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Article ; Online: Protecting workers aged 60-69 years from COVID-19.

Glynn, Judith R

2020 Volume 20, Issue 10, Page(s) 1123

MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Coronavirus Infections/prevention & control ; Humans ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/mortality ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; United Kingdom/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(20)30311-X
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Article: Protecting workers aged 60-69 years from COVID-19

Glynn, Judith R

Lancet Infect Dis

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #90342
Database	COVID19

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Article ; Online: Protecting workers aged 60–69 years from COVID-19

Glynn, Judith R

The Lancet Infectious Diseases

2020 Volume 20, Issue 10, Page(s) 1123

Keywords	Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/s1473-3099(20)30311-x
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between breastfeeding duration and educational attainment in rural Southwest Uganda: a population-based cohort study.

Mohammed, Shamsudeen / Calvert, Clara / O Mugisha, Joseph / Ronald, Makanga / Asiki, Gershim / R Glynn, Judith / Oakley, Laura L / Marston, Milly

Global health action

2024 Volume 17, Issue 1, Page(s) 2338023

Abstract: Background: Breastfeeding is important for early childhood nutrition and health. The positive effects on educational outcomes may be attributed to socioeconomic factors. Socioeconomic status is not a strong predictor of breastfeeding in sub-Saharan ... ...

Abstract	Background: Breastfeeding is important for early childhood nutrition and health. The positive effects on educational outcomes may be attributed to socioeconomic factors. Socioeconomic status is not a strong predictor of breastfeeding in sub-Saharan African countries. Yet, few studies have investigated the association between breastfeeding and educational outcomes in these countries. Objective: This study investigated the association between breastfeeding duration and children's educational attainment in rural Southwest Uganda. Methods: We analysed longitudinal data on 3018 children who had information on breastfeeding and were followed for at least 5 years, with at least one primary school grade recorded by 2005. Data on breastfeeding duration were collected from mothers. The highest school grade was recorded repeatedly between ages 6 and 12 years. We calculated age-for-grade based on whether a child was on, over, or under the official age for a grade. Generalised estimating equations and binary logistic regression estimated the effect of breastfeeding duration on being 2 years, 3 or more years, or any years over-age for grade in primary school, adjusting for socioeconomic status and maternal-child characteristics. Results: Most mothers breastfed for more than a year. Just over one-third breastfed for 18-23 months, and 30% breastfed for longer. By age eight, 42% of the children were two years over-age for their grade. Three or more years over-age for grade increased from 19% at age nine to 56% at age 12. Both adjusted and unadjusted estimates were consistent in showing reduced odds for children being 2 years, 3 or more years, or any years over-age for grade among children breastfed for 7-12, 13-17, 18-23, and > 23 months compared to those breastfed for 0-6 months. There was no evidence to support an overall association between breastfeeding duration and being over-age for grade. There was no evidence of association in the sex and age sub-group analyses. Conclusion: Although we found no association between breastfeeding duration and educational attainment, breastfeeding remains important for children's health and nutrition, and mothers should be encouraged and supported to breastfeed for the recommended duration.
MeSH term(s)	Humans ; Breast Feeding/statistics & numerical data ; Uganda ; Female ; Rural Population/statistics & numerical data ; Educational Status ; Child ; Male ; Longitudinal Studies ; Time Factors ; Socioeconomic Factors ; Adult ; Mothers/psychology ; Mothers/statistics & numerical data ; Infant ; Child, Preschool
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540569-X
ISSN	1654-9880 ; 1654-9880
ISSN (online)	1654-9880
ISSN	1654-9880
DOI	10.1080/16549716.2024.2338023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Age-specific incidence of Ebola virus disease.

Glynn, Judith R

Lancet (London, England)

2015 Volume 386, Issue 9992, Page(s) 432

MeSH term(s)	Age Distribution ; Age Factors ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Incidence ; Liberia/epidemiology ; Sierra Leone/epidemiology
Language	English
Publishing date	2015-08-01
Publishing country	England
Document type	Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(15)61446-5
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Article ; Online: Covid-19: excess all cause mortality in domiciliary care.

Glynn, Judith R / Fielding, Katherine / Shakespeare, Tom / Campbell, Oona

BMJ (Clinical research ed.)

2020 Volume 370, Page(s) m2751

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Home Care Services ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.m2751
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Article ; Online: Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children.

Glynn, Judith R / Moss, Paul A H

Scientific data

2020 Volume 7, Issue 1, Page(s) 329

Abstract: The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with ... ...

Abstract	The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5-14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Communicable Diseases/immunology ; Communicable Diseases/mortality ; Coronavirus Infections ; Datasets as Topic ; Humans ; Immunosenescence ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-020-00668-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Time trends in the prevalence and determinants of age-appropriate breast feeding among children aged 0-23 months in Ghana: a pooled analysis of population-based surveys, 2003-2017.

Mohammed, Shamsudeen / Oakley, Laura L / Marston, Milly / Glynn, Judith R / Calvert, Clara

BMJ open

2022 Volume 12, Issue 8, Page(s) e059928

Abstract: Objective: We assessed the sociodemographic and maternal-child characteristics associated with age-appropriate breast feeding among children aged 0-23 months in Ghana.: Methods: We pooled data on 12 743 children aged 0-23 months from three ... ...

Abstract	Objective: We assessed the sociodemographic and maternal-child characteristics associated with age-appropriate breast feeding among children aged 0-23 months in Ghana. Methods: We pooled data on 12 743 children aged 0-23 months from three Demographic and Health Surveys (2003, 2008 and 2014) and three Multiple Indicator Cluster Surveys (2006, 2011 and 2017-2018). The outcome was age-appropriate breast feeding from birth to 23 months, with age-appropriate breast feeding defined as exclusive breast feeding at 0-5 months (ie, at less than 6 months) and breastfeeding alongside appropriate complementary feeding at 6-23 months. Potential determinants were maternal-child sociodemographic, obstetric and healthcare factors. Logistic regression was used to determine the factors associated with age-appropriate breast feeding. We accounted for the complex sampling design of the cross-sectional surveys in the analysis. Results: Most children aged 0-3 months were exclusively breastfed. Among children aged 4-5 months, the most common feeding pattern was breastfeeding alongside water and/or solid foods. Exclusive breastfeeding prevalence in children less than 6 months peaked in 2008 at 62.8% and declined to 42.9% in 2017. For 6-11 month olds, the percentage experiencing age-appropriate breast feeding has been stable over the last four surveys, ranging from 79.3% in 2008 to 81.1% in 2017. Age-appropriate breast feeding in 12-23 month olds declined from 77.8% in 2003 to 61.2% in 2017. Rural residence, younger age, non-facility births and multiple births were associated with decreased odds of exclusively breast feeding. For 6-11 month olds, age-appropriate breast feeding was less likely if the woman did not receive postnatal care. Younger age, being unmarried, high income, wanting a child later and earlier birth order were associated with decreased odds of age-appropriate breast feeding in 12-23 month olds. Conclusion: Ghanaian children are now less likely to be exclusively breastfed than they were a decade ago. To succeed, breastfeeding promotion programmes should adopt approaches that address the predictors of suboptimal breast feeding at each age, as identified in this study.
MeSH term(s)	Breast Feeding ; Cross-Sectional Studies ; Female ; Ghana/epidemiology ; Humans ; Infant ; Infant Nutritional Physiological Phenomena ; Pregnancy ; Prevalence
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-059928
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The association of breastfeeding with cognitive development and educational achievement in sub-Saharan Africa: A systematic review.

Mohammed, Shamsudeen / Oakley, Laura L / Marston, Milly / Glynn, Judith R / Calvert, Clara

Journal of global health

2022 Volume 12, Page(s) 4071

Abstract: Background: Systematic reviews and meta-analyses of studies mainly from high-income countries suggest that breastfeeding improves cognitive function and educational achievement. However, these associations may be a manifestation of who breastfeeds in ... ...

Abstract	Background: Systematic reviews and meta-analyses of studies mainly from high-income countries suggest that breastfeeding improves cognitive function and educational achievement. However, these associations may be a manifestation of who breastfeeds in these settings rather than an actual effect of breastfeeding. We investigated the association of breastfeeding with cognitive development and educational achievements in sub-Saharan Africa, where breastfeeding is the norm, and socioeconomic status is not strongly correlated with ever breastfeeding. Methods: We searched Medline, Embase, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), and Africa-Wide Information in January 2021 for studies that assessed the cognitive and educational benefits of breastfeeding in children and adolescents in sub-Saharan Africa. Two reviewers independently screened, extracted, and critically appraised the included studies. Results: After reviewing 5552 abstracts and 151 full-text articles, seventeen studies on cognitive development and two on educational achievements met our predefined inclusion criteria. The included studies were from ten sub-Saharan African countries and published between 2013 and 2021, with sample sizes ranging from 54 to 6573. Most of the studies (n = 14) were prospective cohort studies, but only nine collected data on breastfeeding prospectively. The studies differed in analytic approaches and cognitive and educational achievements measurements. Of the 17 studies on cognitive development, only four adjusted sufficiently for key confounders. None of these four studies found an overall association between breastfeeding and cognitive development in children or adolescents in sub-Saharan Africa. The two studies on education measured achievements based on the highest grade of school attained, 12 or more years of education, or grade repetition at age 7-11 years. Both studies adjusted for a range of sociodemographic factors and found no evidence that children exclusively breastfed or breastfed for a longer duration have a better educational outcome than sub-optimally breastfed children. Conclusions: The current evidence from sub-Saharan Africa is limited but does not corroborate previous findings that breastfeeding is associated with improved cognitive development and educational achievement. Registration: This study is registered with PROSPERO, CRD42021236009.
MeSH term(s)	Adolescent ; Africa South of the Sahara/epidemiology ; Breast Feeding ; Child ; Cognition ; Educational Status ; Female ; Humans ; Prospective Studies
Language	English
Publishing date	2022-09-03
Publishing country	Scotland
Document type	Journal Article ; Systematic Review
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.12.04071
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Article ; Online: Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.

Kumar, Mukesh / Quittot, Noé / Dujardin, Simon / Schlaffner, Christoph N / Viode, Arthur / Wiedmer, Anne / Beerepoot, Pieter / Chun, Joshua E / Glynn, Calina / Fernandes, Analiese R / Donahue, Cameron / Steen, Judith A / Hyman, Bradley T

Brain : a journal of neurology

2024 Volume 147, Issue 2, Page(s) 637–648

Abstract: Aggregation prone molecules, such as tau, form both historically well characterized fibrillar deposits (neurofibrillary tangles) and recently identified phosphate-buffered saline (PBS) extract species called proteopathic seeds. Both can cause normal ... ...

Abstract	Aggregation prone molecules, such as tau, form both historically well characterized fibrillar deposits (neurofibrillary tangles) and recently identified phosphate-buffered saline (PBS) extract species called proteopathic seeds. Both can cause normal endogenous tau to undergo templated misfolding. The relationship of these seeds to the fibrils that define tau-related diseases is unknown. We characterized the aqueous extractable and sarkosyl insoluble fibrillar tau species derived from human Alzheimer brain using mass spectrometry and in vitro bioassays. Post-translational modifications (PTMs) including phosphorylation, acetylation and ubiquitination are identified in both preparations. PBS extract seed competent tau can be distinguished from sarkosyl insoluble tau by the presence of overlapping, but less abundant, PTMs and an absence of some PTMs unique to the latter. The presence of ubiquitin and other PTMs on the PBS-extracted tau species correlates with the amount of tau in the seed competent size exclusion fractions, with the bioactivity and with the aggressiveness of clinical disease. These results demonstrate that the PTMs present on bioactive, seed competent PBS extract tau species are closely related to, but distinct from, the PTMs of mature paired helical filaments, consistent with the idea that they are a forme fruste of tau species that ultimately form fibrils.
MeSH term(s)	Humans ; Neurofibrillary Tangles/metabolism ; Alzheimer Disease/metabolism ; tau Proteins/metabolism ; Protein Processing, Post-Translational ; Phosphorylation
Chemical Substances	tau Proteins
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awad378
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