LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU=Merter Ayse Arducoglu
  2. AU="Ewers, U."
  3. AU="Reichling, Jürgen"
  4. AU="Eichner, Timo"
  5. AU="Seunghee Kim-Schulze"
  6. AU=Ozaki Shoichi
  7. AU="Clerici, Giovanna" AU="Clerici, Giovanna"
  8. AU="Firoz Ahmed"
  9. AU="Dżugan, Małgorzata"
  10. AU="Rolf Bjerkvig"
  11. AU=Khosravi-Far Roya
  12. AU="Udeochu, Joe C"
  13. AU="Osoba, Osonde A." AU="Osoba, Osonde A."
  14. AU="Palani, Sowmiya"
  15. AU="Manfred Frick"
  16. AU="Jensen, Leonard"
  17. AU="Pakhomov, Evgeny A."
  18. AU="Subramanyam, Chithirala Bala"
  19. AU=Petrek J A
  20. AU="Thomson-Baker, B"
  21. AU=Shahidi Shahrzad
  22. AU="Taylor, Holly A"
  23. AU="Yeong Jeong Jeon"
  24. AU="Bueno-Cavanillas, Aurora"
  25. AU="Kavčič, Tina"
  26. AU="Arias-Jiménez, José Luís"
  27. AU="Tünçok, Ekin"
  28. AU="Roberto Toro"
  29. AU="Bharti Sahu"
  30. AU="Soo-Yeon Choi"
  31. AU="Nono, Sandra"
  32. AU="Diepens, Robin J W"
  33. AU="Baselga-Garriga, Clara"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Protective effects of amifostine on ischemia-reperfusion injury of rat kidneys

    Ayse Arducoglu Merter / Burhan Mayir / Okan Erdogan / Taner Colak

    Indian Journal of Pharmacology, Vol 47, Iss 2, Pp 185-

    2015  Band 189

    Abstract: Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role ... ...

    Abstract Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist. Materials and Methods: Adult female rats (n = 40) that used in our study were divided into three groups. Group 1: Control (n = 8), group 2: Ischemia-control (n = 16), group 3: Amifostine treated (n = 16). The effect of amifostine on ischemia/reperfusion injury investigated in rat kidneys. Results: At the 7 th day, blood urea nitrogen level was statistically significantly higher in ischemia-control group than all groups (P = 0.001) and mean serum creatinine levels were found to be the highest in ischemia-control group (P = 0.091). Mean malondialdehyde levels in left kidneys removed on the 7 th day were not significantly different (P = 0.105) at all three groups. Between ischemia-control group and amifostine group, there was a significant difference in reduced glutathione (GSH) levels (P = 0.001). In amifostine group, grade 4 necrosis was not detected neither on 7 th day nor day 0. Conclusion: Amifostine could decrease the degree and severity of necrosis after reperfusion. Amifostine could not prevent membrane lipid peroxidation caused by superoxide anion radicals in kidney but they could protect tissues from the harmful effects of ischemia/reperfusion injury by increasing the level of reduced GSH which is a well-known oxygen radical eliminator.
    Schlagwörter Amifostine ; ischemia-reperfusion injury ; kidney ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Protective effects of amifostine on ischemia-reperfusion injury of rat kidneys.

    Merter, Ayse Arducoglu / Mayir, Burhan / Erdogan, Okan / Colak, Taner

    Indian journal of pharmacology

    2015  Band 47, Heft 2, Seite(n) 185–189

    Abstract: Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role ...

    Abstract Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist.
    Materials and methods: Adult female rats (n = 40) that used in our study were divided into three groups. Group 1: Control (n = 8), group 2: Ischemia-control (n = 16), group 3: Amifostine treated (n = 16). The effect of amifostine on ischemia/reperfusion injury investigated in rat kidneys.
    Results: At the 7(th) day, blood urea nitrogen level was statistically significantly higher in ischemia-control group than all groups (P = 0.001) and mean serum creatinine levels were found to be the highest in ischemia-control group (P = 0.091). Mean malondialdehyde levels in left kidneys removed on the 7(th) day were not significantly different (P = 0.105) at all three groups. Between ischemia-control group and amifostine group, there was a significant difference in reduced glutathione (GSH) levels (P = 0.001). In amifostine group, grade 4 necrosis was not detected neither on 7(th) day nor day 0.
    Conclusion: Amifostine could decrease the degree and severity of necrosis after reperfusion. Amifostine could not prevent membrane lipid peroxidation caused by superoxide anion radicals in kidney but they could protect tissues from the harmful effects of ischemia/reperfusion injury by increasing the level of reduced GSH which is a well-known oxygen radical eliminator.
    Mesh-Begriff(e) Amifostine/administration & dosage ; Amifostine/therapeutic use ; Animals ; Antioxidants/administration & dosage ; Antioxidants/therapeutic use ; Disease Models, Animal ; Female ; Glutathione/metabolism ; Kidney/blood supply ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Function Tests ; Lipid Peroxidation/drug effects ; Necrosis ; Rats ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Treatment Outcome ; Warm Ischemia
    Chemische Substanzen Antioxidants ; Glutathione (GAN16C9B8O) ; Amifostine (M487QF2F4V)
    Sprache Englisch
    Erscheinungsdatum 2015-03
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/0253-7613.153427
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1983: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 311: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang