kidney disease in adult patients with latent autoimmune diabetes.

Fu, Xiuli / Xu, Zihui / Tan, Qin / Wei, Wei / Wang, Zhongjing

BMC endocrine disorders

2023 Volume 23, Issue 1, Page(s) 209

Abstract: Background: Insulin resistance (IR) is one of the risk factors for chronic kidney disease (CKD) and diabetes. The triglyceride-glucose (TyG) index is considered a reliable alternative marker of IR. We investigated the correlation between the TyG index ... ...

Abstract	Background: Insulin resistance (IR) is one of the risk factors for chronic kidney disease (CKD) and diabetes. The triglyceride-glucose (TyG) index is considered a reliable alternative marker of IR. We investigated the correlation between the TyG index and the severity of CKD in patients with latent autoimmune diabetes in adults (LADA). Methods: This cross-sectional study included 288 patients with LADA in the department of endocrinology at our hospital between January 2018 and January 2022. The TyG index was calculated as Ln [TG (mg/dl) × fasting blood glucose (FBG) (mg/dl) / 2]. All individuals were divided into either a LADA + CKD group or a LADA + non-CKD group according to the presence or absence of CKD. A correlation analysis, logistic regression analysis and receiver operating characteristics curve analysis were performed. Results: A total of 130 (45.1%) participants were identified as having CKD. Compared with the non-CKD group, the CKD group had a longer disease duration and a higher proportion of smokers; patients were more likely to have hypertension and higher serum creatinine, triglyceride, cholesterol, low-density lipoprotein cholesterol, FBG, uric acid estimated glomerular filtration rates (eGFR) and TyG levels as well as lower high-density lipoprotein cholesterol levels (all P < 0.05). The positive relationship between the TyG index and the urinary albumin/creatinine ratio was significant (r = 0.249, P = 0.010). There was also a significant correlation between the TyG index and the eGFR (r = - 0.211, P = 0.034) after adjusting for confounding factors. The area-under-the-curve value of the TyG index was 0.708 (95% confidence interval: 0.61-0.81, P < 0.001). Conclusions: The TyG index is significantly associated with the severity of CKD in patients with LADA. This conclusion supports the clinical application of the TyG index for the assessment of kidney disease in patients with LADA.
MeSH term(s)	Humans ; Adult ; Diabetes Mellitus, Type 1 ; Triglycerides ; Blood Glucose/analysis ; Cross-Sectional Studies ; Biomarkers ; Glucose Intolerance ; Risk Factors ; Insulin Resistance ; Glucose ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology
Chemical Substances	Triglycerides ; Blood Glucose ; Biomarkers ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-023-01465-5
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Article ; Online: CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p.

Wang, Xuehui / Wang, Jiaying / An, Zihui / Yang, Aifen / Qiu, Mengsheng / Tan, Zhou

Cells

2023 Volume 12, Issue 6

Abstract: Mounting evidence suggests that circular RNAs play important roles in the development and progression of cancers. However, their function in glioblastomas (GBM) is still unclear. By circRNA array analysis, we found that circXPO1 (hsa_circ_102737) was ... ...

Abstract	Mounting evidence suggests that circular RNAs play important roles in the development and progression of cancers. However, their function in glioblastomas (GBM) is still unclear. By circRNA array analysis, we found that circXPO1 (hsa_circ_102737) was significantly upregulated in GBM, and qPCR analysis verified that the circXPO1 expression level was increased in both GBM tissues and cell lines. Functional studies demonstrated that the knockdown of circXPO1 in GBM cell lines repressed cell proliferation and migration; conversely, the overexpression of circXPO1 promoted the malignancy of GBM cells. In line with these findings, circXPO1 inhibition effectively suppressed gliomagenesis in the in situ transplantation model of nude mice. Through bioinformatic analyses and dual-luciferase reporter assays, we showed that circXPO1 directly bound to miR-7-5p, which acted as a tumor suppressor through the negative regulation of
MeSH term(s)	Animals ; Mice ; Brain Neoplasms/metabolism ; Glioblastoma/metabolism ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Humans
Chemical Substances	MicroRNAs ; RNA, Circular
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12060831
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Article ; Online: CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p

Xuehui Wang / Jiaying Wang / Zihui An / Aifen Yang / Mengsheng Qiu / Zhou Tan

Cells, Vol 12, Iss 831, p

2023 Volume 831

Abstract	Mounting evidence suggests that circular RNAs play important roles in the development and progression of cancers. However, their function in glioblastomas (GBM) is still unclear. By circRNA array analysis, we found that circXPO1 (hsa_circ_102737) was significantly upregulated in GBM, and qPCR analysis verified that the circXPO1 expression level was increased in both GBM tissues and cell lines. Functional studies demonstrated that the knockdown of circXPO1 in GBM cell lines repressed cell proliferation and migration; conversely, the overexpression of circXPO1 promoted the malignancy of GBM cells. In line with these findings, circXPO1 inhibition effectively suppressed gliomagenesis in the in situ transplantation model of nude mice. Through bioinformatic analyses and dual-luciferase reporter assays, we showed that circXPO1 directly bound to miR-7-5p, which acted as a tumor suppressor through the negative regulation of RAF1 . In conclusion, our studies suggest that the circXPO1/miR-7-5p/ RAF1 axis promotes brain tumor formation and may be a potential therapeutic target for GBM treatment.
Keywords	circXPO1 ; glioblastomas ; ceRNA ; miR-7-5p ; RAF1 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential for the development of

Dong, Zhen / Liu, Zhiqin / Xu, Yufeng / Tan, Bin / Sun, Wenqing / Ai, Qin / Yang, Zihui / Zeng, Jianguo

Frontiers in immunology

2024 Volume 15, Page(s) 1354040

Abstract: Introduction: Taraxacum mongolicum: Methods: A total of 240 one-day-old Arbor Acker broilers were randomly assigned to four groups and fed a basal diet (Con) supplemented with 500, 1000, and 2000 mg/kg TMAE (Low, Medium, and High groups). The growth ... ...

Abstract	Introduction: Taraxacum mongolicum Methods: A total of 240 one-day-old Arbor Acker broilers were randomly assigned to four groups and fed a basal diet (Con) supplemented with 500, 1000, and 2000 mg/kg TMAE (Low, Medium, and High groups). The growth performance of the broilers was measured on day 21 and day 42. At the end of the trial, the researchers measured slaughter performance and collected serum, liver, spleen, ileum, and intestinal contents to investigate the effects of TMAE on serum biochemistry, antioxidant capacity, immune function, organ coefficient, intestinal morphology, flora composition, and short-chain fatty acids (SCFAs). Results: The results showed that broilers treated with TMAE had a significantly higher average daily gain from 22 to 42 days old compared to the Con group. Various doses of TMAE resulted in different levels of improvement in serum chemistry. High doses increased serum alkaline phosphatase and decreased creatinine. TMAE also increased the antioxidant capacity of serum, liver, and ileum in broilers. Additionally, middle and high doses of TMAE enhanced the innate immune function of the liver (IL-10) and ileum (Occludin) in broilers. Compared to the control group, the TMAE treatment group exhibited an increase in the ratio of villi length to villi crypt in the duodenum. TMAE increased the abundance of beneficial bacteria, such as Conclusion: In conclusion, TMAE is a promising poultry feed additive and 1000 mg/kg is an effective reference dose.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Chickens/microbiology ; Dietary Supplements ; Fatty Acids, Volatile ; Poultry ; Taraxacum
Chemical Substances	Antioxidants ; Fatty Acids, Volatile
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1354040
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Article: Post-operative infection in mechanical circulatory support patients.

Tan, Zihui / Zeng, Ling Antonia

Annals of translational medicine

2020 Volume 8, Issue 13, Page(s) 831

Abstract: The management of end stage heart failure has changed dramatically in recent years with the advent of mechanical circulatory support devices as well as rapid improvement and increased availability of these devices. With the improvements in survival and ... ...

Abstract	The management of end stage heart failure has changed dramatically in recent years with the advent of mechanical circulatory support devices as well as rapid improvement and increased availability of these devices. With the improvements in survival and quality of life in these patients, post-operative infections become a significant contribution to morbidity and mortality. Post-operative infections need to be adequately addressed in a timely fashion by early diagnosis and appropriate treatment. Recognizing risk factors for infection and instituting good infection control measures is also key in caring for these patients. Multiple patient and device factors have been shown to be correlated with increased post-operative infections, and cellular immunity is also impaired in patients on ventricular assist devices (VAD). Cultures should be taken prior to starting antimicrobial treatment. Empirical treatment needs to account for common pathogens, local microbial resistance and subsequently be culture guided once results are available. Patients on extracorporeal membrane oxygenation present a unique challenge with drug dosing due to altered pharmacokinetics. VAD related and VAD specific infections require appropriate wound care and possible surgical intervention. This narrative review summarizes the literature available for the management and prevention of post-operative infections in patients with mechanical circulatory devices. Vigilance in identifying risk factors, prompt treatment and active prevention is crucial to the management.
Language	English
Publishing date	2020-07-22
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-1748
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Article ; Online: Identification for Abutment Stress by Drilling Cuttings

Jian Tan / Yunliang Tan / Zihui Wang / Yubao Zhang

Applied Sciences, Vol 11, Iss 9467, p

2021 Volume 9467

Abstract: The concentration of abutment pressure acting on coal seams induced by mining is a key factor to trigger rock burst. Understanding of abutment pressure or stress concentration is fundamental in preventing and controlling rock burst. The influence on ... ...

Abstract	The concentration of abutment pressure acting on coal seams induced by mining is a key factor to trigger rock burst. Understanding of abutment pressure or stress concentration is fundamental in preventing and controlling rock burst. The influence on abutment pressure fluctuation caused by the inhomogeneity of coal seams needs to be considered, but it is difficult to obtain by the present usual ways such as acoustic transmission, electromagnetic wave transmission, etc. In this article, the relationship between the amount of cuttings drilled in a coal seam and stress level was analyzed by considering the effect of drilling cutting expansion, and the drilling cutting test was carried out in Xinglongzhuang Coal Mine, Shandong Energy Ltd. It is found that the amount of cuttings drilled is positively related to the degree of stress concentration in both the plastic fracture zone and elastic zone. The amount of drilling cuttings is closely related to the roof weighting. In addition, the irregular fluctuation of drilling cuttings is an approximate map of distribution of stress concentration because of the non-uniformity of cracks and other defects in the coal seam. In order to meet the need of rock burst prevention by accurate pressure relief in high-stress zones, enough boreholes are needed.
Keywords	abutment stress ; drilling cutting ; roof weighting ; pressure relief ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Short Physical Performance Battery Cutoff Points Using Clinical Outcomes for At-Risk Older Adults in Singapore

Herb Howard C. Hernandez / Daphne Zihui Yang / Cai Ning Tan / Joanne Kua / Noor Hafizah Ismail / Wee Shiong Lim

Annals of Geriatric Medicine and Research, Vol 27, Iss 4, Pp 358-

An Exploratory Study

2023 Volume 360

Keywords	Medicine ; R ; Geriatrics ; RC952-954.6
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Korea Geriatrics Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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