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  1. Article ; Online: Recruitment, Consent and DNA Sample Acquisition in a U.S. Precision Health Cohort During the COVID-19 Pandemic

    Derry, Allyson M. / Strong, Yvette / Schioppo, Davia / Cotter, Joni / Wilkins, Geisa M. / Siquieros, Laura I. / Ouyang, Andrea / Hulseman, Kathleen / Petrosino, Joseph / Liang, Lorrin / Stevenson, Megan / Aguilera, Tiffany Elianne / Soto, Alexandria L. / Meurer, Katherin / Herman, Alison L. / Cohen, Inessa / Falcone, Guido J. / Longbrake, Erin E. / Ochoa Chaar, Cassius I. /
    Anastasio, Kelly M. / Murray, Michael F.

    medRxiv

    Abstract: Aim: The Yale Generations Project (YGP) is a precision health cohort initiative that began enrollment in New Haven Connecticut USA in July 2019. In March 2020, after nine months of operation, pandemic restrictions prompted abrupt changes to staff ... ...

    Abstract Aim: The Yale Generations Project (YGP) is a precision health cohort initiative that began enrollment in New Haven Connecticut USA in July 2019. In March 2020, after nine months of operation, pandemic restrictions prompted abrupt changes to staff availability as well as changes to the projects recruitment, consenting, and sample acquisition. This manuscript describes the successful addition of remote recruitment, consenting, and DNA sampling to YGP workflows during the initial 27-months of pandemic restrictions ending June 30, 2022. Methods: The initial YGP protocol established face-to-face workflow for recruiting, consenting and peripheral blood collection. A telemedicine consent protocol was initiated in April of 2020, and a remote saliva collection was established in October of 2020. De-identified data was extracted from YGP dataset and reported here. Results: At the completion of YGPs initial 36 months (9-months pre-pandemic and 27-months pandemic) YGP enrolled N=4949 volunteers. There were N=1,950 (216.7 per month) volunteers consented pre-pandemic and N=2,999 (111.1 per month) during pandemic. The peak consenting month was February 2020 with N=428. DNA sample acquisition peaked in the pre-pandemic month of February 2020 with N=291 peripheral blood draws, and in the pandemic period the peak DNA acquisition month was November 2020 with N=176 (N=68 peripheral blood draws and N=108 saliva samples). Conclusion: The YGP successfully transitioned from pre-pandemic recruiting, consenting and sample acquisition model that was exclusively face-to-face, to pandemic model that was predominantly remote. The added value of remote recruiting, consenting, and sampling has led to plans for an optimized hybrid model post-pandemic. Keywords: genomics, precision health, COVID-19, cohort
    Keywords covid19
    Language English
    Publishing date 2023-09-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.09.25.23289158
    Database COVID19

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  2. Article ; Online: Shear-wave velocity structure at Mt. Etna from inversion of Rayleigh-wave dispersion patterns (2 s < T < 20 s)

    Roberto Scarpa / Matthias Ohrnberger / Gilberto Saccorotti / Simona Petrosino / Luigia Cristiano

    Annals of Geophysics, Vol 53, Iss 2, Pp 69-

    2010  Volume 78

    Abstract: ... we investigated the dispersion characteristics of medium-to-long period Rayleigh waves (2 s < T < 20 s) using ... sezione di Napoli. The dispersion curves obtained showed phase velocities ranging from 1.5 km/s to 4.0 km ... s in the frequency band 0.05 Hz to 0.45 Hz. We inverted the average phase velocity dispersion curves ...

    Abstract <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} --> In the present study, we investigated the dispersion characteristics of medium-to-long period Rayleigh waves (2 s < T < 20 s) using both single-station techniques (multiple-filter analysis, and phase-match filter) and multichannel techniques (horizontal slowness [p] and angular frequency [~] stack, and cross-correlation) to determine the velocity structure for the Mt. Etna volcano. We applied these techniques to a dataset of teleseisms, as regional and local earthquakes recorded by two broad-band seismic arrays installed at Mt. Etna in 2002 and 2005, during two seismic surveys organized by the Istituto Nazionale di Geofisica e Vulcanologia (INGV), sezione di Napoli. The dispersion curves obtained showed phase velocities ranging from 1.5 km/s to 4.0 km/s in the frequency band 0.05 Hz to 0.45 Hz. We inverted the average phase velocity dispersion curves using a non-linear approach, to obtain a set of shear-wave velocity models with maximum resolution depths of 25 km to 30 km. Moreover, the presence of lateral velocity contrasts was checked by dividing the whole array into seven triangular sub-arrays and inverting the dispersion curves relative to each triangle.
    Keywords Mount Etna ; Rayleigh-wave dispersion ; S-wave velocity modeL ; Non-linear inversion ; Triangle method ; Geophysics. Cosmic physics ; QC801-809 ; Physics ; QC1-999 ; Science ; Q ; DOAJ:Geophysics and Geomagnetism ; DOAJ:Earth and Environmental Sciences
    Language English
    Publishing date 2010-05-01T00:00:00Z
    Publisher Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Fluid migrations and volcanic earthquakes from depolarized ambient noise.

    Petrosino, S / De Siena, L

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 6656

    Abstract: Ambient noise polarizes inside fault zones, yet the spatial and temporal resolution of polarized noise on gas-bearing fluids migrating through stressed volcanic systems is unknown. Here we show that high polarization marks a transfer structure connecting ...

    Abstract Ambient noise polarizes inside fault zones, yet the spatial and temporal resolution of polarized noise on gas-bearing fluids migrating through stressed volcanic systems is unknown. Here we show that high polarization marks a transfer structure connecting the deforming centre of the caldera to open hydrothermal vents and extensional caldera-bounding faults during periods of low seismic release at Campi Flegrei caldera (Southern Italy). Fluids pressurize the Campi Flegrei hydrothermal system, migrate, and increase stress before earthquakes. The loss of polarization (depolarization) of the transfer and extensional structures maps pressurized fluids, detecting fluid migrations after seismic sequences. After recent intense seismicity (December 2019-April 2020), the transfer structure appears sealed while fluids stored in the east caldera have moved further east. Our findings show that depolarized noise has the potential to monitor fluid migrations and earthquakes at stressed volcanoes quasi-instantaneously and with minimum processing.
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-26954-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The predictive value and clinical use of the neurological pupillary index - Authors' reply.

    Galimberti, Stefania / Petrosino, Matteo / Rebora, Paola / Oddo, Mauro / Taccone, Fabio S / Citerio, Giuseppe

    The Lancet. Neurology

    2024  Volume 23, Issue 3, Page(s) 229–230

    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Letter
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00504-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint.

    Schiano Moriello, Aniello / Di Marzo, Vincenzo / Petrosino, Stefania

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 3

    Abstract: There is growing evidence that perturbation of the gut microbiome, known as "dysbiosis", is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract. In this regard, recent studies have ... ...

    Abstract There is growing evidence that perturbation of the gut microbiome, known as "dysbiosis", is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract. In this regard, recent studies have demonstrated that dysbiosis is linked to the pathogenesis of central neuroinflammatory disorders, supporting the existence of the so-called microbiome-gut-brain axis. The endocannabinoid system is a recently recognized lipid signaling system and termed endocannabinoidome monitoring a variety of body responses. Accumulating evidence demonstrates that a profound link exists between the gut microbiome and the endocannabinoidome, with mutual interactions controlling intestinal homeostasis, energy metabolism and neuroinflammatory responses during physiological conditions. In the present review, we summarize the latest data on the microbiome-endocannabinoidome mutual link in health and disease, focalizing the attention on gut dysbiosis and/or altered endocannabinoidome tone that may distort the bidirectional crosstalk between these two complex systems, thus leading to gastrointestinal and metabolic diseases (e.g., idiopathic inflammation, chronic enteropathies and obesity) as well as neuroinflammatory disorders (e.g., neuropathic pain and depression). We also briefly discuss the novel possible dietary interventions based not only on probiotics and/or prebiotics, but also, and most importantly, on endocannabinoid-like modulators (e.g., palmitoylethanolamide) for intestinal health and beyond.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12030348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries-A Systematic Review.

    Petrosino, Stefania / Schiano Moriello, Aniello

    International journal of molecular sciences

    2020  Volume 21, Issue 24

    Abstract: Neuroinflammation is a physiological response aimed at maintaining the homodynamic balance and providing the body with the fundamental resource of adaptation to endogenous and exogenous stimuli. Although the response is initiated with protective purposes, ...

    Abstract Neuroinflammation is a physiological response aimed at maintaining the homodynamic balance and providing the body with the fundamental resource of adaptation to endogenous and exogenous stimuli. Although the response is initiated with protective purposes, the effect may be detrimental when not regulated. The physiological control of neuroinflammation is mainly achieved via regulatory mechanisms performed by particular cells of the immune system intimately associated with or within the nervous system and named "non-neuronal cells." In particular, mast cells (within the central nervous system and in the periphery) and microglia (at spinal and supraspinal level) are involved in this control, through a close functional relationship between them and neurons (either centrally, spinal, or peripherally located). Accordingly, neuroinflammation becomes a worsening factor in many disorders whenever the non-neuronal cell supervision is inadequate. It has been shown that the regulation of non-neuronal cells-and therefore the control of neuroinflammation-depends on the local "
    MeSH term(s) Alzheimer Disease/diet therapy ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amides/administration & dosage ; Amides/metabolism ; Amyotrophic Lateral Sclerosis/diet therapy ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Autism Spectrum Disorder/diet therapy ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/metabolism ; Endocannabinoids/metabolism ; Ethanolamines/administration & dosage ; Ethanolamines/metabolism ; Humans ; Inflammation/diet therapy ; Inflammation/drug therapy ; Inflammation/metabolism ; Metabolic Networks and Pathways ; Multiple Sclerosis/diet therapy ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Nervous System Diseases/diet therapy ; Nervous System Diseases/drug therapy ; Nervous System Diseases/metabolism ; Neurodegenerative Diseases/diet therapy ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Pain/diet therapy ; Pain/drug therapy ; Palmitic Acids/administration & dosage ; Palmitic Acids/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism
    Chemical Substances Amides ; Endocannabinoids ; Ethanolamines ; Palmitic Acids ; palmidrol (6R8T1UDM3V)
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fluid migrations and volcanic earthquakes from depolarized ambient noise

    S. Petrosino / L. De Siena

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: Deep fluids inside volcanoes disrupt the oscillations of signals produced by wind and sea. Imaging this disruption through space and time allows tracking hazardous fluid migrations leading to earthquakes before they reach the surface. ...

    Abstract Deep fluids inside volcanoes disrupt the oscillations of signals produced by wind and sea. Imaging this disruption through space and time allows tracking hazardous fluid migrations leading to earthquakes before they reach the surface.
    Keywords Science ; Q
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability.

    Novak, Leonore / Petrosino, Maria / Pasquo, Alessandra / Chaikuad, Apirat / Chiaraluce, Roberta / Knapp, Stefan / Consalvi, Valerio

    Cancers

    2023  Volume 15, Issue 11

    Abstract: The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase (MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is involved in the regulation of a large variety of cellular processes. The ERK2, ... ...

    Abstract The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase (MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is involved in the regulation of a large variety of cellular processes. The ERK2, activated by phosphorylation, is the principal effector of a central signaling cascade that converts extracellular stimuli into cells. Deregulation of the ERK2 signaling pathway is related to many human diseases, including cancer. This study reports a comprehensive biophysical analysis of structural, function, and stability data of pure, recombinant human non-phosphorylated (NP-) and phosphorylated (P-) ERK2 wild-type and missense variants in the common docking site (CD-site) found in cancer tissues. Because the CD-site is involved in interaction with protein substrates and regulators, a biophysical characterization of missense variants adds information about the impact of point mutations on the ERK2 structure-function relationship. Most of the P-ERK2 variants in the CD-site display a reduced catalytic efficiency, and for the P-ERK2 D321E, D321N, D321V and E322K, changes in thermodynamic stability are observed. The thermal stability of NP-ERK2 and P-ERK2 D321E, D321G, and E322K is decreased with respect to the wild-type. In general, a single residue mutation in the CD-site may lead to structural local changes that reflects in alterations in the global ERK2 stability and catalysis.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15112938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The needs and difficulties during the return to work after a stroke: a systematic review and meta-synthesis of qualitative studies.

    Nuccio, Emanuela / Petrosino, Francesco / Simeone, Silvio / Alvaro, Rosaria / Vellone, Ercole / Pucciarelli, Gianluca

    Disability and rehabilitation

    2023  , Page(s) 1–14

    Abstract: Purpose: To describe which needs and difficulties are experienced by stroke patients and caregivers regarding their return to work and to synthesise the lived experiences of stroke patients and caregivers.: Materials and methods: A systematic review ... ...

    Abstract Purpose: To describe which needs and difficulties are experienced by stroke patients and caregivers regarding their return to work and to synthesise the lived experiences of stroke patients and caregivers.
    Materials and methods: A systematic review and metasynthesis was conducted on PubMed, CINAHL, Scopus, Web of Sciences and PsycInfo, in according to the Enhancing Transparency in Reporting the Synthesis of Qualitative Research. Studies eligible for the review had to fulfil the following inclusion criteria: qualitative studies, stroke patients and their caregivers in a working age (approximately from 18 to 65 years old), discharged from the hospital.
    Results: Thirty-eight studies involving stroke patients and caregivers were included in this review. For the stroke patients' group, three main themes were identified: (a) Towards the future; (b) Professional support in return to work; and (c) return to work and employment perspective, while for caregivers two main themes were: (a) daily life challenges and role overload; and (b) employment challenges.
    Conclusions: Integrating public employment, social and health services, support for job placement, return to work, and social participation of stroke patients should be more supported in individual rehabilitation programs to help stroke survivors and caregivers in their return-to-work process.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2023.2287016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Directional amplification and ground motion polarization in Casamicciola area (Ischia volcanic island) after the 21 August 2017 Md 4.0 earthquake

    M. Pischiutta / S. Petrosino / R. Nappi

    Frontiers in Earth Science, Vol

    2022  Volume 10

    Abstract: In this paper, we investigated ground motion directional amplification and horizontal polarization using ambient noise measurements performed in the northern sector of Ischia Island which suffered damage (VIII EMS) during the 21 August 2017, Md 4.0 ... ...

    Abstract In this paper, we investigated ground motion directional amplification and horizontal polarization using ambient noise measurements performed in the northern sector of Ischia Island which suffered damage (VIII EMS) during the 21 August 2017, Md 4.0 earthquake. Over 70 temporary seismic stations were installed by the INGV EMERSITO task force, whose aim is to monitor site effects after damaging earthquakes in Italy. To investigate ground motion directional amplification effects, we have applied three different techniques, testing their performance: the HVSR calculation by rotating the two horizontal components, the covariance matrix analysis, and time–frequency domain polarization analysis. These techniques resulted in coherent outcomes, highlighting the occurrence of directional amplification and polarization effects in two main sectors of the investigated area. Our results suggest an interesting pattern for ground motion polarization, that is mainly controlled by recent fault activity and hydrothermal fluid circulation characterizing the northern sector of the Ischia Island.
    Keywords site amplification effects ; directional amplification ; ground motion polarization ; Casamicciola earthquake ; fault damage zone ; coseismic ruptures ; Science ; Q
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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