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  1. Article: Protective effects of coenzyme Q

    Sadighara, Melina / Joktaji, Jalal Pourahamad / Hajhashemi, Valiollah / Minaiyan, Mohsen

    Research in pharmaceutical sciences

    2017  Volume 12, Issue 6, Page(s) 434–443

    Abstract: Statins are widely used in patients with hyperlipidemia and whom with high risk of cardiovascular diseases. Unfortunately, statins also exert some adverse effects on the liver and pancreas and enhance the risk of type 2 diabetes mellitus. The objective ... ...

    Abstract Statins are widely used in patients with hyperlipidemia and whom with high risk of cardiovascular diseases. Unfortunately, statins also exert some adverse effects on the liver and pancreas and enhance the risk of type 2 diabetes mellitus. The objective of the present research was to investigate the protective effects of coenzyme Q
    Language English
    Publishing date 2017-10-30
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.217424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Toxicity of Atorvastatin on Pancreas Mitochondria: A Justification for Increased Risk of Diabetes Mellitus.

    Sadighara, Melina / Amirsheardost, Zahra / Minaiyan, Mohsen / Hajhashemi, Valiollah / Naserzadeh, Parvaneh / Salimi, Ahmad / Seydi, Enayatollah / Pourahmad, Jalal

    Basic & clinical pharmacology & toxicology

    2017  Volume 120, Issue 2, Page(s) 131–137

    Abstract: Statins (including atorvastatin) are a widely used class of drugs, and like all medications, they have a potential for adverse effects. Recently, it has been shown that statins also exert side effects on the pancreas. In vitro studies have suggested that ...

    Abstract Statins (including atorvastatin) are a widely used class of drugs, and like all medications, they have a potential for adverse effects. Recently, it has been shown that statins also exert side effects on the pancreas. In vitro studies have suggested that this class of drugs induced a reduction in insulin secretion. Also, the use of statins is associated with a raised risk of diabetes mellitus (DM), but the mechanisms underlying statin-induced diabetes are poorly known. Literature data indicate that several statins are able to induce apoptosis signalling. This study was designed to examine the mechanism of atorvastatin on mitochondria obtained from rat pancreas. In our study, mitochondria were obtained from the pancreas and then exposed to atorvastatin and vehicle to investigate probable toxic effects. The results showed that atorvastatin (25, 50, 75, 100 and 125 μM) increased reactive oxygen species (ROS) production, mitochondrial swelling, collapse of mitochondrial membrane potential and cytochrome c release, the orchestrating factor for mitochondria-mediated apoptosis signalling. Atorvastatin also reduced the ATP levels. These results propose that the toxicity of atorvastatin on pancreas mitochondria is a key point for drug-induced apoptotic cell loss in the pancreas and therefore a justification for increased risk of DM.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Apoptosis/drug effects ; Atorvastatin Calcium/toxicity ; Cytochromes c/metabolism ; Diabetes Mellitus/chemically induced ; Dose-Response Relationship, Drug ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/toxicity ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Swelling/drug effects ; Oxidative Stress/drug effects ; Pancreas/drug effects ; Pancreas/metabolism ; Pancreas/pathology ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Risk Assessment ; Signal Transduction/drug effects ; Time Factors
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Reactive Oxygen Species ; Atorvastatin Calcium (48A5M73Z4Q) ; Adenosine Triphosphate (8L70Q75FXE) ; Cytochromes c (9007-43-6)
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.12656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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