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  1. Article ; Online: Frequency of colorectal surveillance colonoscopies for adenomatous polyps: systematic review and meta-analysis.

    Ho, Yiu Ming / Merollini, Katharina M D / Gordon, Louisa G

    Journal of gastroenterology and hepatology

    2023  Volume 39, Issue 1, Page(s) 37–46

    Abstract: Background and aim: The purpose of this study was to assess evidence on the frequency of polyp surveillance colonoscopies performed earlier than the recommended follow-up intervals in clinical practice guidelines.: Methods: A systematic review was ... ...

    Abstract Background and aim: The purpose of this study was to assess evidence on the frequency of polyp surveillance colonoscopies performed earlier than the recommended follow-up intervals in clinical practice guidelines.
    Methods: A systematic review was performed based on electronic searches in PubMed and Embase. Research articles, letters to the editors, and review articles, published before April 2022, were included. Studies that focused on the intervals of polyp surveillance in adult populations were selected. The Risk Of Bias In Non-randomized Studies of Exposure (ROBINS-E) was used to assess the risk of bias. A meta-analysis was performed with Forest plots to illustrate the results.
    Results: In total, 16 studies, comprising 11 172 patients from Australia, Europe, and North America, were included for analysis. The quality of the studies was moderate. Overall, 38% (95% CI: 30-47%) of colonoscopies were undertaken earlier than their respective national clinical guidelines. In risk-stratified surveillance, 10 studies contained data relating to low-risk polyp surveillance intervals and 30% (95% CI: 29-31%) of colonoscopies were performed earlier than recommended. Eight studies contained data relating to intermediate-risk polyp surveillance and 15% (95% CI: 14-17%) of colonoscopies were performed earlier than recommended. One study showed that 6% (95% CI: 4-10%) of colonoscopies performed for high-risk polyp surveillance were performed earlier than recommended.
    Conclusions: A significant proportion of polyp surveillance was performed earlier than the guidelines suggested. This provides evidence of the potential overuse of healthcare resources and the opportunity to improve hospital efficiency.
    MeSH term(s) Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Adenomatous Polyps/diagnosis ; Adenomatous Polyps/epidemiology ; Colonoscopy/methods ; Polyps ; North America/epidemiology ; Colonic Polyps/diagnosis ; Colonic Polyps/epidemiology
    Language English
    Publishing date 2023-11-15
    Publishing country Australia
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16397
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    Zs.A 2180: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 299: Show issues

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  2. Article ; Online: Gender differences in ergonomics during simulated ureteroscopy.

    Kim, Erin / Sun, Alec / Rodriguez-Alvarez, Juan Sebastian / Ho, Louisa / O'Laughlin, Kyle / De, Smita

    American journal of surgery

    2024  

    Abstract: Background: Female urologists report higher rates of work-related physical discomfort compared to male urologists. We compared ergonomics during simulated ureteroscopy, the most common surgery for kidney stones, between male and female urologists.: ... ...

    Abstract Background: Female urologists report higher rates of work-related physical discomfort compared to male urologists. We compared ergonomics during simulated ureteroscopy, the most common surgery for kidney stones, between male and female urologists.
    Methods: Surface electromyography was used to measure muscle activation during common ureteroscopic tasks in urology trainees and staff with different surgeon positions and ureteroscopes. Subjective workload was assessed using the NASA Task Load Index (NASA-TLX). Paired t-tests, Wilcoxon rank-sum tests, and multivariate regressions were used to compare muscle activation by gender for each trial condition.
    Results: There was no difference in age or distribution of training level between genders, though men had larger glove sizes. Across all conditions, women required greater muscle activation in multiple muscle groups and had greater NASA-TLX scores compared to men.
    Conclusions: There may be gender differences in ergonomics during ureteroscopy based on muscle activation and subjective workload, suggesting potential for personalizing surgical ecosystems.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2024.02.034
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  3. Article: Factors influencing pharmacists and pharmaceutical scientists' membership in professional organisations: an international survey.

    Sullivan, Louisa / Ho, Jun Ni / Lee, You Zhuan / Khalid, Garba Mohammed / Sandhu, Anisha Kaur / Meilianti, Sherly / Aqqad, Farah / Lim, Renly

    Journal of pharmaceutical policy and practice

    2023  Volume 16, Issue 1, Page(s) 105

    Abstract: Background: Professional organisations exist as international or national organisations, with each country establishing at least one national professional association. There remains a knowledge gap about factors that influence professional ... ...

    Abstract Background: Professional organisations exist as international or national organisations, with each country establishing at least one national professional association. There remains a knowledge gap about factors that influence professional organisational involvement of pharmacists and pharmaceutical scientists. This study aims to explore the motivators and barriers of pharmacy professionals holding organisation membership from a global perspective.
    Methods: An online questionnaire was developed and disseminated between May and July 2021. The survey was open to all pharmacists and pharmaceutical scientists. The survey consisted of four sections; demographic information, questions about professional organisations, about the International Pharmaceutical Federation (FIP) and its impact on the members. Data were analysed descriptively.
    Results: A total of 1033 complete survey responses were received and included in the analysis. Of all respondents, 761 (73.7%) respondents were current members of a professional organisation and 272 (26.3%) were not members of any professional organisation. Overall, findings demonstrated networking, education, training and professional development opportunities as the main interests and anticipated activities, while the lack of clarity or need to join organisation, time, and financial constraints as the main barriers of pharmacy professionals holding membership. The majority of FIP members are satisfied with current FIP activities, and anticipate further networking opportunities, educational resources and grants made available to members.
    Conclusions: Understanding the perceptions and needs, as well as factors that influence engagement of pharmacists and pharmaceutical scientists is the key to enhancing membership. Professional organisations are highly encouraged to strengthen and target activities according to the identified motivators and barriers.
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1186/s40545-023-00620-6
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  4. Article ; Online: Cancer Survivors' Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q).

    Merollini, Katharina M D / Gordon, Louisa G / Ho, Yiu M / Aitken, Joanne F / Kimlin, Michael G

    International journal of environmental research and public health

    2022  Volume 19, Issue 15

    Abstract: Worldwide, the number of cancer survivors is rapidly increasing. The aim of this study was to quantify long-term health service costs of cancer survivorship on a population level. The study cohort comprised residents of Queensland, Australia, diagnosed ... ...

    Abstract Worldwide, the number of cancer survivors is rapidly increasing. The aim of this study was to quantify long-term health service costs of cancer survivorship on a population level. The study cohort comprised residents of Queensland, Australia, diagnosed with a first primary malignancy between 1997 and 2015. Administrative databases were linked with cancer registry records to capture all health service utilization. Health service costs between 2013-2016 were analyzed using a bottom-up costing approach. The cumulative mean annual healthcare expenditure (2013-2016) for the cohort of N = 230,380 individuals was AU$3.66 billion. The highest costs were incurred by patients with a history of prostate (AU$538 m), breast (AU$496 m) or colorectal (AU$476 m) cancers. Costs by time since diagnosis were typically highest in the first year after diagnosis and decreased over time. Overall mean annual healthcare costs per person (2013-2016) were AU$15,889 (SD: AU$25,065) and highest costs per individual were for myeloma (AU$45,951), brain (AU$30,264) or liver cancer (AU$29,619) patients. Our results inform policy makers in Australia of the long-term health service costs of cancer survivors, provide data for economic evaluations and reinforce the benefits of investing in cancer prevention.
    MeSH term(s) Australia/epidemiology ; Cancer Survivors ; Health Care Costs ; Health Services ; Humans ; Information Storage and Retrieval ; Male ; Neoplasms/epidemiology ; Neoplasms/therapy ; Queensland/epidemiology
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19159473
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  5. Article ; Online: HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity

    Andrew Nguyen / Louisa Ho / Richard Hogg / Lan Chen / Scott R. Walsh / Yonghong Wan

    The Journal of Clinical Investigation, Vol 132, Iss

    2022  Volume 19

    Abstract: Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity represents a longitudinal challenge for durable clinical responses due to the therapeutic ... ...

    Abstract Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity represents a longitudinal challenge for durable clinical responses due to the therapeutic selective pressure for immune escape variants. Here, we demonstrated that delivery of the class I histone deacetylase inhibitor MS-275 promoted sustained tumor regression by synergizing with ACT in a coordinated manner to enhance cellular apoptosis. We found that MS-275 altered the tumor inflammatory landscape to support antitumor immunoactivation through the recruitment and maturation of cross-presenting CD103+ and CD8+ DCs and depletion of Tregs. Activated endogenous CD8+ T cell responses against nontarget tumor antigens were critically required for the prevention of tumor recurrence. Importantly, MS-275 altered the immunodominance hierarchy by directing epitope spreading toward the endogenous retroviral tumor–associated antigen p15E. Our data suggest that MS-275 in combination with ACT multimechanistically enhanced epitope spreading and promoted long-term clearance of solid tumors.
    Keywords Immunology ; Vaccines ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Retrospective Comparison of Titanium Hybrid Locking Plate with Stainless Steel Hybrid Dynamic Compression Plate for Pancarpal Arthrodesis: 23 Dogs.

    Chong, Wye Li / Eckart, Louisa Ho / Sul, Rui / Jermyn, Kieri / Michelsen, Jacob

    Veterinary and comparative orthopaedics and traumatology : V.C.O.T

    2022  Volume 35, Issue 4, Page(s) 270–278

    Abstract: Objective:  The aim of this study was to evaluate outcomes and complications of dogs that had pancarpal arthrodesis (PCA) using a titanium hybrid advanced locking plate system (ALPS) and stainless steel hybrid dynamic compression plate (HDCP).: Study ... ...

    Abstract Objective:  The aim of this study was to evaluate outcomes and complications of dogs that had pancarpal arthrodesis (PCA) using a titanium hybrid advanced locking plate system (ALPS) and stainless steel hybrid dynamic compression plate (HDCP).
    Study design:  Retrospective observational study.
    Methods:  Medical records (2007-2020) were reviewed for cases that had PCA performed using ALPS or HDCP. Implant characteristics including metacarpal coverage (MCov), metacarpal width occupied by screw diameter percentage and carpal arthrodesis angle (CAA), complications and outcomes were recorded.
    Results:  Pancarpal arthrodesis was performed with ALPS on 15 limbs from 12 dogs, and HDCP on 14 limbs from 11dogs. Median follow-up time was 1,157 days (range: 62-1,902 days) for ALPS group and 340 days (range: 43-1,465 days) for HDCP. Median MCov for ALPS group was 74% (range: 60-87.5%) compared with 56.5% (range: 49.7-91.3%) for HDCP (
    Conclusion:  The use of ALPS offers comparable performance to HDCP for PCA.
    MeSH term(s) Animals ; Arthrodesis/veterinary ; Bone Plates/veterinary ; Dogs ; Retrospective Studies ; Stainless Steel ; Titanium
    Chemical Substances Stainless Steel (12597-68-1) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2022-05-24
    Publishing country Germany
    Document type Journal Article ; Observational Study, Veterinary
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0042-1748198
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    Zs.A 2352: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity.

    Nguyen, Andrew / Ho, Louisa / Hogg, Richard / Chen, Lan / Walsh, Scott R / Wan, Yonghong

    The Journal of clinical investigation

    2022  Volume 132, Issue 19

    Abstract: Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity represents a longitudinal challenge for durable clinical responses due to the therapeutic ... ...

    Abstract Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity represents a longitudinal challenge for durable clinical responses due to the therapeutic selective pressure for immune escape variants. Here, we demonstrated that delivery of the class I histone deacetylase inhibitor MS-275 promoted sustained tumor regression by synergizing with ACT in a coordinated manner to enhance cellular apoptosis. We found that MS-275 altered the tumor inflammatory landscape to support antitumor immunoactivation through the recruitment and maturation of cross-presenting CD103+ and CD8+ DCs and depletion of Tregs. Activated endogenous CD8+ T cell responses against nontarget tumor antigens were critically required for the prevention of tumor recurrence. Importantly, MS-275 altered the immunodominance hierarchy by directing epitope spreading toward the endogenous retroviral tumor-associated antigen p15E. Our data suggest that MS-275 in combination with ACT multimechanistically enhanced epitope spreading and promoted long-term clearance of solid tumors.
    MeSH term(s) Antigens, Neoplasm/genetics ; Benzamides ; CD8-Positive T-Lymphocytes ; Epitopes ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Neoplasms/pathology ; Pyridines ; Tumor Microenvironment
    Chemical Substances Antigens, Neoplasm ; Benzamides ; Epitopes ; Histone Deacetylase Inhibitors ; Pyridines ; entinostat (1ZNY4FKK9H)
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI159283
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    Ua VI Zs.184: Show issues Location:
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  8. Article ; Online: Mid- to Long-Term Outcome after Arthroscopy and Proximal Abducting Ulnar Osteotomy Versus Arthroscopy Alone in Dogs with Medial Compartment Disease: Thirty Cases.

    Coghill, Fiona J / Ho-Eckart, Louisa K / Baltzer, Wendy I

    Veterinary and comparative orthopaedics and traumatology : V.C.O.T

    2020  Volume 34, Issue 2, Page(s) 85–90

    Abstract: Objective:  The aim of this study was to determine owner-assessed mid- to long-term outcome for dogs with medial compartment disease treated arthroscopically with fragment removal with or without proximal abducting ulnar osteotomy (PAUL).: Study ... ...

    Abstract Objective:  The aim of this study was to determine owner-assessed mid- to long-term outcome for dogs with medial compartment disease treated arthroscopically with fragment removal with or without proximal abducting ulnar osteotomy (PAUL).
    Study design:  This was a retrospective clinical study.
    Materials and methods:  Records from 30 dogs with medial compartment disease treated with arthroscopy with or without PAUL were retrospectively reviewed over a 5-year period. Proximal abducting ulnar osteotomy cases were matched to arthroscopy-alone controls based on bodyweight and modified Outerbridge score. Outcome was assessed via owner questionnaire using the Canine Brief Pain Inventory (CBPI), frequency of non-steroidal anti-inflammatory drug (NSAID) administration and owner-assessed overall improvement.
    Results:  Canine Brief Pain Inventory score for dogs in the PAUL group was not significantly different from the control group (
    Clinical significance:  Proximal abducting ulnar osteotomy showed no owner-assessed benefit over arthroscopic medial coronoid fragment removal for dogs with medial compartment disease and modified Outerbridge score of 3 or greater. A prospective, blinded, controlled clinical trial is warranted to determine the appropriate clinical application of the PAUL procedure.
    MeSH term(s) Animals ; Arthroscopy/methods ; Arthroscopy/veterinary ; Compartment Syndromes/surgery ; Compartment Syndromes/veterinary ; Dog Diseases/surgery ; Dogs/surgery ; Female ; Male ; Osteotomy/methods ; Osteotomy/veterinary ; Retrospective Studies ; Treatment Outcome ; Ulna/surgery
    Language English
    Publishing date 2020-10-01
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0040-1716843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2352: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia

    Katharina M. D. Merollini / Louisa G. Gordon / Yiu M. Ho / Joanne F. Aitken / Michael G. Kimlin

    International Journal of Environmental Research and Public Health, Vol 19, Iss 9473, p

    Results of a Population-Level Data Linkage Study (Cos-Q)

    2022  Volume 9473

    Abstract: Worldwide, the number of cancer survivors is rapidly increasing. The aim of this study was to quantify long-term health service costs of cancer survivorship on a population level. The study cohort comprised residents of Queensland, Australia, diagnosed ... ...

    Abstract Worldwide, the number of cancer survivors is rapidly increasing. The aim of this study was to quantify long-term health service costs of cancer survivorship on a population level. The study cohort comprised residents of Queensland, Australia, diagnosed with a first primary malignancy between 1997 and 2015. Administrative databases were linked with cancer registry records to capture all health service utilization. Health service costs between 2013–2016 were analyzed using a bottom-up costing approach. The cumulative mean annual healthcare expenditure (2013–2016) for the cohort of N = 230,380 individuals was AU$3.66 billion. The highest costs were incurred by patients with a history of prostate (AU$538 m), breast (AU$496 m) or colorectal (AU$476 m) cancers. Costs by time since diagnosis were typically highest in the first year after diagnosis and decreased over time. Overall mean annual healthcare costs per person (2013–2016) were AU$15,889 (SD: AU$25,065) and highest costs per individual were for myeloma (AU$45,951), brain (AU$30,264) or liver cancer (AU$29,619) patients. Our results inform policy makers in Australia of the long-term health service costs of cancer survivors, provide data for economic evaluations and reinforce the benefits of investing in cancer prevention.
    Keywords cancer survivors ; health service use ; costs and cost analysis ; health economics ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions.

    Ho, Louisa A / Raston, Colin L / Stubbs, Keith A

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2018  Volume 24, Issue 35, Page(s) 8869–8874

    Abstract: The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by ... ...

    Abstract The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A
    Language English
    Publishing date 2018-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201801109
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