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Article: Prevalence of medication errors and its related factors in Iranian nurses: an updated systematic review and meta-analysis.

Fathizadeh, Hadis / Mousavi, Samaneh-Sadat / Gharibi, Zahra / Rezaeipour, Hamidreza / Biojmajd, Abdol-Rahim

2024 Volume 23, Issue 1, Page(s) 175

Abstract: Background: Nurses may make medication errors during the implementation of therapeutic interventions, which initially threaten the patient's health and safety and prolong their hospital stay. These errors have always been a challenge for healthcare ... ...

Abstract	Background: Nurses may make medication errors during the implementation of therapeutic interventions, which initially threaten the patient's health and safety and prolong their hospital stay. These errors have always been a challenge for healthcare systems. Given that factors such as the timing, type, and causes of medication errors can serve as suitable predictors for their occurrence, we have decided to conduct a review study aiming to investigate the prevalence of medication errors and the associated factors among Iranian nurses. Methods: In this systematic review and meta-analysis, studies were searched on PubMed, Web of Science, Scopus, Google Scholar, IranMedex, Magiran, and SID databases using a combination of keywords and Boolean functions. The study that reported the prevalence of medication errors among nurses in Iran without time limitation up to May 2023 was included in this study. Results: A total of 36 studies were included in the analysis. The analysis indicates that 54% (95% CI: 43, 65; I2 = 99.3%) of Iranian nurses experienced medication errors. The most common types of medication errors by nurses were wrong timing 27.3% (95% CI: 19, 36; I2 = 95.8%), and wrong dosage 26.4% (95% CI: 20, 33; I2 = 91%). Additionally, the main causes of medication errors among nurses were workload 43%, fatigue 42.7%, and nursing shortage 38.8%. In this study, just 39% (95% CI: 27, 50; I2 = 97.1%) of nurses with medication errors did report their errors. Moreover, the prevalence of medication errors was more in the night shift at 41.1%. The results of the meta-regression showed that publication year and the female-to-male ratio are good predictors of medical errors, but they are not statistically significant(p > 0.05). Conclusions: To reduce medication errors, nurses need to work in a calm environment that allows for proper nursing interventions and prevents overcrowding in departments. Additionally, considering the low reporting of medication errors to managers, support should be provided to nurses who report medication errors, in order to promote a culture of reporting these errors among Iranian nurses and ensure patient safety is not compromised.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-024-01836-w
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Article: Antimicrobial effect of silver and gold nanoparticles in combination with linezolid on

Sabzi, Niloofar / Moniri, Rezvan / Sehat, Mojtaba / Fathizadeh, Hadis / Nazari-Alam, Ali

Iranian journal of microbiology

2023 Volume 14, Issue 6, Page(s) 863–873

Abstract: Background and objectives: In the past few years, application of new antimicrobial e.g. nanoparticles (NPs) to treat infection caused by drug-resistant bacteria has increased. This study aimed to determine antimicrobial property of silver nanoparticles ( ...

Abstract	Background and objectives: In the past few years, application of new antimicrobial e.g. nanoparticles (NPs) to treat infection caused by drug-resistant bacteria has increased. This study aimed to determine antimicrobial property of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) in combination with linezolid on Materials and methods: A total of forty-eight isolates of Results: Twenty-two Conclusion: The antibiofilm activity of AgNPs and AuNPs increased when both agents were used in combination with linezolid in comparison with each agent alone.
Language	English
Publishing date	2023-01-27
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652849-6
ISSN	2008-4447 ; 2008-3289
ISSN (online)	2008-4447
ISSN	2008-3289
DOI	10.18502/ijm.v14i6.11261
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Article ; Online: Prevalence of needle stick and its related factors in Iranian health worker: an updated systematic review and meta-analysis.

Fathizadeh, Hadis / Alirezaie, Zahra / Saeed, Fatemeh / Saeed, Bita / Gharibi, Zahra / Biojmajd, Abdol R

Journal of global health

2023 Volume 13, Page(s) 4104

Abstract: Background: Healthcare workers (HCWs) are at risk of acquiring blood-borne infections such as hepatitis B, hepatitis C, and human immunodeficiency virus through needlestick injuries (NSIs). We aimed to investigate the prevalence of needlestick injuries ... ...

Abstract	Background: Healthcare workers (HCWs) are at risk of acquiring blood-borne infections such as hepatitis B, hepatitis C, and human immunodeficiency virus through needlestick injuries (NSIs). We aimed to investigate the prevalence of needlestick injuries and other related indicators among HCWs in Iran through a systematic review and meta-analysis. Methods: We searched various databases until the end of May 2023 for studies reporting the prevalence of NSIs among healthcare workers in Iran. We used a random model with 95% confidence intervals (CIs) to analyse the data and the Joanna Briggs Institute (JBI) tool to evaluate the quality of included studies. We conducted and reported the study according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: We included 87 studies in the analysis and found that 47% (95% CI = 42-52, I Conclusions: To reduce the high prevalence of NSIs, HCWs, especially those in emergency departments, should use safety equipment. Healthcare managers should provide a calm and stress-free environment for HCWs, educate them on safety principles and standards, and support experienced HCWs with NSIs.
MeSH term(s)	Humans ; Needlestick Injuries/epidemiology ; Needlestick Injuries/etiology ; Iran/epidemiology ; Prevalence ; Health Personnel ; Protective Devices/adverse effects
Language	English
Publishing date	2023-10-02
Publishing country	Scotland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.13.04104
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Article: Epigenetic roles of PIWI proteins and piRNAs in lung cancer.

Fathizadeh, Hadis / Asemi, Zatollah

Cell & bioscience

2019 Volume 9, Page(s) 102

Abstract: Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding and developing new and effective therapeutic ...

Abstract	Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding and developing new and effective therapeutic and diagnostic are needed. A variety of internal and external factors could be involved in lung cancer pathogenesis. Among internal factors, epigenetic mechanisms have been emerged as very important players in the lung cancer. Non-coding RNAs is known as one of epigenetic regulators which exert their effects on a sequence of cellular and molecular mechanisms. P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs or piR) is one of small non-coding RNAs that the deregulation of these molecules is associated with initiation and progression of different cancers such as lung cancer. Several activities are related to PIWI/piRNA pathway such as suppression of transposons and mobile genetic elements. In vitro and in vivo studies demonstrated the upregulation or downregulation of PIWI proteins and piRNAs could lead to the increasing of cell proliferation, apoptosis reduction and promoting tumor growth in the lung cancer. Hence, PIWI proteins and piRNA could be introduced as new diagnostic and therapeutic biomarkers in the lung cancer therapy. Herein, we have focused on PIWI proteins and piRNA functions and their impact on the progression of lung cancer.
Language	English
Publishing date	2019-12-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-019-0368-x
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Article ; Online: Recent Advances in Nanotechnology for the Management of

Barani, Mahmood / Fathizadeh, Hadis / Arkaban, Hassan / Kalantar-Neyestanaki, Davood / Akbarizadeh, Majid Reza / Turki Jalil, Abduladheem / Akhavan-Sigari, Reza

Biosensors

2022 Volume 12, Issue 12

Abstract: Klebsiella ... ...

Abstract	Klebsiella pneumoniae
Language	English
Publishing date	2022-12-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12121155
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Article ; Online: Circular RNAs as diagnostic biomarker in pancreatic cancer.

Fathizadeh, Hadis / Hallajzadeh, Jamal / Asemi, Zatollah

Pathology, research and practice

2020 Volume 216, Issue 9, Page(s) 153075

Abstract: Pancreatic cancer is one of the causes of death in the world. Unfortunately, common imaging technologies did not succeed in identifying this disease, and because of the absence of sensitive and specific biomarkers, it is not possible to screen and ... ...

Abstract	Pancreatic cancer is one of the causes of death in the world. Unfortunately, common imaging technologies did not succeed in identifying this disease, and because of the absence of sensitive and specific biomarkers, it is not possible to screen and diagnose the disease. Therefore, this disease is usually diagnosed when patient is at an advanced stage of cancer and has lost the chance of surgery, and routine treatments such as radiotherapy and chemotherapy are not very effective. For this reason, the discovery of new biomarkers to overcome the diagnostic and therapeutic problems of pancreatic cancer is essential. Recently, circular RNAs (circRNAs) have been introduced as a group of noncoding RNAs that can play the role of critical regulators in various human diseases including cancer. A lot of studies revealed that circRNAs can have diverse roles in various cancers, including breast, colorectal, lung, renal, gastric, and hepatocellular carcinoma. The results of these researches have demonstrated that change in circRNAs expression levels in the tumor cells affects carcinogenesis, the stages of progression and metastasis of cancer through various mechanisms. Given that several studies have tested the role of circRNAs in pancreatic cancer, we decided to review the mechanisms proposed in these studies to conclude and summarize the work done in this regard.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/diagnosis ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; RNA, Circular/metabolism ; Pancreatic Neoplasms
Chemical Substances	Biomarkers, Tumor ; RNA, Circular
Language	English
Publishing date	2020-06-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2020.153075
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Article ; Online: Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications.

Hosseini, Sayedeh Azimeh / Haddadi, Mohammad Hossein / Fathizadeh, Hadis / Nemati, Foroogh / Aznaveh, Hooman Mahmoudi / Taraj, Farima / Aghabozorgizadeh, AmirArsalan / Gandomkar, Golmaryam / Bazazzadeh, Elaheh

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114407

Abstract: The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, ... ...

Abstract	The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC development and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for GC-related lncRNAs.
MeSH term(s)	Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism
Chemical Substances	RNA, Long Noncoding ; Biomarkers, Tumor
Language	English
Publishing date	2023-04-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114407
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Article ; Online: Designing a novel fusion protein from Streptococcus agalactiae with apoptosis induction effects on cervical cancer cells.

Marzhoseyni, Zeynab / Shayestehpour, Mohammad / Salimian, Morteza / Esmaeili, Davoud / Saffari, Mahmood / Fathizadeh, Hadis

Microbial pathogenesis

2022 Volume 169, Page(s) 105670

Abstract: Cervical cancer remains life-threatening cancer in women around the world. Due to the limitations of conventional treatment approaches, there is an urgent need to develop novel and more efficient strategies against cervical cancer. Therefore, the ... ...

Abstract	Cervical cancer remains life-threatening cancer in women around the world. Due to the limitations of conventional treatment approaches, there is an urgent need to develop novel and more efficient strategies against cervical cancer. Therefore, the researchers attend to the alternative anti-cancer compounds like bacterial products. Rib and α are known as surface proteins of Streptococcus agalactiae with immunologic effects. In the present study, we designed a new anti-cancer fusion protein (Rib-α) originating from S. agalactiae with in silico methods, and then, the recombinant gene was cloned in the pET-22 (+) expression vector. The recombinant protein was expressed in E. coli BL21. To purify the expressed protein, we applied the Ni-NTA column. The molecular mechanism by which Rib-α is cytotoxic to cancer cells has been discussed based on MTT, flow cytometry, and real-time PCR methods. The engineered fusion protein suppressed the proliferation of the cancer cells at 180 μg/ml. Cytotoxic assessment and morphological changes, augmentation of apoptotic-related genes, upregulation of caspase-3 mRNA, and flow cytometric analysis confirmed that apoptosis might be the principal mechanism of cell death. According to our findings, Rib-α fusion protein motivated the intrinsic apoptosis pathway. Therefore, it can be an exciting candidate to discover a new class of antineoplastic agents.
MeSH term(s)	Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis ; Escherichia coli ; Female ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Streptococcus agalactiae/genetics ; Uterine Cervical Neoplasms
Chemical Substances	Antineoplastic Agents ; Recombinant Proteins
Language	English
Publishing date	2022-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105670
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Article ; Online: Evaluation of the effect of Saccharomyces cerevisiae on the expression of enterotoxin genes in Escherichia coli O157: H7 (EHEC) and Escherichia coli H10407 (ETEC).

Koupaei, Maryam / Saderi, Horieh / Amin Marashi, Seyed Mahmoud / Fathizadeh, Hadis / Owlia, Parviz

Microbial pathogenesis

2022 Volume 164, Page(s) 105450

Abstract: Enterotoxigenic (ETEC) and enterohemorrhagic Escherichia coli (EHEC) are the most important intestinal pathogens. Probiotics play an effective role in reducing the expression of virulence factor genes in intestinal pathogenic bacteria. The aim of the ... ...

Abstract	Enterotoxigenic (ETEC) and enterohemorrhagic Escherichia coli (EHEC) are the most important intestinal pathogens. Probiotics play an effective role in reducing the expression of virulence factor genes in intestinal pathogenic bacteria. The aim of the present study is to investigate the effect of probiotic Saccharomyces cerevisiae S3 on the expression of enterotoxin genes in both ETEC and EHEC. Supernatant and lysate of S. cerevisiae S3 are prepared. Subminimal inhibitory concentrations (sub-MIC) of supernatant and lysate are individually exerted to O157: H7 and H10407. The genes' expression of enterotoxins (elt, est, stx1, and stx2) are then determined using real-time PCR technique. The results showed, the yeast supernatant could decrease the expression of the elt gene in ETEC and that of stx1 in EHEC. Of note, in other cases, stx1 and est genes' expression increased. The lysate had no inhibitory effect on the expressions of elt, est, and stx2 genes, but it increased the expression of genes in both ETEC and EHEC. Lysate extract only decreased the expression of stx1 in O157: H7. Our study shows some interesting results regarding the effectiveness of the compounds produced by S. cerevisiae S3 in the expressions of toxin genes in both ETEC and EHEC. We recommend more similar studies be performed in this regard.
MeSH term(s)	Enterohemorrhagic Escherichia coli ; Enterotoxigenic Escherichia coli ; Enterotoxins/genetics ; Escherichia coli Infections/microbiology ; Escherichia coli O157/genetics ; Humans ; Saccharomyces cerevisiae/genetics
Chemical Substances	Enterotoxins
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105450
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Article ; Online: Colistin resistance mechanisms in Gram-negative bacteria: a Focus on Escherichia coli.

Abavisani, Mohammad / Bostanghadiri, Narjess / Ghahramanpour, Hossein / Kodori, Mansoor / Akrami, Fariba / Fathizadeh, Hadis / Hashemi, Ali / Rastegari-Pouyani, Mohsen

Letters in applied microbiology

2023 Volume 76, Issue 2

Abstract: Multidrug-resistant (MDR) Escherichia coli strains have rapidly increased worldwide, and effective antibiotic therapeutic options are becoming more restricted. As a polymyxin antibiotic, colistin has a long history of usage, and it is used as a final ... ...

Abstract	Multidrug-resistant (MDR) Escherichia coli strains have rapidly increased worldwide, and effective antibiotic therapeutic options are becoming more restricted. As a polymyxin antibiotic, colistin has a long history of usage, and it is used as a final line of treatment for severe infections by Gram-negative bacteria (GNB) with high-level resistance. However, its application has been challenged by the emergence of E. coli colistin resistance. Hence, determining the mechanism that confers colistin resistance is crucial for monitoring and controlling the dissemination of colistin-resistant E. coli strains. This comprehensive review summarizes colistin resistance mechanisms in E. coli strains and concentrates on the history, mode of action, and therapeutic implications of colistin. We have mainly focused on the fundamental mechanisms of colistin resistance that are mediated by chromosomal or plasmid elements and discussed major mutations in the two-component systems (TCSs) genes and plasmids that transmit the mobilized colistin resistance resistant genes in E. coli strains.
MeSH term(s)	Humans ; Colistin/pharmacology ; Escherichia coli ; Escherichia coli Proteins/genetics ; Drug Resistance, Bacterial/genetics ; Anti-Bacterial Agents/pharmacology ; Plasmids ; Escherichia coli Infections/microbiology ; Microbial Sensitivity Tests
Chemical Substances	Colistin (Z67X93HJG1) ; Escherichia coli Proteins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1093/lambio/ovad023
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