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Article ; Online: Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn's Disease after COVID-19 Vaccination: A Twin Case.

Melgaço, Fabiana Gil / Azamor, Tamiris / Villar, Livia Melo / Ano Bom, Ana Paula Dinis / Melgaço, Juliana Gil

2021 Volume 13, Issue 11

Abstract: Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. ...

Abstract	Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn's disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn's disease's twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.
MeSH term(s)	Adult ; Antibodies, Viral/blood ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; ChAdOx1 nCoV-19/immunology ; Crohn Disease/drug therapy ; Crohn Disease/immunology ; Female ; Humans ; Immunity, Humoral ; Infliximab/therapeutic use ; Interferon-gamma/analysis ; Lymphocyte Activation ; Memory B Cells/immunology ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Twins, Monozygotic
Chemical Substances	Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Interferon-gamma (82115-62-6) ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2021-10-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112143
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 and dialysis: humoral response, clinical and laboratory impacts before vaccination.

Santos, Alanna Calheiros / Costa, Vanessa Duarte da / Silva, Lucas Lima da / Miguel, Juliana Custódio / Jardim, Rodrigo / Dávila, Alberto Martín Rivera / Paula, Vanessa Salete de / Melgaço, Juliana Gil / Lago, Barbara Vieira do / Villar, Livia Melo

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

2024 Volume 28, Issue 2, Page(s) 103735

Abstract: Background: Patients with kidney disease on Hemodialysis (HD) are susceptible to Coronavirus Disease (COVID-19) due to multiple risk factors.: Aim: This study aims to report the prevalence of antibodies against SARS-CoV-2 among patients on ... ...

Abstract	Background: Patients with kidney disease on Hemodialysis (HD) are susceptible to Coronavirus Disease (COVID-19) due to multiple risk factors. Aim: This study aims to report the prevalence of antibodies against SARS-CoV-2 among patients on hemodialysis before vaccination in Brazil and to compare with clinical, demographic, and laboratory data. Methods: Blood samples from 398 Chronic Kidney Disease (CKD) patients treated in three different private institutions in Rio de Janeiro State, Brazil were submitted to the total anti-SARS-CoV-2 testing. Kidney, liver, and hematological markers were also determined. Respiratory samples were tested by real-time PCR for SARS-CoV-2 RNA and positive samples were subjected to high-throughput sequencing on the MinION device. Results: Overall, anti-SARS-CoV-2 prevalence was 54.5 % (217/398) and two individuals had SARS-CoV-2 RNA with variant B.1.1. High anti-SARS-CoV-2 seroprevalence was found in male gender and those with hospital admission in the last 3-months before the inclusion in the study. Lower red blood cell count was observed in the anti-SARS-CoV-2 seropositive group. High levels of anti-SARS-CoV-2 were found in those who reported symptoms, had low levels of eosinophils and low hematocrit, and who practiced physical activity. Conclusion: High prevalence of anti-SARS-CoV-2 was found in CKD patients before the universal immunization in Brazil suggesting that dialysis patients were highly exposed to SARS-CoV-2.
Language	English
Publishing date	2024-03-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2041400-6
ISSN	1678-4391 ; 1413-8670
ISSN (online)	1678-4391
ISSN	1413-8670
DOI	10.1016/j.bjid.2024.103735
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Zs.A 5633: Show issues

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Article: Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case

Melgaço, Fabiana Gil / Azamor, Tamiris / Villar, Livia Melo / Ano Bom, Ana Paula Dinis / Melgaço, Juliana Gil

Viruses. 2021 Oct. 24, v. 13, no. 11

2021

Abstract	Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn’s disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn’s disease’s twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.
Keywords	B-lymphocytes ; CD4-positive T-lymphocytes ; CD8-positive T-lymphocytes ; COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibody detection ; antibody formation ; autoimmune diseases ; memory ; patients ; vaccination
Language	English
Dates of publication	2021-1024
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112143
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Melgaço, Juliana Gil / Azamor, Tamiris / Ano Bom, Ana Paula Dinis

Cellular immunology

2020 Volume 353, Page(s) 104114

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.
MeSH term(s)	Antibodies, Viral/immunology ; Antibody Formation ; Betacoronavirus/physiology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/transmission ; Humans ; Immunoglobulin G/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Keywords	covid19
Language	English
Publishing date	2020-04-28
Publishing country	Netherlands
Document type	Letter
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2020.104114
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Zs.A 417: Show issues

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Article ; Online: Protective immunity after COVID-19 has been questioned

Melgaço, Juliana Gil / Azamor, Tamiris / Ano Bom, Ana Paula Dinis

Cellular Immunology

What can we do without SARS-CoV-2-IgG detection?

2020 Volume 353, Page(s) 104114

Keywords	Immunology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2020.104114
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 417: Show issues

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Article ; Online: Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine.

de Brito, Wagner Izidoro / de Oliveira, Rode Martinho / Silva, Jane / Tubarão, Luciana Neves / Bom, Ana Paula Dinis Ano / Melgaço, Juliana Gil / Pinto, Marcelo Alves / Souto, Francisco José Dutra

Journal of viral hepatitis

2023 Volume 30, Issue 7, Page(s) 615–620

Abstract: In 2014, the Brazilian National Immunization Program implemented the universal vaccination against the hepatitis A virus (HAV) for children aged 12 months and older, applying a single dose of the inactivated virus vaccine. It is essential to carry out ... ...

Abstract	In 2014, the Brazilian National Immunization Program implemented the universal vaccination against the hepatitis A virus (HAV) for children aged 12 months and older, applying a single dose of the inactivated virus vaccine. It is essential to carry out follow-up studies in this population, aiming to verify the longevity of HAV immunological memory. This study evaluated the humoral and cellular immune response of a cohort of children vaccinated between 2014 and 2015, and further investigated between 2015 and 2016, and who had their initial antibody response assessed after the single dose. A second evaluation took place in January 2022. We examined 109 children out of the 252 that took part in the initial cohort. Seventy (64.2%) of them had anti-HAV IgG antibodies. Cellular immune response assays were performed in 37 anti-HAV-negative and 30 anti-HAV-positive children. Production of interferon-gamma (IFN-y) stimulated with the VP1 antigen was demonstrated in 34.3% of these 67 samples. Of the 37 negative anti-HAV samples, 12 (32.4%) produced IFN-y. Among the 30 anti-HAV-positive, 11 (36.7%) produced IFN-y. In total, 82 (76.6%) children presented some type of immune response against HAV. These findings demonstrate the persistence of immunological memory against HAV in the majority of children vaccinated between 6 and 7 years with a single dose of the inactivated virus vaccine.
MeSH term(s)	Humans ; Child ; Hepatitis A/epidemiology ; Hepatitis A Vaccines ; Hepatitis A Antibodies ; Brazil/epidemiology ; Vaccines, Inactivated ; Vaccination ; Hepatitis A virus
Chemical Substances	Hepatitis A Vaccines ; Hepatitis A Antibodies ; Vaccines, Inactivated
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1212497-7
ISSN	1365-2893 ; 1352-0504
ISSN (online)	1365-2893
ISSN	1352-0504
DOI	10.1111/jvh.13819
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Zs.A 4119: Show issues

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Article ; Online: Neutralizing antibody titers against D8 genotype and persistence of measles humoral and cell-mediated immunity eight years after the first dose of measles, mumps, and rubella vaccine in Brazilian children.

Kegele Lignani, Letícia / de Vasconcellos Carvalhaes de Oliveira, Raquel / Matos Dos Santos, Eliane / Antonio Bastos Camacho, Luiz / Reis Xavier, Janaína / Regina da Silva E Sá, Gloria / Mendonça Siqueira, Marilda / Marques Vieira da Silva, Andréa / Gil Melgaço, Juliana / Dos Santos Alves, Nathalia / de Lourdes de Sousa Maia, Maria / Caetano Prates Melo, Enirtes

Vaccine

2024 Volume 42, Issue 8, Page(s) 2065–2071

Abstract: Objective: Assess the level of measles vaccine-induced neutralizing antibodies against the D8 genotype and the persistence of humoral and cell-mediated immunity in children who received their first dose of the measles, mumps, and rubella vaccine eight ... ...

Abstract	Objective: Assess the level of measles vaccine-induced neutralizing antibodies against the D8 genotype and the persistence of humoral and cell-mediated immunity in children who received their first dose of the measles, mumps, and rubella vaccine eight years previously. Methods: Measles-specific IgG and neutralizing antibodies were determined in serum using ELISA and plaque reduction neutralization test, respectively. Cellular response was evaluated from peripheral blood mononuclear cells (PBMC). IFN-γ-secreting cells, memory B and T cells, and immunological mediators were assayed by ELISpot, flow cytometry, and multiplex liquid microarray assay, respectively. Results: Antibody concentrations declined over time; however, the vaccine-induced neutralizing antibodies' effect against D8 and vaccinal genotypes persisted. PBMC stimulated with the vaccine virus exhibited specific IFN- γ-measles-secreting responses in most participants. Participants with high levels of neutralizing antibodies showed a higher proportion of activated B cells compared to participants with low levels of neutralizing antibodies, while proportions of memory CD4+ and CD8+ T cells were similar between these groups. PBMC supernatant cytokine levels showed a significant difference between stimulated and non-stimulated conditions for IL-2, TNF-α, IL-10, and CXCL10. Conclusion: Despite the decline in antibody concentrations over time, the participants still demonstrated neutralizing capacity against the measles D8 genotype five to eight years after the second dose of the measles, mumps, and rubella vaccine. Additionally, most of the enrolled children exhibited cell-mediated immunity responses to measles virus stimulation.
MeSH term(s)	Child ; Humans ; Mumps/prevention & control ; Leukocytes, Mononuclear ; Measles-Mumps-Rubella Vaccine ; Brazil ; Antibodies, Viral ; Measles ; Antibodies, Neutralizing ; Measles Vaccine ; Immunity, Cellular ; Rubella/prevention & control
Chemical Substances	Measles-Mumps-Rubella Vaccine ; Antibodies, Viral ; Antibodies, Neutralizing ; Measles Vaccine
Language	English
Publishing date	2024-02-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.060
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article: Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug.

de Brito E Cunha, Danielle / Frederico, Ana Beatriz Teixeira / Azamor, Tamiris / Melgaço, Juliana Gil / da Costa Neves, Patricia Cristina / Bom, Ana Paula Dinis Ano / Tilli, Tatiana Martins / Missailidis, Sotiris

Pharmaceuticals (Basel, Switzerland)

2022 Volume 15, Issue 5

Abstract: The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic ... ...

Abstract	The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic degradation of siRNAs by serum endonucleases and RNAases, renal clearance of the siRNA delivery system, the impermeability of biological membranes for siRNA, activation of the immune system, plasma protein sequestration, and capillary endothelium crossing. To overcome the intrinsic difficulties of the use of siRNA molecules, therapeutic applications require nanometric delivery carriers aiming to protect double-strands and deliver molecules to target cells. This review discusses the history of siRNAs, siRNA design, and delivery strategies, with a focus on progress made regarding siRNA molecules in clinical trials and how siRNA has become a valuable asset for biopharmaceutical companies.
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15050575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Melgaço, Juliana Gil / Azamor, Tamiris / Ano Bom, Ana Paula Dinis

Cell Immunol

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #133309
Database	COVID19

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Article ; Online: Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil.

Pacheco, Vanessa / Cuber Guimarães, Rosane / Corrêa-Moreira, Danielly / Magalhães, Carlos Eduardo / Figueiredo, Douglas / Guttmann, Patricia / Trindade, Gisela Freitas / da Silva, Juliana Fernandes Amorim / Ano Bom, Ana Paula Dinis / de Lourdes Maia, Maria / Melgaço, Juliana Gil / da Costa Barros, Tamiris Azamor / da Silva, Andrea Marques Vieira / Group, Collaborative / Oliveira, Manoel Marques Evangelista

Viruses

2023 Volume 15, Issue 7

Abstract: Objectives: The aim of this study is to evaluate some mechanisms of the immune response of people infected with SARS-CoV-2 in both acute infection and early and late convalescence phases.: Methods: This is a cohort study of 70 cases of COVID-19, ... ...

Abstract	Objectives: The aim of this study is to evaluate some mechanisms of the immune response of people infected with SARS-CoV-2 in both acute infection and early and late convalescence phases. Methods: This is a cohort study of 70 cases of COVID-19, confirmed by RT-PCR, followed up to 60 days. Plasma Samples and clinical data were. Viral load, blood count, indicators inflammation were the parameters evaluated. Cellular immune response was evaluated by flow cytometry and Luminex immunoassays. Results: In the severe group, hypertension was the only reported comorbidity. Non severe patients have activated memory naive CD4+ T cells. Critically ill patients have central memory CD4+ T cell activation. Severe COVID-19 patients have both central memory and activated effector CD8+ T cells. Non-severe COVID-19 cases showed an increase in IL1β, IL-6, IL-10 and TNF and severely ill patients had higher levels of the cytokines IL-6, IL-10 and CXCL8. Conclusions: The present work showed that different cellular responses are observed according to the COVID-19 severity in patients from Brazil an epicenter the pandemic in South America. Also, we notice that some cytokines can be used as predictive markers for the disease outcome, possibility implementation of strategies effective by health managers.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/genetics ; Interleukin-10 ; Cohort Studies ; Interleukin-6 ; Brazil/epidemiology ; Immunogenetics ; Cytokines ; Immunity, Cellular
Chemical Substances	Interleukin-10 (130068-27-8) ; Interleukin-6 ; Cytokines
Language	English
Publishing date	2023-07-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15071609
Database	MEDical Literature Analysis and Retrieval System OnLINE

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