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  1. Article ; Online: Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia.

    Roux, Hélène M / Marouf, Amira / Dutrieux, Jacques / Charmeteau-De Muylder, Bénédicte / Figueiredo-Morgado, Suzanne / Avettand-Fenoel, Véronique / Cuvelier, Pelagia / Naudin, Cécile / Bouaziz, Fatma / Geri, Guillaume / Couëdel-Courteille, Anne / Squara, Pierre / Marullo, Stefano / Cheynier, Rémi

    Science advances

    2023  Volume 9, Issue 38, Page(s) eadh7969

    Abstract: Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. ... ...

    Abstract Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The
    MeSH term(s) Humans ; Thymus Gland ; COVID-19/genetics ; SARS-CoV-2 ; Pneumonia ; Genotype
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh7969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correlation between thymic output and disease severity in critically ill COVID-19 patients: extended abstract.

    Marouf, Amira / Cuvelier, Pelagia / Roux, Hélène / Couëdel-Courteille, Anne / Dutrieux, Jacques / Naudin, Cécile / Charmeteau de Muylder, Bénédicte / Cheynier, Rémi / Squara, Pierre / Marullo, Stefano

    Mediastinum (Hong Kong, China)

    2022  Volume 6, Page(s) 30

    Language English
    Publishing date 2022-09-25
    Publishing country China
    Document type Editorial
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-22-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome.

    Cuvelier, Pelagia / Roux, Hélène / Couëdel-Courteille, Anne / Dutrieux, Jacques / Naudin, Cécile / Charmeteau de Muylder, Bénédicte / Cheynier, Rémi / Squara, Pierre / Marullo, Stefano

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 4

    Abstract: Background: Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment of patients with severe pulmonary ...

    Abstract Background: Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment of patients with severe pulmonary forms, thymus involvement and reactivation have not been investigated so far.
    Methods: In this observational study, we systematically scored the enlargement of the thymus and the lung involvement, using CT scans, in all adult patients admitted to the ICU for COVID or any other cause (control group) at one centre between March and April 2020. Initial biological investigations included nasal detection of SARS-CoV-2 ribonucleic acid by polymerase chain reaction (PCR). In a subgroup of 24 patients with different degrees of pulmonary involvement and thymus hypertrophy, plasma cytokine concentrations were measured and the export of mature T cells from the thymus was estimated simultaneously by PCR quantification of T cell receptor excision circles (TRECs).
    Results: Eighty-seven patients were studied: 50 COVID patients and 37 controls. Non-atrophic or enlarged thymus was more commonly observed in COVID patients than in controls (66% vs. 24%, p < 0.0001). Thymus enlargement in COVID patients was associated with more extensive lung injury score on CT scans (4 [3-5] vs. 2 [1.5-4], p = 0.01), but a lower mortality rate (8.6% vs. 41.2%, p < 0.001). Other factors associated with mortality were age, lymphopaenia, high CRP and co-morbidities. COVID patients had higher concentrations of IL-7 (6.00 [3.72-9.25] vs. 2.17 [1.76-4.4] pg/mL; p = 0.04) and higher thymic production of new lymphocytes (sj/βTREC ratio = 2.88 [1.98-4.51] vs. 0.23 [0.15-0.60]; p = 0.004). Thymic production was also correlated with the CT scan thymic score (r = 0.38, p = 0.03) and inversely correlated with the number of lymphocytes (r = 0.56, p = 0.007).
    Conclusion: In COVID patients, thymus enlargement was frequent and associated with increased T lymphocyte production, which appears to be a beneficial adaptation to virus-induced lymphopaenia. The lack of thymic activity/reactivation in older SARS-CoV-2 infected patients could contribute to a worse prognosis.
    MeSH term(s) Aged ; COVID-19/complications ; Case-Control Studies ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Respiratory Distress Syndrome/virology ; Thorax/diagnostic imaging ; Thymus Hyperplasia/diagnostic imaging ; Thymus Hyperplasia/virology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03440-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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