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Article ; Online: Oncolytic virus-based combination therapy in breast cancer.

Bahreyni, Amirhossein / Mohamud, Yasir / Luo, Honglin

2024 Volume 585, Page(s) 216634

Abstract: Breast cancer continues to pose significant challenges in the field of oncology, necessitating innovative treatment approaches. Among these, oncolytic viruses have emerged as a promising frontier in the battle against various types of cancer, including ... ...

Abstract	Breast cancer continues to pose significant challenges in the field of oncology, necessitating innovative treatment approaches. Among these, oncolytic viruses have emerged as a promising frontier in the battle against various types of cancer, including breast cancer. These viruses, often genetically modified, have the unique ability to selectively infect and destroy cancer cells while leaving healthy cells unharmed. Their efficacy in tumor eradication is not only owing to direct cell lysis but also relies on their capacity to activate the immune system, thereby eliciting a potent and sustained antitumor response. While oncolytic viruses represent a significant advancement in cancer treatment, the complexity and adaptability inherent to cancer require a diverse array of therapies. The concept of combining oncolytic viruses with other treatment modalities, such as chemotherapy, immunotherapy, and targeted therapies, has received significant attention. This synergistic approach capitalizes on the strengths of each therapy, thus creating a comprehensive strategy to tackle the heterogeneous and evolving nature of breast cancer. The purpose of this review is to provide an in-depth discussion of preclinical and clinical viro-based combination therapy in the context of breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/therapy ; Breast Neoplasms/pathology ; Oncolytic Viruses/genetics ; Oncolytic Virotherapy ; Neoplasms/pathology ; Immunotherapy ; Combined Modality Therapy
Language	English
Publishing date	2024-02-01
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2024.216634
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Article ; Online: Mitochondria Dysfunction at the Heart of Viral Myocarditis: Mechanistic Insights and Therapeutic Implications.

Mohamud, Yasir / Li, Boaz / Bahreyni, Amirhossein / Luo, Honglin

Viruses

2023 Volume 15, Issue 2

Abstract: The myocardium/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume. As the resident "powerhouse" of cells, mitochondria help to fuel the high energy demands of a ... ...

Abstract	The myocardium/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume. As the resident "powerhouse" of cells, mitochondria help to fuel the high energy demands of a continuously beating myocardium. It is no surprise that mitochondrial dysfunction underscores the pathogenesis of many cardiovascular ailments, including those of viral origin such as virus-induced myocarditis. Enteroviruses have been especially linked to injuries of the myocardium and its sequelae dilated cardiomyopathy for which no effective therapies currently exist. Intriguingly, recent mechanistic insights have demonstrated viral infections to directly damage mitochondria, impair the mitochondrial quality control processes of the cell, such as disrupting mitochondrial antiviral innate immune signaling, and promoting mitochondrial-dependent pathological inflammation of the infected myocardium. In this review, we briefly highlight recent insights on the virus-mitochondria crosstalk and discuss the therapeutic implications of targeting mitochondria to preserve heart function and ultimately combat viral myocarditis.
MeSH term(s)	Humans ; Myocarditis/therapy ; Myocardium ; Virus Diseases/therapy ; Myocytes, Cardiac ; Mitochondria
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020351
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Article ; Online: Recent advancements in immunotherapy of melanoma using nanotechnology-based strategies.

Bahreyni, Amirhossein / Mohamud, Yasir / Luo, Honglin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 159, Page(s) 114243

Abstract: Melanoma is a malignant tumor that accounts for the deadliest form of skin cancers. Despite the significant efforts made recently for development of immunotherapeutic strategies including using immune checkpoint inhibitors and cancer vaccines, the ... ...

Abstract	Melanoma is a malignant tumor that accounts for the deadliest form of skin cancers. Despite the significant efforts made recently for development of immunotherapeutic strategies including using immune checkpoint inhibitors and cancer vaccines, the clinical outcomes are unsatisfying. Different factors affect efficient cancer immunotherapy such as side-effects, immunosuppressive tumor microenvironment, and tumor heterogeneity. In the past decades, various nanotechnology-based approaches have been developed to enhance the efficacy of cancer immunotherapy, in addition to diminishing the toxicity associated with it. Several studies have shown that proper application of nanomaterials can revolutionize the outcome of immunotherapy in diverse melanoma models. This review summarizes the recent advancement in the integration of nanotechnology and cancer immunotherapy in melanoma treatment. The importance of nanomaterials and their therapeutic advantages for patients with melanoma are also discussed.
MeSH term(s)	Humans ; Melanoma/pathology ; Immunotherapy ; Skin Neoplasms/therapy ; Nanotechnology ; Tumor Microenvironment
Language	English
Publishing date	2023-01-13
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114243
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Article ; Online: Glycerol/organic acid-based ternary deep eutectic solvents as a green approach to recover chitin with different molecular weight from seafood waste.

Wang, Yi / Zhu, Honglin / Qiao, Mingyu / Luo, Yangchao

International journal of biological macromolecules

2023 Volume 257, Issue Pt 2, Page(s) 128714

Abstract: In this study, we designed a green and efficient approach for the fractionation of high-purity chitin with tunable molecular weights from seafood waste. This was achieved by using ternary deep eutectic solvents (TDESs) composed of choline chloride as a ... ...

Abstract	In this study, we designed a green and efficient approach for the fractionation of high-purity chitin with tunable molecular weights from seafood waste. This was achieved by using ternary deep eutectic solvents (TDESs) composed of choline chloride as a hydrogen bond acceptor, glycerol as the polyol-based hydrogen bond donor, together with lactic acid or malic acid. Two binary DESs and four TDESs were evaluated for their ability to recover chitin. The extracted chitin exhibited not only high yield with excellent protein and mineral removal, but also high purity with similar crystallinity patterns as standard chitin. However, the average molecular weights, viscosity behavior and morphology of chitin extracted by DESs were varied and influenced by organic acid to glycerol molar ratios. The molecular weights of chitin extracted by lactic acid-based TDES ranged from 264 kDa to 541 kDa, but malic acid-based TEDS displayed a stronger depolymerization effect, resulting in chitin with a smaller molecular weight of less than 300 kDa. Lactic acid-based TDES revealed that the purity of chitin remained higher than 92 % after three cycles. This sustainable and environmentally friendly extraction system holds great potential to recover chitin from seafood waste, opening a new era for chitin extraction and applications.
MeSH term(s)	Chitin/chemistry ; Glycerol ; Solvents/chemistry ; Molecular Weight ; Deep Eutectic Solvents ; Organic Chemicals ; Lactic Acid ; Seafood ; Choline/chemistry ; Malates
Chemical Substances	Chitin (1398-61-4) ; Glycerol (PDC6A3C0OX) ; malic acid (817L1N4CKP) ; Solvents ; Deep Eutectic Solvents ; Organic Chemicals ; Lactic Acid (33X04XA5AT) ; Choline (N91BDP6H0X) ; Malates
Language	English
Publishing date	2023-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128714
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Article ; Online: Engineering a facile and versatile nanoplatform to facilitate the delivery of multiple agents for targeted breast cancer chemo-immunotherapy.

Bahreyni, Amirhossein / Mohamud, Yasir / Zhang, Jingchun / Luo, Honglin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114789

Abstract: There is growing evidence showing that single administration of immunotherapeutic agents has limited efficacy in a number of cancer patients mainly due to tumor heterogeneity and immunosuppressive tumor microenvironment. In this study, a novel ... ...

Abstract	There is growing evidence showing that single administration of immunotherapeutic agents has limited efficacy in a number of cancer patients mainly due to tumor heterogeneity and immunosuppressive tumor microenvironment. In this study, a novel nanoparticle-based strategy was applied to achieve efficient tumor-targeted therapy by combining chemotherapeutic agents, i.e., doxorubicin (Dox) and melittin (Mel), with an immune checkpoint inhibitor (PD-L1 DsiRNA). The proposed nanoparticle was prepared by the formation of a complex between Mel and PD-L1 DsiRNA (Dicer-substrate short-interfering RNA), followed by the loading of Dox. The surface of the resultant particles (DoxMel/PD-L1 DsiRNA) was then modified with hyaluronic acid (HA) to increase their stability and distribution. In addition, HA can also act as a tumor-targeting agent through binding to its receptor CD44 on the surface of cancer cells. We demonstrated that the surface engineering of DoxMel/PD-L1 DsiRNA with HA significantly enhances its specificity towards breast cancer cells. Moreover, we observed a noticeable reduction in PD-L1 expression together with a synergistic effect of Dox and Mel on killing cancer cells and inducing immunogenic cell death, leading to significantly diminished tumor growth in 4T1-breast tumor bearing Balb/c mice, improved survival rate and extensive infiltration of immune cells including cytotoxic T cells into the tumor microenvironment. Safety analysis revealed that there is no significant toxicity associated with the developed nanoparticle. All in all, the proposed targeted combination treatment strategy can be considered as a useful method to reduce cancer-associated mortality.
MeSH term(s)	Animals ; Mice ; B7-H1 Antigen ; Drug Delivery Systems/methods ; Doxorubicin ; Neoplasms/drug therapy ; Nanoparticles ; Immunotherapy ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; Doxorubicin (80168379AG)
Language	English
Publishing date	2023-04-27
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114789
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Article ; Online: Adsorption mechanisms of hydrogels for heavy metal and organic dyes removal

Honglin Zhu / Sunni Chen / Yangchao Luo

Journal of Agriculture and Food Research, Vol 12, Iss , Pp 100552- (2023)

A short review

2023

Abstract: Heavy metal and organic dyes produced in modern industrialization development have polluted the natural resources human live by due to their adverse effects on all biological organisms. Developing effective, economical and friendly strategies to tackle ... ...

Abstract	Heavy metal and organic dyes produced in modern industrialization development have polluted the natural resources human live by due to their adverse effects on all biological organisms. Developing effective, economical and friendly strategies to tackle environmental pollution has been a hotspot in recent years, among which adsorption of chemical pollutants from water has been considered of utmost importance. Hydrogel-based adsorbents with three-dimensional porous structures and versatile functional groups have become the first choice, whose adsorption involves several mechanisms. In this perspective article, electrostatic interactions, hydrogen bonding, π-π interactions, ion exchange, surface complexation and coordination/chelation were introduced in detail to provide an overview for a better understanding of the action mechanisms of various hydrogels. Combining two or more mechanisms is advantageous to gain great adsorption capacity, which could be achieved via physical or chemical modification of hydrogels. This short review aims to provide theoretical guidance to design and prepare hydrogels for applications in water treatment.
Keywords	Hydrogel ; Adsorption mechanism ; Pollutant ; Water treatment ; Agriculture (General) ; S1-972 ; Nutrition. Foods and food supply ; TX341-641
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of Group B Coxsackievirus as an Oncolytic Virus: Opportunities and Challenges.

Liu, Huitao / Luo, Honglin

Viruses

2021 Volume 13, Issue 6

Abstract: Oncolytic viruses have emerged as a promising strategy for cancer therapy due to their dual ability to selectively infect and lyse tumor cells and to induce systemic anti-tumor immunity. Among various candidate viruses, coxsackievirus group B (CVBs) have ...

Abstract	Oncolytic viruses have emerged as a promising strategy for cancer therapy due to their dual ability to selectively infect and lyse tumor cells and to induce systemic anti-tumor immunity. Among various candidate viruses, coxsackievirus group B (CVBs) have attracted increasing attention in recent years. CVBs are a group of small, non-enveloped, single-stranded, positive-sense RNA viruses, belonging to species
MeSH term(s)	Animals ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Enterovirus B, Human/genetics ; Enterovirus B, Human/physiology ; Genetic Engineering/methods ; Genetic Therapy/adverse effects ; Genetic Therapy/methods ; Genetic Vectors/genetics ; Humans ; Neoplasms/therapy ; Oncolytic Virotherapy/adverse effects ; Oncolytic Virotherapy/methods ; Oncolytic Viruses/genetics ; Treatment Outcome ; Virus Replication
Language	English
Publishing date	2021-06-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13061082
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Article ; Online: Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray.

Huang, Jing / Zhu, Honglin / Liu, Sijia / Li, Mengtao / Li, Yisha / Luo, Hui / Zuo, Xiaoxia

Arthritis research & therapy

2024 Volume 26, Issue 1, Page(s) 29

Abstract: Background: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild ... ...

Abstract	Background: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild and in the early stages to improve the prognosis. Methods: We screened for serum biomarkers using a proteomic antibody microarray that simultaneously assessed 1000 proteins. Differentially expressed proteins were further verified using ELISA. Finally, we performed a correlation analysis using clinical data. Results: We identified 125 differentially expressed proteins, of which calcitonin, sclerostin (SOST), CD40, and fibronectin were selected for further verification. Serum calcitonin and SOST levels were significantly elevated in all SSc pulmonary complication subgroups, whereas serum calcitonin levels were higher in the SSc with PAH subgroup than in the SSc without PAH and ILD subgroup. Serum SOST levels were possibly associated with the presence of ILD and positively related to the presence of cardiac and gastrointestinal involvement. Serum CD40 and calcitonin levels appeared to be positively related to the presence of renal involvement, and serum calcitonin was also positively related to the presence of gastrointestinal involvement. Conclusions: This study indicated that serum calcitonin and SOST levels may be promising biomarkers for SSc-related PAH and ILD, respectively. Further research is needed to verify this result and understand the underlying mechanisms.
MeSH term(s)	Humans ; Calcitonin ; Hypertension, Pulmonary/diagnosis ; Proteomics ; Scleroderma, Systemic/diagnosis ; Lung Diseases, Interstitial/etiology ; Pulmonary Arterial Hypertension ; Biomarkers ; Antibodies
Chemical Substances	Calcitonin (9007-12-9) ; Biomarkers ; Antibodies
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-024-03267-z
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Zs.A 5490: Show issues

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Article ; Online: Synergistic Viro-chemoimmunotherapy in Breast Cancer Enabled by Bioengineered Immunostimulatory Exosomes and Dual-Targeted Coxsackievirus B3.

Bahreyni, Amirhossein / Mohamud, Yasir / Ashraf Nouhegar, Sanaz / Zhang, Jingchun / Luo, Honglin

ACS nano

2024 Volume 18, Issue 5, Page(s) 4241–4255

Abstract: Breast cancer's immunosuppressive environment hinders effective immunotherapy, but oncolytic viruses hold promise for addressing this challenge by targeting tumor cells and altering the microenvironment. Yet, neutralizing antibodies and immune clearance ... ...

Abstract	Breast cancer's immunosuppressive environment hinders effective immunotherapy, but oncolytic viruses hold promise for addressing this challenge by targeting tumor cells and altering the microenvironment. Yet, neutralizing antibodies and immune clearance impede their clinical utility. This study explored microRNA-modified coxsackievirus B3 (miR-CVB3), an innovative oncolytic virus, and its potential in breast cancer treatment. It investigated miR-CVB3's impact on immune-related proteins and utilized exosomes as both protective shields and delivery carriers. Results demonstrated miR-CVB3's capacity to reshape immune-related protein profiles toward a more immunostimulatory state and enhance exosome-mediated immune cell activation. Notably, cancer cell-released exosomes encapsulating miR-CVB3 (ExomiR-CVB3) maintained its antitumor cytotoxicity and bolstered its immunostimulatory effects. Moreover, ExomiR-CVB3 shielded miR-CVB3 from neutralizing antibodies and rapid immune clearance when it was systemically administered. Building on these findings, ExomiR-CVB3 was engineered with the AS1411 aptamer and doxorubicin (ExomiR-CVB3/DoxApt), enhancing therapeutic efficacy. This notable approach, combining genomic modification, aptamer surface decoration, and doxorubicin addition, demonstrated safe delivery of CVB3 to cancer cells. Comprehensive
MeSH term(s)	Humans ; Female ; Enterovirus B, Human/genetics ; Breast Neoplasms/drug therapy ; Exosomes ; Immunization ; MicroRNAs/genetics ; Antibodies, Neutralizing ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Tumor Microenvironment
Chemical Substances	MicroRNAs ; Antibodies, Neutralizing ; Doxorubicin (80168379AG)
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09491
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Article ; Online: Strong, tough, and elastic poly(vinyl alcohol)/polyacrylamide DN hydrogels based on the Hofmeister effect for articular cartilage replacement.

Yin, Cheng / Huang, Zhiwu / Zhang, Yunge / Ren, Kaijing / Liu, Songtao / Luo, Honglin / Zhang, Quanchao / Wan, Yizao

Journal of materials chemistry. B

2024 Volume 12, Issue 12, Page(s) 3079–3091

Abstract: Traditional hydrogels are usually weak and brittle, which limit their application in articular cartilage replacement because cartilage is generally strong, tough, and elastic in nature. Therefore, it is highly desirable to construct hydrogels to mimic ... ...

Abstract	Traditional hydrogels are usually weak and brittle, which limit their application in articular cartilage replacement because cartilage is generally strong, tough, and elastic in nature. Therefore, it is highly desirable to construct hydrogels to mimic the mechanical properties of the native articular cartilage. Herein, in this work, poly(vinyl alcohol)/polyacrylamide (PVA/PAM) DN hydrogels were prepared by
MeSH term(s)	Cartilage, Articular ; Polyvinyl Alcohol/chemistry ; Ethanol ; Hydrogels/chemistry ; Ions ; Acrylic Resins
Chemical Substances	Polyvinyl Alcohol (9002-89-5) ; polyacrylamide (9003-05-8) ; Ethanol (3K9958V90M) ; Hydrogels ; Ions ; Acrylic Resins
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02637j
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