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Article: Protective Adaptive Immunity Against Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) and Implications for Vaccines.

Manners, Christopher / Larios Bautista, Erick / Sidoti, Hannah / Lopez, Osvaldo J

2020 Volume 12, Issue 6, Page(s) e8399

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging human coronavirus responsible for coronavirus disease 2019 (COVID-19), a predominantly respiratory disease that has become a global pandemic. Millions of people worldwide are ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging human coronavirus responsible for coronavirus disease 2019 (COVID-19), a predominantly respiratory disease that has become a global pandemic. Millions of people worldwide are suffering from COVID-19, and hundreds of thousands of those infected have died. Nevertheless, many more people who have been infected with SARS-CoV-2 are asymptomatic or suffer a mild disease characterized by dry cough and mild fever. This new pandemic poses a threat to public health on a global scale, and an intervention to prevent continued spread of SARS-CoV-2 virus is of the utmost importance. To assess preventive and therapeutic strategies, it is imperative to understand the pathogenesis and immune response against SARS-CoV-2. In this review, we concentrate on the protective adaptive immune response elicited by this novel coronavirus as well as requirements for a successful vaccine inducing optimal protection.
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.8399
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Article ; Online: m

Manners, Oliver / Baquero-Perez, Belinda / Mottram, Timothy J / Yonchev, Ivaylo D / Trevelyan, Christopher J / Harper, Katherine L / Menezes, Sarah / Patterson, Molly R / Macdonald, Andrew / Wilson, Stuart A / Aspden, Julie L / Whitehouse, Adrian

Viruses

2023 Volume 15, Issue 6

Abstract: The epitranscriptomic ... ...

Abstract	The epitranscriptomic modification
MeSH term(s)	Herpesvirus 8, Human/genetics ; Virus Latency/genetics ; Cell Line, Tumor ; Signal Transduction ; RNA, Messenger/genetics ; Virus Replication ; Gene Expression Regulation, Viral
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061381
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Article ; Online: Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma.

Nature communications

2024 Volume 15, Issue 1, Page(s) 3422

Abstract: Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine kinase inhibitors (ALK TKI) is a distinct possibility necessitating drug ... ...

Abstract	Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine kinase inhibitors (ALK TKI) is a distinct possibility necessitating drug combination therapeutic approaches. Using high-throughput, genome-wide CRISPR-Cas9 knockout screens, we identify miR-1304-5p loss as a desensitizer to ALK TKIs in aberrant ALK-expressing neuroblastoma; inhibition of miR-1304-5p decreases, while mimics of this miRNA increase the sensitivity of neuroblastoma cells to ALK TKIs. We show that miR-1304-5p targets NRAS, decreasing cell viability via induction of apoptosis. It follows that the farnesyltransferase inhibitor (FTI) lonafarnib in addition to ALK TKIs act synergistically in neuroblastoma, inducing apoptosis in vitro. In particular, on combined treatment of neuroblastoma patient derived xenografts with an FTI and an ALK TKI complete regression of tumour growth is observed although tumours rapidly regrow on cessation of therapy. Overall, our data suggests that combined use of ALK TKIs and FTIs, constitutes a therapeutic approach to treat high risk neuroblastoma although prolonged therapy is likely required to prevent relapse.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/metabolism ; Anaplastic Lymphoma Kinase/antagonists & inhibitors ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Dibenzocycloheptenes ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Farnesyltranstransferase/antagonists & inhibitors ; Farnesyltranstransferase/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mutation ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Neuroblastoma/metabolism ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Xenograft Model Antitumor Assays
Chemical Substances	ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Dibenzocycloheptenes ; Farnesyltranstransferase (EC 2.5.1.29) ; GTP Phosphohydrolases (EC 3.6.1.-) ; lonafarnib (IOW153004F) ; Membrane Proteins ; MicroRNAs ; NRAS protein, human (EC 3.6.1.-) ; Piperidines ; Protein Kinase Inhibitors ; Pyridines
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47771-x
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Article: Protective Adaptive Immunity Against Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) and Implications for Vaccines

Manners, Christopher / Larios Bautista, Erick / Sidoti, Hannah / Lopez, Osvaldo J.

Cureus

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging human coronavirus responsible for coronavirus disease 2019 (COVID-19), a predominantly respiratory disease that has become a global pandemic Millions of people worldwide are suffering from COVID-19, and hundreds of thousands of those infected have died Nevertheless, many more people who have been infected with SARS-CoV-2 are asymptomatic or suffer a mild disease characterized by dry cough and mild fever This new pandemic poses a threat to public health on a global scale, and an intervention to prevent continued spread of SARS-CoV-2 virus is of the utmost importance To assess preventive and therapeutic strategies, it is imperative to understand the pathogenesis and immune response against SARS-CoV-2 In this review, we concentrate on the protective adaptive immune response elicited by this novel coronavirus as well as requirements for a successful vaccine inducing optimal protection
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #540107
Database	COVID19

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Article ; Online: Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): A Pilot Randomized Clinical Trial.

American journal of respiratory and critical care medicine

2022 Volume 205, Issue 9, Page(s) 1093–1101

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Australia ; Community-Acquired Infections/complications ; Community-Acquired Infections/drug therapy ; Dexamethasone/therapeutic use ; Humans ; Pilot Projects ; Pleural Effusion/drug therapy ; Pneumonia/complications ; Steroids/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Steroids ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202107-1600OC
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Article ; Online: Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma.

An, Dong / House, Philip / Barry, Christopher / Turpin, Andrew / McKendrick, Allison M / Chauhan, Balwantray C / Manners, Siobhan / Graham, Stuart / Yu, Dao-Yi / Morgan, William H

Ophthalmology. Glaucoma

2020 Volume 3, Issue 6, Page(s) 443–452

Abstract: Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression.: Design: Prospective, observational study.: Participants: Patients with bilateral glaucoma or unilateral glaucoma ... ...

Abstract	Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Design: Prospective, observational study. Participants: Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Methods: Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Main outcome measures: Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. Results: A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P < 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with >8 ODH had faster VF progression than all other groups (all P < 0.001). Conclusions: High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.
MeSH term(s)	Aged ; Disease Progression ; Female ; Glaucoma/complications ; Glaucoma/diagnosis ; Glaucoma/physiopathology ; Humans ; Intraocular Pressure/physiology ; Male ; Optic Disk/blood supply ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/etiology ; Prospective Studies ; Retinal Hemorrhage/diagnosis ; Retinal Hemorrhage/etiology ; Tomography, Optical Coherence/methods ; Visual Fields/physiology
Language	English
Publishing date	2020-06-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	2589-4196
ISSN (online)	2589-4196
DOI	10.1016/j.ogla.2020.06.004
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Article ; Online: Decompression alone vs. decompression plus fusion for claudication secondary to lumbar spinal stenosis.

Thomas, Kenneth / Faris, Peter / McIntosh, Greg / Manners, Simon / Abraham, Edward / Bailey, Christopher S / Paquet, Jerome / Cadotte, David / Jacobs, W Bradley / Rampersaud, Y Raja / Manson, Neil A / Hall, Hamilton / Fisher, Charles G

The spine journal : official journal of the North American Spine Society

2019 Volume 19, Issue 10, Page(s) 1633–1639

Abstract: Background: Degenerative lumbar spinal stenosis is a common condition, predominantly affecting middle-aged and elderly people. This study focused on patients with neurogenic claudication secondary to lumbar stenosis without spondylolisthesis or ... ...

Abstract	Background: Degenerative lumbar spinal stenosis is a common condition, predominantly affecting middle-aged and elderly people. This study focused on patients with neurogenic claudication secondary to lumbar stenosis without spondylolisthesis or deformity. Purpose: To determine whether the addition of fusion to decompression resulted in improved clinical outcomes at 3, 12, and 24 months postsurgery. Study design/setting: The Canadian Spine Outcomes and Research Network (CSORN) prospective database that includes pre- and postoperative data from tertiary care hospitals. Patient sample: The CSORN database was queried for consecutive spine surgery cases of degenerative lumbar stenosis receiving surgical decompression for neurogenic claudication or radiculopathy. Neurogenic claudication patients with baseline and 2-year follow-up data, from four sites, formed the study sample (n=306). The sample was categorized into two groups: (1) those that had decompression alone, and (2) those that underwent decompression plus fusion. Outcome measures: Change in modified Oswestry Disability Index (ODI), numerical rating scale for back/leg pain, the EuroQol EQ5D, the SF-12 physical, and mental component scores. The primary outcome measure was the ODI at 2 years postoperative. Methods: We conducted a multicenter, ambispective review of consecutive spine surgery patients enrolled between October 2012 and January 2018. Results: Baseline characteristics were comparable between groups except for female sex and multilevel pathology (both with greater proportion in the decompression plus fusion group). The decompression plus fusion group had clinically meaningfully more operative time, blood loss, rate of perioperative complication, and length of hospital stay (p<.05). These differences were preserved following adjustment for baseline differences between the groups. Both decompression and decompression plus fusion had a large clinically meaningful impact on generic and disease-specific patient-reported outcome measures within 3 months of surgery which was maintained out to 24-month follow-up. At any follow-up time point, there was no statistical evidence of a difference in these effects favoring decompression plus fusion over decompression alone. Conclusions: The addition of fusion to decompression did not result in improved outcomes at 3-, 12-, or 24-month follow-up. The addition of fusion to decompression provides no advantage to decompression alone for the treatment of patients with neurogenic claudication secondary to lumbar stenosis without spondylolisthesis or deformity.
MeSH term(s)	Aged ; Decompression, Surgical/adverse effects ; Decompression, Surgical/methods ; Female ; Gait ; Humans ; Intermittent Claudication/etiology ; Intermittent Claudication/surgery ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Postoperative Complications/epidemiology ; Spinal Stenosis/complications ; Spinal Stenosis/surgery
Language	English
Publishing date	2019-06-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2037072-6
ISSN	1878-1632 ; 1529-9430
ISSN (online)	1878-1632
ISSN	1529-9430
DOI	10.1016/j.spinee.2019.06.003
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Article ; Online: Polyaminoborane main chain scission using N-heterocyclic carbenes; formation of donor-stabilised monomeric aminoboranes.

Stubbs, Naomi E / Jurca, Titel / Leitao, Erin M / Woodall, Christopher H / Manners, Ian

Chemical communications (Cambridge, England)

2013 Volume 49, Issue 80, Page(s) 9098–9100

Abstract: The reaction of N-heterocyclic carbenes with polyaminoboranes [MeNH-BH2]n or [NH2-BH2]n at 20 °C led to depolymerisation and the formation of labile, monomeric aminoborane-NHC adducts, RNH-BH2-NHC (R = Me or H); a similar NHC adduct of Ph2N=BCl2 was ... ...

Abstract	The reaction of N-heterocyclic carbenes with polyaminoboranes [MeNH-BH2]n or [NH2-BH2]n at 20 °C led to depolymerisation and the formation of labile, monomeric aminoborane-NHC adducts, RNH-BH2-NHC (R = Me or H); a similar NHC adduct of Ph2N=BCl2 was characterized by single crystal X-ray diffraction.
Language	English
Publishing date	2013-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c3cc44373f
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Article ; Online: Low rates of eligibility for lung cancer screening in patients undergoing computed tomography coronary angiography.

Lyne, Christopher / Zaw, Shane / King, Bridget / See, Katharine / Manners, David / Al-Kaisey, Ahmed / Joshi, Subodh / Farouque, Omar / Irving, Louis / Johnson, Douglas / Steinfort, Daniel

Internal medicine journal

2018 Volume 48, Issue 10, Page(s) 1265–1268

Abstract: Incidental findings, including pulmonary nodules, on computed tomography coronary angiography (CTCA) are common. Previous authors have suggested CTCA could allow opportunistic screening for lung cancer, though the lung cancer risk profile of this patient ...

Abstract	Incidental findings, including pulmonary nodules, on computed tomography coronary angiography (CTCA) are common. Previous authors have suggested CTCA could allow opportunistic screening for lung cancer, though the lung cancer risk profile of this patient group has not previously been established. Smoking histories of 229 patients undergoing CTCA at two tertiary hospitals were reviewed and only 25% were current or former smokers aged 55-80 years old. Less than half of this group were eligible for screening based on the PLCO
MeSH term(s)	Aged ; Australia/epidemiology ; Coronary Angiography ; Cross-Sectional Studies ; Early Detection of Cancer/statistics & numerical data ; Eligibility Determination/statistics & numerical data ; Female ; Humans ; Incidental Findings ; Lung Neoplasms/diagnostic imaging ; Male ; Mass Screening ; Middle Aged ; Multiple Pulmonary Nodules/diagnostic imaging ; Smoking/epidemiology ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-10-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.14061
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article: Homogeneous, titanocene-catalyzed dehydrocoupling of amine-borane adducts.

Clark, Timothy J / Russell, Christopher A / Manners, Ian

Journal of the American Chemical Society

2006 Volume 128, Issue 30, Page(s) 9582–9583

Abstract: Transition metal catalysis represents a relatively unexplored but potentially useful route to form bonds between main group elements. Previous work in the area of amine-borane adduct dehydrocoupling has exclusively employed late transition metal (e.g., ... ...

Abstract	Transition metal catalysis represents a relatively unexplored but potentially useful route to form bonds between main group elements. Previous work in the area of amine-borane adduct dehydrocoupling has exclusively employed late transition metal (e.g., Rh) catalysts which were found to predominantly operate via a heterogeneous mechanism. Herein, we present a new, early transition-metal-catalyzed, homogeneous system which exhibits higher activity.
Language	English
Publishing date	2006-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja062217k
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