Article ; Online: Targeting regulatory T cells for improving cancer therapy: Challenges and prospects.
Cancer reports (Hoboken, N.J.)
2018 Volume 1, Issue 1, Page(s) e21105
Abstract: Objective: Regulatory T cells (Tregs) play a central role in immune responses to infectious agents and tumors. Paradoxically, Tregs protect self-cells from the immune response as a part of peripheral tolerance and prevents autoimmune disorders, whereas ... ...
Abstract | Objective: Regulatory T cells (Tregs) play a central role in immune responses to infectious agents and tumors. Paradoxically, Tregs protect self-cells from the immune response as a part of peripheral tolerance and prevents autoimmune disorders, whereas during the process of carcinogenesis, they are exploited by tumor cells for protection against antitumor immune responses. Therefore, Tregs are often considered as a major obstacle in anticancer therapy. The objective of this review is to provide a current understanding on Tregs as a potential cellular target for achieving therapeutic gain and discuss various approaches that are implicated at preclinical and clinical scenario. Recent findings: Several approaches like immunotherapy and adjuvant chemotherapy, which reduce Tregs population, have been found to be useful in improving local tumor control. Our recent observations with the glycolytic inhibitor, 2-deoxy-D-glucose, established as an adjuvant in radiotherapy and chemotherapy of tumors also show that potential of 2-deoxy-D-glucose to improve local tumor control is linked with its ability to reduce the Tregs pool. Conclusions: Several published studies and emerging evidences indicate that suppression of Treg numbers, infiltration into the tumors, and function can improve the cancer therapy by enhancing the antitumor immunity. |
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MeSH term(s) | Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cancer Vaccines/administration & dosage ; Chemoradiotherapy/methods ; Humans ; Lymphocyte Depletion/methods ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/radiation effects ; Tumor Escape/drug effects ; Tumor Escape/radiation effects ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology |
Chemical Substances | Cancer Vaccines |
Language | English |
Publishing date | 2018-05-15 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ISSN | 2573-8348 |
ISSN (online) | 2573-8348 |
DOI | 10.1002/cnr2.1105 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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