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  1. Article ; Online: Concordance of Abundance for Mutational

    Wang, Youping / Liu, Hong / Yu, Ningjuan / Xiang, Xueping

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 9, Page(s) 8464–8476

    Abstract: The present study aimed to investigate the influence of the mutation abundance of the epidermal growth factor receptor ( ...

    Abstract The present study aimed to investigate the influence of the mutation abundance of the epidermal growth factor receptor (
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Adenocarcinoma of Lung ; ErbB Receptors/genetics ; Mutation ; Tumor Suppressor Protein p53/genetics
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; TP53 protein, human ; Tumor Suppressor Protein p53 ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30090616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article: Carnitine metabolites and cognitive improvement in patients with schizophrenia treated with olanzapine: a prospective longitudinal study.

    Zhao, Lei / Liu, Hua / Wang, Wenjuan / Wang, Youping / Xiu, Meihong / Li, Shuyun

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1255501

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1255501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Insights into metabolic characteristics and biological activity changes in Zangju (

    Wang, Peng / Wang, Haifan / Xiao, Yang / Zou, Jialiang / Chen, Hongping / Chen, Lin / Wang, Fu / Hu, Yuan / Liu, Youping

    Food chemistry: X

    2024  Volume 21, Page(s) 101197

    Abstract: In this study, comprehensive and systematic nontargeted metabolomics analysis was performed with the metabolites of Zangju peel ( ...

    Abstract In this study, comprehensive and systematic nontargeted metabolomics analysis was performed with the metabolites of Zangju peel (
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2024.101197
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  4. Article: Effects of the epiphytic patterns on endophytes and metabolites of

    Yu, Chengxin / Wang, Peng / Ding, Haiyan / Hu, Yuan / Wang, Fu / Chen, Hongping / Chen, Lin / Liu, Youping

    Frontiers in plant science

    2024  Volume 15, Page(s) 1326998

    Abstract: Introduction: Dendrobium: Methods: In the study, the : Results: A total of 1,032 metabolites were annotated in : Discussion: This study confirmed that Dendrobium quality was affected by its epiphytic patterns and revealed its possible causes ... ...

    Abstract Introduction: Dendrobium
    Methods: In the study, the
    Results: A total of 1,032 metabolites were annotated in
    Discussion: This study confirmed that Dendrobium quality was affected by its epiphytic patterns and revealed its possible causes from a microbiological point of view.
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1326998
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  5. Article ; Online: Regulating the hydroxyl groups reactivity of cellulose by grafting the quaternary ammonium group to achieve a salt-free and low alkali dyeing process for reactive dye.

    Zhu, Qiuyu / Yu, Youping / Hu, Hanchang / Wang, Lei / Mi, Xiang

    International journal of biological macromolecules

    2023  Volume 258, Issue Pt 2, Page(s) 129057

    Abstract: In this work, a salt-free and low alkali dyeing process was developed through cationic modification of cotton fabric with a series of quaternary ammonium salts (QAS). The dyeing performance indicated that the cationic cotton fabric treated with 3-chloro- ... ...

    Abstract In this work, a salt-free and low alkali dyeing process was developed through cationic modification of cotton fabric with a series of quaternary ammonium salts (QAS). The dyeing performance indicated that the cationic cotton fabric treated with 3-chloro-2-hydroxypropyldimethyloctane ammonium chloride (CT-8) achieved better K/S value (8.87) and dye fixation (90.47 %) compared to the conventional dyeing process. Notably, the CT-8 treated fabric performed exceptionally under salt-free conditions and with a Na
    MeSH term(s) Coloring Agents/chemistry ; Cellulose/chemistry ; Cotton Fiber ; Ammonium Compounds ; Textiles ; Quaternary Ammonium Compounds ; Cations/chemistry
    Chemical Substances Coloring Agents ; Cellulose (9004-34-6) ; Ammonium Compounds ; Quaternary Ammonium Compounds ; Cations
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.129057
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  6. Article ; Online: Diachronic shifts in lithic technological transmission between the eastern Eurasian Steppe and northern China in the Late Pleistocene

    Chao Zhao / Youping Wang / John P. Walden

    PLoS ONE, Vol 17, Iss

    2022  Volume 11

    Abstract: The successful occupation of the eastern Eurasian Steppe in the Late Pleistocene improved cultural connections between western Eurasia and East Asia. We document multiple waves of lithic technological transmission between the eastern Eurasian Steppe and ... ...

    Abstract The successful occupation of the eastern Eurasian Steppe in the Late Pleistocene improved cultural connections between western Eurasia and East Asia. We document multiple waves of lithic technological transmission between the eastern Eurasian Steppe and northern China during 50–11 cal. ka BP. These waves are apparent in the sequential appearance of three techno-complexes in northern China: (1) the Mousterian techno-complex, (2) the blade techno-complex mixed with Mousterian elements, (3) and the microlithized blade techno-complex. These lithic techno-complexes were transmitted under different paleoenvironmental conditions along different pathways through the eastern Eurasian Steppe. The Mousterian techno-complex and the blade techno-complex mixed with Mousterian elements were only dispersed in the north and west peripheries of northern China (50–33 cal. ka BP). We argue that these techno-complexes failed to penetrate into the hinterland of northern China because they were not well suited to local geographical conditions. In contrast, the microlithized blade technology which diffused from the eastern Eurasian Steppe was locally modified into a Microblade techno-complex which was highly suited to local environmental conditions, and proliferated across the hinterland of northern China (28/27-11 cal. ka BP). The subsequent spread of microblade technology over vast regions of Mongolia and Siberia indicates that the Pleistocene inhabitants of northern China not only adopted and modified technologies from their neighbors in the Eurasian Steppe, but these modified variants were subsequently transmitted back into the Eurasian Steppe. These episodes of technological transmission indicate complicated patterns of population dispersal and technological interaction across northern China and the eastern Eurasian Steppe.
    Keywords Medicine ; R ; Science ; Q
    Subject code 950
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Diachronic shifts in lithic technological transmission between the eastern Eurasian Steppe and northern China in the Late Pleistocene.

    Chao Zhao / Youping Wang / John P Walden

    PLoS ONE, Vol 17, Iss 11, p e

    2022  Volume 0275162

    Abstract: The successful occupation of the eastern Eurasian Steppe in the Late Pleistocene improved cultural connections between western Eurasia and East Asia. We document multiple waves of lithic technological transmission between the eastern Eurasian Steppe and ... ...

    Abstract The successful occupation of the eastern Eurasian Steppe in the Late Pleistocene improved cultural connections between western Eurasia and East Asia. We document multiple waves of lithic technological transmission between the eastern Eurasian Steppe and northern China during 50-11 cal. ka BP. These waves are apparent in the sequential appearance of three techno-complexes in northern China: (1) the Mousterian techno-complex, (2) the blade techno-complex mixed with Mousterian elements, (3) and the microlithized blade techno-complex. These lithic techno-complexes were transmitted under different paleoenvironmental conditions along different pathways through the eastern Eurasian Steppe. The Mousterian techno-complex and the blade techno-complex mixed with Mousterian elements were only dispersed in the north and west peripheries of northern China (50-33 cal. ka BP). We argue that these techno-complexes failed to penetrate into the hinterland of northern China because they were not well suited to local geographical conditions. In contrast, the microlithized blade technology which diffused from the eastern Eurasian Steppe was locally modified into a Microblade techno-complex which was highly suited to local environmental conditions, and proliferated across the hinterland of northern China (28/27-11 cal. ka BP). The subsequent spread of microblade technology over vast regions of Mongolia and Siberia indicates that the Pleistocene inhabitants of northern China not only adopted and modified technologies from their neighbors in the Eurasian Steppe, but these modified variants were subsequently transmitted back into the Eurasian Steppe. These episodes of technological transmission indicate complicated patterns of population dispersal and technological interaction across northern China and the eastern Eurasian Steppe.
    Keywords Medicine ; R ; Science ; Q
    Subject code 950
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia.

    Lei, Hu / Xu, Hanzhang / Yang, Li / Wang, Yingying / Zhang, Youping / Wu, Yingli

    Oncogene

    2023  Volume 43, Issue 7, Page(s) 539–542

    MeSH term(s) Humans ; Ubiquitin-Protein Ligases ; Cell Line, Tumor ; Leukemia, Myeloid, Acute/genetics ; Y-Box-Binding Protein 1
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Y-Box-Binding Protein 1 ; YBX1 protein, human
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Letter
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-023-02921-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Exploring the roles of microorganisms and metabolites in the 30-year aging process of the dried pericarps of Citrus reticulata 'Chachi' based on high-throughput sequencing and comparative metabolomics.

    Wang, Fu / Hu, Yuan / Chen, Hongping / Chen, Lin / Liu, Youping

    Food research international (Ottawa, Ont.)

    2023  Volume 172, Page(s) 113117

    Abstract: GuangChenpi (GCP), the dried pericarps of Citrus reticulata 'Chachi', has been consumed daily as a food and dietary supplement in China for centuries. Its health benefits are generally recognized to be dependent on storage time. However, the specific ... ...

    Abstract GuangChenpi (GCP), the dried pericarps of Citrus reticulata 'Chachi', has been consumed daily as a food and dietary supplement in China for centuries. Its health benefits are generally recognized to be dependent on storage time. However, the specific roles of microorganisms and metabolites during long-term storage are still unclear. In this study, comparative metabolomics and high-throughput sequencing techniques were used to investigate the effects of co-existing microorganisms on the metabolites in GCP stored from 1 to 30 years. In total, 386 metabolites were identified and characterized. Most compounds were flavonoids (37%), followed by phenolic acids (20%). Seventeen differentially upregulated metabolites were identified as potential key metabolites in GCP, and 8 of them were screened out as key active ingredients by Venn diagram comparative analyses and verified by network pharmacology and molecular docking. In addition, long-term storage could promote the accumulation of secondary metabolites. Regarding the GCP microbiota, Xeromyces dominated the whole 30-year aging process.Moreover, Spearman correlation analysis indicated that Bacillus thuringiensis and Xeromyces bisporus, the dominant bacterial and fungal species, were strongly associated with the key active metabolites. Our results suggested that the change of active ingredients caused by the dominant microbial is one of the mechanisms affecting the GCP aging process. Our study provides novel functional insights and research perspectives on microorganism-associated metabolite changes that may improve the GCP aging process.
    MeSH term(s) Molecular Docking Simulation ; Citrus ; Dietary Supplements ; High-Throughput Nucleotide Sequencing ; Metabolomics
    Language English
    Publishing date 2023-06-12
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113117
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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  10. Article ; Online: Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy.

    Wang, Youping / Pan, Chi / Zhang, Xia / Zhao, Aiqi / Dong, Ying

    Journal of leukocyte biology

    2023  Volume 113, Issue 5, Page(s) 504–517

    Abstract: Acute myeloid leukemia is a heterogeneous hematologic malignancy with high mortality in the world. NPM1 gene mutations are a frequent occurrence in acute myeloid leukemia, leading to abnormal autophagy, while the mechanism of NPM1 mutation-driven acute ... ...

    Abstract Acute myeloid leukemia is a heterogeneous hematologic malignancy with high mortality in the world. NPM1 gene mutations are a frequent occurrence in acute myeloid leukemia, leading to abnormal autophagy, while the mechanism of NPM1 mutation-driven acute myeloid leukemia pathogenesis remains to be fully elucidated. GEO microarrays were used to screen for dysregulated autophagy-related genes in NPM1-mutant acute myeloid leukemia and analysis of RASGRP3 expression and prognosis. Next, we explored the potential molecular mechanisms relationship between RASGRP3 and NPM1 through utilizing immunoprecipitation, Western blot, and cycloheximide assay. Further, CCK8, EdU staining, immunofluorescence, and Western blot were performed to explore the effect of RASGRP3 on cell proliferation and apoptosis in NPM1-mutated acute myeloid leukemia. Finally, Western blot was used to study the mechanism of action of RASGRP3. RASGRP3 expression was upregulated in NPM1-mutated acute myeloid leukemia. Mislocalized NPM1-mA in the cytoplasm could bind to E3 ubiquitin-protein ligase MID1 to block degradation of the RASGRP3 protein. RASGRP3 could also activate the EGFR-STAT3 axis to promote proliferation and autophagy in acute myeloid leukemia. In conclusion, our results identified RASGRP3 as a proto-oncogene in NPM1-mutated acute myeloid leukemia. The RASGRP3-EGFR/STAT3 axis may be a promising therapeutic target for this unique leukemic subtype.
    MeSH term(s) Humans ; Autophagy/genetics ; Cell Proliferation ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Nuclear Proteins/metabolism ; Nucleophosmin ; Protein Stability ; Ubiquitin-Protein Ligases/metabolism ; ras Guanine Nucleotide Exchange Factors/metabolism
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; MID1 protein, human (EC 2.3.2.27) ; Nuclear Proteins ; Nucleophosmin (117896-08-9) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; ras Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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