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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Zs.A 5995: Show issues

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Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117480

Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

Abstract	Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated. Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism. Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments. Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry. Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
MeSH term(s)	Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-11-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117480
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Article ; Online: Seasonal variations, source apportionment and dry deposition of chemical species of total suspended particulate in Pengjia Yu Island, East China Sea.

Yu-Xiao, Li / Shu-Han, Liu / Li, Luo / Shu-Di, Yang / Bin-Yu, Lu / Chen, Wang / Shih-Chieh, Hsu / Shuh-Ji, Kao

Marine pollution bulletin

2023 Volume 187, Page(s) 114608

Abstract: ... and analyzed from January to December 2010 in Pengjia Yu Island, an open region in East China Sea (ECS ...

Abstract	Total of 172 total suspended particulate (TSP) samples and its chemical compositions were collected and analyzed from January to December 2010 in Pengjia Yu Island, an open region in East China Sea (ECS). Despite the predominance of sea-salt major ions (Na
MeSH term(s)	Particulate Matter/analysis ; Air Pollutants/analysis ; Seasons ; Dust/analysis ; China ; Ions/analysis ; Minerals ; Coal/analysis ; Environmental Monitoring ; Aerosols/analysis
Chemical Substances	Particulate Matter ; Air Pollutants ; Dust ; Ions ; Minerals ; Coal ; Aerosols
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.114608
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Article ; Online: Correction: Yu et al. Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy.

Yu, Albert / Dai, Xiaoyong / Wang, Zixian / Chen, Huaqing / Guo, Bing / Huang, Laiqiang

Biosensors

2022 Volume 12, Issue 10

Abstract: In the published publication [ ... ]. ...

Abstract	In the published publication [...].
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12100794
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Article: Prescription characteristics of Xue-Fu-Zhu-Yu-Tang in pain management: a population-based study using the National Health Insurance Research Database in Taiwan.

Kuo, Chun-En / Hsu, Sheng-Feng / Chen, Ching-Chih / Wu, Szu-Ying / Hung, Yu-Chiang / Hsu, Chung Y / Tsai, I-Ju / Hu, Wen-Long

Frontiers in pharmacology

2023 Volume 14, Page(s) 1233156

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1233156
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Article ; Online: In reply of the comment "Is oral lichen planus potentially malignant: A reply to Yu-Wei Chiu et al".

Chiu, Yu-Wei / Su, Yee-Fun / Yang, Cheng-Chieh / Liu, Chung-Ji / Chen, Yi-Ju / Cheng, Han-Chieh / Wu, Cheng-Hsien / Chen, Pei-Yin / Lee, Yu-Hsien / Chen, Yen-Lin / Chen, Yi-Tzu / Peng, Chih-Yu / Lu, Ming-Yi / Yu, Chuan-Hang / Kao, Shou-Yen / Fwu, Chyng-Wen / Huang, Yu-Feng

Oral diseases

2022 Volume 29, Issue 5, Page(s) 2317–2318

MeSH term(s)	Humans ; Lichen Planus, Oral/complications ; Cell Transformation, Neoplastic ; Mouth Neoplasms
Language	English
Publishing date	2022-05-04
Publishing country	Denmark
Document type	Letter
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14214
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Zs.A 4427: Show issues

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Article ; Online: Correction for Yu et al., "A Mouse

Yu, Zhenbao / Chen, Taiping / Hébert, Josée / Li, En / Richard, Stéphane

Molecular and cellular biology

2017 Volume 37, Issue 17

Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00298-17
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Zs.A 1666: Show issues

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Article ; Online: Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

Lv, Shuquan / Fan, Lirong / Chen, Xiaoting / Su, Xiuhai / Dong, Li / Wang, Qinghai / Wang, Yuansong / Zhang, Hui / Cui, Huantian / Zhang, Shufang / Wang, Lixin

Journal of diabetes research

2024 Volume 2024, Page(s) 9990304

Abstract: ... effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment ...

Abstract	Background: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. Purpose: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis. Materials and methods: We established a DN mouse model to investigate the therapeutic effect of JPGS in a DN mouse model. Subsequently, we examined the effects of JPGS on ferroptosis- and glutathione peroxidase 4 (GPX4) pathway-related indices. Finally, we validated whether JPGS inhibited ferroptosis in DN mice via the GPX4 pathway using GPX4 inhibitor and ferroptosis inhibitors. Results: The results indicate that JPGS has a therapeutic effect on DN mice by improving kidney function and reducing inflammation. Additionally, JPGS treatment decreased iron overload and oxidative stress levels while upregulating the expression of GPX4 pathway-related proteins. Moreover, JPGS demonstrated a similar therapeutic effect as Fer-1 in the context of DN treatment, and RSL3 was able to counteract the therapeutic effect of JPGS and antiferroptotic effect. Conclusion: JPGS has significant therapeutic and anti-inflammatory effects on DN mice, and its mechanism is mainly achieved by upregulating the expression of GPX4 pathway-related proteins, thereby alleviating iron overload and ultimately reducing ferroptosis.
MeSH term(s)	Animals ; Mice ; Diabetic Nephropathies/drug therapy ; Ferroptosis ; Disease Models, Animal ; Inflammation ; Iron Overload/complications ; Iron Overload/drug therapy ; Diabetes Mellitus
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2024/9990304
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Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage.

Xue, Dao-Jin / Zhen, Zheng / Wang, Ke-Xin / Zhao, Jia-Lin / Gao, Yao / Chen, Yu-Peng / Shen, You-Bi / Peng, Zi-Zhuang / Guan, Dao-Gang / Huang, Tao

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 103

Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

Abstract	Background: Chinese herbal medicine (CHM) is characterized by "multi- compounds, multi-targets and multi-pathway", which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Methods: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. Results: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Conclusions: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
MeSH term(s)	Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Reproducibility of Results
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03577-2
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Article: Effect of different drying temperatures on the rehydration of the fruiting bodies of Yu Muer (

Chen, Yanqi / Lv, Zhiwen / Liu, Zhirun / Li, Xiao / Li, Changtian / Sossah, Frederick Leo / Song, Bing / Li, Yu

Food science & nutrition

2020 Volume 8, Issue 11, Page(s) 6037–6046

Abstract: ... the browning of Yu Muer fruiting bodies under room temperature water rehydration conditions, with a citric acid ... of the Yu Muer industry and for promoting the commercial processing of Yu Muer fruiting bodies slices. ...

Abstract	In this study, the color of the dry fruiting bodies, fresh weight (FW): dry weight (DW) ratio, amino acids, and total phenolics, which are of nutritional or commercial interest, were compared among different drying temperature treatments. The effect of rehydration methods and color protection reagents on the fruiting body color, polyphenol oxidase (PPO) activity, and browning inhibition rate were evaluated. The results showed that drying with hot air at 65℃ was quickest and resulted in a better color without compromising the FW:DW ratio and rehydration ratio of the fruiting bodies. Furthermore, some reactions that occurred under high temperatures increased the content of protein, amino acids, and total phenolics. Soaking after boiling was the most suitable rehydration method, leading to the lowest PPO activity (39.87 ± 1.35 U/g). All of the four analyzed color protection reagents could significantly inhibit the browning of Yu Muer fruiting bodies under room temperature water rehydration conditions, with a citric acid content of 6 g/L showing the best performance. These results provide technical support for the development of the Yu Muer industry and for promoting the commercial processing of Yu Muer fruiting bodies slices.
Language	English
Publishing date	2020-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.1891
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