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  1. Article ; Online: Nutrient supplementation among pregnant women in China: an observational study - ERRATUM.

    Han, Tao / Dong, Jingwen / Zhang, Jiangtao / Zhang, Chenxiao / Wang, Yuxuan / Zhang, Zhiruo / Xiang, Mi

    Public health nutrition

    2023  Volume 26, Issue 5, Page(s) 1112

    MeSH term(s) Female ; Pregnancy ; Humans ; Pregnant Women ; Dietary Supplements ; Folic Acid ; Nutrients ; China
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Observational Study ; Journal Article ; Published Erratum
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980023000290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 6998: Show issues

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  2. Article ; Online: HgCl2 exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3

    Jiaqi Wang / Yilin Yin / Qirui Zhang / Xinrui Deng / Zhiruo Miao / Shiwen Xu

    Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115779- (2024)

    1481  

    Abstract: Mercury (Hg) is a serious metal environmental pollutant. HgCl2 exposure causes pyroptosis. When macrophages are severely stimulated, they often undergo M1 polarization and release inflammatory factors. However, the mechanisms by which mercuric chloride ... ...

    Abstract Mercury (Hg) is a serious metal environmental pollutant. HgCl2 exposure causes pyroptosis. When macrophages are severely stimulated, they often undergo M1 polarization and release inflammatory factors. However, the mechanisms by which mercuric chloride exposure induces macrophage apoptosis, M1 polarization, and inflammatory factors remain unclear. HD11 cells were exposed to different concentrations of Hg chloride (180, 210 and 240 nM HgCl2). The results showed that mercury chloride exposure up-regulated ROS, C-Nrf2 and its downstream factors (NQO1 and HO-1), and down-regulated N-Nrf2. In addition, the expressions of focal death-related indicators (Caspase-1, NLRP3, GSDMD, etc.), M1 polarization marker CD86 and inflammatory factors (TNF-α, IL-1β) increased, and the above changes were related to mercury. Oxidative stress inhibitor (NAC) can block ROS/ NrF2-mediated oxidative stress, inhibit mercury-induced pyroptosis and M1 polarization, and effectively reduce the release of inflammatory factors. The addition of Vx-765 to inhibit pyroptosis can effectively alleviate M1 polarization of HD11 cells and reduce the expression of inflammatory factors. HgCl2 mediates pyroptosis of HD11 cells by regulating ROS/Nrf2/NLRP3, promoting M1 polarization and the release of inflammatory factors.
    Keywords HgCl2 ; Pyroptosis ; ROS/Nrf2/NLRP3 pathway ; M1 polarization ; Inflammatory factor ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Does Health Insurance Reduce the Alcohol Consumption? Evidence from China Health and Nutrition Survey

    Chenhao Yu / Huigang Liang / Zhiruo Zhang

    Sustainability, Vol 14, Iss 5693, p

    2022  Volume 5693

    Abstract: Whether health insurance reduces alcohol consumption has been debated. To identify it, the authors used three-wave balance panel data from China Health and Nutrition Survey and applied a two-way fixed-effect model. The authors found that (1) health ... ...

    Abstract Whether health insurance reduces alcohol consumption has been debated. To identify it, the authors used three-wave balance panel data from China Health and Nutrition Survey and applied a two-way fixed-effect model. The authors found that (1) health insurance reduces alcohol consumption, (2) the effect would be deducted when they have been diagnosed with diabetes, (3) the heterogeneity existed between old and young individuals as well as rural and urban areas, those old individuals would behave more cautious, and urban individuals would consume more alcohol. This study identified the effects of health insurance and the moderating effect of diabetes, which were helpful for policymakers to optimize health insurance policy to ensure the sustainability of health insurance and suggested that primary medical staff should assist patients to establish healthy living habits and reduce their risky behaviors.
    Keywords health insurance ; ex-ante moral hazard ; alcohol consumption ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dual-parameter sensing of refractive index and pressure by dual-polarization microresonators.

    Zhang, Ping / Yan, Zhiruo / Zhang, Chen

    Applied optics

    2022  Volume 60, Issue 35, Page(s) 10849–10854

    Abstract: We propose a dual-polarization microring resonator that can simultaneously measure refractive index and pressure. Since the transverse electric (TE) mode and the transverse magnetic (TM) mode of a silicon waveguide have different energy distributions, TE ...

    Abstract We propose a dual-polarization microring resonator that can simultaneously measure refractive index and pressure. Since the transverse electric (TE) mode and the transverse magnetic (TM) mode of a silicon waveguide have different energy distributions, TE and TM polarization have significant differences in sensitivity to environmental refractive index and pressure changes. Different responses to external refractive index and pressure changes can be obtained by simultaneously exciting TE and TM modes in a microring resonator. The refractive index sensitivities obtained in the experiment were 132.97 and 40.54 nm/RIU; the pressure sensitivities were 1.41 and 1.59 pm/KPa, respectively. By inversion of the second-order sensitivity matrix, it is verified that the effective refractive index and pressure response can be obtained simultaneously through a single measurement to realize the dual-parameter sensing of the surrounding refractive index and the pressure of the device structure.
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.441079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Photoredox Coupling of CO

    Du, Zisheng / Gong, Kexin / Yu, Zhiruo / Yang, Yang / Wang, Peixian / Zheng, Xiuzhen / Wang, Zhongliao / Zhang, Sujuan / Chen, Shifu / Meng, Sugang

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 18

    Abstract: Integrating photocatalytic ... ...

    Abstract Integrating photocatalytic CO
    Language English
    Publishing date 2023-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28186553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Platinum Nanoparticles Prevent the Resistance of

    Zhou, Zhiruo / Lian, Yulu / Zhu, Lin / Zhang, Haibo / Li, Zhangqiang / Wang, Meizhen

    ACS nano

    2023  Volume 17, Issue 24, Page(s) 24685–24695

    Abstract: Metal nanoparticles (MNPs) have recently gained extensive attention due to their broad-spectrum prospect, particularly in biomedical application. Here, we reveal that long-term exposure to platinum nanoparticles (Pt NPs) increases the susceptibility ... ...

    Abstract Metal nanoparticles (MNPs) have recently gained extensive attention due to their broad-spectrum prospect, particularly in biomedical application. Here, we reveal that long-term exposure to platinum nanoparticles (Pt NPs) increases the susceptibility of
    MeSH term(s) Humans ; Imipenem/pharmacology ; Ciprofloxacin/pharmacology ; Pseudomonas aeruginosa ; Platinum/pharmacology ; Metal Nanoparticles ; Anti-Bacterial Agents/pharmacology ; Pseudomonas Infections ; Mutation ; Microbial Sensitivity Tests ; Bacterial Proteins/genetics
    Chemical Substances Imipenem (71OTZ9ZE0A) ; Ciprofloxacin (5E8K9I0O4U) ; Platinum (49DFR088MY) ; Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c04167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tetracycline antibiotics: Potential anticancer drugs.

    Li, Jiayu / Qin, Yuan / Zhao, Chenhao / Zhang, Zhi / Zhou, Zhiruo

    European journal of pharmacology

    2023  Volume 956, Page(s) 175949

    Abstract: In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics ... ...

    Abstract In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidence indicated that they have anticancer properties and are able to control cancer progression through different mechanisms, such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. In addition, studies have shown that these three tetracycline antibiotics can be utilized in conjunction with chemotherapeutic and targeted drugs to inhibit cancer progression and improve the quality of patient survival. Therefore, doxycycline, minocycline, and tigecycline are taken as examples in this work. Their mechanisms of action in different cancers and related combination therapies are introduced. Their current roles in alleviating the suffering of patients undergoing chemotherapy when used as adjuvant drugs in clinical treatment are also described. Finally, the research gaps and potential research directions at this stage are briefly summarized.
    MeSH term(s) Humans ; Doxycycline/pharmacology ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Tigecycline ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/chemically induced ; Heterocyclic Compounds
    Chemical Substances Doxycycline (N12000U13O) ; Minocycline (FYY3R43WGO) ; Tigecycline (70JE2N95KR) ; Anti-Bacterial Agents ; Antineoplastic Agents ; Heterocyclic Compounds
    Language English
    Publishing date 2023-08-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Children's Dental Fear: Occurrence Mechanism and Prevention Guidance.

    Ying, Jiaxun / Tao, Hanbo / He, Qingyuan / Zhang, Zhiruo / Hu, Wenfei / Chen, Shuting / Guan, Ye

    Journal of multidisciplinary healthcare

    2023  Volume 16, Page(s) 2013–2021

    Abstract: Children's dental fear (CDF) has become one of the main reasons affecting the quality of dental treatment. In order to reduce the incidence of CDF in China before and after children's dental visits, this review applies literature analysis and empirical ... ...

    Abstract Children's dental fear (CDF) has become one of the main reasons affecting the quality of dental treatment. In order to reduce the incidence of CDF in China before and after children's dental visits, this review applies literature analysis and empirical summary methods to analyze and summarize academic discussions on this topic, including occurrence mechanism, prevention guidance, and the conclusion that the occurrence and prevention of CDF is closely related with children's internal characteristics and external influences. In the end, we propose a breakthrough of combining the CFSS-DS scale and three-grade prevention theory together in the future to provide new ideas and hypotheses for the prevention of CDF.
    Language English
    Publishing date 2023-07-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S412412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular targets and mechanisms of anti-cancer effects of withanolides.

    Zhang, Zhiruo / Yang, Yueying / Xu, Yang / Liu, Yang / Li, Hua / Chen, Lixia

    Chemico-biological interactions

    2023  Volume 384, Page(s) 110698

    Abstract: Withanolides are a class of natural products with a steroidal lactone structure that exhibit a broad spectrum of anti-cancer effects. To date, several studies have shown that their possible mechanisms in cancer development and progression are associated ... ...

    Abstract Withanolides are a class of natural products with a steroidal lactone structure that exhibit a broad spectrum of anti-cancer effects. To date, several studies have shown that their possible mechanisms in cancer development and progression are associated with the regulation of cell proliferation, apoptosis, metastasis, and angiogenesis. Withanolides can also attenuate inflammatory responses, as well as modulate the genomic instability and energy metabolism of cancer cells. In addition, they may improve the safety and efficacy of cancer treatments as adjuvants to traditional cancer therapeutics. Herein, we summarize the molecular targets and mechanisms of withanolides in different cancers, as well as their current clinical studies on them.
    Language English
    Publishing date 2023-09-09
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2023.110698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: HgCl

    Wang, Jiaqi / Yin, Yilin / Zhang, Qirui / Deng, Xinrui / Miao, Zhiruo / Xu, Shiwen

    Ecotoxicology and environmental safety

    2023  Volume 269, Page(s) 115779

    Abstract: Mercury (Hg) is a serious metal environmental pollutant. ... ...

    Abstract Mercury (Hg) is a serious metal environmental pollutant. HgCl
    MeSH term(s) Chickens/metabolism ; Chlorides ; Inflammation/metabolism ; Mercury/adverse effects ; Mercury/toxicity ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis ; Reactive Oxygen Species/metabolism ; Animals
    Chemical Substances Chlorides ; Mercury (FXS1BY2PGL) ; NF-E2-Related Factor 2 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species
    Language English
    Publishing date 2023-12-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2023.115779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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