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Article: Erratum: Protective effect of astragalosides from Radix Astragali on adriamycin-induced podocyte injury.

Sai, Yi-Pa / Song, Yuan-Chun / Chen, Xing-Xing / Luo, Xuan / Liu, Jing / Cui, Wei-Jing

2018 Volume 16, Issue 3, Page(s) 2168

Abstract: This corrects the article DOI: 10.3892/etm.2018.5933.]. ...

Abstract	[This corrects the article DOI: 10.3892/etm.2018.5933.].
Language	English
Publishing date	2018-06-27
Publishing country	Greece
Document type	Journal Article ; Published Erratum
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2018.6361
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Article: Protective effect of astragalosides from Radix Astragali on adriamycin-induced podocyte injury.

Sai, Yi-Pa / Song, Yuan-Chun / Chen, Xing-Xing / Luo, Xuan / Liu, Jing / Cui, Wei-Jing

Experimental and therapeutic medicine

2018 Volume 15, Issue 5, Page(s) 4485–4490

Abstract: Nephrotic syndrome (NS) is the most common kidney disease in clinical practice and may lead to end-stage renal failure. Astragalosides (AST) have been clinically tested for the treatment of NS, but their mechanism of action has remained to be elucidated. ...

Abstract	Nephrotic syndrome (NS) is the most common kidney disease in clinical practice and may lead to end-stage renal failure. Astragalosides (AST) have been clinically tested for the treatment of NS, but their mechanism of action has remained to be elucidated. The aim of the present study was to investigate the effect of AST on the structure and function of podocytes with adriamycin (ADR)-induced damage and to elucidate the underlying molecular mechanisms. The mouse podocyte clone 5 (MPC5) immortalized mouse podocyte cell line was treated with 0.5 µmol/l ADR to establish a podocyte injury model. The MPC5 podocytes were divided into a control group, a podocyte injury group and a low-, medium- and high-concentration AST treatment group. The results indicated that the survival rate of the podocyte injury group was significantly decreased compared with that in the control group and each AST-treated group had an increased survival rate compared with that in the podocyte injury group. Furthermore, each dose of AST significantly inhibited the ADR-associated increases the levels of lactate dehydrogenase and malondialdehyde and the decrease in the activity of superoxide dismutase in MPC5 podocytes. In addition, AST improved the migration ability of MPC5 podocytes and suppressed the cytoskeletal rearrangement associated with ADR-induced damage. Furthermore, matrix metalloproteinase (MMP)-2 and -9 were decreased in the podocyte injury group, which was inhibited by different concentrations of AST. Thus, AST was able to maintain the balance of oxidative stress in podocytes cultured with ADR and protect them from ADR-induced injury. The mechanism may be associated with the upregulation of MMPs.
Language	English
Publishing date	2018-03-06
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2018.5933
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Article ; Online: Relationship between genotypes and clinical manifestation, pathology, and cccDNA in Chinese children with hepatitis B virus-associated glomerulonephritis.

Sun, Yong-Hong / Lei, Xiao-Yan / Sai, Yi-Pa / Chen, Jun-Hui / Sun, Yuan-Chun / Gao, Xia

World journal of pediatrics : WJP

2016 Volume 12, Issue 3, Page(s) 347–352

Abstract: Background: Hepatitis B virus-associated glomerulonephritis (HBV-GN) is one of the extrahepatic manifestations after HBV infection, which would cause great clinical harm to people. The present study was undertaken to investigate the HBV-GN genotypes and ...

Abstract	Background: Hepatitis B virus-associated glomerulonephritis (HBV-GN) is one of the extrahepatic manifestations after HBV infection, which would cause great clinical harm to people. The present study was undertaken to investigate the HBV-GN genotypes and its clinical relevance in Chinese children. Methods: A total of 41 HBV-infected children diagnosed with HBV-GN were enrolled in the study. All patients underwent liver and kidney biopsy. The genotypes and cccDNA were detected in their serum samples to analyze the relationship between HBV genotypes and clinical characteristics, cccDNA, and pathology. Results: Among the 41 children with HBV-GN, 29 (70.7%) had genotype C, 10 (24.4%) had genotype B, 2 (4.9%) had genotype B/C, and none of them had genotype non-B/C. Most children had genotypes B or C; moreover, the genotype C was the most frequent one. The incidence of hematuria and albuminuria, reduction in complement C3, increase in serum alanine aminotransferase levels and renal insufficiency in the children with genotype C were significantly higher than those in the children with genotype B (P<0.05); however, there was no statistically significant difference in hypertension and hepatomegaly (P>0.05). The frequency of HBV cccDNA positive in the genotype C group was significantly higher than that in the genotype B group (72.4% vs. 30.0%, P<0.05). No difference was observed in hepatic inflammation grades and stages of fibrosis between the two groups (P>0.05). Conclusions: Genotype C was the most frequent genotype in the described group of patients with HBV-GN, and the liver and kidney damage indicators were more likely to occur in patients with genotype C.
Language	English
Publishing date	2016-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-016-0015-0
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Article: [Relationship between B/C genotype of hepatitis B virus and hepatitis B virus related-nephritis in children].

Lei, Xiao-yan / Gao, Xia / Yang, Ju-lan / Sun, Yong-hong / Sai, Yi-pa / Yuan, Hong

Zhonghua er ke za zhi = Chinese journal of pediatrics

2012 Volume 50, Issue 5, Page(s) 376–379

Abstract: Objective: To investigate the relationship between genotype of hepatitis B virus and hepatitis B virus related-glomerular nephritis in (HBV-GN) children.: Method: Totally 176 HBV-DNA positive children with chronic hepatitis B were randomly collected. ...

Abstract	Objective: To investigate the relationship between genotype of hepatitis B virus and hepatitis B virus related-glomerular nephritis in (HBV-GN) children. Method: Totally 176 HBV-DNA positive children with chronic hepatitis B were randomly collected. Among the 176 patients, 92 were HBV carriers, 84 were cases with chronic hepatitis. The genotypes of their serum HBV, liver function, and HBV-DNA load were detected. When children showed nephrotic syndrome, renal biopsy was performed. Result: Of the serum samples of 176 cases, 85 (48.3%) were genotype C, 72 (40.9%) were genotype B, 13 (7.4%) were genotype B/C, and 6 (3.4%) were non-B/C genotype which were excluded. Among the analyzed 157 cases, the ratio of HBV-GN in the HBeAg positive group (78.3%) was significantly higher than that in the negative group (21.7%) (χ(2) = 18.301, P < 0.001). And, the ratio of HBV-GN in the genotype C group (73.9%) was significantly higher than that in the genotype B group (26.1%) (P < 0.039). The ratio of hematuria or proteinuria in the genotype C group (20%, 18.8%) was significantly higher than that in the genotype B group (8.3%, 5.6%) (P < 0.039; P value = 0.013); and the alteration of ALT or C3 in the genotype C group (10.2%, 15.3%) was more frequent than those in the genotype B group (2.8%, 2.8%) (P = 0.005; P = 0.008). There were no significant differences in kidney dysfunction or hepatomegaly. Further, the ratio of HBV-GN was more significantly frequent in HBV-DNA highly loading group (79.2%) than which in HBV-DNA lowly loading group (20.8%) (P = 0.000). Finally, in HBV-GN group, genotype C cases (88.2%) more frequently had high HBV-DNA load condition than genotype B cases (11.8%) (P = 0.021). Conclusion: Children with HBV infection in Gansu province showed mainly genotypes C or B, while genotype C seemingly predominant. Patients with genotype C more frequently showed proteinuria or hematuria. The high HBV-DNA load may be related with HBV-GN. It is a potential reason in the mechanism of HBV-GN that patients with genotype C had more possibility to have HBV-DNA high load. Analysis of HBV genotype for HBV patients maybe helpful in diagnosis and treatment.
MeSH term(s)	Adolescent ; Biopsy, Needle ; Child ; Child, Preschool ; China/epidemiology ; DNA, Viral/blood ; DNA, Viral/genetics ; Female ; Genotype ; Hepatitis B/blood ; Hepatitis B/epidemiology ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Humans ; Infant ; Male ; Nephritis/epidemiology ; Nephritis/pathology ; Nephritis/virology ; Viral Load
Chemical Substances	DNA, Viral
Language	Chinese
Publishing date	2012-05
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
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Article: [Evaluation of the applicability of three prediction equations for estimating glomerular filtration rate in children with chronic kidney disease].

Wang, Fang / Yao, Yong / Zhu, Sai-nan / Huang, Jian-ping / Xiao, Hui-jie / Ding, Jie / Sai, Yi-pa

Zhonghua er ke za zhi = Chinese journal of pediatrics

2010 Volume 48, Issue 11, Page(s) 855–859

Abstract: Objective: Accurate and reliable assessment of renal function is important in the management of children with chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of assessing kidney function. For assessment of GFR, both gold ...

Abstract	Objective: Accurate and reliable assessment of renal function is important in the management of children with chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of assessing kidney function. For assessment of GFR, both gold standard tests and prediction equations have been used. The well-known 24-hour endogenous creatinine clearance (Ccr), the Schwartz formula and the Filler formula are increasingly used in daily clinical practice. However, there are few studies on the applicability of these prediction equations for estimating GFR in Chinese children with CKD. The aim of this study was to compare these prediction equations estimating GFR with an isotope clearance method [isotope glomerular filtration rate (rGFR)] in such patients. Method: Children aged 1-16 years who underwent isotope (99m)Tc-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) GFR testing (Gates' method) between the year of 2002 and 2005 were studied retrospectively. GFR was estimated using: (1) 24-hour Ccr, which was calculated using the standard formula: [urine creatinine (milligrammes per millilitre) × 24-hour urine volume/serum creatinine (milligrammes per millilitre) × 1440] × [1.73 (m(2))/body surface area (m(2))]; (2) the Schwartz formula, which is: eGFR (ml/min per 1.73 m(2)) = k × height (centimetres)/serum creatinine (micromoles per litre), where k is 62 in males at 13 years of age and older, 40 in infants, and 49 in all other children; and (3) the Filler formula, which is: logGFR = 1.962 + [1.123 × log(1/Cys C)], where cystatin C is measured in milligrammes per litre. Serum and urinary creatinine levels were detected by alkaline kinetic method. Serum cystatin C was analysed by particle-enhanced immunoturbidimetric assay. Bias and precision were evaluated. Result: Thirty subjects (18 males and 12 females; mean age 9.4 years) fulfilling both inclusion criteria and exclusion criteria were included in this study. The mean (SD) rGFR was 81.57 (36.92) ml/min per 1.73 m(2); 18 subjects were in CKD stage I, 8 in CKD stage II, 8 in CKD stage III, and 1 in CKD stage IV. Only the mean 24 h Ccr-eGFR was slightly higher than rGFR (0.4 ml/min per 1.73 m(2) higher). Within 95% limits of agreement, the maximum absolute value of bias was about 50 ml/min per 1.73 m(2). Accuracy (estimated GFR values within ± 30% of rGFR) for all formulae was poor, ranging from 23.3% to 43.3%. All formulae overestimate or underestimate rGFR in different CKD stages. Conclusion: In Chinese children with CKD, there was a significant difference between measured GFR and estimated GFR using 24h Ccr, Schwartz formula and Filler formula. More suitable GFR predictive equations to assess glomerular function of such patients should be developed.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Glomerular Filtration Rate ; Humans ; Infant ; Kidney Failure, Chronic/physiopathology ; Kidney Function Tests ; Male ; Renal Insufficiency, Chronic/physiopathology
Language	Chinese
Publishing date	2010-11
Publishing country	China
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
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Article ; Online: Folliculitis in prurigo pigmentosa: a proposed pathogenesis based on clinical and pathological observation.

Kafle, Santosh U / Swe, Sai Myint / Hsiao, Pa-Fan / Tsai, Yi-Chiun / Wu, Yu-Hung

Journal of cutaneous pathology

2017 Volume 44, Issue 1, Page(s) 20–27

Abstract: Background: Prurigo pigmentosa is a rare inflammatory dermatosis whose exact etiology is not understood yet. The purpose of this study was to provide evidence of hair follicle involvement in the pathogenesis by analyzing its clinicopathologic features.!# ...

Abstract	Background: Prurigo pigmentosa is a rare inflammatory dermatosis whose exact etiology is not understood yet. The purpose of this study was to provide evidence of hair follicle involvement in the pathogenesis by analyzing its clinicopathologic features. Methods: Patients who fulfilled both the clinical and histological diagnostic criteria of prurigo pigmentosa were recruited. Their histopathologic findings, clinical features and medical histories were analyzed. Results: A total of 32 confirmed patients were enrolled from 2002 to 2013. Their ages ranged from 11 to 79 years with a female predominance. Patient lesions were primarily reddish-brown and located on the back. A total of 25 patients (78%) had pathological involvement of hair follicles, either bacterial colonies in the hair follicles (21/32, 66%), folliculitis (8/32, 25%) or perifolliculitis (15/32, 47%). There was a significantly higher proportion of patients with hair follicle involvement compared with control groups with either noninflammatory (5/43, 12%, p < 0.001) or inflammatory skin diseases (12/32, 38%, p = 0.002) on the back. Minocycline was an effective antibiotic treatment either singly or in combination with steroids. Conclusions: The frequent presence of bacterial colonies along with sequelae of inflammatory changes on biopsy provides new evidence to support the theory that prurigo pigmentosa is a reactive inflammation associated with bacterial folliculitis.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Child ; Female ; Folliculitis/complications ; Folliculitis/drug therapy ; Folliculitis/pathology ; Histamine Antagonists/therapeutic use ; Humans ; Male ; Middle Aged ; Prurigo/drug therapy ; Prurigo/etiology ; Prurigo/pathology ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Histamine Antagonists
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.12829
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Article ; Online: Factors associated with physical activity promotion efforts in individuals with chronic diseases: A systematic review from the perspective of patients.

Hu, Rui / Hui, Stanley Sai-Chuen / Lee, Eric Kam-Pui / Stoutenberg, Mark / Wong, Samuel Yeung-Shan / Yang, Yi-Jian

Patient education and counseling

2023 Volume 109, Page(s) 107641

Abstract: Objectives: To determine factors associated with healthcare provider physical activity (PA ... healthcare provider PA promotion in chronic diseases from the perspective of adult patients. Retrieved factors were ... related to healthcare provider PA promotion (e.g., having emotional support or public programs for PA ...

Abstract	Objectives: To determine factors associated with healthcare provider physical activity (PA) promotion in individuals with chronic diseases from the perspective of patients. Methods: A systematic review of literature was conducted between March and April 2022 by searching five databases. Studies were included if they used survey data, published in English or Chinese, and investigated factors influencing healthcare provider PA promotion in chronic diseases from the perspective of adult patients. Retrieved factors were extracted and mapped to Anderson's Behavioral Model of Health Services Use. Quality of each study was assessed using the NIH Quality Assessment Tool. Results: Thirteen articles were included for final analysis. The quality of the included studies ranged from fair to good. A series of factors were positively related to healthcare provider PA promotion (e.g., having emotional support or public programs for PA). Conflicting results were found for other factors (e.g., age and gender). Conclusions: A series of factors may impact the incorporation of PA promotion into clinical care. More studies with well-designed surveys using primary data collection are suggested to confirm these findings. Practice implications: Factors identified from this review provide insights for developing of strategies related to healthcare provider PA promotion for individuals with chronic diseases.
MeSH term(s)	Adult ; Humans ; Health Promotion/methods ; Exercise/psychology ; Health Personnel ; Counseling ; Chronic Disease
Language	English
Publishing date	2023-01-20
Publishing country	Ireland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	605590-4
ISSN	1873-5134 ; 0738-3991
ISSN (online)	1873-5134
ISSN	0738-3991
DOI	10.1016/j.pec.2023.107641
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Article: Range of Varicella Zoster Co-Infections with COVID-19, Singapore.

Loh, Jerold / Tham, Sai Meng / Tambyah, Paul Anantharajah / Yan, Gabriel / Lee, Chun Kiat / Chai, Louis Yi Ann

Infection & chemotherapy

2021 Volume 53, Issue 2, Page(s) 391–394

Abstract: There have been recent descriptions of the novel coronavirus disease 2019 (COVID-19) presenting as 'varicella-like exanthem'. We report three cases of patients with Varicella-Zoster Virus (VZV) and COVID-19 co-infections, presenting in three varied ways. ...

Abstract	There have been recent descriptions of the novel coronavirus disease 2019 (COVID-19) presenting as 'varicella-like exanthem'. We report three cases of patients with Varicella-Zoster Virus (VZV) and COVID-19 co-infections, presenting in three varied ways. These cases highlight the need for heightened alertness to how such co-infections can present, to pick up overlapping 'dual pathologies' during this current pandemic given that infection control measures including airborne precautions are crucial for both COVID-19 and VZV.
Language	English
Publishing date	2021-07-02
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2020.0154
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Article ; Online: Controlling the supramolecular ordering of fish gelatin via simultaneous assembly with fucoidan resulting in nanostructural modification and enhanced rheological performance

Li, Rui / Tai, Min-Rui / Wu, Yue-Rong / Zhou, Qing-Ling / Xia, Qiu-Yu / Zhong, Sai-Yi / Qi, Yi / Barrow, Colin J. / Williams, Dick

LWT. 2023 July, v. 184 p.115078-

2023

Abstract: ... gelation mixing. When the fucoidan concentration was at 2 and 4 mg/mL, the storage moduli were 476.7 Pa and ... 537.7 Pa, respectively, both were about twice that of FG (218.3 Pa), and similar to that of porcine ... gelatin (479.9 Pa). The microscopic morphology observation revealed denser networks and thicker bundles ...

Abstract	Fish gelatin (FG) has been identified as a promising alternative to mammalian gelatin for the formation of materials, yet it has poor rheological performance and usually requires extensive modification. Therefore, the aim of this study is to overcome this problem through coassembling FG with a polyanion polysaccharide fucoidan, thereby exploiting intermolecular forces to strengthen the resultant material. Coassembly was superior in the improvement of the rheological properties of composite hydrogels compared with post gelation mixing. When the fucoidan concentration was at 2 and 4 mg/mL, the storage moduli were 476.7 Pa and 537.7 Pa, respectively, both were about twice that of FG (218.3 Pa), and similar to that of porcine gelatin (479.9 Pa). The microscopic morphology observation revealed denser networks and thicker bundles formed of the FG-fucoidan composite hydrogels, indicating the incorporation of fucoidan may bind single FG nanofibrils together creating thicker bundles during the coassembly process. The increased formation of intermolecular hydrogen bonds induced helical structures and a partial renaturation of the triple helix-like structure of collagen. This provides a facile, easily adapted and scalable approach for the coassembly of non-mammalian gelatins with other polysaccharides.
Keywords	anions ; collagen ; fish ; fucoidan ; gelatin ; gelation ; hydrogels ; hydrogen ; nanofibers ; swine ; Protein ; Polysaccharide ; Rheological properties ; Intermolecular forces ; Helical structures
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2023.115078
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Article ; Online: Serum creatinine to absolute lymphocyte count ratio effectively risk stratifies patients who require intensive care in hospitalized patients with coronavirus disease 2019.

Ngiam, Jinghao Nicholas / Liong, Tze Sian / Chew, Nicholas W S / Li, Tony Yi-Wei / Chang, Zi Yun / Lim, Zhen Yu / Chua, Horny Ruey / Tham, Sai Meng / Tambyah, Paul Anantharajah / Santosa, Amelia / Cross, Gail Brenda / Sia, Ching-Hui

Medicine

2022 Volume 101, Issue 38, Page(s) e30755

Abstract: Patients with preexisting kidney disease or acute kidney injury had poorer outcomes in coronavirus disease 2019 (COVID-19) illness. Lymphopenia was associated with more severe illness. Risk stratification with simple laboratory tests may help appropriate ...

Abstract	Patients with preexisting kidney disease or acute kidney injury had poorer outcomes in coronavirus disease 2019 (COVID-19) illness. Lymphopenia was associated with more severe illness. Risk stratification with simple laboratory tests may help appropriate site patients in a cost-effective manner and ease the burden on healthcare systems. We examined a ratio of serum creatinine level to absolute lymphocyte count at presentation (creatinine-lymphocyte ratio, CLR) in predicting outcomes in hospitalized patients with COVID-19. We analyzed 553 consecutive polymerase chain reaction-positive SARS-COV-2 hospitalized patients. Patients with end-stage kidney disease were excluded. Serum creatinine and full blood count (FBC) examination were obtained within the first day of admission. We examined the utility of CLR in predicting adverse clinical outcomes (requiring intensive care, mechanical ventilation, acute kidney injury requiring renal replacement therapy or death). An optimized cutoff of CLR > 77 was derived for predicting adverse outcomes (72.2% sensitivity, and 83.9% specificity). Ninety-seven patients (17.5%) fell within this cut off. These patients were older and more likely to have chronic medical conditions. A higher proportion of these patients had adverse outcomes (13.4% vs 1.1%, P < .001). On receiver operating curve analyses, CLR predicted patients who had adverse outcomes well (area under curve [AUC] = 0.82, 95%CI 0.72-0.92), which was comparable to other laboratory tests like serum ferritin, C-reactive protein and lactate dehydrogenase. Elevated CLR on admission, which may be determined by relatively simple laboratory tests, was able to reasonably discriminate patients who had experienced adverse outcomes during their hospital stay. This may be a simple and cost-effective means of risk stratification and triage.
MeSH term(s)	Acute Kidney Injury/therapy ; C-Reactive Protein/analysis ; COVID-19/therapy ; Creatinine ; Critical Care ; Ferritins ; Humans ; L-Lactate Dehydrogenase ; Lymphocyte Count ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; Creatinine (AYI8EX34EU) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030755
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